Introduction to Whole Transcriptome Analysis
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10.1016/J.OMTN.2021.05.008
Here we verified radioprotection of NOFD against GI tract by animal model and performed whole-transcriptome analysis to fully elucidate radioprotective mechanism from FIH/HIF axis against GI syndrome.
Here we verified radioprotection of NOFD against GI tract by animal model and performed whole-transcriptome analysis to fully elucidate radioprotective mechanism from FIH/HIF axis against GI syndrome.
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10.1093/molbev/msab102
Whole-transcriptome analysis revealed consistent differentiation between ancestral and soft-selected populations, and that both emergent phenotypes and gene expression tended to revert in the soft-selected lines.
Whole-transcriptome analysis revealed consistent differentiation between ancestral and soft-selected populations, and that both emergent phenotypes and gene expression tended to revert in the soft-selected lines.
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10.3390/ijms221910810
Whole-transcriptome analysis using microarray technology unraveled the molecular signatures of these cells.
Whole-transcriptome analysis using microarray technology unraveled the molecular signatures of these cells.
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10.1016/j.jid.2021.08.437
Whole-transcriptome analysis showed that type I interferon-related genes were significantly upregulated in the combination treatment group.
Whole-transcriptome analysis showed that type I interferon-related genes were significantly upregulated in the combination treatment group.
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10.3389/fgene.2021.585556
In this review, we aim to summarize the studies that associate the tissue microbiome, rather than gut microbiome, with cancer and other diseases using whole-transcriptome analysis, along with 16S rRNA analysis.
In this review, we aim to summarize the studies that associate the tissue microbiome, rather than gut microbiome, with cancer and other diseases using whole-transcriptome analysis, along with 16S rRNA analysis.
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10.1038/s41419-021-03409-0
A whole-transcriptome analysis of embryos lacking Wwc2 revealed a massive deregulation of gene expression with impact on cell fate determination, cell metabolism, and angiogenesis.
A whole-transcriptome analysis of embryos lacking Wwc2 revealed a massive deregulation of gene expression with impact on cell fate determination, cell metabolism, and angiogenesis.
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10.1016/j.ijrobp.2021.07.909
Cell viability was performed by Real-time Cell assay (RTCA), whole-transcriptome analysis by RNA sequencing, western blot analyses, immunofluorescent quantification of γ-H2AX double strand break foci, and colonogenic survival.
Cell viability was performed by Real-time Cell assay (RTCA), whole-transcriptome analysis by RNA sequencing, western blot analyses, immunofluorescent quantification of γ-H2AX double strand break foci, and colonogenic survival.
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10.1038/s41389-021-00344-9
In this study, we combined whole-transcriptome analysis with multiple research methods to investigate the role of CtBP1/2 in genomic stability.
In this study, we combined whole-transcriptome analysis with multiple research methods to investigate the role of CtBP1/2 in genomic stability.
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10.1016/J.ENVEXPBOT.2021.104588
Whole-transcriptome analysis was carried out after 1 day of 15 % PEG treatment in 22-day Trichoderma-inoculated and non-inoculated plants.
Whole-transcriptome analysis was carried out after 1 day of 15 % PEG treatment in 22-day Trichoderma-inoculated and non-inoculated plants.
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10.3390/jof7050398
In this study we identified a novel PKS family responsible for the biosynthesis of biruloquinone through whole-transcriptome analysis.
In this study we identified a novel PKS family responsible for the biosynthesis of biruloquinone through whole-transcriptome analysis.
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10.7554/eLife.67714
Whole-transcriptome analysis of cholinergic interneurons and medium spiny projection neurons laser-microdissected from the human putamen showed selective expression of GNRH1 and GNRHR1 autoreceptors in the cholinergic cell population and uncovered the detailed transcriptome profile and molecular connectome of these two cell types.
Whole-transcriptome analysis of cholinergic interneurons and medium spiny projection neurons laser-microdissected from the human putamen showed selective expression of GNRH1 and GNRHR1 autoreceptors in the cholinergic cell population and uncovered the detailed transcriptome profile and molecular connectome of these two cell types.
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10.1101/2021.03.12.435150
Whole-transcriptome analysis identified 394 up- and 1,471 down-regulated genes.
Whole-transcriptome analysis identified 394 up- and 1,471 down-regulated genes.
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10.1016/j.stemcr.2021.03.010
Whole-transcriptome analysis demonstrated that these iMGs resemble human fetal/adult microglia but not human monocytes.
Whole-transcriptome analysis demonstrated that these iMGs resemble human fetal/adult microglia but not human monocytes.
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10.1007/s11103-021-01148-6
Here, we performed whole-transcriptome analysis and de novo assembly using next generation sequencing in S.
Here, we performed whole-transcriptome analysis and de novo assembly using next generation sequencing in S.
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10.52547/rbmb.9.4.478
Methods
In this study, whole-transcriptome analysis was performed with RNA sequencing on tumoral and non-tumoral tissue samples from patients with early-stage gastric cancer.
Methods
In this study, whole-transcriptome analysis was performed with RNA sequencing on tumoral and non-tumoral tissue samples from patients with early-stage gastric cancer.
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10.1042/BSR20203005
Whole-transcriptome analysis was performed by RNA sequencing (RNA-Seq) to evaluate the profiling of long non-coding RNAs (lncRNAs) and messenger RNAs (mRNAs).
Whole-transcriptome analysis was performed by RNA sequencing (RNA-Seq) to evaluate the profiling of long non-coding RNAs (lncRNAs) and messenger RNAs (mRNAs).
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10.21203/RS.3.RS-735519/V1
ConclusionsWhole-transcriptome analysis of serum NDEs reveals specific signature for ASD in Chinese children, which may help detect predictive biomarkers and molecular mechanisms of ASD, and provide reference for diagnoses and therapeutic management of the disease.
ConclusionsWhole-transcriptome analysis of serum NDEs reveals specific signature for ASD in Chinese children, which may help detect predictive biomarkers and molecular mechanisms of ASD, and provide reference for diagnoses and therapeutic management of the disease.
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10.3390/ijms22116059
Whole-transcriptome analysis of BET-dependent gene networks suggests a major role of nuclear-factor kappa b and transforming growth factor-beta in the development of cardiac fibrosis and systolic dysfunction.
Whole-transcriptome analysis of BET-dependent gene networks suggests a major role of nuclear-factor kappa b and transforming growth factor-beta in the development of cardiac fibrosis and systolic dysfunction.
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10.1073/pnas.2026327118
Whole-transcriptome analysis of WDR77 mutant patient-derived thyroid tissue showed changes in pathways enriched in the processes of cell cycle promotion and apoptosis inhibition.
Whole-transcriptome analysis of WDR77 mutant patient-derived thyroid tissue showed changes in pathways enriched in the processes of cell cycle promotion and apoptosis inhibition.
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10.1101/2021.03.04.433872
Whole-transcriptome analysis of cholinergic interneurons and medium spiny projection neurons laser-microdissected from the human putamen confirmed selective expression of GNRH1 and GNRHR1 autoreceptors in cholinergic cells and uncovered the detailed transcriptome profile and molecular connectome of these two cell types.
Whole-transcriptome analysis of cholinergic interneurons and medium spiny projection neurons laser-microdissected from the human putamen confirmed selective expression of GNRH1 and GNRHR1 autoreceptors in cholinergic cells and uncovered the detailed transcriptome profile and molecular connectome of these two cell types.
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10.1186/s12863-021-00959-2
Results We conducted a whole-transcriptome analysis of the differentially expressed genes (DEGs) in the mutant and normal capitula using third-generation and second-generation sequencing techniques.
Results We conducted a whole-transcriptome analysis of the differentially expressed genes (DEGs) in the mutant and normal capitula using third-generation and second-generation sequencing techniques.
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10.1186/s13567-021-00898-x
In whole-transcriptome analysis of bMECs at 6 h post-infection (hpi), there were 3453 up-regulated and 3470 down-regulated genes for HLJ-D2, whereas for HB-AF5, there were 2891 up-regulated and 3278 down-regulated genes ( P < 0.
In whole-transcriptome analysis of bMECs at 6 h post-infection (hpi), there were 3453 up-regulated and 3470 down-regulated genes for HLJ-D2, whereas for HB-AF5, there were 2891 up-regulated and 3278 down-regulated genes ( P < 0.
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10.3389/fvets.2021.680182
However, whole-transcriptome analysis for GCs of buffalo has yet to be reported.
However, whole-transcriptome analysis for GCs of buffalo has yet to be reported.
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10.1016/j.jaad.2021.06.013
The genetic basis of many of these conditions has been deciphered, and mutation analysis by next-generation sequencing approaches, including whole-exome sequencing, whole-genome sequencing, and whole-transcriptome analysis, are now increasingly part of the diagnostic process.
The genetic basis of many of these conditions has been deciphered, and mutation analysis by next-generation sequencing approaches, including whole-exome sequencing, whole-genome sequencing, and whole-transcriptome analysis, are now increasingly part of the diagnostic process.
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10.3390/cancers13030527
We performed an in vivo study and a whole-transcriptome analysis to determine whether PARP inhibition enhanced gemcitabine-based chemoradiosensitization of pancreatic cancer xenografts, combined with either proton or photon irradiation.
We performed an in vivo study and a whole-transcriptome analysis to determine whether PARP inhibition enhanced gemcitabine-based chemoradiosensitization of pancreatic cancer xenografts, combined with either proton or photon irradiation.
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10.1016/j.omtn.2021.05.008
Here we verified radioprotection of NOFD for the GI tract by an animal model and performed whole-transcriptome analysis to fully elucidate the radioprotective mechanism from the FIH/HIF axis against GI syndrome.
Here we verified radioprotection of NOFD for the GI tract by an animal model and performed whole-transcriptome analysis to fully elucidate the radioprotective mechanism from the FIH/HIF axis against GI syndrome.
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10.1007/s11060-021-03823-6
Histopathological review revealed embryonal-type rhabdomyosarcoma, and whole-transcriptome analysis revealed PAX3 (EX6)-NCOA2 (EX12) fusion.
Histopathological review revealed embryonal-type rhabdomyosarcoma, and whole-transcriptome analysis revealed PAX3 (EX6)-NCOA2 (EX12) fusion.
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10.3390/cells8080878
Here, we performed whole-transcriptome analysis in xenograft mouse tumors induced by KRASG12D mutation-bearing LS174T CRC cells following treatment with either cetuximab or PBS.
Here, we performed whole-transcriptome analysis in xenograft mouse tumors induced by KRASG12D mutation-bearing LS174T CRC cells following treatment with either cetuximab or PBS.
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10.1016/j.neuroscience.2019.01.029
To identify molecular pathways underlying this heterogeneity, we applied whole-transcriptome analysis using RNA-Seq in consanguineous families with ID.
To identify molecular pathways underlying this heterogeneity, we applied whole-transcriptome analysis using RNA-Seq in consanguineous families with ID.
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10.1038/s41598-019-43600-0
RNA-Seq is a whole-transcriptome analysis method used to research biological mechanisms and functions but its use in large-scale experiments is limited by its high cost and labour requirements.
RNA-Seq is a whole-transcriptome analysis method used to research biological mechanisms and functions but its use in large-scale experiments is limited by its high cost and labour requirements.
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10.1007/s12031-019-01452-3
A whole-transcriptome analysis of dermal fibroblasts obtained from three pairs of monozygotic twins discordant for PD was carried out in this work.
A whole-transcriptome analysis of dermal fibroblasts obtained from three pairs of monozygotic twins discordant for PD was carried out in this work.
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10.1101/513986
However, whole-transcriptome analysis revealed a striking response to the surrounding collagen density including the differential regulation of many immune regulatory genes and genes encoding chemokines.
However, whole-transcriptome analysis revealed a striking response to the surrounding collagen density including the differential regulation of many immune regulatory genes and genes encoding chemokines.
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10.1016/j.freeradbiomed.2019.09.037
METHODS
Here, we present a complete whole-transcriptome analysis of gamma-induced mutants (GIM) and gamma irradiated control (CON) segregants isolated from the CGL1 (HeLa x normal fibroblast) human hybrid cell-system exposed to high doses of radiation.
METHODS
Here, we present a complete whole-transcriptome analysis of gamma-induced mutants (GIM) and gamma irradiated control (CON) segregants isolated from the CGL1 (HeLa x normal fibroblast) human hybrid cell-system exposed to high doses of radiation.
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10.1038/s41598-019-50766-0
In this work, we conducted a whole-transcriptome analysis of wild-type (WT) and heterozygous rag1 mutant (rag1 +/−) zebrafish after infection with the pathogen spring viraemia of carp virus (SVCV).
In this work, we conducted a whole-transcriptome analysis of wild-type (WT) and heterozygous rag1 mutant (rag1 +/−) zebrafish after infection with the pathogen spring viraemia of carp virus (SVCV).
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10.1186/s12974-019-1433-4
MethodsWe performed peripheral blood whole-transcriptome analysis of ICH and matched vascular risk factor control subjects (n = 66).
MethodsWe performed peripheral blood whole-transcriptome analysis of ICH and matched vascular risk factor control subjects (n = 66).
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10.1016/J.FOODCONT.2019.03.036
Here, we employed Caenorhabditis elegans as a host model system and compared specific host responses during EHEC O157:H7 infection using whole-transcriptome analysis.
Here, we employed Caenorhabditis elegans as a host model system and compared specific host responses during EHEC O157:H7 infection using whole-transcriptome analysis.
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10.1186/s40425-019-0556-6
Whole-transcriptome analysis of 3D-cultured T cells revealed that a high-density matrix induces downregulation of cytotoxic activity markers and upregulation of regulatory T cell markers.
Whole-transcriptome analysis of 3D-cultured T cells revealed that a high-density matrix induces downregulation of cytotoxic activity markers and upregulation of regulatory T cell markers.
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10.1016/j.jns.2018.11.027
Whole-transcriptome analysis indicated that DHA treatment mainly regulates the genes associated with receptor binding, oxidoreductase activity, organic acid transmembrane transporter activity, and carboxylic acid transmembrane transporter activity.
Whole-transcriptome analysis indicated that DHA treatment mainly regulates the genes associated with receptor binding, oxidoreductase activity, organic acid transmembrane transporter activity, and carboxylic acid transmembrane transporter activity.
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10.1038/S42255-019-0052-9
Whole-transcriptome analysis of single-cell-derived clones reveals a link between osimertinib tolerance and pseudohypoxia responses irrespective of oxygen levels.
Whole-transcriptome analysis of single-cell-derived clones reveals a link between osimertinib tolerance and pseudohypoxia responses irrespective of oxygen levels.
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10.1016/J.POSTHARVBIO.2019.05.025
In particular, we artificially induced berry botrytization of two grape varieties (Garganega and Moller-Thurgau) and sampled them at different stages of noble rot for comparative whole-transcriptome analysis, highlighting important common transcriptional reprogramming in both varieties reflecting an accelerated withering process.
In particular, we artificially induced berry botrytization of two grape varieties (Garganega and Moller-Thurgau) and sampled them at different stages of noble rot for comparative whole-transcriptome analysis, highlighting important common transcriptional reprogramming in both varieties reflecting an accelerated withering process.
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10.1016/j.molcel.2019.01.009
To overcome this, we developed TARGET-seq, a method for the high-sensitivity detection of multiple mutations within single cells from both genomic and coding DNA, in parallel with unbiased whole-transcriptome analysis.
To overcome this, we developed TARGET-seq, a method for the high-sensitivity detection of multiple mutations within single cells from both genomic and coding DNA, in parallel with unbiased whole-transcriptome analysis.
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10.1371/journal.pone.0221810
Whole-transcriptome analysis of microdissected regions of acinar-to-ductal metaplasia and histological validation experiments demonstrated that regions of acinar-to-ductal metaplasia are characterized by the deposition of the extracellular matrix component hyaluronan.
Whole-transcriptome analysis of microdissected regions of acinar-to-ductal metaplasia and histological validation experiments demonstrated that regions of acinar-to-ductal metaplasia are characterized by the deposition of the extracellular matrix component hyaluronan.
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10.1158/1078-0432.CCR-19-1038
Experimental Design: We performed a whole-transcriptome analysis of SweBCG91-RT, a randomized phase III trial of ± radiotherapy after breast-conserving surgery for node-negative stage I–IIA breast cancer.
Experimental Design: We performed a whole-transcriptome analysis of SweBCG91-RT, a randomized phase III trial of ± radiotherapy after breast-conserving surgery for node-negative stage I–IIA breast cancer.
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10.1016/j.gene.2019.02.068
Isolated RNA served as a template for the whole-transcriptome analysis using GeneChip Chicken Gene 1.
Isolated RNA served as a template for the whole-transcriptome analysis using GeneChip Chicken Gene 1.
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10.1164/rccm.201812-2371ED
mRNASeq whole-transcriptome analysis of a single cell.
mRNASeq whole-transcriptome analysis of a single cell.
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10.1161/CIRCRESAHA.119.315125
These findings were confirmed in vivo through whole-transcriptome analysis of cardiac fibroblasts from mice subjected to transverse aortic constriction (TAC) and treated with the small molecule BRD4 inhibitor, JQ1.
These findings were confirmed in vivo through whole-transcriptome analysis of cardiac fibroblasts from mice subjected to transverse aortic constriction (TAC) and treated with the small molecule BRD4 inhibitor, JQ1.
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10.3892/mmr.2019.10896
Whole-transcriptome analysis was used to investigate the effects of PCA on gene expression.
Whole-transcriptome analysis was used to investigate the effects of PCA on gene expression.
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10.1242/dmm.040782
Interestingly, our whole-transcriptome analysis showed that gabrg2 KO does not alter the expression of genes in the larval brain.
Interestingly, our whole-transcriptome analysis showed that gabrg2 KO does not alter the expression of genes in the larval brain.
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10.1186/s40478-019-0871-7
In these escapers, whole-transcriptome analysis demonstrated early disease signatures, affecting pathways related to development, corticogenesis and synapses.
In these escapers, whole-transcriptome analysis demonstrated early disease signatures, affecting pathways related to development, corticogenesis and synapses.
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10.1017/S0007485319000257
Here, we present the first whole-transcriptome analysis of differential expression genes in insecticide-resistant and susceptible G.
Here, we present the first whole-transcriptome analysis of differential expression genes in insecticide-resistant and susceptible G.
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10.1007/s00018-019-03078-5
Whole-transcriptome analysis showed restricted transcriptional changes in optic nerves that were distinct from those found in sciatic nerves.
Whole-transcriptome analysis showed restricted transcriptional changes in optic nerves that were distinct from those found in sciatic nerves.
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