Introduction to Whole Body Physiologically

Sentence Examples

Discover more insights into Whole Body Physiologically

Keywords frequently search together with Whole Body Physiologically

Narrow sentence examples with built-in keyword filters

More Whole Body Physiologically sentence examples
10.3390/pharmaceutics13050698

We aimed to develop a whole-body physiologically based pharmacokinetic (PBPK) model characterizing interplay of OCTs and MATEs in the intestine, liver, and kidney to predict metformin DDIs with cimetidine, pyrimethamine, trimethoprim, ondansetron, rabeprazole, and verapamil.

A Whole-Body Physiologically Based Pharmacokinetic Model Characterizing Interplay of OCTs and MATEs in Intestine, Liver and Kidney to Predict Drug-Drug Interactions of Metformin with Perpetrators

More Whole Body Physiologically sentence examples
10.1002/jcph.1947

This study utilizes a whole-body physiologically-based pharmacokinetic (PBPK) model to compare the pharmacokinetics of brexpiprazole in obese and normal-weight (BMI 18-25 kg/m2 ) individuals known to be CYP2D6 extensive (EM) and poor metabolizers (PMs).

Impact of Obesity on Brexpiprazole Pharmacokinetics: Proposal for Improved Initiation of Treatment (JCP-21-Apr-212-R1).

More Whole Body Physiologically sentence examples
10.1002/jcph.1946

This study uses a whole-body physiologically-based pharmacokinetic (PBPK) model to compare the pharmacokinetics of brexpiprazole in patients known to be extensive (EM) and poor metabolizers (PMs).

Brexpiprazole pharmacokinetics in CYP2D6 poor metabolizers: Using physiologically-based pharmacokinetic modeling to optimize time-to-effective concentrations (JCP-21-Apr-211-R2).

More Whole Body Physiologically sentence examples
10.1007/s00204-021-03041-z

Based on these PK results, a whole-body physiologically-based pharmacokinetic (PBPK) model of PE and PAA after dermal application and inhalation in rats was successfully developed.

Pharmacokinetics of 2-phenoxyethanol and its major metabolite, phenoxyacetic acid, after dermal and inhaled routes of exposure: application to development PBPK model in rats.

More Whole Body Physiologically sentence examples
10.1016/J.COMPCHEMENG.2021.107461

Methods In this study, a comprehensive whole-body physiologically-based pharmacokinetic (PBPK) model for THC metabolism was developed to track blood THC concentrations accounting for interindividual variations such as age, sex, body composition, bioavailability and drug metabolizing enzyme (DME) polymorphisms after various dosages.

Physiologically-based pharmacokinetic model for predicting blood and tissue tetrahydrocannabinol concentrations

More Whole Body Physiologically sentence examples
10.2147/DDDT.S297981

Aim The study was aimed to understand the underlying causes for the differences in propranolol pharmacokinetics (PK) between healthy and cirrhosis populations by using a systematic whole-body physiologically based pharmacokinetic (PBPK) model-building approach for suggesting model informed propranolol dosing in liver cirrhosis patients with different stages of disease severity.

Development and Evaluation of a Physiologically Based Pharmacokinetic Drug-Disease Model of Propranolol for Suggesting Model Informed Dosing in Liver Cirrhosis Patients

More Whole Body Physiologically sentence examples
10.1101/2021.09.01.456741

Whole-body physiologically-based pharmacokinetic (PBPK) modeling and simulation of tumor-derived limonene predicts detection of tumors as small as 7 mm in humans, equivalent to the detection limit of clinical imaging modalities, such as PET, yet far more economical.

Engineering genetically-encoded synthetic biomarkers for breath-based cancer detection

More Whole Body Physiologically sentence examples
10.3390/pharmaceutics13030331

The aim of this study was to build a whole-body physiologically based pharmacokinetic (PBPK) model of bupropion including its DDI-relevant metabolites, and to qualify the model using clinical drug–gene interaction (DGI) and DDI data.

Physiologically Based Pharmacokinetic Modeling of Bupropion and Its Metabolites in a CYP2B6 Drug-Drug-Gene Interaction Network

More Whole Body Physiologically sentence examples
10.1016/j.xphs.2019.01.024

In the present study, we evaluated the pharmacokinetics (PK) of trastuzumab and sought to predict human PK based on animal studies, through the use of optical imaging and a whole-body physiologically based pharmacokinetic (WB-PBPK) modeling approach.

Whole-Body Physiologically Based Pharmacokinetic Modeling of Trastuzumab and Prediction of Human Pharmacokinetics.

More Whole Body Physiologically sentence examples
10.1016/j.xphs.2018.09.001

Essential input parameters in whole-body physiologically based pharmacokinetic models are the tissue-to-plasma partition coefficients and the resulting volume of distribution at steady-state (Vss).

Application of the Tissue Composition-Based Model to Minipig for Predicting the Volume of Distribution at Steady State and Dermis-to-Plasma Partition Coefficients of Drugs Used in the Physiologically Based Pharmacokinetics Model in Dermatology.

More Whole Body Physiologically sentence examples
10.1007/s40262-019-00777-x

ObjectivesThe first objective of this study was to provide whole-body physiologically based pharmacokinetic (PBPK) models of important cytochrome P450 (CYP) 2C8 perpetrator and victim drugs, built and evaluated for DDI and DGI studies.

Physiologically Based Pharmacokinetic Models for Prediction of Complex CYP2C8 and OATP1B1 (SLCO1B1) Drug–Drug–Gene Interactions: A Modeling Network of Gemfibrozil, Repaglinide, Pioglitazone, Rifampicin, Clarithromycin and Itraconazole

More Whole Body Physiologically sentence examples
10.1007/s40262-019-00856-z

These results were combined with 93 published concentration–time datasets of voriconazole from clinical trials in healthy volunteers to develop a whole-body physiologically based PK (PBPK) model in PK-Sim ®.

A Physiologically Based Pharmacokinetic Model of Voriconazole Integrating Time-Dependent Inhibition of CYP3A4, Genetic Polymorphisms of CYP2C19 and Predictions of Drug–Drug Interactions

More Whole Body Physiologically sentence examples
10.1371/journal.pone.0209587

We present a methodology to combine whole-body physiologically-based pharmacokinetic (PBPK) models with mechanistic intracellular models of signal transduction in the liver for therapeutic proteins.

Quantitative systems pharmacology of interferon alpha administration: A multi-scale approach

Learn more from Whole Body Physiologically

Keywords related to Whole

Whole Body Physiologically
Encyclopedia

What is/are Whole Body Physiologically?

Whole Body Physiologically - We aimed to develop a whole-body physiologically based pharmacokinetic (PBPK) model characterizing interplay of OCTs and MATEs in the intestine, liver, and kidney to predict metformin DDIs with cimetidine, pyrimethamine, trimethoprim, ondansetron, rabeprazole, and verapamil. [1] This study utilizes a whole-body physiologically-based pharmacokinetic (PBPK) model to compare the pharmacokinetics of brexpiprazole in obese and normal-weight (BMI 18-25 kg/m2 ) individuals known to be CYP2D6 extensive (EM) and poor metabolizers (PMs). [2] This study uses a whole-body physiologically-based pharmacokinetic (PBPK) model to compare the pharmacokinetics of brexpiprazole in patients known to be extensive (EM) and poor metabolizers (PMs). [3] Based on these PK results, a whole-body physiologically-based pharmacokinetic (PBPK) model of PE and PAA after dermal application and inhalation in rats was successfully developed. [4] Methods In this study, a comprehensive whole-body physiologically-based pharmacokinetic (PBPK) model for THC metabolism was developed to track blood THC concentrations accounting for interindividual variations such as age, sex, body composition, bioavailability and drug metabolizing enzyme (DME) polymorphisms after various dosages. [5] Aim The study was aimed to understand the underlying causes for the differences in propranolol pharmacokinetics (PK) between healthy and cirrhosis populations by using a systematic whole-body physiologically based pharmacokinetic (PBPK) model-building approach for suggesting model informed propranolol dosing in liver cirrhosis patients with different stages of disease severity. [6] Whole-body physiologically-based pharmacokinetic (PBPK) modeling and simulation of tumor-derived limonene predicts detection of tumors as small as 7 mm in humans, equivalent to the detection limit of clinical imaging modalities, such as PET, yet far more economical. [7] The aim of this study was to build a whole-body physiologically based pharmacokinetic (PBPK) model of bupropion including its DDI-relevant metabolites, and to qualify the model using clinical drug–gene interaction (DGI) and DDI data. [8] In the present study, we evaluated the pharmacokinetics (PK) of trastuzumab and sought to predict human PK based on animal studies, through the use of optical imaging and a whole-body physiologically based pharmacokinetic (WB-PBPK) modeling approach. [9] Essential input parameters in whole-body physiologically based pharmacokinetic models are the tissue-to-plasma partition coefficients and the resulting volume of distribution at steady-state (Vss). [10] ObjectivesThe first objective of this study was to provide whole-body physiologically based pharmacokinetic (PBPK) models of important cytochrome P450 (CYP) 2C8 perpetrator and victim drugs, built and evaluated for DDI and DGI studies. [11] These results were combined with 93 published concentration–time datasets of voriconazole from clinical trials in healthy volunteers to develop a whole-body physiologically based PK (PBPK) model in PK-Sim ®. [12] We present a methodology to combine whole-body physiologically-based pharmacokinetic (PBPK) models with mechanistic intracellular models of signal transduction in the liver for therapeutic proteins. [13]