Introduction to Vulvar Lichen

What is/are Vulvar Lichen?

Vulvar Lichen - The aim of this study is to investigate the efficacy of fractional CO2 laser in reducing symptoms of vulvar lichen sclerosus (VLS) during maintenance therapy with topical steroids (application twice weekly or less);(ii) to assess how long this reduction of symptoms persists during followup; (iii) histological comparison before and after treatment. ^[1] BACKGROUND As a chronic inflammatory skin disease of unknown etiology, vulvar lichen sclerosus (VLS) mainly affects postmenopausal and perimenopausal women. ^[2] This study aimed to analyze changes in melanocyte density and epidermal thickness in vulvar lichen sclerosus (VLS). ^[3] Objectives The purpose of this cross-sectional study was to prepare a reliable and easy-to-use architectural classification for vulvar lichen sclerosus (VLS) aimed at defining the morphological patterns of this condition. ^[4] Most commonly, these are vulvar lichen sclerosus (VLS) and squamous cell hyperplasia of the vulva (SCHV). ^[5] Fractionated carbon dioxide is not an effective monotherapy treatment for vulvar lichen sclerosus. ^[6] Objective：The aim of this study was to investigate the expression profile of circRNA in Vulvar Lichen Sclerosus, and to identify the underlying core genes of Vulvar Lichen Sclerosus. ^[7] Vulvar vitiligo (VV) and vulvar lichen sclerosus (VLS), both feature skin and mucosal hypo-/depigmentation. ^[8] A complete clearance of vulvar lichen sclerosus (VLS) is achieved in a minority of patients treated with a standard 12‐week duration corticosteroid treatment. ^[9] Multi-omics analysis reveals the elevation of HCV poly U/UC sequences, which induces abnormal inflammation and related metabolic disorder in vulvar lichen sclerosis. ^[10] Vulvar lichen sclerosus (VLS) is a chronic, distressing, inflammatory disease with an enormous impact on quality of life. ^[11] Vulvar lichen sclerosis (VLS) is a chronic mucocutaneous disorder, the pathogenesis of which is poorly understood. ^[12] Aim: to comparatively assess sexual function and intensity of vulvovaginal symptoms in patients with vulvar lichen sclerosus and mixed vulvar dystrophy. ^[13] The article presents current data on the clinical features of vulvar lichen sclerosus at both early and late stages, the need for timely diagnosis, the possibilities of local and systemic therapy, dosage regimens and its duration. ^[14] Study Objective: To assess the therapeutic efficiency of liposomal gelcoat with dihydroquercetin Flamena in combination therapy of vulvar lichen sclerosus (VLS). ^[15] Topical corticosteroids are often utilized as the first-line treatment for vulvar lichen sclerosus (VLS). ^[16] Objective The aim of the study was to investigate the quality of life in vulvar lichen sclerosus (VLS) patients treated with long-term, individualized topical corticosteroids. ^[17] The etiology of vulvar lichen sclerosus (LS) remains unclear; however, alterations in cutaneous and gut microbiota may be contributing to the pathogenesis of this inflammatory condition. ^[18] The analysis of the main results of more than 30 years experience in the use of enterosorbent polymethylsiloxane polyhydrate was conducted, taking into account the mechanisms of its medical and prophylactic effects in the treatment of pre-eclampsia, arterial hypertension of pregnant women, miscarriage, endometriosis, chronic pelvic inflammatory disease, urogenital disorders, vulvar lichen sclerosus. ^[19] For instance, vulvar lichen sclerosus (VLS) is characterized by homogenization of collagen fibers with increasing risk of malignant transformation. ^[20] dVIN: Differentiated vulvar intraepithelial neoplasm LS: Lichen sclerosus VAAD: vulvar acanthosis with altered differentiation vLS: vulvar lichen sclerosus vSCC: vulvar squamous cell carcinoma INTRODUCTION Lichen sclerosus (LS) is a chronic, idiopathic inflammatory disorder with a predilection for the vulva, perineum, and perianal skin. ^[21] Vulvar lichen sclerosus (vLS) is an inflammatory skin condition that predominantly affects the vulvar and perianal regions. ^[22] There are two original contributions on ultrasound-based biomedical research, covering most recent progress in highintensity focused ultrasound (HIFU) based vulvar lichen sclerosus treatment (Qu et al. ^[23] OBJECTIVE To compare the efficacy and safety of the treatment of vulvar lichen simplex chronicus (VLSC) using high-intensity focused ultrasound (HIFU) at different powers. ^[24] Vulvar lichen sclerosus (VLS) is a chronic inflammatory disorder, which affects women of all ages. ^[25] Vulvar lichen sclerosus (VLS) is a chronic inflammatory skin disease of the anogenitalarea leading to itch, burning, sexual dysfunction and impaired quality of life. ^[26] Vulvar lichen sclerosus (VLS) is a chronic inflammatory condition affecting the anogenital region, which may present in a prepubertal or adolescent patient. ^[27] The objective of this document is to provide guidance in the diagnosis and management of vulvar lichen sclerosus (LS) in the pediatric and adolescent patient in order to treat patient symptoms and reduce long-term sequelae. ^[28] Case presentation We report a North-Indian patient with oro-vaginal-vulvar lichen planus who presented to us with complaints of recurrent vulvovaginal symptoms for the last 5 years. ^[29]

chronic inflammatory disease

Context: Vulvar lichen sclerosus (VLS) is a chronic inflammatory disease affecting prepubertal girls and postmenopausal women. ^[1] OBJECTIVE Vulvar Lichen sclerosus (LS) is a chronic inflammatory disease in which architectural changes and symptoms like itching, soreness, pain and dyspareunia can affect quality of life and sexual activity. ^[2] Dear Editor, Vulvar lichen sclerosus (VLS) is a chronic inflammatory disease of the skin, predominantly affecting the anogenital region. ^[3]

Symptomatic Vulvar Lichen

OBJECTIVE To compare 6-month safety and efficacy outcomes of fractionated CO2 laser (laser) with topical clobetasol propionate (steroid) for treatment of symptomatic vulvar lichen sclerosus. ^[1] OBJECTIVES: To assess the clinical response to and the histomorphometric effects of microablative fractional radiofrequency (MFR) in women with symptomatic vulvar lichen sclerosus (VLS). ^[2]

vulvar lichen sclerosu

The aim of this study is to investigate the efficacy of fractional CO2 laser in reducing symptoms of vulvar lichen sclerosus (VLS) during maintenance therapy with topical steroids (application twice weekly or less);(ii) to assess how long this reduction of symptoms persists during followup; (iii) histological comparison before and after treatment. ^[1] BACKGROUND As a chronic inflammatory skin disease of unknown etiology, vulvar lichen sclerosus (VLS) mainly affects postmenopausal and perimenopausal women. ^[2] OBJECTIVES Uncontrolled vulvar lichen sclerosus (VLS) is often associated with distressful symptoms of genital itch, irritation, and pain and can lead to a pathological process including anatomical changes, scarring, and an elevated risk of cancer in the genital area. ^[3] This study aimed to analyze changes in melanocyte density and epidermal thickness in vulvar lichen sclerosus (VLS). ^[4] Objectives The purpose of this cross-sectional study was to prepare a reliable and easy-to-use architectural classification for vulvar lichen sclerosus (VLS) aimed at defining the morphological patterns of this condition. ^[5] OBJECTIVE To compare 6-month safety and efficacy outcomes of fractionated CO2 laser (laser) with topical clobetasol propionate (steroid) for treatment of symptomatic vulvar lichen sclerosus. ^[6] Most commonly, these are vulvar lichen sclerosus (VLS) and squamous cell hyperplasia of the vulva (SCHV). ^[7] Fractionated carbon dioxide is not an effective monotherapy treatment for vulvar lichen sclerosus. ^[8] Objective：The aim of this study was to investigate the expression profile of circRNA in Vulvar Lichen Sclerosus, and to identify the underlying core genes of Vulvar Lichen Sclerosus. ^[9] OBJECTIVES: To assess the clinical response to and the histomorphometric effects of microablative fractional radiofrequency (MFR) in women with symptomatic vulvar lichen sclerosus (VLS). ^[10] Vulvar vitiligo (VV) and vulvar lichen sclerosus (VLS), both feature skin and mucosal hypo-/depigmentation. ^[11] A complete clearance of vulvar lichen sclerosus (VLS) is achieved in a minority of patients treated with a standard 12‐week duration corticosteroid treatment. ^[12] Vulvar lichen sclerosus (VLS) is a chronic, distressing, inflammatory disease with an enormous impact on quality of life. ^[13] Context: Vulvar lichen sclerosus (VLS) is a chronic inflammatory disease affecting prepubertal girls and postmenopausal women. ^[14] Aim: to comparatively assess sexual function and intensity of vulvovaginal symptoms in patients with vulvar lichen sclerosus and mixed vulvar dystrophy. ^[15] The article presents current data on the clinical features of vulvar lichen sclerosus at both early and late stages, the need for timely diagnosis, the possibilities of local and systemic therapy, dosage regimens and its duration. ^[16] Study Objective: To assess the therapeutic efficiency of liposomal gelcoat with dihydroquercetin Flamena in combination therapy of vulvar lichen sclerosus (VLS). ^[17] Topical corticosteroids are often utilized as the first-line treatment for vulvar lichen sclerosus (VLS). ^[18] Objective The aim of the study was to investigate the quality of life in vulvar lichen sclerosus (VLS) patients treated with long-term, individualized topical corticosteroids. ^[19] The etiology of vulvar lichen sclerosus (LS) remains unclear; however, alterations in cutaneous and gut microbiota may be contributing to the pathogenesis of this inflammatory condition. ^[20] The analysis of the main results of more than 30 years experience in the use of enterosorbent polymethylsiloxane polyhydrate was conducted, taking into account the mechanisms of its medical and prophylactic effects in the treatment of pre-eclampsia, arterial hypertension of pregnant women, miscarriage, endometriosis, chronic pelvic inflammatory disease, urogenital disorders, vulvar lichen sclerosus. ^[21] For instance, vulvar lichen sclerosus (VLS) is characterized by homogenization of collagen fibers with increasing risk of malignant transformation. ^[22] dVIN: Differentiated vulvar intraepithelial neoplasm LS: Lichen sclerosus VAAD: vulvar acanthosis with altered differentiation vLS: vulvar lichen sclerosus vSCC: vulvar squamous cell carcinoma INTRODUCTION Lichen sclerosus (LS) is a chronic, idiopathic inflammatory disorder with a predilection for the vulva, perineum, and perianal skin. ^[23] Vulvar lichen sclerosus (vLS) is an inflammatory skin condition that predominantly affects the vulvar and perianal regions. ^[24] There are two original contributions on ultrasound-based biomedical research, covering most recent progress in highintensity focused ultrasound (HIFU) based vulvar lichen sclerosus treatment (Qu et al. ^[25] OBJECTIVE Vulvar Lichen sclerosus (LS) is a chronic inflammatory disease in which architectural changes and symptoms like itching, soreness, pain and dyspareunia can affect quality of life and sexual activity. ^[26] Vulvar lichen sclerosus (VLS) is a chronic inflammatory disorder, which affects women of all ages. ^[27] Vulvar lichen sclerosus (VLS) is a chronic inflammatory skin disease of the anogenitalarea leading to itch, burning, sexual dysfunction and impaired quality of life. ^[28] Vulvar lichen sclerosus (VLS) is a chronic inflammatory condition affecting the anogenital region, which may present in a prepubertal or adolescent patient. ^[29] Dear Editor, Vulvar lichen sclerosus (VLS) is a chronic inflammatory disease of the skin, predominantly affecting the anogenital region. ^[30] The objective of this document is to provide guidance in the diagnosis and management of vulvar lichen sclerosus (LS) in the pediatric and adolescent patient in order to treat patient symptoms and reduce long-term sequelae. ^[31] OBJECTIVE The objective of this preliminary study is to use Video Thermography in the evaluation of Vulvar Lichen Sclerosus before and after PRP therapy. ^[32] 2 patients suffered from squamous cell hyperplasia, 2 patients from vulvar lichen sclerosus, 1 - genital warts, 1 - VIN I ( current terminology: LSIL/Flat condyloma ), 2 - CIN III ( HSIL ), 2 - CIN I ( LSIL ). ^[33] We report 3 additional instances of MMV associated to Zoon vulvitis and vulvar lichen sclerosus et atrophicus. ^[34] Conclusion: Our results indicated the complementary effects of an ointment added to treatments for vulvar lichen sclerosus, psoriasis, condyloma acuminata and for vulvodynia. ^[35] Objective The aim of the study was to summarize and review the evidence for the efficacy and safety of adipose-derived stem cells (ADSCs) and platelet-rich plasma (PRP) for the treatment of vulvar lichen sclerosus (LS). ^[36] OBJECTIVE The purpose of the present systematic review is to evaluate the available medical treatments for vulvar lichen sclerosus, using an arm based network meta-analysis protocol. ^[37] Objective The aim of this research was to evaluate the efficacy and safety of Er:YAG lasers to improve signs and symptoms of vulvar lichen sclerosus. ^[38] Introduction/Background vulvar lichen sclerosus (VLS) is a chronic inflammatory dermatosis usually associated with symptoms that cause significant physical discomfort and emotional distress. ^[39] BACKGROUND This study aimed to evaluate the effects of 5-aminolevulinic acid photodynamic therapy (ALA-PDT) on the improvement of symptoms and recurrence rate in patients with vulvar lichen sclerosus (VLS) and observe its side effects. ^[40] Objective There is no agreed upon standard way to measure vulvar lichen sclerosus disease severity. ^[41] CASE We describe a case of iatrogenic Cushing syndrome from the administration of high-potency topical steroids for vulvar lichen sclerosus in a 6-year-old girl. ^[42] Objective Vulvar lichen sclerosus (LS) is known to occur in families, suggesting a genetic link. ^[43] BACKGROUND Vulvar lichen sclerosus (VLS) occurring in juveniles (children and adolescents) may have repercussions throughout life. ^[44] We present a case of a 60-year-old woman who had several chronic diseases and had been diagnosed with vulvar lichen sclerosus for 20 years, with no response to multiple treatments (topical corticosteroids, immunomodulators). ^[45] Kraurosis vulvae or vulvar lichen sclerosus (VLS) is a non-neoplastic skin disease that affects the female genital area. ^[46] METHODS This is a planned sub-analysis of a cross-sectional study comparing the prevalence of bowel and bladder symptoms in women with biopsy-proven vulvar lichen sclerosus (LS) to a control group of women with non-lichenoid vulvar diseases. ^[47]

vulvar lichen sclerosi

Multi-omics analysis reveals the elevation of HCV poly U/UC sequences, which induces abnormal inflammation and related metabolic disorder in vulvar lichen sclerosis. ^[1] Vulvar lichen sclerosis (VLS) is a chronic mucocutaneous disorder, the pathogenesis of which is poorly understood. ^[2] It was initially described by Stuhmer in 1928, named after its pathological features, and is considered the male equivalent of vulvar lichen sclerosis (LS). ^[3]

vulvar lichen simplex

OBJECTIVE To compare the efficacy and safety of the treatment of vulvar lichen simplex chronicus (VLSC) using high-intensity focused ultrasound (HIFU) at different powers. ^[1] Vulvar lichen simplex chronicus is a common dermatosis characterized by skin lichenification following excessive scratching. ^[2]

vulvar lichen planu

Case presentation We report a North-Indian patient with oro-vaginal-vulvar lichen planus who presented to us with complaints of recurrent vulvovaginal symptoms for the last 5 years. ^[1] Case: A 15-year-old girl with vulvar lichen planus since she was 2 years old and suspected Crohn’s disease (CD) was first seen at our hospital. ^[2]