Introduction to Validation Cohort
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Validation Cohort sentence examples within training cohort n
Radiological (R), DCNN, and combined nomograms were constructed in a training cohort (n = 892) respectively based on clinicoradiological factors, DCNN probabilities, and all factors; the performance of each model was confirmed in a validation cohort (n = 244).
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Methods This study enrolled 647 consecutive AIS patients who were randomly divided into a training cohort ( n = 431) and a validation cohort ( n = 216).
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Validation Cohort sentence examples within receiver operating characteristic
A noninvasive algorithm was developed by using multivariate logistic regression, receiver operating characteristic (ROC) curves, and decision curve analysis (DCA) to diagnose significant fibrosis in the training cohort, and the algorithm was subsequently validated in the validation cohort.
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We select the best model and confirm the accuracy in a validation cohort using the area under the receiver operating characteristic curve (AUC-ROC).
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Validation Cohort sentence examples within derivation cohort n
The whole analysed population (n = 94) was divided into the following two groups: derivation cohort (n = 41) and validation cohort (n = 53).
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MEASUREMENTS AND MAIN RESULTS
The clinical data were divided into the following two groups: a derivation cohort (n = 43,799) and a validation cohort (n = 14,600).
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Validation Cohort sentence examples within retrospective study included
METHODS
This retrospective study included 129 LN from 77 patients (training cohort: 102 LN from 59 patients; validation cohort: 27 LN from 18 patients) with postoperative esophageal squamous cell carcinoma (ESCC).
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Materials and Methods This retrospective study included a training cohort of 200 patients, an internal validation cohort of 40 patients, and an external validation cohort of 60 patients.
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Validation Cohort sentence examples within patients training cohort
A primary cohort of 163 patients (training cohort, 113; and internal validation cohort, 50) and an external validation cohort of 53 patients with clinical stage cT1N0M0 were retrospectively included.
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We analyzed SpiroNose exhaled breath data of 94 patients (training cohort n = 62, validation cohort n = 32).
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Validation Cohort sentence examples within least absolute shrinkage
A radiomics signature was constructed using least absolute shrinkage and selection operator (LASSO) Cox regression in the training cohort and validated in the validation cohort.
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A novel 10-MRGs risk model for prognosis was established by the univariate Cox regression analysis and the least absolute shrinkage and selection operator (Lasso) regression analysis, and then verified in both internal and external validation cohort.
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Validation Cohort sentence examples within low risk group
In the GEO validation cohort, a better OS was observed in patients from the low-risk group in comparison to those in the high-risk group.
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Patients with high-risk scores had a higher probability of death earlier than the low-risk group both in the TCGA construction cohort and in the GEO validation cohort (all P < 0.
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Validation Cohort sentence examples within high risk group
Validation Cohort sentence examples within risk prediction model
Validation Cohort sentence examples within discovery cohort n
The larger cohort (discovery cohort, n = 655) was used to build the model and the second cohort (validation cohort, n = 225) was applied to test the prediction of the model.
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Here, we detected global 5hmC levels in two independent medulloblastoma patient cohorts (discovery cohort: n = 81; validation cohort: n = 171) using ultra-high performance liquid chromatography-tandem mass spectrometry analysis.
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Validation Cohort sentence examples within enzyme linked immunosorbent
Indirect enzyme-linked immunosorbent assay (ELISA) was used to verify and validate TAAbs in two independent datasets with 1,054 participants (310 in verification cohort, 744 in validation cohort).
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Enzyme-linked immunosorbent assay (ELISA) was used to verify and validate the titer of the candidate TAAbs in the verification cohort (80 GC cases and 80 HCs) and validation cohort (192 GC cases, 128 benign gastric disease cases, and 192 HCs), respectively.
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Validation Cohort sentence examples within quantitative real time
Moreover, 36 genes selected from the eDEGs via bioinformatics analyses were verified in a mouse validation cohort via quantitative real-time PCR.
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Our validation cohort consisted of FOXD1 mRNA expression in 162 paired HNSCC and adjacent normal tissues, as determined using quantitative real-time polymerase chain reaction.
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Validation Cohort sentence examples within training cohort 70
Validation Cohort sentence examples within whole exome sequencing
In this study, we analyzed the clinical characteristics of 431 patients with DCIS and performed whole-exome sequencing analysis in a 21-patient discovery cohort and targeted deep sequencing analysis in a 72-patient validation cohort.
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Design, Setting, and Participants
A 2-stage, case-control, whole-exome sequencing association study with a discovery cohort and 2 independently ascertained validation cohorts.
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Validation Cohort sentence examples within patients derivation cohort
In 30 patients (derivation cohort), LA-EF and LAS cut-off values for the presence of relevant ACM (high-density endocardial contact mapping in sinus rhythm prior to PVI at 3000 ± 1249 sites) were established in sinus rhythm and tested in a validation cohort (n = 30).
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Results Overall, 489 patients (derivation cohort: 300, validation cohort: 189) were analyzed.
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Validation Cohort sentence examples within c statistic 0
Using LASSO regression analysis, a four-risk-group model was constructed and the new model showed better discrimination in the validation cohort when compared with The Fujimoto PTLD score (C-statistic: 0.
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However, this decrement in discrimination was due mostly to narrower case-mix in the validation cohorts compared to derivation cohorts, as reflected in the median model based c-statistic [0.
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Validation Cohort sentence examples within negative predictive value
Application of the algorithm to the validation cohort showed a negative predictive value of 99.
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Results: A 20-gene classifier established in the EXPRESSION cohort using a Youden index–based cut-off point predicted pCR in the validation cohorts with an accuracy, AUC, negative predictive value (NPV), positive predictive value, sensitivity, and specificity of 0.
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Validation Cohort sentence examples within progression free survival
Validation Cohort sentence examples within retrospective observational study
Methods This retrospective observational study was performed based on patient data collected from electronic health records across 2 independent health systems; 1 was used for the derivation cohort and the other for the validation cohort.
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This retrospective observational study was conducted in the emergency department of Asan Medical Center (Seoul, Korea) between 02/2017 and 09/2017 for the development cohort and between 06/2018 and 02/2019 for the validation cohort.
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Validation Cohort sentence examples within random forest model
The multivariate random forest model showed excellent performance in predicting IDH and PTPN11 mutations in the discovery cohort, which were validated in the external validation cohorts (areas under the receiver operator characteristic curve [AUCs] of 0.
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The classifier based on eight optimal microbial markers is constructed through a random forest model and reached great diagnostic efficacy in both discovery and validation cohorts.
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Validation Cohort sentence examples within 90 day mortality
Validation Cohort sentence examples within patients mean age
STUDY DESIGN AND SETTING
Data from 3651 patients (mean age: 83 years) from a Norwegian University Hospital were retrospectively obtained and randomly divided into two cohorts: a model cohort (n = 1825) to develop two prediction models with CCI and ASA as the main predictors, and a validation cohort (n = 1826) to assess the predictive ability of both models.
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Results This study evaluated 4154 patients (mean age, 58 years ± 6 [standard deviation]; 3777 men; primary cohort, 3442 patients [mean age, 58 years ± 6; 3129 men]; validation cohort, 712 patients [mean age, 58 years ± 7; 648 men]).
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Validation Cohort sentence examples within consecutive patients undergoing
Methods
From a multicenter database, consecutive patients undergoing curative resection for HCC were enrolled and divided into the developing and validation cohorts.
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Methods From a multicenter database, consecutive patients undergoing curative resection for HCC were enrolled and divided into the developing and validation cohorts.
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Validation Cohort sentence examples within positive predictive value
Conclusion
This is the first validation cohort to show that IIM ICD code combinations in HES have high positive predictive values, and sensitivities of up to 72.
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Results In the independent validation cohort, our algorithm demonstrated 71% sensitivity, 90% specificity, 56% positive predictive value, and 95% negative predictive value, allowing for construction of a prototype survival prediction score.
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Validation Cohort sentence examples within two cohorts training
Materials and Methods: The current study was a single-center study based on the Chinese population and performed in two cohorts (training cohort and validation cohort).
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These patients were randomly divided into two cohorts: training cohort (n = 1046) and validation cohort (n = 448).
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Validation Cohort sentence examples within model accurately predicted
When applied to the external validation set (DEFUSE 3, n = 160), the model accurately predicted the 90-day mRS score within one point for 78% of the patients in the validation cohort.
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The model accurately predicted the prognosis of liver cancer patients in both the training cohort and validation cohort.
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Validation Cohort sentence examples within # 1 training
METHODS
Data on 278 consecutive patients from Hospital #1 (training cohort) and 123 cases from Hospital #2 (external validation cohort) referred for breast US with subsequent histopathologic analysis between May 2017 and October 2019 were retrospectively collected.
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METHODS
Patients with locally advanced breast cancer (LABC) proved by biopsy who proceeded to undergo preoperative NAC were enrolled from hospital #1 (training cohort, 356 cases) and hospital #2 (independent external validation cohort, 236 cases).
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Validation Cohort sentence examples within proportional hazards regression
Multivariate cox proportional hazards regression model was trained on the training cohort of 342 patients using the selected features, and the predictive performance was validated on the validation cohort of 147 patients using the concordance index (C-index).
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After dividing the PRO-ACT database into development and validation cohorts with dysphagia defined from the ALS Functional Rating Scale (ALSFRS), a multivariable Cox proportional hazards regression model estimated the probability of dysphagia at 3, 6, and 12-months with subsequent evaluation of model discrimination and calibration.
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Validation Cohort sentence examples within intensive care unit
We retrospectively analyzed the outcome associations of NK cell count and KIR genotype of patients with COVID-19 related severe ARDS treated on our tertiary intensive care unit (ICU) between February and June 2020 and validated our findings in an independent validation cohort of patients with moderate COVID-19 admitted to our tertiary medical center.
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SAMS cutoffs derived from the COVID-19 Discovery cohort were used to predict intensive care unit (ICU) status, need for mechanical ventilation, and in-hospital mortality in the COVID-19 Validation cohort.
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Validation Cohort sentence examples within test cohort n
Then, we analyzed DSCR1 expression in two independent CRC cohorts (test cohort: n = 70; validation cohort: n = 58) and tested its overall survival (OS) by Kaplan-Meier survival analyses.
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A radiomics signature was constructed based on preoperative multiparametric MRI from the training dataset (n = 126) of center 1, then tested in the validation cohort (n = 42) from center 1 and an external test cohort (n = 62) from center 2.
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