Introduction to Trials Studying

Anacetrapib displayed no adverse effects throughout extensive preclinical safety evaluation, and no major safety signals were observed in clinical trials studying anacetrapib, including REVEAL.

Secondly, the excellent interand intrarater reliability for CLASI activity scores in paediatric dermatologists and rheumatologists broadens the ability of clinical trials studying paediatric patients with CLE to recruit both groups of physicians to participate as investigators.

This enhanced method facilitates the design and analysis of group sequential clinical trials studying survival endpoints by increasing implemental flexibility.

We selected only randomized clinical trials studying with treatment of HC-BPPV employ by the Gufoni maneuver.

SELECTION CRITERIA We included all randomized or quasi-randomized controlled trials studying preterm infants born at less than 37 weeks' gestational age, requiring CMV and undergoing randomization to either different PEEP levels (RDS or BPD); or, two or more alternative methods for individualizing PEEP levels (RDS only).

STUDY SELECTION OOHS (ie, skilled nursing facilities, outpatient clinics, or community-based at home) randomized trials studying the effect of multidisciplinary rehabilitation were selected, including those assessing exercise in older patients (mean age ≥65y) after discharge from hospital after an acute illness.

Our objective was to determine the frequency of noncompletion and nonpublication of trials studying rare diseases.

BackgroundThe recruitment of participants into community-based randomized controlled trials studying childhood obesity is often challenging, especially from low-income racial/ethnical minorities and when long-term participant commitments are required.

Dactylitis treatment strategies are however controversial due to the absence of evidence from randomized controlled trials studying dactylitis as a primary outcome.

We plan on including cohort studies and secondary analyses of randomized controlled trials studying adult lung transplant recipients undergoing their first lung transplant, without any simultaneous organ transplant.

There is also growing evidence for a clinical synergy between radiation and immunotherapy, with several ongoing trials studying the abscopal effect.

METHODS Subjects were enrolled in investigator-initiated trials studying proliferative diabetic retinopathy, neovascular age-related macular degeneration, diabetic macular edema, and retinal venous occlusive disease.

Conclusion: To our knowledge, this is the largest metaanalysis of randomized controlled trials studying multivessel PCI vs culprit artery only PCI in STEMI patients without shock, among whom lesion severity was graded by angiography alone.

Indeed, HFpEF-associated mortality has remained largely unchanged over the past two decades despite a surge of clinical trials studying novel therapies.

There are still no comparative trials studying this new hemostatic modality.

Methods A systematic literature search through September 2018 identified randomized trials studying these pharmacologic therapies for extended anticoagulation following VTE.

Sixty percent were initiating trials studying immunotherapeutic agents.

Prespecified subgroup analyses showed more improvement with iron in those trials studying participants on dialysis.

PurposeRandomized trials studying endocrine therapy (ET) with and without radiation therapy (RT) following breast-conserving surgery (BCS) have detected differences in local recurrence (LR) but not survival among elderly women with hormone receptor positive stage I breast cancer (BC).

Trials studying additional solid cancers, such as pancreatic cancer, head and neck cancer, glioblastoma, and glioma are reviewed in this section and accompanied by advanced practitioner commentaries.

Results from ongoing prospective clinical trials studying preoperative SRS are important to further investigate these two techniques.

Further prospective studies and clinical trials studying this question with separate groups classified as per the index event are required to shed more light on the subject.

This article reviewed recent clinical controlled trials studying effects of flaxseed on both blood pressure and lipid profiles in different populations, and its potential hypotensive as well as lipid-lowering mechanisms, in order to lay a solid foundation for further studies.

Conclusions: In the absence of randomized trials studying the role of center size, experience, and standardization procedure for ASCT outcome, these results may suggest that ASCT in peripheral accredited small-sized centers could be a viable option to facilitate follow up and enable access to this treatment, especially for elderly patients, in comparison with referring the patient to central large hospitals to undergo ASCT.

No trials studying this topic in subcrestal-positioned implants were found.

Oral anticoagulant therapy protects against and resolves both clinical valve thrombosis and subclinical leaflet thrombosis; however, large-scale randomized clinical trials studying different antithrombotic strategies after TAVR are still under way.

There is a limitation of use for patients with moderate-to-severe hepatic and severe renal impairment; trials studying glasdegib in these patient populations are required as a condition of this approval.

PURPOSE The goal of this review was to summarize, analyze, and compare trials studying the efficacy of colchicine in the prevention of atrial fibrillation (AF) post-operatively (POAF) and post-catheter ablation.

The PUBMED and Cochrane online databases were reviewed for randomized controlled trials studying the efficacy of each ingredient.

Options for patients with non–small cell lung cancer have expanded following trials studying the safety and efficacy of checkpoint inhibitors and targeted therapies.

, individual data of large clinical trials studying angiotensinconverting enzyme (ACE)inhibitors and the incidence of dry cough have revealed a rather lower number of intolerance than anticipated.

STUDY SELECTION Randomized controlled trials studying supervised home-based exercise therapy after hospitalization in older patients (≥65y) after hip fracture.

For this reason, many experimental and clinical trials studying the effects of hydrogen against ischemic stroke have been published.

Better trials studying individual clinical applications of epidermal grafting are needed.

Recently, large-scale randomized controlled trials studying the utility of levosimendan in cardiac surgery have been conducted.

SUMMARY This review highlights ongoing clinical trials studying therapeutic options in calciphylaxis and emphasizes the causal pathways that led to the development of such therapies.

In comparative trials studying novel micro-invasive glaucoma surgeries in open angle glaucoma, the control group undergoing cataract extraction alone routinely achieved significant reductions in IOP and medication use postoperatively.

There are very few randomized controlled trials studying treatment of super refractory status epilepticus (SE), despite estimated occurrence in about 15% of SE cases and its association with high morbidity and mortality rates.

Children comprised 34% of the 20 million DALYs resulting from NTDs, but pediatric trials contributed just 17% (63/369) of trials studying these conditions (p<0.

Methods Randomized controlled trials studying the effects of AH-LTRA versus AH alone on rhinoconjuncitivits symptoms in patients with AR were included.

For trials studying preeclampsia, fetal growth restriction, and gestational diabetes, 17%, 8%, and 2% recruited both singletons and multiples, respectively.

Results: Sixty-two double-blind randomized clinical trials studying 2914 patients with schizophrenia met the inclusion criteria for quantitative analysis.

RECENT FINDINGS Three large randomized trials studying aspirin in various primary prevention populations including individuals with diabetes, an elderly population, and middle-aged adults at high cardiovascular risk have recently been completed.

Only randomized controlled trials studying the administration of probiotic supplements compared to placebo on immune and inflammatory markers in healthy adults (aged 18 to 65 years), without acute or chronic disease, and in generally good health were examined.

Randomised controlled trials studying rosiglitazone and glimepiride use in children have been performed.

Prospective studies and multi center trials studying troponin levels and SI in all TBI patients, with the inclusion of outcome scores will prove or disprove the predictability of the new index.

Recommendations The majority of randomized controlled trials studying the efficacy of preventive medications for pediatric migraine fail to demonstrate superiority to placebo.

With the advent of personalized medicine, clinical trials studying treatment effects in subpopulations are receiving increasing attention.

We await the results of clinical trials studying the efficacy of this approach.