Introduction to Trials Reporting

A search was conducted for randomised controlled trials reporting clinical outcomes following adjunctive antibiotic for patients divided by baseline microbiological profiles.

AIMS To answer the question: 'What is the clinical benefit in periodontitis patients taking adjunctive systemic antimicrobials to non-surgical therapy, depending on pre-treatment detection of periodontopathogenic bacteria?' MATERIALS AND METHODS A search was conducted in 4 electronic databases for randomised controlled trials reporting clinical outcomes following adjunctive antibiotic therapy for patients divided by baseline microbiological profiles.

METHODS This systematic review included double-blinded, randomized, placebo-controlled trials reporting heavy drinking days, amount of alcohol consumption, overall dropouts, or dropouts due to adverse events.

METHODS We performed a meta-analysis by including all randomized, placebo-controlled trials reporting edema and headache with amlodipine in patients with arterial hypertension and CAD.

A systematic review and meta-analysis examined methylphenidate trials reporting sleep-related adverse events, to determine in part whether risk varies by drug formulation and type of sleep problem.

A systematic review and meta-analysis examined methylphenidate trials reporting sleep-related adverse events, to determine in part whether risk varies by drug formulation and type of sleep problem.

A search was conducted for randomised controlled trials reporting clinical outcomes following adjunctive antibiotic for patients divided by baseline microbiological profiles.

METHODS This systematic review included double-blinded, randomized, placebo-controlled trials reporting heavy drinking days, amount of alcohol consumption, overall dropouts, or dropouts due to adverse events.

MATERIAL AND METHODS Electronic database and manual searches were conducted to identify cohort studies and clinical trials reporting on the OHRQoL of individuals receiving implant-supported crowns (ISCs), implant-supported fixed dental prostheses (IFDPs), implant-supported removable dental prostheses (IRDPs), tooth-supported fixed dental prostheses (TFDPs), and removable partial dentures (RPDs).

The purpose of this study was to systematically review existing clinical trials reporting about intra oral scanning procedures on sound teeth.

A systematic review and meta-analysis examined methylphenidate trials reporting sleep-related adverse events, to determine in part whether risk varies by drug formulation and type of sleep problem.

A systematic review and meta-analysis examined methylphenidate trials reporting sleep-related adverse events, to determine in part whether risk varies by drug formulation and type of sleep problem.

Four trials reporting concurrent GDMT (statins, beta-blockers and ACEI/ARB) at least at baseline or discharge were selected using MEDLINE, EMBASE and CENTRAL (inception–10 October 2018) (Table 1).

Thirty-four trials reporting on 2647 patients were included.

We included trials reporting long-term effects (≥ 12-months) on objective PA levels with community-based participants, aged ≥18 years, with no specific medical conditions.

We included trials reporting PCI with stent implantation in 70% or more of the patients and statin therapy in 50% or more patients in the study population.

Early benefits were not maintained in the two trials reporting follow‐up 1 to 3 years later.

Physical therapy: Two trials reporting three comparisons suggest that physical therapy using transcutaneous electrical nerve stimulation (TENS) may reduce the mean number of incontinent episodes in 24 hours (MD -4.

Methods: MEDLINE, PubMed, EMBASE, and the Cochrane Central Register of Controlled Trials had been searched for randomized control trials reporting the probiotics strategy for premature infants.

Included studies were published cohort, case-control or cross-sectional studies, and randomized control trials reporting the prevalence of AF in patients with CRAO or CRVO.

Prospective and retrospective trials reporting outcomes for women who underwent ART or RH for the management of early stages CC, were considered eligible for inclusion.

Prospective and retrospective trials reporting outcomes for women with gynecological malignancies who underwent laparoscopic extraperitoneal or transperitoneal lymphadenectomy were enrolled.

SUMMARY Although those innovative agents were assessed in phase II trials reporting on variable antitumor efficacy in terms of response and survival, in selected and limited cohorts of patients, a better understanding of systemic treatment sequences in a real-life setting is mandatory to analyze the actual efficacy of each line of treatment one after another, define the best clinical-pathological selection of patients for the administration of chemotherapy, targeted agents, and immunotherapy, and develop individualized decision-making to optimize the survival of patients with advanced thymic malignancies.

One randomized phase III clinical trial and three phase II trials reporting outcomes of checkpoint-inhibitors in conjunction with cCRT for stage III unresectable NSCLC were identified.

Observational studies and randomized trials reporting adjusted HF incidence by stratified socioeconomic measures were included.

Randomized trials reporting the following outcomes were included: Apgar score at 1- or 5-min; umbilical arterial and venous pH; umbilical arterial pH <7.

However, the five trials reporting health-related quality of life at the end of the intervention, each showed little or no evidence of a difference between exercise-based cardiac rehabilitation and control.

MAIN RESULTS We included five trials reporting data for 330 eyes (326 participants).

METHODS We conducted a network meta-analysis (NMA) of the randomized controlled Phase III trials reporting on the second-line drug treatment options in R/M SCCHN.

Among these trials a total of three GBM Phase III trials reporting OS benefit, including the EORTC/NCIC study (PMID: 15758009), EF-14 (NCT00916409) and CeTeG (NCT01149109).

Prospective and retrospective trials reporting outcomes for women who underwent ART or RH for the management of early stages CC, were considered eligible for inclusion.

METHODS A systematic review and meta-analysis of randomized controlled trials reporting outcomes of muscle mass, strength, and physical function was performed.

A search was conducted for randomised controlled trials reporting clinical outcomes following adjunctive antibiotic for patients divided by baseline microbiological profiles.

AIMS To answer the question: 'What is the clinical benefit in periodontitis patients taking adjunctive systemic antimicrobials to non-surgical therapy, depending on pre-treatment detection of periodontopathogenic bacteria?' MATERIALS AND METHODS A search was conducted in 4 electronic databases for randomised controlled trials reporting clinical outcomes following adjunctive antibiotic therapy for patients divided by baseline microbiological profiles.

Considering only trials reporting data for BoD, the experimental arms significantly improved the PFS [HR 0.

Results Eight prospective trials reporting data on postpartum depression were included in our meta-analysis.

We included trials reporting long-term effects (≥ 12-months) on objective PA levels with community-based participants, aged ≥18 years, with no specific medical conditions.

We included trials reporting long-term effects (≥12 months) on objective physical activity (step count and moderate-to-vigorous physical activity) with community-based participants, aged 18 years and older, without specific medical conditions.

A systematic review and meta-analysis examined methylphenidate trials reporting sleep-related adverse events, to determine in part whether risk varies by drug formulation and type of sleep problem.

A systematic review and meta-analysis examined methylphenidate trials reporting sleep-related adverse events, to determine in part whether risk varies by drug formulation and type of sleep problem.

Results: We identified 90 publications on 69 unique trials reporting efficacy and safety outcomes in patients with early RA, including 43 RCTs and 26 observational studies.

The clinical trials reporting efficacy and immune function of JOI combined with chemotherapy versus chemotherapy in advanced NSCLC were included according to the inclusion and exclusion criteria.

3 Recent clinical trials reporting cardiovascular benefit of drugs used to treat diabetes have sparked even more interest.

Cardiovascular outcome trials and renal outcome trials reporting cardiovascular outcomes on GLP-1 RAs, SGLT-2 and DPP-4 inhibitors in patients with type 2 diabetes mellitus were included.

Included studies were published cohort studies or randomised controlled trials reporting rates of mortality and/or rehospitalization in HF patients, married and unmarried.

These findings are in contrast with a recently published Cochrane review and previous trials reporting rates of ORN (non-HBO) of 14% to 30% and challenge a long-established standard of care.

RESULTS Nineteen RCTs and two randomized crossover trials reporting results from 3519 participants were included.

For trials reporting results, average median age at diagnosis of trial participants was 55.

Observational studies and randomized trials reporting adjusted HF incidence by stratified socioeconomic measures were included.

The majority reported a stratified block method (69%) of allocation, and of the trials reporting adjusted analyses, 91% were pre-specified.

Randomized controlled trials reporting effects of RT on self-reported disability/function in ≥65 year-old adults with defined, functional limitations or self-reported disability were eligible.

Trials reporting effect estimates on healthcare appointment attendance and medicine adherence were assessed for risk of bias and included in meta-analyses using random-effects models.

Although there is some convincing evidence that meeting requirements of high intakes in carbohydrate and protein and avoiding deficiencies in nutrients such as vitamin D and antioxidants is integral for optimal immune health, well-powered randomised controlled trials reporting improvements in URS beyond such intakes are lacking.

Preterm infant formula was supplemented with the omega-3 docosahexaenoic acid and the omega-6 arachidonic acid from 2000 (to the level found in the breast milk of women consuming a western diet) based on trials reporting improvements in visual acuity.