Introduction to Trials Involving

Results Four randomized controlled trials involving 7201 patients were included.

Results Four randomized, controlled clinical trials involving 5199 patients were included in this study.

Results This meta-analysis included six randomized controlled trials involving 304 patients.

RESULTS The meta-analysis included 20 randomized controlled trials involving 2188 men (n = 1105 in intervention groups; n = 1083 in control groups).

We evaluated the efficacy, tolerability, and safety of double-blinded, randomized, controlled trials involving only adult participants and comparing combination therapy (CT: ≥ 2 drugs) to a placebo and/or at least one other comparator with an NP indication.

We evaluated the efficacy, tolerability and safety of double-blind randomized controlled trials involving only adult participants comparing combination therapy (CT: ≥ 2 drugs) to placebo and/or at least one other comparator with NP indication.

Results In this meta-analysis, we included 2659 patients from eight randomized controlled trials involving non-small-cell lung cancer, prostate, epithelial ovarian, fallopian tube, and primary peritoneal carcinoma.

Results Twenty-eight randomized controlled trials involving a total of 17,488 children were included.

RESULTS We identified nine eligible trials involving 14799 patients and five treatments: conventional or moderately hypofractionated whole breast irradiation (CF/MFWBI), ultra hypofractionated whole breast irradiation (UFWBI), accelerated ultra hypofractionated whole breast irradiation (AUFWBI), moderately hypofractionated partial breast irradiation (MFPBI) and accelerated partial breast irradiation (APBI).

The rising number of publications with substantial results on the valuable therapeutic innovation of CBD for treating SUD, the undeniable need of new therapeutic agents to improve the clinical outcome of patients with SUD, and the upcoming clinical trials involving CBD endorse the relevance of this review.

Small molecule inhibitors of glycogen synthase kinase-3 beta have demonstrated therapeutic potential in pre-clinical models and are currently being evaluated in early phase clinical trials involving pancreatic cancer patients with interim results showing favorable results.

We searched all randomized controlled trials involving ICI drugs published in PubMed, Web of Science, and EMBASE from 2010 to June 2020.

RESULTS Seven publications from 6 randomised controlled trials involving 391 prostate cancer patients were included.

Results A total of 7 randomized trials involving 757 participants fulfilled the eligibility criteria.

RESULTS Numbers of subdural hematoma were available from thirteen randomized trials involving 155,554 participants comparing aspirin (dosage range 25 mg twice daily to 325 mg daily) to placebo (ten double-blind trials) or no aspirin (three trials).

Results: Seven trials involving 603 patients were reviewed.

RESULTS Twenty-seven trials involving 7,006 participants were included.

Results: Eighteen eligible trials involving 4930 patients and 15 treatment regimens were included.

RESULTS Eight eligible trials involving 3,941 participants published between 2004 and 2018 were identified.

SELECTION CRITERIA All randomised and quasi-randomised trials involving agents that reduce gastric acidity compared to placebo or a comparator treatment.

Larger randomised trials involving all intensive healthcare clinicians are required to evaluate multifaceted interventions.

Four trials involving 13 193 patients (10 479 males; 2714 females) were included.

Results Four trials involving 453 patients were included.

MAIN RESULTS We included 14 trials involving a total of 4033 infants (2804 infants participated in one large trial).

MAIN RESULTS We included 14 trials involving a total of 2278 CEAs with patch closure operations: seven trials compared vein closure with PTFE closure, five compared Dacron grafts with other synthetic materials, and two compared bovine pericardium with other synthetic materials.

Results: Two trials involving 121 patients were included.

RESULTS Fifty-two trials involving 4,568 participants were included.

6 Survival benefit of carvedilol can be gathered from three trials involving less than 200 patients.

Results Three trials involving 1584 patients were included.

Results: Eight trials involving 488 participants undergoing lung resection with one-lung ventilation were included.

RESULTS Thirty-eight trials involving 3,836 participants were included in this NMA, the vast majority of which had a low or unclear risk of selection bias, detection bias, reporting bias, attrition bias, but had a high risk of performance bias.

Methods Sixteen trials involving 324 animals obtained from MEDLINE (PubMed), EMBASE, the Cochrane library, the Chinese National Knowledge Infrastructure, Wan-Fang, Cqvip, the Korean Studies Information Service System, and the Oriental Medicine Advanced Searching Integrated System met the inclusion criteria.

RESULTS  Sixteen trials involving 1,000 patients were included in this meta-analysis.

Nineteen trials involving 2839 eyes were included.

Results Nineteen trials involving 4571 patients were included in the analysis.

Of 3,190 citations, we included nine trials involving 10,974 participants.

RESULTS Twenty-nine trials involving 4,107 participants were included, informing low to very-low certainty evidence.

RESULTS We analyzed five trials involving 1134 participants and found that the MHFA program could significantly increase the student's knowledge (SMD: 0.

Twenty-five trials involving 19 806 patients (10 023 randomised to revascularisation plus medical therapy and 9783 to medical therapy alone) were included.

However, studies involving winemaking trials are often limited by the availability of suitable quantities of smoke-affected grapes, either from vineyards exposed to smoke or from field trials involving the application of smoke to grapevines.

Field trials involving three tomato cultivars: Celebrity, Mountain magic and Rocky top were conducted at the George Washington Carver Agricultural Experiment Station Organic Research Farm, Tuskegee University Alabama in 2018 and 2019.

Results Fourteen trials involving 14 regimens matched our eligibility criteria.

RESULTS Fourteen trials involving 936 participants had poor reporting and methodological quality.

We included 12 trials involving 1095 participants.

Treatment of COVID‐19 disease We included 12 trials involving 8569 participants, all of whom were adults.

A total of 22 trials involving 3709 patients were included.

Supplementation with vitamin D alone versus placebo/no interventionA total of 22 trials involving 3725 pregnant women were included in this comparison; 19 trials were assessed as having low-to-moderate risk of bias for most domains and three trials were assessed as having high risk of bias for most domains.

A total of 21 trials involving 2277 participants and 8 immunotherapies were eligible for this study.

MAIN RESULTS We included 21 trials involving 421 participants in the qualitative synthesis.

Hyperpolarized magnetic resonance (hMR) is a novel approach to gain insights into these pathways, and human trials involving hMR and skeletal muscle metabolism are imminent.

Finally, we discuss their attractive role as prognostic biomarkers for HF, highlighting the most relevant human trials involving these miRNAs.

Eighteen trials involving 972 participants with T2DM were included in this meta-analysis, of whom 523 were assigned to an exercise group and 449 were assigned to a control group.

Results: There are Eighteen trials involving 1,697 patients were included in this study.

A meta-analysis of 11 intervention trials involving a total of 724 participants was performed.

Guidelines for the management of dyslipidaemia from the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS) were updated in late 2019 in light of recent intervention trials involving the use of innovative lipid-lowering agents in combination with statins.

We conducted a systematic literature review in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) Statement guidelines for reporting to identify all neuroendocrine biomarkers used to evaluate psychological stress in randomized control trials involving music interventions.

RESULTS A total of 9 clinical control trials involving 4,351 patients (2,123 in the Seprafilm group and 2,228 in the control group) were included.

Results: Ten trials involving 3938 participants were included in this study.

Results Ten trials involving 770 participants were included.

Herein, we report the application of ESMO MCBS to systemic treatment trials involving metastatic STS patients.

Randomized controlled treatment trials involving large number of patients with histological end point are required to assess the efficacy of different modalities.

Methods: This analysis consists of patients enrolled in one of three prospective trials involving activity monitoring (NCT02649569, NCT03115398, NCT03102229) during chemoradiation.

Prospective trials involving fall assessments and fall-prevention interventions are needed in this population.

However, further investigation is required to confirm the efficacy of future trials involving the use of these compounds with high-risk human populations exposed to asbestos, such as workers involved in asbestos-handling activities.

This review provides intervention scientists with a synthesis of information that may inform future trials involving Fitbit devices.

An overview of ongoing trials involving therapeutic agents targeting complement in glomerular diseases is also provided.

Moreover, past and ongoing trials involving personalized bioactive materials and promising agents such as cell/bacteria-based micro/nano-biorobotics are further discussed, which may become another powerful tool for treatment in the near future.

MAIN RESULTS We included 28 trials involving 24,025 participants.

Results In total 28 trials involving 1,926 participants were included.

Results Data from 16 high-quality trials involving 10,643 NSCLC patients receiving either immunotherapy or chemotherapy/placebo enabled direct comparison of the survival impact of smoking.

We recommend that rigorous, as well as high-quality trials involving large samples sizes should be conducted to confirm our findings.

RESULTS In total, 25 trials involving 2258 patients with symptomatic LDH were included.

There were 25 trials involving 10,320 mother–child pairs, and 71 assessments of behavior in 6867 of the children (66.

Patients and Methods: We conducted two phase II open-label trials involving 60 patients with previously untreated and R/R advanced-stage iNHL.

A total of six randomized, controlled trials (RCTs) and 13 open-label trials involving the use of gabapentin and pregabalin in BD patients were reviewed.

Participant accrual and retention, program adherence, and safety statistics in this trial were within the range of similar exercise trials involving individuals with cancer.

Randomised, controlled, exercise trials involving cancer survivors were eligible.

3 kg/m2 completed 3 trials involving a 2-h oral glucose tolerance test whilst, in a randomized counterbalanced order, (1) sitting motionless (SIT), (2) standing motionless (STAND); and (3) sitting motionless with NMES of quadriceps and calves at a self-selected tolerable intensity.

METHODS We conducted two replicate international, double-blind, 24-week, phase 3 trials involving women with fibroid-associated heavy menstrual bleeding.

We included 13 trials involving 7557 patients: three trials with erenumab, two trials with galcanezumab, two trials with fremanezumab, one trial with eptinezumab, and five trials with topiramate, for the prophylaxis of episodic migraine in adults.

A total of 13 trials involving 2584 patients, of whom 893 (34.

MAIN RESULTS Six trials involving 687 patients were included, all of which received total knee arthroplasty only.

Forty‐six trials involving 4256 patients were included.

Detection of the Wolbachia endosymbiont in Aedes aegypti mosquitoes through real-time PCR assays is widely used during and after Wolbachia releases in dengue reduction trials involving the wMel and wAlbB strains.

Detection of the Wolbachia endosymbiont in Aedes aegypti mosquitoes through real-time polymerase chain reaction assays is widely used during and after Wolbachia releases in dengue reduction trials involving the wMel and wAlbB strains.

RESULTS Across 19 included trials involving 2585 participants, smartphone application-based interventions were associated with a clinically and statistically significant reduction of glycated haemoglobin (HbA1c).

Forty‐eight included trials involving 4,704 participants were included.

We excluded trials involving children with severe or very severe pneumonia, and non-RCTs.

We excluded trials involving other types of treatment for varicose veins (either as a comparator to stockings or as an initial non-randomised treatment), including sclerotherapy and surgery.

As an inexpensive pharmacological agent which has relatively few adverse effects that tend to be mild and tolerable, the role of colchicine in secondary prevention of atherothrombotic events has been the focus of multiple recent large-scale randomized controlled trials involving patients with stable CAD (LoDoCo and LoDoCo2 trials), a recent myocardial infarction (COLCOT, COPS, and CLEAR SYNERGY trials), and undergoing percutaneous coronary interventions (PCI) (COLCHICINE-PCI trial).

Methods: The Web of Science, PubMed, Cochrane Library, Embase, and Clinical Trials databases were electronically searched to collect randomized controlled trials involving patients with type 2 diabetes mellitus through June 2020.

” Randomized controlled trials or controlled trials involving adults who have hand function problems caused by stroke are included in this study.

Methods SONG-CKD involves four phases: a systematic review to identify outcomes (domains and measures) that have been reported in randomised controlled trials involving adults with CKD who do not require kidney replacement therapy; stakeholder key informant interviews with health professionals involved in the care of adults with CKD to ascertain their views on establishing core outcomes in CKD; an international two-round online Delphi survey with patients, caregivers, clinicians, researchers, policy makers and industry representatives to obtain consensus on critically important outcome domains; and stakeholder consensus workshops to review and finalise the set of core outcome domains for trials in CKD.

RESULTS Fifty-two trials involving 4,568 participants were included.

RESULTS Twenty-nine trials involving 4,107 participants were included, informing low to very-low certainty evidence.

Results: There are Eighteen trials involving 1,697 patients were included in this study.

Results Eleven clinical trials involving 1,113 patients with NSCLC were eligible for analysis.

Results Data from 16 high-quality trials involving 10,643 NSCLC patients receiving either immunotherapy or chemotherapy/placebo enabled direct comparison of the survival impact of smoking.

METHODS Between 2011-2013 and 2016-2018, 2 randomized controlled trials involving 10 centers across the United States accrued 631 patients with stage 0-3 breast cancer, all of whom underwent breast conserving surgery.