Introduction to Trials Exploring

Thus, prospective randomized controlled trials exploring the safety and efficacy of CAMs in cancer patients are needed.

Further research in the form of prospective randomized controlled trials exploring the optimal dose and time of nutritional therapy is necessary to examine nutritional needs of critical care patients.

By contrast to clinical trials exploring osteoporosis, clinical trials specifically designed for the osteopenic population are limited.

Using data derived from two clinical trials exploring CPI in metastatic UC, we demonstrate no statistically significant difference in response rates in patients with FGFR3-mutant versus wild-type UC.

BACKGROUND Contemporary randomized controlled trials exploring adjuvant chemotherapy (AC) for bladder cancer (BCa) have yielded inconsistent results due to premature termination and/or poor patient accrual.

Methods and analysis: Through October 2019, Web of Science, PubMed, the Cochrane Library, EMBASE, and Clinical Trials will be systematically searched to identify randomized controlled trials exploring the efficacy of hypotensive resuscitation in traumatic hemorrhagic shock.

Prospective trials exploring the safety and efficacy of this combination in relapsed/refractory DLBCL are under way.

There is a need for prospective trials exploring the use of ablative radiotherapy in metastatic disease in paediatric/teenage and young adult patients in order to establish safe and effective treatment schedules.

In this review, we summarise planned and ongoing trials exploring the potential benefit, or harm, of old and new pharmacological interventions that might offer further improvements in treatment for those with HFrEF and extend success to the treatment of patients with heart failure with preserved left ventricular ejection fraction (HFpEF) and other heart failure phenotypes.

In this review, we provide an extensive overview of published and ongoing trials exploring PARP inhibitors in treatment of prostate cancer and discuss the underlying biology.

To our knowledge, in spite of several trials exploring the beneficial effect of n-3 polyunsaturated fatty acids (PUFA) on polycystic ovary syndrome (PCOS), no comprehensive evidence has investigated the effects of n-3 PUFA consumption on PCOS complications.

The first of a series of three articles, Patrick Holmes discusses the findings of several trials exploring the pharmaceutical manangement of type 2 diabetes which will aid nurses advising patients.

With further research effort, the integration of tumor molecular profiling in trials exploring targeted immunotherapy will lead to better understanding of the predictive role of various molecular and immune biomarkers and ultimately shine the horizon for this patient population.

Clinical trials exploring targeted and untargeted sequencing to improve the outcomes of ctDNA detection are showing promising results, having reached a limit of detection as low as 0.

Moreover, the applicability of a unique Nanostring-based assay to routine biopsies may facilitate the stratification of patients at diagnosis and their inclusion in future trials exploring novel therapeutic approaches.

However, in trials exploring novel fields, in which limited a priori consensus exists about clear-cut endpoints, such as in overreaching/overtraining (Urhausen & Kindermann, 2002), predefinition of primary endpoints is more complex.

There are a variety of clinical trials exploring different therapeutic approaches including checkpoint inhibition, novel chemotherapy and drug delivery, viral and gene therapy, vaccines, and targeted therapy.

Adjuvant therapy in resected renal cell carcinoma (RCC) is a discussed and complex issue due to conflicting results obtained in several clinical trials exploring different agents in this setting (1-4).

Aim: With the final aim to explore the first-line treatment options for non-small-cell lung cancer (NSCLC) patients, we performed a systematic review and literature-based meta-analysis of available clinical trials exploring immunotherapy in combination versus standard histology-based chemotherapy.

Success of immunotherapy for the treatment of metastatic bladder cancer has led to promising trials exploring immunotherapy in muscle-invasive disease.