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This literature review includes medication treatment data from clinical trials enrolling individuals with features of OPT, including acquired pendular nystagmus (APN).
This literature review includes medication treatment data from clinical trials enrolling individuals with features of OPT, including acquired pendular nystagmus (APN).
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Gene therapy using adenoviruses encoding the immunostimulatory gene CD40L (AdCD40L) has shown promise in initial clinical trials enrolling human patients with various malignancies including melanoma.
Gene therapy using adenoviruses encoding the immunostimulatory gene CD40L (AdCD40L) has shown promise in initial clinical trials enrolling human patients with various malignancies including melanoma.
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RESULTS
A total of 2,500 AMICS patients have been enrolled in 15 clinical trials over 21 years with only four trials enrolling >80 patients.
RESULTS
A total of 2,500 AMICS patients have been enrolled in 15 clinical trials over 21 years with only four trials enrolling >80 patients.
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Trials Enrolling sentence examples within Randomized Trials Enrolling
The primary endpoint was pCR, with sub-analyses based on PD-L1 expression and risk of relapse RESULTS: Five randomized trials enrolling 1496 TNBC patients were included.
The primary endpoint was pCR, with sub-analyses based on PD-L1 expression and risk of relapse RESULTS: Five randomized trials enrolling 1496 TNBC patients were included.
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Two randomized trials enrolling 529 patients and 23 observational studies enrolling 7296 patients proved eligible.
Two randomized trials enrolling 529 patients and 23 observational studies enrolling 7296 patients proved eligible.
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Trials Enrolling sentence examples within trials enrolling patient
The aim of our systematic review is to gain more insight in reporting of bone metastases, skeletal-related events, and bone-specific outcome of treatment in clinical trials enrolling patients with EGFR-mutated lung cancer.
The aim of our systematic review is to gain more insight in reporting of bone metastases, skeletal-related events, and bone-specific outcome of treatment in clinical trials enrolling patients with EGFR-mutated lung cancer.
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Objective: The purpose of this study was to provide a cross-sectional view of all registered clinical trials enrolling patients with osteonecrosis of the jaw (ONJ).
Objective: The purpose of this study was to provide a cross-sectional view of all registered clinical trials enrolling patients with osteonecrosis of the jaw (ONJ).
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Trials Enrolling sentence examples within trials enrolling participant
Meaning The studied formulation of FRM-0334 should not be investigated in future clinical trials enrolling participants with GRN haploinsufficiency; this study did not fully address the potential of histone deacetylase inhibition to alter GRN expression.
Meaning The studied formulation of FRM-0334 should not be investigated in future clinical trials enrolling participants with GRN haploinsufficiency; this study did not fully address the potential of histone deacetylase inhibition to alter GRN expression.
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The present work systematically reviewed any clinical trials enrolling participants with constitutional thinness and bibliographic researches were performed between December 2018 and June 2020.
The present work systematically reviewed any clinical trials enrolling participants with constitutional thinness and bibliographic researches were performed between December 2018 and June 2020.
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Trials Enrolling sentence examples within trials enrolling adult
Articles included expert recommendations and those reporting pain education programs used in clinical trials enrolling adults with chronic neuromusculoskeletal pain and published in English between 1990 and 2021.
Articles included expert recommendations and those reporting pain education programs used in clinical trials enrolling adults with chronic neuromusculoskeletal pain and published in English between 1990 and 2021.
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SELECTION CRITERIA
We included randomized controlled trials enrolling adults with bipolar disorder who were treated with lamotrigine, placebo or lithium.
SELECTION CRITERIA
We included randomized controlled trials enrolling adults with bipolar disorder who were treated with lamotrigine, placebo or lithium.
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10.1007/s00228-021-03196-9
RESULTS
A total of eleven trials enrolling 6291 patients were included, of which 75.
RESULTS
A total of eleven trials enrolling 6291 patients were included, of which 75.
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10.1007/s13760-021-01761-8
This literature review includes medication treatment data from clinical trials enrolling individuals with features of OPT, including acquired pendular nystagmus (APN).
This literature review includes medication treatment data from clinical trials enrolling individuals with features of OPT, including acquired pendular nystagmus (APN).
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10.4253/wjge.v13.i5.137
RESULTS Thirteen randomized controlled trials enrolling 1111 patients were included.
RESULTS Thirteen randomized controlled trials enrolling 1111 patients were included.
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10.3389/fvets.2021.695222
Gene therapy using adenoviruses encoding the immunostimulatory gene CD40L (AdCD40L) has shown promise in initial clinical trials enrolling human patients with various malignancies including melanoma.
Gene therapy using adenoviruses encoding the immunostimulatory gene CD40L (AdCD40L) has shown promise in initial clinical trials enrolling human patients with various malignancies including melanoma.
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10.1080/14779072.2021.1902806
However, no sex-specific guidelines on PCI and the use of DES are available as current evidence was derived from clinical trials enrolling predominantly male patients.
However, no sex-specific guidelines on PCI and the use of DES are available as current evidence was derived from clinical trials enrolling predominantly male patients.
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10.1001/jamanetworkopen.2021.13749
Key Points Question How is disease burden associated with female representation in US-based clinical trials, and how are disease category and other clinical trial features associated with female representation in clinical trials? Findings In this cross-sectional study of 20 020 clinical trials enrolling more than 5 million participants between 2000 and 2020, clinical trials in the fields of oncology, neurology, immunology, and nephrology had the lowest female participant representation relative to corresponding disability-adjusted life-years.
Key Points Question How is disease burden associated with female representation in US-based clinical trials, and how are disease category and other clinical trial features associated with female representation in clinical trials? Findings In this cross-sectional study of 20 020 clinical trials enrolling more than 5 million participants between 2000 and 2020, clinical trials in the fields of oncology, neurology, immunology, and nephrology had the lowest female participant representation relative to corresponding disability-adjusted life-years.
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10.1158/1078-0432.CCR-21-0134
Experimental Design: We pooled data from seven European multicenter phase II/III clinical trials enrolling 2,190 patients with newly diagnosed MM from 2003 to 2017.
Experimental Design: We pooled data from seven European multicenter phase II/III clinical trials enrolling 2,190 patients with newly diagnosed MM from 2003 to 2017.
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10.1002/14651858.CD002053.pub4
SELECTION CRITERIA
We included trials enrolling infants with NAS born to mothers with an opioid dependence with more than 80% follow-up and using randomised, quasi-randomised and cluster-randomised allocation to sedative or control.
SELECTION CRITERIA
We included trials enrolling infants with NAS born to mothers with an opioid dependence with more than 80% follow-up and using randomised, quasi-randomised and cluster-randomised allocation to sedative or control.
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10.1016/j.carrev.2021.05.013
RESULTS
Five trials enrolling 11,542 patients allocated to antithrombotic regimens omitting (n = 5795) or including aspirin (n = 5747) were included.
RESULTS
Five trials enrolling 11,542 patients allocated to antithrombotic regimens omitting (n = 5795) or including aspirin (n = 5747) were included.
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10.2174/1574888X16666210816111031
RESULTS
After a literature search and detailed evaluation, 9 randomized controlled trials enrolling 460 patients were included in the quantitative analysis.
RESULTS
After a literature search and detailed evaluation, 9 randomized controlled trials enrolling 460 patients were included in the quantitative analysis.
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10.1016/j.pec.2021.09.021
Articles included expert recommendations and those reporting pain education programs used in clinical trials enrolling adults with chronic neuromusculoskeletal pain and published in English between 1990 and 2021.
Articles included expert recommendations and those reporting pain education programs used in clinical trials enrolling adults with chronic neuromusculoskeletal pain and published in English between 1990 and 2021.
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10.1111/vde.12932
BACKGROUND
To estimate the extent and severity of atopic dermatitis (AD)-related skin lesions, clinical trials enrolling dogs with AD often use categorical scales such as the Canine Atopic Dermatitis Extent and Severity Index, 4th iteration (CADESI-04) and Canine Atopic Dermatitis Lesion Index (CADLI).
BACKGROUND
To estimate the extent and severity of atopic dermatitis (AD)-related skin lesions, clinical trials enrolling dogs with AD often use categorical scales such as the Canine Atopic Dermatitis Extent and Severity Index, 4th iteration (CADESI-04) and Canine Atopic Dermatitis Lesion Index (CADLI).
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10.1080/00325481.2021.1912466
Two trials enrolling 195 adolescents accounted for 13.
Two trials enrolling 195 adolescents accounted for 13.
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10.1016/j.jclinane.2021.110330
MAIN RESULTS
Thirty-one trials enrolling 1684 participants were included in the systematic review.
MAIN RESULTS
Thirty-one trials enrolling 1684 participants were included in the systematic review.
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10.3390/cancers13133144
The aim of our systematic review is to gain more insight in reporting of bone metastases, skeletal-related events, and bone-specific outcome of treatment in clinical trials enrolling patients with EGFR-mutated lung cancer.
The aim of our systematic review is to gain more insight in reporting of bone metastases, skeletal-related events, and bone-specific outcome of treatment in clinical trials enrolling patients with EGFR-mutated lung cancer.
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10.1371/journal.pone.0244689
Results Fourteen trials enrolling 3,157,259 patients were included.
Results Fourteen trials enrolling 3,157,259 patients were included.
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10.1001/jamanetworkopen.2021.25584
Meaning The studied formulation of FRM-0334 should not be investigated in future clinical trials enrolling participants with GRN haploinsufficiency; this study did not fully address the potential of histone deacetylase inhibition to alter GRN expression.
Meaning The studied formulation of FRM-0334 should not be investigated in future clinical trials enrolling participants with GRN haploinsufficiency; this study did not fully address the potential of histone deacetylase inhibition to alter GRN expression.
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10.1542/peds.2020-021204
RESULTS: Ten trials enrolling 1502 preterm newborns were included.
RESULTS: Ten trials enrolling 1502 preterm newborns were included.
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10.1158/1538-7445.SABCS20-SP97
The CTneoBC analysis, which included 12 trials enrolling over 11,950 patients, showed that patients experiencing a pathologic complete response (pCR; ypT0ypN0 or ypT0/isN0) have improved event-free and overall survival with the association between pCR and longterm outcomes being strongest in patients with triple negative breast cancer (TNBC) and in those with HER2+/hormone receptor-negative breast cancer receiving trastuzumab.
The CTneoBC analysis, which included 12 trials enrolling over 11,950 patients, showed that patients experiencing a pathologic complete response (pCR; ypT0ypN0 or ypT0/isN0) have improved event-free and overall survival with the association between pCR and longterm outcomes being strongest in patients with triple negative breast cancer (TNBC) and in those with HER2+/hormone receptor-negative breast cancer receiving trastuzumab.
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10.1007/s11154-021-09650-4
The present work systematically reviewed any clinical trials enrolling participants with constitutional thinness and bibliographic researches were performed between December 2018 and June 2020.
The present work systematically reviewed any clinical trials enrolling participants with constitutional thinness and bibliographic researches were performed between December 2018 and June 2020.
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10.1007/s11255-021-02922-7
However, large-scale clinical trials enrolling heterogeneous patients are required to evaluate the clinical value of miRNAs.
However, large-scale clinical trials enrolling heterogeneous patients are required to evaluate the clinical value of miRNAs.
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10.1161/JAHA.120.020513
0002) and in trials enrolling younger patients (P=0.
0002) and in trials enrolling younger patients (P=0.
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10.1016/j.critrevonc.2021.103223
The primary endpoint was pCR, with sub-analyses based on PD-L1 expression and risk of relapse RESULTS: Five randomized trials enrolling 1496 TNBC patients were included.
The primary endpoint was pCR, with sub-analyses based on PD-L1 expression and risk of relapse RESULTS: Five randomized trials enrolling 1496 TNBC patients were included.
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10.1186/s13054-021-03697-0
Two authors independently selected the investigations according to the following criteria: (1) observational study or randomized clinical trials enrolling ≥ 50 hospitalized patients undergoing NIRS outside the ICU, (2) laboratory-confirmed COVID-19, and (3) at least the intra-hospital mortality reported.
Two authors independently selected the investigations according to the following criteria: (1) observational study or randomized clinical trials enrolling ≥ 50 hospitalized patients undergoing NIRS outside the ICU, (2) laboratory-confirmed COVID-19, and (3) at least the intra-hospital mortality reported.
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10.7759/cureus.17984
Objective: The purpose of this study was to provide a cross-sectional view of all registered clinical trials enrolling patients with osteonecrosis of the jaw (ONJ).
Objective: The purpose of this study was to provide a cross-sectional view of all registered clinical trials enrolling patients with osteonecrosis of the jaw (ONJ).
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10.1111/jdv.17734
METHODS
The data from two Phase 3, multicenter, randomized, investigator-blind, active, and vehicle-controlled trials enrolling patients with psoriasis were pooled and analysed.
METHODS
The data from two Phase 3, multicenter, randomized, investigator-blind, active, and vehicle-controlled trials enrolling patients with psoriasis were pooled and analysed.
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10.1097/MCC.0000000000000875
This stands in contrast to several recent trials enrolling up to several thousand patients and finding no difference.
This stands in contrast to several recent trials enrolling up to several thousand patients and finding no difference.
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10.1101/2021.08.24.21262515
In 2021 two large pragmatic trials enrolling critically ill patients will add substantial new data to address this controversy.
In 2021 two large pragmatic trials enrolling critically ill patients will add substantial new data to address this controversy.
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10.1002/ccd.29710
RESULTS
A total of 2,500 AMICS patients have been enrolled in 15 clinical trials over 21 years with only four trials enrolling >80 patients.
RESULTS
A total of 2,500 AMICS patients have been enrolled in 15 clinical trials over 21 years with only four trials enrolling >80 patients.
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10.1002/14651858.CD013575.pub2
SELECTION CRITERIA
We included randomized controlled trials enrolling adults with bipolar disorder who were treated with lamotrigine, placebo or lithium.
SELECTION CRITERIA
We included randomized controlled trials enrolling adults with bipolar disorder who were treated with lamotrigine, placebo or lithium.
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10.1016/j.ejim.2021.09.016
RESULTS
Four randomized controlled trials enrolling 33718 patients were included.
RESULTS
Four randomized controlled trials enrolling 33718 patients were included.
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10.3390/cells10082034
However, only a few clinical trials enrolling HCC patients actually distinguished NAFLD/NASH-related cases from other non-cirrhotic causes and therefore evidence is still lacking in this subset of patients.
However, only a few clinical trials enrolling HCC patients actually distinguished NAFLD/NASH-related cases from other non-cirrhotic causes and therefore evidence is still lacking in this subset of patients.
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10.1053/j.seminoncol.2021.01.001
In this review, we study two decades of efforts to improve upon the gemcitabine backbone - 67 phase II and III trials enrolling 16,446 patients - that culminated in the approvals of gemcitabine/nab-paclitaxel (Gem/NabP) and FOLFIRINOX.
In this review, we study two decades of efforts to improve upon the gemcitabine backbone - 67 phase II and III trials enrolling 16,446 patients - that culminated in the approvals of gemcitabine/nab-paclitaxel (Gem/NabP) and FOLFIRINOX.
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10.2337/dc20-2386
In addition, two recent small trials enrolling non-ICU patients confirm the feasibility of using remote real-time CGM in the hospital (4,5).
In addition, two recent small trials enrolling non-ICU patients confirm the feasibility of using remote real-time CGM in the hospital (4,5).
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10.1007/s00125-021-05529-w
Several cardiovascular outcome trials on sodium–glucose cotransporter 2 inhibitors (SGLT2i) have been released recently, including trials enrolling patients with congestive heart failure (CHF) and chronic kidney disease (CKD).
Several cardiovascular outcome trials on sodium–glucose cotransporter 2 inhibitors (SGLT2i) have been released recently, including trials enrolling patients with congestive heart failure (CHF) and chronic kidney disease (CKD).
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10.1136/bmjopen-2020-048179
Methods and analysis A systematic search of electronic databases including MEDLINE and the Cochrane Library will be conducted to find clinical trials enrolling patients on haemodialysis that measure quality of life using either the kidney disease quality of life (KDQoL) or the short form 36 health survey (SF-36) (or any variation of these two measures).
Methods and analysis A systematic search of electronic databases including MEDLINE and the Cochrane Library will be conducted to find clinical trials enrolling patients on haemodialysis that measure quality of life using either the kidney disease quality of life (KDQoL) or the short form 36 health survey (SF-36) (or any variation of these two measures).
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10.46883/ONC.2021.3508.0480
Due to the lack of large-scale prospective studies, most published data come from single-institution, small-cohort studies, and treatment recommendations are based on the extrapolation of data from clinical trials enrolling only women.
Due to the lack of large-scale prospective studies, most published data come from single-institution, small-cohort studies, and treatment recommendations are based on the extrapolation of data from clinical trials enrolling only women.
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10.1161/JAHA.120.018304
Methods and Results We performed a meta‐analysis of aggregate data from randomized clinical trials enrolling participants receiving a percutaneous coronary intervention with stenting and assigned to either early aspirin discontinuation or DAPT.
Methods and Results We performed a meta‐analysis of aggregate data from randomized clinical trials enrolling participants receiving a percutaneous coronary intervention with stenting and assigned to either early aspirin discontinuation or DAPT.
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10.1002/14651858.CD011466.pub2
MAIN RESULTS
Four trials enrolling 317 infants met the inclusion criteria.
MAIN RESULTS
Four trials enrolling 317 infants met the inclusion criteria.
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10.1001/jamanetworkopen.2021.31744
Conclusions and Relevance
These findings suggest that NEN trials enrolling over the last decade were more focused on select tumor populations, compared with studies that began enrollment before 2010.
Conclusions and Relevance
These findings suggest that NEN trials enrolling over the last decade were more focused on select tumor populations, compared with studies that began enrollment before 2010.
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10.1371/journal.pone.0246353
We included 31 trials enrolling 3,759 infants.
We included 31 trials enrolling 3,759 infants.
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10.1007/s11523-021-00838-x
Future clinical trials enrolling higher numbers of Asian patients, and an increased understanding of differences in patient and tumor genetics between Asians and non-Asians, have the potential to incrementally improve the management of BC in Asian patients.
Future clinical trials enrolling higher numbers of Asian patients, and an increased understanding of differences in patient and tumor genetics between Asians and non-Asians, have the potential to incrementally improve the management of BC in Asian patients.
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10.1111/jpc.15294
Nirsevimab is currently being investigated in Phase 3 trials enrolling healthy late-preterm and full-term infants.
Nirsevimab is currently being investigated in Phase 3 trials enrolling healthy late-preterm and full-term infants.
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10.1371/journal.pone.0249087
Two randomized trials enrolling 529 patients and 23 observational studies enrolling 7296 patients proved eligible.
Two randomized trials enrolling 529 patients and 23 observational studies enrolling 7296 patients proved eligible.
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10.4103/atm.ATM_475_20
RESULTS: We included six clinical trials enrolling a total of 375 patients.
RESULTS: We included six clinical trials enrolling a total of 375 patients.
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10.1093/cvr/cvab271
A strong renal protective role of SGLT2i has also emerged in trials enrolling patients with and without T2DM.
A strong renal protective role of SGLT2i has also emerged in trials enrolling patients with and without T2DM.
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10.24875/RECICE.M21000210
Results: Four trials enrolling 1086 patients were included.
Results: Four trials enrolling 1086 patients were included.
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10.1097/HCO.0000000000000849
Trials enrolling from North America exclusively had more proportional representation, enrolling an average of 31.
Trials enrolling from North America exclusively had more proportional representation, enrolling an average of 31.
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10.3390/nu13093045
Altogether, 10 randomized controlled trials enrolling 594 participants were included.
Altogether, 10 randomized controlled trials enrolling 594 participants were included.
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10.1001/jamainternmed.2021.5726
For trials enrolling patients before 2000 (R2 = 0.
For trials enrolling patients before 2000 (R2 = 0.
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10.1177/10998004211015424
Thirty-one trials enrolling 2,202 participants were included.
Thirty-one trials enrolling 2,202 participants were included.
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10.1097/PCC.0000000000002667
Understanding characteristics of early deaths may yield recruitment considerations for clinical trials enrolling children at high risk of early death.
Understanding characteristics of early deaths may yield recruitment considerations for clinical trials enrolling children at high risk of early death.
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10.1371/journal.pone.0248132
We included 82 randomized clinical trials enrolling a total of 40,249 participants.
We included 82 randomized clinical trials enrolling a total of 40,249 participants.
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10.1016/j.critrevonc.2021.103460
Randomized phase III, and for tyrosine kinase inhibitors (TKIs) also randomized phase II trials enrolling advanced/metastatic NSCLC patients were included.
Randomized phase III, and for tyrosine kinase inhibitors (TKIs) also randomized phase II trials enrolling advanced/metastatic NSCLC patients were included.
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10.21203/RS.3.RS-439425/V1
Results: Eight trials enrolling 3272 patients were included.
Results: Eight trials enrolling 3272 patients were included.
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