Introduction to Trials Assessing

What is/are Trials Assessing?

Trials Assessing - INTRODUCTION Results from recent trials assessing the effect of oral vitamin C supplementation on serum uric acid (SUA) have been inconsistent. ^[1] The ALS-FRS accounted for the full number of trials assessing saliva in this review. ^[2] Trials assessing complete symptom relief showed lower placebo response rates even in trials for <8 weeks. ^[3] Based on our results, we would recommend use of AQoL-8D in addition to EQ-5D-5L in trials assessing patient's quality of life in patients with epilepsy or schizophrenia. ^[4] Outcome measures are inconsistent, with some trials assessing only nonspecific routine diagnostic parameters or fecal scores. ^[5] Trials assessing the potential of BETi in rational combination with ICB are underway. ^[6] MAIN RESULTS The searches identified 40 trials; 17 of these, with 273 participants, were suitable for inclusion, but the number of trials assessing each of the different agents was small. ^[7] Aim: To identify and evaluate the similarity of all trials assessing recommended treatments for advanced hepatocellular carcinoma. ^[8] Trials assessing SC numbers before and at least one timepoint after acute exercise, were identified in a systematic computerized search. ^[9] Trials assessing dupilumab in atopic dermatitis (AD) showed transient eosinophilia in less than 2% of patients (1). ^[10] Trials assessing continuous therapy against dosing as-needed therapy (including infliximab, etanercept and secukinumab) have demonstrated superior efficacy for continuous regimes. ^[11] METHODS We searched PubMed, Scopus and Cochrane Library for trials assessing the use of MBIs to treat binge eating severity in both clinical and non-clinical samples. ^[12] Prior to clinical use, trials assessing synthetic blood components must evaluate meaningful safety and effectiveness outcomes in relatively large numbers of critically ill patients. ^[13] Areas covered: Herein, we will critically discuss the current state of the art of ivosidenib in IDH-mutant CCA, especially focusing on efficacy and safety results of recent trials assessing this IDH-1 inhibitor. ^[14] Trials assessing the effect of UCM on important clinical and long-term outcomes among non-vigorous mature preterm infants are urgently required. ^[15] The aim of this study was to assess clinician awareness of trials assessing the optimal duration of CRC adjuvant therapy, their attitudes towards shorter treatment and their self-reported practice. ^[16] 9%) were based on trials assessing overall survival (OS) as a primary endpoint (PEP), two (0. ^[17] A participant may be classified as meeting the endpoint if they experience an event in one or several components (eg, a favorable outcome based on a composite of being alive and attaining negative culture results in trials assessing tuberculosis treatments). ^[18] Overall, we agree that further trials assessing the benefits of triple therapy on mortality would be welcome. ^[19] An index reflecting the change in HR on hyperventilation might be predictive of the risk of SUDEP and could be used to select patients at risk of SUDEP for inclusion in trials assessing protective measures. ^[20] The total number of combined patients from both trials assessing 6MWT distance in sGC vs placebo therapy were 620 with 309 in the treatment group and 311 in the placebo group. ^[21] int/ictrp/en/) were queried in March 2020 for trials assessing the outcome of neuromodulation for psychiatric disorders. ^[22] A systematic search of PubMed, Embase, Cochrane, and CINAHL was performed from database inception to May 2020 for trials assessing the efficacy of steroids (inhaled/systemic or both) in neonates with MAS. ^[23] What are the epistemic and ethical considerations of clinically implementing Artificial Intelligence (AI) algorithms in embryo selection? AI embryo selection algorithms used to date are “black-box” models with significant epistemic and ethical issues, and there are no trials assessing their clinical effectiveness. ^[24] Using standardized criteria, PubMed, Web of Science, Scopus, EMBASE and Cochrane Collaboration were searched for trials assessing the effect of sCPR vs. ^[25] We performed a systematic review and meta-analysis of trials assessing the efficacy of corticosteroids to prevent PPS in patients submitted to cardiac surgery. ^[26] The findings of trials assessing the glucose control (time in range, HbA1c values, hypoglycemic events), the health-related quality of life and the existing limits of the use of these technologies are reported. ^[27] Design A review of trials assessing the effectiveness of manual therapy and exercise in the management of patients with shoulder subacromial pain. ^[28] There were no trials assessing, obesity, waist circumference, or MetS as a whole. ^[29] Trials assessing nutraceuticals successful in the treatment of mitochondrial cytopathies including magnesium, coenzyme q10 and riboflavin have also been conducted in migraine. ^[30] Trials assessing efficacy of a combination of cytotoxic agents and nivolumab as first-line treatment, nivolumab-containing chemoradiotherapy, and neoadjuvant chemotherapy are ongoing. ^[31] Insomnia severity and the risk of obstructive sleep apnea remained unchanged in the trials assessing these metrics. ^[32]

randomized placebo controlled

Methods: This post hoc analysis pooled data from two randomized, placebo-controlled clinical trials assessing methylnaltrexone for opioid-induced constipation in the outpatient setting. ^[1] This study emphasizes the need for randomized placebo-controlled trials assessing the efficacy and safety profile of cannabinoids for the treatment of insomnia. ^[2] Methods of Study Selection We identified randomized placebo-controlled trials assessing the primary outcome of pain and opioid consumption after paracervical block or uterosacral infiltration in benign laparoscopic, vaginal, or robotic hysterectomy. ^[3]

Clinical Trials Assessing

In particular, nephrotic syndrome has been highlighted by the FDA and National Kidney Foundation as a kidney disease that may be amenable to symptom assessments with PROMs, and they have called for the development of PRO endpoints for clinical trials assessing interventions for this syndrome. ^[1] SELECTION CRITERIA Randomised clinical trials assessing the effects of antibiotics versus placebo or no intervention for secondary prevention of coronary heart disease in adult participants (≥18 years). ^[2] Nevertheless, there are numerous continuing clinical trials assessing the impending treatments and vaccines. ^[3] Methods Using the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) approach, PubMed, Web of Science, Scopus, and PEDro databases were searched for randomized clinical trials assessing the effect of tDCS on gait in patients with PD. ^[4] CONCLUSIONS Body mass index might be a useful biomarker of disease severity, particularly in male patients with spinocerebellar ataxia type 2 in the context of nutritional interventions or clinical trials assessing the efficacy of promising new drugs. ^[5] METHODS We conducted a random-effects meta-analysis of randomised clinical trials assessing PCSK9-targeting therapies, namely alirocumab, evolocumab and inclisiran, in patients with clinically diagnosed HeFH and restricted analyses to those patients in whom genotypic data were available. ^[6] However, randomized clinical trials assessing NE outcomes in children randomized to adenotonsillectomy (AT) vs watchful waiting are lacking. ^[7] We describe a review of the main olaparib clinical trials assessing its efficacy, safety and tolerance in metastatic castration-resistant prostate cancer patients. ^[8] Currently, clinical trials assessing the effects of vitamin D supplementation in individuals with COVID-19 infection are extremely limited. ^[9] We will include randomised clinical trials assessing interventions theoretically based on guided self-determination or self-determination theory provided face-to-face or digitally by any healthcare professional in any setting. ^[10] Clinical trials assessing the safety and efficacy of immunosuppressive agents in older adults are lacking. ^[11] EXPERT OPINION Although numerous preclinical studies have revealed significant anti-tumor effects, several clinical trials assessing MSC-based cancer gene therapy have failed to demonstrate corroborative results, documenting limited therapeutic effects. ^[12] Methods: This post hoc analysis pooled data from two randomized, placebo-controlled clinical trials assessing methylnaltrexone for opioid-induced constipation in the outpatient setting. ^[13] In the past years, translational approaches have led to early-stage clinical trials assessing safety and efficacy of tolerance-inducing cell-based treatments in patients. ^[14] Recently there has been a large increase in the number of clinical trials assessing systemic immunomodulatory drugs in Sjögren’s syndrome. ^[15] Study Selection: Randomized clinical trials assessing the effects of adding glucocorticosteroids to standard care for children with sepsis. ^[16] In the present review, the authors discuss the findings of published reports and ongoing clinical trials assessing the role of targeted therapies in nonmetastatic disease. ^[17] Purpose Patients with preexisting autoimmune disease (PAD) are often excluded from clinical trials assessing immune checkpoint inhibitors (ICIs). ^[18] Efficient delivery facilitated through C16 conjugation to optimized siRNA designs has enabled candidate selection for investigational human clinical trials assessing therapeutic silencing beyond the liver with infrequent (e. ^[19] This may improve the accuracy of power calculation for future clinical trials assessing the role of cardioprotective therapy. ^[20] A systematic review and meta-analysis were performed of randomized clinical trials assessing the effects of Hormone Based Therapies (Spironolactone and Combined Oral Contraceptives) in the management of Acne Vulgaris in Women. ^[21] gov database, this review included the literature reporting the immune escape mechanisms of UBC and clinical trials assessing the effect of immunotherapeutic strategies on tumor or immune cells in UBC patients published in English between 1999 and 2020. ^[22] Methods An electronic literature search was performed in databases and conference proceedings of prospective clinical trials assessing the combination of ICIs and TRT for patients with NSCLC. ^[23] Small clinical trials assessing selenium supplementation in patients with HF showed improvement of clinical symptoms (NYHA class), left ventricular ejection fraction, and lipid profile, while governmental interventional programs in endemic areas have significantly decreased the incidence of Keshan disease. ^[24] STUDY SELECTION All relevant English-language, late phase clinical trials assessing the safety and efficacy of the identified drugs were included. ^[25] There are no clinical trials assessing the best approach to diagnosis, treatment or long-term management of LVAD infections. ^[26] Despite these emerging data, robust controlled clinical trials assessing patient-centered outcomes remain imperative. ^[27] We also review its value as a potential target for cancer immunotherapy, by reporting the results of Phase I and II clinical trials assessing the use of drugs targeting VISTA. ^[28] Herein data was pooled from clinical trials assessing the safety and efficacy of elagolix with and without add-back therapy. ^[29] Apart from their glucose-lowering effects, large clinical trials assessing certain SGLT2 inhibitors have revealed cardiac and renal protective effects in non-diabetic patients. ^[30] Recent results from randomized clinical trials assessing extreme hypofractionated radiotherapy for whole or partial breast radiotherapy are practice changing. ^[31] Clinical trials assessing AZM in PA acute pneumonia are scarce. ^[32] DESIGN Clinical trials assessing the effectiveness and clinical outcomes associated with two electrode systems to activate the expiratory muscles. ^[33] A systematic review and meta-analysis was performed of randomized clinical trials assessing the effects of pH 4 emulsion on skin barrier function in the elderly. ^[34] Aim of this work was to systematically review the literature in search for clinical trials assessing green tea for managing periodontitis and caries. ^[35] Larger randomised clinical trials assessing the benefits and harms of band ligation compared with sham treatment for primary prophylaxis of oesophageal variceal bleeding in children and adolescents with chronic liver disease or portal vein thrombosis are needed. ^[36] OBJECTIVE The aim of this review is to methodically study the placebo response extracted from the control arms of randomized clinical trials assessing therapy in patients with OAB. ^[37] The purpose of the subsequent descriptive review is to provide an introduction to the concept of probiotic microorganisms and their multifaceted health-promoting interactions with the human host and microbial competitors, followed by a detailed comparison of the results of available controlled clinical trials assessing the use of probiotics in the control of gingival and periodontal inflammations. ^[38] Expert opinion: Several clinical trials assessing the efficacy and safety of combination treatments with various drugs and ICIs have been conducted. ^[39] the sum of major bleeding and thrombotic events, as a potential surrogate for all-cause mortality in clinical trials assessing antithrombotics. ^[40] Despite the completion of several clinical trials assessing a variety of drugs targeted at different parts of nonalcoholic steatohepatitis development and progression, there is presently no approved treatment for this condition other than risk factor management. ^[41] For instance, the date of doxorubicin-loaded quaternary ammonium palmitoyl glycol chitosan (DOX-GCPQ) particles serves as translational link for clinical trials assessing anticancer efficacy and diagnostic potential, via DOX optical imaging of formulation after appropriate testing and guidance for further studies, leading to clinical evaluation to determine safety margins of formulation. ^[42] Efforts to develop more effective therapies are ongoing, and patient enrollment in clinical trials assessing the efficacy of new treatments is crucial to improve outcomes. ^[43] However, clinical trials assessing the prophylactic use of botulinum toxin (BTX) for parotidectomy have not been conducted yet. ^[44] The literature was revised using PubMed (Medline) and Embase (Elsevier) up to September 2020 to identify clinical trials assessing medical or surgical treatment to manage diabetic foot osteomyelitis. ^[45] Randomized clinical trials assessing RSV supplementation on changes in the sirtuins’ gene expression/protein levels was the primary outcome. ^[46] A comprehensive systematic search was conducted in PubMed, Scopus, Web of Science and Google Scholar up to March 2020 to identify clinical trials assessing the effect of curcumin/turmeric alone or in combination with other herbs or nutrients on GI diseases. ^[47] A systematic search of the medical databases, PubMed, Scopus, ISI, Science Direct, and Google Scholar was performed up to March 30, 2020, to identify clinical trials assessing the effect of curcumin on aphthous ulcers. ^[48] We conducted a systematic review of controlled clinical trials assessing treatment with convalescent plasma for hospitalized patients with a diagnosis of SARS-CoV-2 infection. ^[49] This is a review on clinical trials assessing polypill in secondary prevention of cardiovascular diseases (CVD), followed by design of Persian Polypill study. ^[50]

Controlled Trials Assessing

Methods: We have searched PubMed, EMbase, Web of science, EBSCO, and Cochrane library databases through November 2019 for randomized controlled trials assessing the effect of pregabalin versus placebo on pain control of shoulder arthroscopy. ^[1] PATIENTS AND METHODS We performed a systematic review and meta-analysis of phase III randomized controlled trials assessing ICIs, from inception until April 23rd, 2020. ^[2] Randomized controlled trials assessing the effectiveness and safety of acupuncture as add-on therapies to conventional Western medications in patients with FD will be included. ^[3] There is a need for further well-designed controlled trials assessing dosimetry, powered for both effectiveness and safety outcomes. ^[4] We performed a systematic review and frequentist network meta-analysis of randomized controlled trials assessing the effect of angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, β-blockers, calcium channel blockers, and thiazide diuretics on EF compared to each other and to placebo (PROSPERO: CRD42020189529). ^[5] We searched Cochrane Central Register of Controlled Trials, MEDLINE, EMBASE, and Web of Knowledge without language, publication, or date restrictions from inception through November 2018 for randomized controlled trials assessing 12 classes of DMOADs with at least 12 months of follow-up. ^[6] OBJECTIVE To investigate the frequency and perform a qualitative analysis of spin bias in publications of controlled trials assessing the therapeutic use of cannabis derivatives and their synthetic analogues. ^[7] Objective This study presents an updated meta-analysis of randomized controlled trials assessing the effects of online MBIs on mental health and the potential moderators of these effects. ^[8] We conducted a Bayesian network meta-analysis of randomized controlled trials assessing the effect of artificial or bioartificial liver support systems on survival in patients with ACLF. ^[9] PubMed, Web of Science, Embase, EBSCO, and Cochrane library databases (updated March 2020) were searched for randomized controlled trials assessing music therapy in reducing pain and anxiety in patients undergoing ESWL. ^[10] Methods We have searched several databases including PubMed, EMbase, Web of science, EBSCO, and Cochrane library databases through November 2020 and included randomized controlled trials assessing the efficacy and safety of adjuvant temozolomide to radiotherapy for glioblastoma. ^[11] METHODS Randomized controlled trials assessing the effects of CBT-i in adults with fibromyalgia, published in English or Spanish, were eligible. ^[12] Eligibility criteria for studies Randomised controlled trials assessing the effect of music on sleep quality in critically ill and surgical patients. ^[13] Large-scale deployment of COVID-19 vaccines will seriously affect the ongoing phases 2 and 3 randomised placebo-controlled trials assessing SARS-CoV-2 vaccine candidates. ^[14] Randomized controlled trials assessing the effect of DCD on lung function and clinical effectiveness rate in children with asthma were included in this meta-analysis. ^[15] Two authors independently selected randomised controlled trials assessing the effectiveness of treatments to reduce thoracic hyperkyphosis in adults. ^[16] In this systematic review, the authors summarize the design and results of controlled trials assessing the effects of THC and CBD on affective disorders, anxiety disorders, and posttraumatic stress disorder (PTSD). ^[17] Review methods: We included randomized controlled trials assessing the effectiveness of extracorporeal shockwave therapy alone or as an additive intervention compared with sham or other interventions. ^[18] Methods We search PubMed, EMbase, Web of science, EBSCO, and Cochrane library databases through February 2020 for randomized controlled trials assessing the effect of memantine versus placebo on treatment efficacy in migraine patients. ^[19] METHOD We performed a systematic review and meta-analysis of randomized and nonrandomized controlled trials assessing the impact on recidivism among juveniles aged 12-17. ^[20] The present study aimed to systematically review and analyse randomized controlled trials assessing the effect of Artemisia extract on glycemic status in patients with impaired glycemic control. ^[21] Compared with the previous literature review, randomized controlled trials assessing bioequivalence among branded drugs and generics are currently available. ^[22] Seven randomized controlled trials assessing the outcomes of PSR and POMR were analyzed in accordance with the PRISMA statement. ^[23] There is a paucity of evidence for the treatment due to the absence of randomized controlled trials assessing dactylitis as a primary endpoint and current practice arises from the analysis of dactylitis as a secondary outcome. ^[24] METHODS A systematic search was conducted in PubMed and Web of Science until March 2021 for randomized controlled trials assessing the effect of exercise interventions (compared with no exercise) on patients with AD. ^[25] Hence the results of 7 controlled trials assessing FMD were included for meta-analysis (n=384 participants) which showed a significant increase in brachial FMD by yoga practice (Mean difference = −2. ^[26] In 2017, a retrospective before/after study reported promising results using a combination of thiamine, ascorbic acid, and hydrocortisone called "metabolic resuscitation cocktail" and several randomized controlled trials assessing its effectiveness were performed. ^[27] This systematic review will seek to summarise and integrate the existing findings from randomised controlled trials assessing the effects of prayer and prayer-based interventions on pain experience. ^[28] The aim of this systematic review and meta-analysis was to pool data from previous randomised controlled trials assessing the efficacy of blood pressure-lowering and antibiotic medications in limiting AAA growth and AAA-related events, that is, rupture or repair. ^[29] High-quality randomised controlled trials assessing laser-assisted delivery for drugs in the context of hypertrophic and/or keloid scarring are needed. ^[30] This study emphasizes the need for randomized placebo-controlled trials assessing the efficacy and safety profile of cannabinoids for the treatment of insomnia. ^[31] Methods We performed a systematic review and frequentist network meta-analysis of randomized controlled trials assessing the effect of antihypertensive agents on EF (PROSPERO: CRD42020189529). ^[32] Methods A systematic literature review was conducted using four medical databases to identify randomized, controlled trials assessing IA therapies in RA patients. ^[33] All randomized controlled trials assessing the efficacy and safety of YMJ on the symptoms of AD will be included. ^[34] METHODS We search PubMed, EMbase, Web of Science, EBSCO, and Cochrane library databases through April 2020 for randomized controlled trials assessing the effect of vitamin D versus placebo on treatment efficacy in migraine patients. ^[35] All published randomized controlled trials assessing the association of levothyroxine treatment with pregnancy outcomes in euthyroid women with thyroid autoantibody-positive were included. ^[36] To systematically review randomized controlled trials assessing effects of sodium–glucose cotransporter 2 inhibitors (SGLT2is) on hospitalization for heart failure (HHF) and cardiac structure/function and explore randomized controlled trial (RCT)‐derived evidence for SGLT2i efficacy mechanisms in heart failure (HF). ^[37] Methods Randomized controlled trials assessing the efficacy of a prevention programme for children (6–25 years) of parents with mood and/or anxiety disorders were included. ^[38] We selected randomized controlled trials assessing finerenone treatment in patients with CKD. ^[39] Methods of Study Selection We identified randomized placebo-controlled trials assessing the primary outcome of pain and opioid consumption after paracervical block or uterosacral infiltration in benign laparoscopic, vaginal, or robotic hysterectomy. ^[40] INCLUSION CRITERIA This systematic review will include randomized controlled trials assessing the effectiveness and safety of self-management interventions among adult type 2 diabetes mellitus patients in sub-Saharan Africa. ^[41] We performed a systematic review of randomized controlled trials assessing the effect of heparin (low molecular weight heparin [LMWH] or unfractionated heparin [UFH]), aspirin, or both on live birth rates in women with persistent antiphospholipid antibodies and recurrent pregnancy loss. ^[42] At present there are only three randomised controlled trials assessing heat therapy for patients with IC. ^[43] Although randomised controlled trials assessing fracture risk following denosumab cessation are unavailable, these case reports raise concerns regarding optimal transition from denosumab therapy. ^[44] Methods Employing the Cochrane methodology, we systematically searched Ovid MEDLINE, Embase, Cochrane Clinical Answers, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, and PsycINFO for clinical case-controlled trials assessing the NFRthr in individuals with and without fibromyalgia from inception to July 2019. ^[45] This is a secondary data analysis from three randomized controlled trials assessing the impact of a "high," "medium," and "low" intensity intervention primarily targeting canteen managers on school's implementation of a healthy canteen policy. ^[46] Randomized controlled trials assessing the immunogenicity of any dose of COVID-19 vaccine in adults by anti–severe acute respiratory syndrome coronavirus 2 immunoglobulin G antibodies geometric mean titers (GMTs) and neutralizing antibodies GMT response at 28 days postimmunization compared with the control groups in the healthy adults were considered for inclusion. ^[47] SELECTION CRITERIA We included all randomised controlled trials assessing the effectiveness or safety of progestogen treatment for the prevention of miscarriage. ^[48] Methods Randomized, quasi-randomized, and single-arm controlled trials assessing temperature change after SWD application in healthy adults were included. ^[49] There is a lack of randomized controlled trials assessing the efficacy of various treatment options for GPP. ^[50]

Randomized Trials Assessing

gov identified 477 randomized trials assessing immunomodulatory therapies, including 168 different therapies against 83 different pathways. ^[1] Randomized trials assessing colchicine compared with placebo/standard therapy in patients with CAD were included. ^[2] Methods: Randomized trials assessing gliflozins in HF patients were included. ^[3] We aimed at providing an overview of randomized trials assessing NPIs to prevent COVID-19. ^[4] Household contact tracing (HHCT), for which households of newly diagnosed cases are actively screened for additional infected individuals is a potentially efficient approach to finding new cases of tuberculosis, however randomized trials assessing the population-level effects of such interventions in settings with sustained community transmission have shown mixed results. ^[5] BACKGROUND AND PURPOSE Whereas a clear benefit of endovascular treatment for anterior circulation stroke has been established, randomized trials assessing the posterior circulation have failed to show efficacy. ^[6] To date there have been no randomized trials assessing the impact of psychological intervention on depression and FOP in this patient group. ^[7] Randomized and quasi-randomized trials assessing the effects of submucosal dexamethasone in adult patients undergoing mandibular third molar surgery were included. ^[8]

Control Trials Assessing

Here, we examine the biological activities of tumour necrosis factor inhibitors indicative of their potential in COVID-19 and briefly outline the randomised control trials assessing their benefit-risk profile in COVID-19 therapy. ^[1] PURPOSE OF REVIEW This review examines recent contradictory large, well-controlled randomized control trials assessing the effects of omega-3 fatty acids and colchicine on cardiovascular (CV) outcomes. ^[2] Further large scale, randomized control trials assessing the effect of bariatric surgery on women with obesity‐related UI are needed to confirm this study's findings. ^[3]

Randomised Trials Assessing

BACKGROUND The use of placebo comparisons for randomised trials assessing the efficacy of surgical interventions is increasingly being considered. ^[1] Outcomes of HIVST research have also focused on ‘realworld’ implementation and relevance to policymakers, with randomised trials assessing linkage to HIV treatment, HIV prevention services for those who test HIVnegative and costeffectiveness. ^[2] Methods We did a collaborative meta-analysis of individual patient data from randomised trials assessing chemotherapy plus trastuzumab versus the same chemotherapy alone. ^[3]

Interventional Trials Assessing

We included all types of interventional trials assessing hypnotherapy for intubated patients whom were undergoing the weaning process or extubation. ^[1] Limitations: The study was restricted to interventional trials assessing clinical outcomes and to studies in developed countries, which likely excluded some research contributing to this field. ^[2]

Human Trials Assessing

Based on the PRISMA guidelines, human trials assessing the effects of ashwagandha on mental and/or physical conditions, and/or human performance, used as a stand-alone or adjunct intervention, and delivered as a single ingredient, were eligible for inclusion in this systematic review. ^[1] OBJECTIVE To evaluate randomised controlled, human trials assessing the effects of single plants or phytonutrients on HPA-axis related hormones. ^[2]

Designed Trials Assessing

Additional well-designed trials assessing screening and treatment of PICU delirium are needed. ^[1] Our findings also underline the importance and need for well-designed trials assessing long-term efficacy and safety of opioids for CNCP and CLBP. ^[2]

Intervention Trials Assessing

We included randomized intervention trials assessing the effects of vitamin D3 supplementation (with or without calcium), compared to placebo, in adults with prediabetes. ^[1] The MEDLINE (via PubMed), Scopus, EMBASE and Cochrane electronic databases were systematically searched from inception through December 14th 2020 for randomized or crossover intervention trials assessing the effects of LCD or LFD on IHTG (measured by MRS or MRI) and body weight. ^[2]

Future Trials Assessing

The model may be helpful for identifying patients for future trials assessing the possible benefit of adjuvant systemic treatment after chemoradiation. ^[1] The evaluation of current evidence will also inform future trials assessing the impact of NET on surgical outcomes and QoL. ^[2]

Quality Trials Assessing

The current evidence regarding the effect of meat consumption on health is potentially confounded, and there is a need for sufficiently powered high-quality trials assessing the health effects of meat consumption. ^[1] However, there is still need for well-designed high-quality trials assessing perinatal outcomes between naturally conceived pregnancies and different ART protocols based on different maternal and treatment characteristics. ^[2]

trials assessing immune

Purpose Patients with preexisting autoimmune disease (PAD) are often excluded from clinical trials assessing immune checkpoint inhibitors (ICIs). ^[1] Furthermore, we review mechanistic insights gained from preclinical studies and summarize clinical trials assessing immune checkpoint blockade for relapse after allo-HCT. ^[2] Patients with preexisting autoimmune disease (PAD) are often excluded from clinical trials assessing immune checkpoint inhibitors (ICIs). ^[3] INTRODUCTION Immunotherapy has recently taken on an extremely important role in medical oncology, as first- or later-line treatment in several tumor types, and recent years have seen the emerging of clinical trials assessing immune checkpoint inhibitors (ICIs) in unresectable hepatocellular carcinoma (HCC). ^[4]

trials assessing treatment

We conducted a systematic review of controlled clinical trials assessing treatment with convalescent plasma for hospitalized patients with a diagnosis of SARS-CoV-2 infection. ^[1] We conducted a systematic review of randomized clinical trials assessing treatment with remdesivir, chloroquine, hydroxychloroquine, lopinavir, ritonavir, dexamethasone, and convalescent plasma, for hospitalized patients with a diagnosis of SARS-CoV-2 infection. ^[2] Methods: We conducted a systematic review of controlled clinical trials assessing treatment with convalescent plasma for hospitalized patients diagnosed with SARS-CoV-2 infection. ^[3]

trials assessing therapy

OBJECTIVE The aim of this review is to methodically study the placebo response extracted from the control arms of randomized clinical trials assessing therapy in patients with OAB. ^[1] In order to identify the practical implications for both health care practitioners and patients in understanding differences between the results of trials assessing therapies for ulcerative colitis [UC], we reviewed clinical trials of therapies for moderate to severe UC, with a focus on trial design. ^[2]

trials assessing intervention

In particular, nephrotic syndrome has been highlighted by the FDA and National Kidney Foundation as a kidney disease that may be amenable to symptom assessments with PROMs, and they have called for the development of PRO endpoints for clinical trials assessing interventions for this syndrome. ^[1] We will include randomised clinical trials assessing interventions theoretically based on guided self-determination or self-determination theory provided face-to-face or digitally by any healthcare professional in any setting. ^[2]

trials assessing patient

Based on our results, we would recommend use of AQoL-8D in addition to EQ-5D-5L in trials assessing patient's quality of life in patients with epilepsy or schizophrenia. ^[1] Despite these emerging data, robust controlled clinical trials assessing patient-centered outcomes remain imperative. ^[2]

trials assessing effect

Results We included 31 trials assessing effects of long-chain omega-3 (n = 41 470), one of alpha-linolenic acid (n = 4837), one of total polyunsaturated fat (n = 4997) and none of omega-6. ^[1] To systematically review randomized controlled trials assessing effects of sodium–glucose cotransporter 2 inhibitors (SGLT2is) on hospitalization for heart failure (HHF) and cardiac structure/function and explore randomized controlled trial (RCT)‐derived evidence for SGLT2i efficacy mechanisms in heart failure (HF). ^[2]

trials assessing different

Further randomized clinical trials assessing different treatment of FFD is now warranted. ^[1] Most studies that evaluated the efficacy and safety of moxifloxacin and levofloxacin in treating CAP as initial empirical treatment were single-centered trials assessing different clinical end points. ^[2]

trials assessing immunotherapy

Methods The PubMed and Cochrane library were searched to identify all English publications of clinical trials assessing immunotherapy for cancer. ^[1] Limited data from clinical trials assessing immunotherapy effects on bone metastases [abstract]. ^[2]

trials assessing efficacy

Methods This is a secondary analysis of 2 multicenter randomized controlled trials assessing efficacy of onabotulinumtoxinA in women with nonneurogenic urgency incontinence; one compared 100 U to anticholinergics and the other 200 U to sacral neuromodulation. ^[1] Trials assessing efficacy of a combination of cytotoxic agents and nivolumab as first-line treatment, nivolumab-containing chemoradiotherapy, and neoadjuvant chemotherapy are ongoing. ^[2]