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genome wide association

Methods We performed a genome-wide association study (GWAS) on subjects with inguinal hernias using BioBank Japan (BBJ) data with 1,983 cases and 172,507 controls, followed by a trans-ethnic meta-analysis with UK Biobank (UKBB) data.

Susceptibility loci and polygenic architecture highlight population specific and common genetic features in inguinal hernias

genome wide association

We further incorporated 1401 genotyped and 948 sequenced ancestry-matched population controls, and tested genome-wide association on 1072 severe cases versus 3875 mild or population controls, followed by trans-ethnic meta-analysis with summary statistics of 3199 hospitalized cases and 897,488 population controls from the COVID-19 Host Genetics Initiative.

Trans-ethnic genome-wide association study of severe COVID-19

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10.1038/s41398-021-01272-3

A trans-ethnic meta-analysis combining the results of the Japanese data sets with summary statistics from stage 1 data of the International Genomics of Alzheimer’s Project identified an additional novel susceptibility locus in OR2B2.

Ethnic and trans-ethnic genome-wide association studies identify new loci influencing Japanese Alzheimer’s disease risk

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10.1016/j.ebiom.2021.103532

Methods We performed a genome-wide association study (GWAS) on subjects with inguinal hernias using BioBank Japan (BBJ) data with 1,983 cases and 172,507 controls, followed by a trans-ethnic meta-analysis with UK Biobank (UKBB) data.

Susceptibility loci and polygenic architecture highlight population specific and common genetic features in inguinal hernias

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10.1093/gerona/glab255

In trans-ethnic meta-analysis, two genes interacted with childhood socioeconomic context (FDR <0.

Trans-ethnic Meta-analysis of Interactions between Genetics and Early Life Socioeconomic Context on Memory Performance and Decline in Older Americans.

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10.1038/s42003-021-02549-5

We further incorporated 1401 genotyped and 948 sequenced ancestry-matched population controls, and tested genome-wide association on 1072 severe cases versus 3875 mild or population controls, followed by trans-ethnic meta-analysis with summary statistics of 3199 hospitalized cases and 897,488 population controls from the COVID-19 Host Genetics Initiative.

Trans-ethnic genome-wide association study of severe COVID-19

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10.1101/2021.05.07.21256849

When trans-ethnic information is used, polygenic risk scores constructed from GWAS loci in our trans-ethnic meta-analysis showed similar efficacy in independent Latino (LAT) and non-Latino white (NLW) ALL cohorts (AUC ~ 0.

Genome-wide transethnic meta-analysis identifies novel susceptibility loci for childhood acute lymphoblastic leukemia

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10.1101/2021.05.27.445969

Trans-ethnic meta-analysis of the three ancestries showed a small-to-moderate impact of uncorrected population stratification on the resulting effect size estimates.

Ancestral diversity improves discovery and fine-mapping of genetic loci for anthropometric traits - the Hispanic/Latino Anthropometry Consortium

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10.1038/s41467-021-23899-y

We identify 148, 35, and 4 novel associations among Europeans, African Americans, and Hispanics, respectively, and an additional 186 novel associations through a trans-ethnic meta-analysis.

A multi-ethnic epigenome-wide association study of leukocyte DNA methylation and blood lipids

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10.1093/humrep/deab086

A trans-ethnic meta-analysis was also carried out to assess heterogeneity due to different ancestry.

Large trans-ethnic meta-analysis identifies AKR1C4 as a novel gene associated with age at menarche.

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10.1186/s13148-021-01082-w

Results We identified 23 significant associations in our large trans-ethnic meta-analysis ( p  < 1.

DNAm-based signatures of accelerated aging and mortality in blood are associated with low renal function

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10.1101/2021.09.28.21263911

The analysis was performed within each ancestry group in the MVP, adjusting for sex, age, age2, and first twenty principal components followed by a trans-ethnic meta-analysis.

A MUC5B gene polymorphism, rs35705950-T, confers protective effects in COVID-19 infection

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10.1101/2021.06.18.21259075

We identify five loci associated with cervical cancer in the trans-ethnic meta-analysis: 1p36.

GWAS meta-analysis and gene expression data link reproductive tract development, immune response and cellular proliferation/apoptosis with cervical cancer and clarify overlap with other cervical phenotypes

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10.1016/j.ebiom.2021.103564

They followed up with a trans-ethnic meta-analysis including UK Biobank (UKBB) data that identified five additional novel loci: TGFB2, RNA5SP214/VGLL2, LOC646588, HMCN2, and ATP5F1CP1/CDKN3.

New insights into the genetic architecture of inguinal hernia

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10.1016/j.jaci.2021.04.019

METHODS This study conducted a GWAS for AD comprising 2,639 cases and 115,648 controls in the Japanese population, followed by a trans-ethnic meta-analysis with UK Biobank data and downstream analyses including partitioning heritability analysis by linkage disequilibrium score regression.

Eight novel susceptibility loci and putative causal variants in atopic dermatitis.

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10.1038/s42003-019-0339-0

Furthermore, trans-ethnic meta-analysis across our own meta-analysis and the Global Urate Genetics Consortium has revealed 15 more novel loci associated with SUA.

Genome-wide meta-analysis identifies multiple novel loci associated with serum uric acid levels in Japanese individuals.

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10.1093/gerona/glz245

A significant association was also identified in a trans-ethnic meta-analysis across cohorts that included an additional 708 European American ARIC study participants (fully adjusted model: β = -0.

Epigenetic Age Acceleration and Cognitive Function in African-American Adults in Midlife: The Atherosclerosis Risk in Communities Study.

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10.1093/biostatistics/kxz061

Trans-ethnic meta-analysis is a powerful tool for detecting novel loci in genetic association studies.

Trans-ethnic meta-analysis of rare variants in sequencing association studies.

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10.1136/annrheumdis-2019-eular.4039

We also performed the trans-ethnic meta-analysis across the present study and the Global Urate Genetics Consortium (GUGC)-based study to carry out fine-mapping analysis.

OP0048 GENOME-WIDE META-ANALYSIS REVEALED MULTIPLE NOVEL LOCI ASSOCIATED WITH SERUM URIC ACIDLEVELS IN JAPANESE

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10.1038/s42003-019-0339-0

Furthermore, trans-ethnic meta-analysis across our own meta-analysis and the Global Urate Genetics Consortium has revealed 15 more novel loci associated with SUA.

Genome-wide meta-analysis identifies multiple novel loci associated with serum uric acid levels in Japanese individuals

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10.1038/s41467-019-13145-x

We present genome-wide association studies in British and Japanese populations and a trans-ethnic meta-analysis that include 12,123 cases and 417,378 controls, and identify 20 nephrolithiasis-associated loci, seven of which are previously unreported.

Genetic variants of calcium and vitamin D metabolism in kidney stone disease

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10.1016/j.euroneuro.2017.08.039

We applied trans-ethnic meta-analysis models to improve fine-mapping of variants in the region.

38: GENOME-WIDE META-ANALYSIS OF >14,000 ALCOHOL DEPENDENT INDIVIDUALS HIGHLIGHTS PSYCHIATRIC COMORBIDITIES

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10.1016/j.euroneuro.2017.06.039

These results are then combined with the European-ancestry GWAS in order to identify additional ADHD-associated loci through trans-ethnic meta-analysis.

Increasing Trans-Ethnic Diversity In Genome-Wide Association Meta-Analysis Of ADHD

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10.1038/s41467-019-10808-7

Furthermore, 4 genes, MSMB, NCOA4, PCAT1, and PPP1R14A, are associated with PrCa in a trans-ethnic meta-analysis (N = 9117).

Association of imputed prostate cancer transcriptome with disease risk reveals novel mechanisms

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Trans Ethnic Meta Analysis - A trans-ethnic meta-analysis combining the results of the Japanese data sets with summary statistics from stage 1 data of the International Genomics of Alzheimer’s Project identified an additional novel susceptibility locus in OR2B2. [1] Methods We performed a genome-wide association study (GWAS) on subjects with inguinal hernias using BioBank Japan (BBJ) data with 1,983 cases and 172,507 controls, followed by a trans-ethnic meta-analysis with UK Biobank (UKBB) data. [2] In trans-ethnic meta-analysis, two genes interacted with childhood socioeconomic context (FDR <0. [3] We further incorporated 1401 genotyped and 948 sequenced ancestry-matched population controls, and tested genome-wide association on 1072 severe cases versus 3875 mild or population controls, followed by trans-ethnic meta-analysis with summary statistics of 3199 hospitalized cases and 897,488 population controls from the COVID-19 Host Genetics Initiative. [4] When trans-ethnic information is used, polygenic risk scores constructed from GWAS loci in our trans-ethnic meta-analysis showed similar efficacy in independent Latino (LAT) and non-Latino white (NLW) ALL cohorts (AUC ~ 0. [5] Trans-ethnic meta-analysis of the three ancestries showed a small-to-moderate impact of uncorrected population stratification on the resulting effect size estimates. [6] We identify 148, 35, and 4 novel associations among Europeans, African Americans, and Hispanics, respectively, and an additional 186 novel associations through a trans-ethnic meta-analysis. [7] A trans-ethnic meta-analysis was also carried out to assess heterogeneity due to different ancestry. [8] Results We identified 23 significant associations in our large trans-ethnic meta-analysis ( p  < 1. [9] The analysis was performed within each ancestry group in the MVP, adjusting for sex, age, age2, and first twenty principal components followed by a trans-ethnic meta-analysis. [10] We identify five loci associated with cervical cancer in the trans-ethnic meta-analysis: 1p36. [11] They followed up with a trans-ethnic meta-analysis including UK Biobank (UKBB) data that identified five additional novel loci: TGFB2, RNA5SP214/VGLL2, LOC646588, HMCN2, and ATP5F1CP1/CDKN3. [12] METHODS This study conducted a GWAS for AD comprising 2,639 cases and 115,648 controls in the Japanese population, followed by a trans-ethnic meta-analysis with UK Biobank data and downstream analyses including partitioning heritability analysis by linkage disequilibrium score regression. [13] Furthermore, trans-ethnic meta-analysis across our own meta-analysis and the Global Urate Genetics Consortium has revealed 15 more novel loci associated with SUA. [14] A significant association was also identified in a trans-ethnic meta-analysis across cohorts that included an additional 708 European American ARIC study participants (fully adjusted model: β = -0. [15] Trans-ethnic meta-analysis is a powerful tool for detecting novel loci in genetic association studies. [16] We also performed the trans-ethnic meta-analysis across the present study and the Global Urate Genetics Consortium (GUGC)-based study to carry out fine-mapping analysis. [17] Furthermore, trans-ethnic meta-analysis across our own meta-analysis and the Global Urate Genetics Consortium has revealed 15 more novel loci associated with SUA. [18] We present genome-wide association studies in British and Japanese populations and a trans-ethnic meta-analysis that include 12,123 cases and 417,378 controls, and identify 20 nephrolithiasis-associated loci, seven of which are previously unreported. [19] We applied trans-ethnic meta-analysis models to improve fine-mapping of variants in the region. [20] These results are then combined with the European-ancestry GWAS in order to identify additional ADHD-associated loci through trans-ethnic meta-analysis. [21] Furthermore, 4 genes, MSMB, NCOA4, PCAT1, and PPP1R14A, are associated with PrCa in a trans-ethnic meta-analysis (N = 9117). [22]

genome wide association

Methods We performed a genome-wide association study (GWAS) on subjects with inguinal hernias using BioBank Japan (BBJ) data with 1,983 cases and 172,507 controls, followed by a trans-ethnic meta-analysis with UK Biobank (UKBB) data. [1] We further incorporated 1401 genotyped and 948 sequenced ancestry-matched population controls, and tested genome-wide association on 1072 severe cases versus 3875 mild or population controls, followed by trans-ethnic meta-analysis with summary statistics of 3199 hospitalized cases and 897,488 population controls from the COVID-19 Host Genetics Initiative. [2] We present genome-wide association studies in British and Japanese populations and a trans-ethnic meta-analysis that include 12,123 cases and 417,378 controls, and identify 20 nephrolithiasis-associated loci, seven of which are previously unreported. [3]