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siRNA Therapeutics for Protein Misfolding Diseases of the Central Nervous System.



Lipopeptide Delivery of siRNA to the Central Nervous System.


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The valency of fatty acid conjugates impacts siRNA pharmacokinetics, distribution, and efficacy in vivo.



Diverse lipid conjugates for functional extra-hepatic siRNA delivery in vivo


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Tyrosine-modified linear PEIs for highly efficacious and biocompatible siRNA delivery in vitro and in vivo.



Lipid Nanoparticle Technology for Clinical Translation of siRNA Therapeutics.



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10.1007/978-1-0716-1554-6_31

Case Study 12: Roadmap to Quantifying Ago2-Mediated siRNA Metabolic Activation Kinetics.


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10.1016/J.APSB.2021.02.009

Synchronous conjugation of i-motif DNA and therapeutic siRNA on the vertexes of tetrahedral DNA nanocages for efficient gene silence


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10.1007/978-1-0716-1298-9_20

siRNA Therapeutics for Protein Misfolding Diseases of the Central Nervous System.


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10.1016/j.nano.2021.102403

Tyrosine-modified linear PEIs for highly efficacious and biocompatible siRNA delivery in vitro and in vivo.



Carbon Dioxide-Derived Biodegradable and Cationic Polycarbonates as a New siRNA Carrier for Gene Therapy in Pancreatic Cancer



Kim-1 Targeted Extracellular Vesicles: A New Therapeutic Platform for RNAi to Treat AKI.


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10.1016/j.omtn.2021.04.018

Improved cardiac-specific delivery of RAGE siRNA within small extracellular vesicles engineered to express intense cardiac targeting peptide attenuates myocarditis


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10.1080/09205063.2021.1938859

Dendrimer as a promising nanocarrier for the delivery of doxorubicin as an anticancer therapeutics


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10.1101/2021.04.15.440012

Albumin-binding Aptamer Chimeras for Improved siRNA Bioavailability


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10.3390/pharmaceutics13050676

Targeted RNAi of BIRC5/Survivin Using Antibody-Conjugated Poly(Propylene Imine)-Based Polyplexes Inhibits Growth of PSCA-Positive Tumors



PEGylated cationic nanoassemblies based on triblock copolymers to combine siRNA therapeutics with anticancer drugs.


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10.1101/2021.07.28.454207

Development of lipidoid nanoparticles for siRNA delivery to neural cells


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10.1016/j.bioactmat.2020.08.019

Self-crosslinkable chitosan-hyaluronic acid dialdehyde nanoparticles for CD44-targeted siRNA delivery to treat bladder cancer



A Positioning Device for the Placement of Mice During Intranasal siRNA Delivery to the Central Nervous System.


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10.1016/j.ejpb.2019.01.006

Polyamidoamine dendrimers‐based nanomedicine for combination therapy with siRNA and chemotherapeutics to overcome multidrug resistance



Binary Targeting of siRNA to Hematologic Cancer Cells In Vivo using Layer-by-Layer Nanoparticles.


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10.1016/j.jconrel.2019.03.028

The valency of fatty acid conjugates impacts siRNA pharmacokinetics, distribution, and efficacy in vivo.


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10.1016/j.biomaterials.2019.119501

Near-infrared boosted ROS responsive siRNA delivery and cancer therapy with sequentially peeled upconversion nano-onions.


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10.1021/acs.accounts.9b00368

Lipid Nanoparticle Technology for Clinical Translation of siRNA Therapeutics.


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10.3390/pharmaceutics11110615

Efficient Delivery of Therapeutic siRNA by Fe3O4 Magnetic Nanoparticles into Oral Cancer Cells


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10.1039/9781788015714-00233

CHAPTER 11:Liver-targeted RNAi Therapeutics: Principles and Applications


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10.1080/15257770.2019.1666277

Synthesis and characterization of 4′-C-guanidinomethyl-2′-O-methyl-modified RNA oligomers


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10.1016/j.ijbiomac.2019.12.048

Alkylation enhances biocompatibility and siRNA delivery efficiency of cationic curdlan nanoparticles.


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10.1038/s41598-019-40187-4

Application of Locked Nucleic Acid Oligonucleotides for siRNA Preclinical Bioanalytics


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10.1016/j.apsb.2018.12.010

Small interfering RNA delivery to the neurons near the amyloid plaques for improved treatment of Alzheimer׳s disease



Coming in and Finding Out: Blending Receptor‐Targeted Delivery and Efficient Endosomal Escape in a Novel Bio‐Responsive siRNA Delivery System for Gene Knockdown in Pulmonary T Cells


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10.1021/acs.nanolett.9b01660

Stimuli-Responsive Polymer-Prodrug Hybrid Nanoplatform for Multistage siRNA Delivery and Combination Cancer Therapy.



Diverse lipid conjugates for functional extra-hepatic siRNA delivery in vivo


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10.1007/978-1-4939-9220-1_21

Bioconjugated Gold Nanoparticles Enhance siRNA Delivery in Prostate Cancer Cells.


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10.1007/978-1-4939-9220-1_5

VEGFA Gene Silencing in CXCR4-Expressing Cells via siRNA Delivery by Means of Targeted Peptide Carrier.


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10.1371/journal.pone.0225835

A siRNA mediated hepatic dpp4 knockdown affects lipid, but not glucose metabolism in diabetic mice



Anti-EGF Receptor Aptamer-Guided Co-Delivery of Anti-Cancer siRNAs and Quantum Dots for Theranostics of Triple-Negative Breast Cancer


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10.1007/978-1-4939-9092-4_26

Lipopeptide Delivery of siRNA to the Central Nervous System.



Hydrophobicity drives the systemic distribution of lipid-conjugated siRNAs via lipid transport pathways


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10.1021/acsomega.9b01465

Optimizing Mannose “Click” Conjugation to Polymeric Nanoparticles for Targeted siRNA Delivery to Human and Murine Macrophages


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10.1016/j.ymthe.2019.08.008

Increased Survival by Pulmonary Treatment of Established Lung Metastases with Dual STAT3/CXCR4 Inhibition by siRNA Nanoemulsions.


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