Introduction to Targeted Ablation

In this study, we conducted experiments on a zebrafish model of targeted ablation of liver cells to clarify the role of fibroblast growth factor 21 (FGF21).

Here, by targeted ablation of pDCs and various in vitro and in vivo mouse models of viral infection and inflammation, we identified that IFN-I is a significant driver of somatostatin (SST).

Conversely, targeted ablation of MeA neurons projecting to VMH significantly reduced blood glucose and blunted the hyperglycemic response to stress.

To query the essential nature of the eIF4F subunits in normal development, we used CRISPR/Cas9 to generate mouse strains with targeted ablation of each gene encoding the different eIF4F subunits.

Intense pulsed electric fields (PEF) are a novel modality for the efficient and targeted ablation of tumors by electroporation.

Targeted ablation of PSC-derived CAFs within their host tissue revealed non-redundant functions for this defined CAF population in shaping the PDAC microenvironment, including production of specific components of the extracellular matrix.

Targeted ablation of FIT2 reduced β-cell LD numbers, lowered β-cell ATP levels, reduced Ca2+ signaling, downregulated β-cell transcription factors (RNA sequencing analysis), and exacerbated diet-induced diabetes in mice.

Targeted ablation of CSF-CN dramatically aggravated pain sensitivity.

One of the limitations of the LP-targeted ablation was suggested by our case and the possibility of VT recurrence due to an insufficient ablation procedure was revealed, which would likely be overlooked after a modification of the arrhythmogenic substrate.

Our results also demonstrate that targeted ablation of IRE1α reduces skeletal muscle regeneration in the mdx model of Duchenne muscular dystrophy.

If this really happens, then the targeted ablation may be the solution; otherwise, more rough techniques such as atrial compartmentalization may prove to be more effective.

Targeted ablation of MyD88 suppresses the components of ubiquitin‐proteasome system, autophagy, and FOXO transcription factors in skeletal muscle during denervation.

Here we show that targeted ablation of the histone chaperone HIRA in myogenic cells leads to extensive transcriptional modifications, consistent with a role in maintaining skeletal muscle cellular identity.

Targeted ablation was applied in all cases, with 5 overlapping pulsations at the targeted HSILs (delivering 12 J/cm2 per application) followed by circumferential, 2-pulsation (12 J/cm2) overlapping anal ablation, to cover the entire anal transition zone.

Targeted ablation of adaptive immune cell subsets reveal a necessary role for CD4+ Foxp3+ T-regulatory cells, but not B cells or CD8+ T cells, in FMT-mediated resolution of C.

The former two prodrugs have applications in GDEPT, while the latter has been employed for targeted ablation experiments and as a precise ‘off-switch’ in GDEPT models to eliminate nitroreductase-expressing cells.

Surprisingly, targeted ablation of Sox9 in GCPs (Math1Cre:Sox9lox/lox) revealed no overt phenotype and loss of Sox9 in SHH-MB (Math1Cre:Ptch1lox/lox;Sox9lox/lox) does not affect tumour formation.

Targeted ablation of Lgr5+ cells resulted in severe exacerbation of chronic, antibody-induced IL-10-deficient colitis, but had only modest effects in TNBS-induced colitis.

This high‐resolution and sensitive intraoperative approach is versatile and can be potentially used for targeted ablation of residual tumor after resection within different organs.

Advanced mapping capabilities were useful to pinpoint the search for PVGs, enabling a more targeted ablation approach vs relying on voltage mapping.

Reduced Nampt and inflammatory gene expression are present in specific myeloid and APC populations; moreover, targeted ablation of NRE1 in macrophage lineages results in greater tumor burden.

A better and more targeted ablation strategy is urgently needed to optimize outcomes of AF treatment.

His PC treatment regimen extended over 10 years with multiple systemic, radiation, and targeted ablation therapies.

Targeted ablation of Procr+ cells disrupted ovarian follicle development, leading to phenotypes of polycystic ovary syndrome.

Coherent mapping with visualization of velocity vectors allowed the correct interpretation and the targeted ablation of the AT.

Ultrasound transmitted through the skull can be focused on tumors and used for targeted ablation or opening the vascular barriers for drug delivery.

However, there is a continuing need to develop new catheters for high-accuracy, targeted ablation.

Meanwhile, the improved efficiency of HIFU-mediated tumor ablation reduced the dependence of the tumor ablation on the ultrasound energy dose, which improved the safety of HIFU-mediated tumor ablation to the non-targeted ablation tissue.

Further, that targeted ablation of V3-INs reduces the proportion of active MNs during fictive swimming, but ablation does not affect the locomotor frequencies produced.

Targeted ablation of PSC-derived CAFs within their host tissue revealed non-redundant functions for this defined CAF population in shaping the PDAC microenvironment, including production of specific extracellular matrix components and tissue stiffness regulation.

We further gain direct mechanistic insight into the core components of this circuit by loss-of-function perturbations using targeted ablations and gene knockouts.

Targeted ablation of these sources using Focal Impulse and Rotor Modulation (FIRM™) shows promise.

However, there is a continuing need to develop new catheters for high-accuracy, targeted ablation.

, mTOR, AKT, and S6K1), unveiling a potential strategy for targeted ablation of these cells.