Introduction to Strategies Beyond

Simple Summary The aim of this innovative review is to highlight the treatment strategies beyond immune-checkpoint inhibitor (ICI)-based first-line therapy failure according to different patterns of progression (i.

Conclusion This study in heavily pre-treated pancreatic adenocarcinoma patients suggests alternative strategies beyond single agent MEK inhibition are required for this unique, molecular subset of pancreatic cancer patients.

Social media platforms such as Facebook offer flexible environments where strategies beyond product- and brand-related aspects can be used.

In response to the supposed increasing incidence of cancer, some medical men sought strategies beyond the clinic to elucidate the evasive malady.

1 The article is inspired by the important question of how to treat chronic back pain with therapeutic strategies beyond the use of pharmacological agents that have inherent shortcomings.

The knowledge of strategies beyond conventional treatments may be helpful in the development of new coronavirus drugs, treatments/medicines, or formulations.

A shared theme included the concern that providers do not actively inquire about patient concerns at appointments, and they fail to offer practical strategies beyond pharmaceutical interventions.

The impacts of climate change in the three basins could result in significant limitations for crops if adaptive strategies beyond irrigation and growing cycle issues are not applied.

It is particularly challenging when it comes to organic groups and non-planar objects such as nanoparticles and necessitates the development of strategies beyond the techniques (i.

PURPOSE Tuberculosis, a cost and life threatening disease, was being subjected for improving vaccine strategies beyond BCG.

Implementing active screening strategies beyond a risk-based approach is required as a General Practitioners' task.

The thorough documentation of the complexity inherent in social access suggests increased attention from researchers, designers, and planners is warranted to a) expand notion of access to urban green space beyond proximity, such as incorporating programming and cultural identity and b) support efforts to use innovative community engagement strategies beyond traditional evaluative methods (e.

However, treatment strategies beyond T-DM1 are still in development with insufficient evidence of their effectiveness.

We and others have previously shown that strategic orthogonal testing and leveraging systematic data-driven modeling approach to account for asymptomatics and waning cases may situationally have a compelling role in informing efficient vaccination strategies beyond prevalence reporting.

Strategies beyond waste-to-energy that can harness the circular chemical potential of such feed-stocks are needed.

The knowledge of strategies beyond conventional treatments may be helpful in the development of new coronavirus drugs, treatments/medicines, or formulations.

In this conception, the work presents positive results, extending the benefits of the use of active learning strategies beyond basic education, reaching undergraduate students, even in times of distance education.

It is time to reflect on the exit strategies beyond the existing cultural model.

Due to the continued risk of mycotoxin co-occurrence, expanding mitigation strategies beyond adsorption by mycotoxin deactivation with biotransformation and additional support of immune and liver function is essential.

Further, we discuss innovative strategies beyond conventional therapeutics that could be developed to target the interaction of vector-borne pathogens with the fibrinolytic proteins and prevent their transmission.

This approach expands the scope of suicide prevention strategies beyond the individual level and tertiary prevention strategies.

EXPERT OPINION Multiple immunotherapeutic strategies beyond PD-(L)1 blockade have been tested for TNBC, including the targeting of further inhibitory checkpoints, the agonism of costimulatory molecules, the intratumoral administration of immunotherapies and cancer vaccines.

Background: Diabetes is a complex, chronic illness requiring continuous medical care with multi-factorialrisk-reduction strategies beyond glycemic control.

This flexible statistical method helps ecologists leverage localized mapping efforts to expand models of species distributions, population dynamics, and management strategies beyond the political boundaries that frequently delineate land cover datasets.

STI prevention strategies beyond condoms are needed for Black MSM taking PrEP.

Practical implicationsProposed buffering model offers customized strategies beyond pre-set CSL by varying it dynamically to reduce wastages.

This will provide an overview on the current state of research and an outlook on treatment strategies beyond the usual antimicrobial options.

In this article, based on the mechanisms involved in myocardial infarction prognosis, we review the new interventional strategies beyond stenting that may solve the suboptimal results that STEMI patients still experience.

The delivery of safe, visible wavelengths of light can be an effective, pathogen-agnostic, countermeasure that would expand the current portfolio of SARS-CoV-2 intervention strategies beyond the conventional approaches of vaccine, antibody, and antiviral therapeutics.

Currently, growers have few management strategies beyond removal of infected vines, which may be particularly costly in vineyards with high disease incidence.

Often occurring in waters that are difficult to control, and across multi-sector, transboundary, value chains that are hard to regulate, such a complex and heterogeneous problem requires multiple strategies beyond sovereign nations’ legislation alone.

Further research is needed to focus on specific mitigation strategies beyond opioid agent selection, such as dosing adjustment recommendations.

A focus across a range of PSP, including paramedics, corrections officers, and emergency dispatchers, using implementation strategies beyond group training, is suggested.

On the other hand, the modularity and programmability in software-based networks enabled by technologies like Software-Defined Networking (SDN) and Network Function Virtualization (NFV) provide new opportunities for operators to realize advanced network and service management strategies beyond the classical techniques.

Strategies beyond early antiviral treatment such as counseling, education are also necessary in the management of acute hepatitis C.

This paradigm has recently shifted, and strategies beyond tables and numbers to assist in interpreting models' decisions are increasing in importance.

However, continuing growth-promoting strategies beyond the point of necessity, coupled with poverty and food insecurity which are more common among families of children born preterm, may increase the risk of obesity.

As past low-carbon technology transitions suggest, this calls for policy and political strategies beyond carbon pricing.

Therefore, basic research is needed to bridge between bedside and bench and eventually improve clinical decision making and further development of interventional strategies beyond the field of stroke rehabilitation.

CONCLUSION Patients with EGFR-amplified mCRC represent a biologically defined subgroup and merit dedicated clinical trials with novel and more potent EGFR targeting strategies beyond single-agent monoclonal antibodies.

Purpose: This study explores the uses of motivational strategies beyond Dörnyei’s taxonomy, and the factors that cause English teachers to use them.

These data might help to focus future research on a set of highly sensitive elements, which might prospectively facilitate neuroprotective strategies beyond the traditional single target perspective.

Improving vocational education and skills training for rural residents, especially for the youth, is also important in developing new livelihood strategies beyond their traditional lifestyle.

This project demonstrated that data obtained through social media posts have value to monk seal research and management strategies beyond traditional data collection, and further development of social media platforms as data resources is warranted.

Management strategies beyond the use of systemic corticosteroids, which incur a high burden of deleterious side effects, have not been extensively explored.

To this end, we look for understanding the importance of the didactic-pedagogical planning establishing in it the valorization for the learning that will make viable in the teaching-learning relation the socialization of didactic-geographic knowledge embodied in the normative documents of the Brazilian education as the Law of Guidelines and Bases of the National Education, and also the From the discussions of Freire (1996), Kaercher (2002), Lima and Pimenta (2005/2006), Callai (2011), Oliveira (2015), Rodrigues (2015) we will reflect the relationship of construction and reaffirmation of teacher identity based on operational strategies beyond knowledge of the school space and the classroom, but also of soci some content, concepts and themes reaffirming the importance of geographic education.

Numerous ancillary ablation strategies beyond PVI have been investigated, but the absence of a clear mechanistic and evidence-based endpoint, unlike in other arrhythmias, has remained a universal limitation.

Advantages of our approach are threefold: (1) the use of simulation allows exploring therapeutic strategies beyond clinical practice and available data, (2) advances in DRL accommodate learning complex therapeutic strategies for complex biological systems, and (3) optimized treatments respond to a patient's individual disease progression over time, therefore, capturing both differences across patients and the inherent randomness of disease progression within a single patient.

CONCLUSION Given the high proportion of women with low mammographic density, our findings suggest that women living in Riyadh may not require additional imaging strategies beyond mammography to detect breast cancers.

For persuasion strategies beyond products, setting up inappropriate reference groups, displaying inaccurate brand awareness or fame, and errors in interpretation of technical information were deduced as problematic aspects.

As such, the present article contributes to the institutional research stream by (1) presenting an empirical investigation at the micro level of subsidiary organisational practices to operationalise legitimation strategies in managerial terms; (2) revealing rhetoric proactive strategies beyond the passive or reactive paths identified previously; and (3) discussing the internal implications of implementing legitimation strategies directed at external recipients within the intraorganisational network of multinational banks, using the resource-based view.

Ensuring a safe blood supply, implementing innovative screening strategies beyond a risk-based approach, and intensifying prevention efforts among persons who inject drugs are necessary steps to reach Georgia’s HCV elimination goal.

This framework should guide individual, familial and collective care discussions and research strategies beyond the scope of CP.

Diabetes is a complex, chronic illness requiring continuous medical care with multifactorial risk-reduction strategies beyond glycemic control.

Several large randomised trials such as COMPASS, PEGASUS or DAPT have shown that intensified antithrombotic treatment strategies beyond the setting of acute myocardial infarction and/or coronary intervention are associated with a significant reduction of cardiovascular events.

Rebel groups employ a number of strategies beyond violence, and these alternative tactics are often thought to improve the reputation and legitimacy of rebel actors.

Preventive strategies beyond ART will be required to end the pediatric HIV epidemic.

A case is made fo organizational development efforts that prioritize time for strategic thinking that includes participation from stakeholders across the organization's functions; staff care policies that prevent secondary trauma and promote wellbeing and retention; clarity surrounding organizational structure and roles; financial management systems that position the organization for growth and fund diversification strategies beyond the project-based international agency funding model.

Although there have been attempts to assess for responders to reperfusion strategies beyond 6 h (“late window”) using collateral grades, the only evidence for treatment of this group of patients is based on selection using multimodal CT including CTP.

Exploring different strategies beyond the inpatient clinic setting is key for successful asthma management.

scoparia across the North American Great Plains has renewed research efforts to devise integrated weed management strategies beyond herbicide use.

However, the participants were observed to implement strategies beyond those described by the rights framework that ensured safe and timely medication administration.