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Somatic Cell sentence examples within induced pluripotent stem
Induced pluripotent stem cells (iPSCs) originate from the reprogramming of adult somatic cells using four Yamanaka transcription factors.
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Forced and maintained expression of four transcription factors OCT4, SOX2, KLF4 and c-MYC (OSKM), can reprogram somatic cells into induced Pluripotent Stem Cells (iPSCs) and a limited OSKM induction is able to rejuvenate the cell physiology without changing the cell identity.
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Somatic Cell sentence examples within pluripotent stem cell
On the basis of the knowledge obtained through such endeavors, notable progress has been made over the past decade on research aiming at reconstituting germ cell development in vitro using pluripotent stem cells (PSCs), including embryonic stem cells (ESCs) derived from preimplantation embryos and induced PSCs (iPSCs) generated from somatic cells through transcription factor (TF)–induced reprogramming.
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Up to now, differentiation protocols utilizing such environmental stresses have been reported to obtain various types of somatic cells from pluripotent stem cells.
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Somatic Cell sentence examples within embryonic stem cell
applied what is known about differentiation processes in vivo to determine a culture condition to differentiate embryonic stem cells into gonadal somatic cell–like cells (see the Perspective by Yang and Ng).
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Ovarian somatic cells are derived in vitro from pluripotent embryonic stem cells Nudging germ cell precursors into functionally mature oocytes and spermatozoa is a key aspect of in vitro gametogenesis and a major challenge in the study of reproductive biology.
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Somatic Cell sentence examples within total bacterial count
The main aim of our study was to assess changes in the somatic cell count (SCC) and total bacterial count (TBC) in the raw milk of White Short-haired (WSH) goats (n = 13) during lactation and their.
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Objectives were to investigate somatic cell counts (SCC) and total bacterial counts (TBC) in raw bulk-tank milk of goat herds in Greece, study factors influencing SCC and TBC therein and evaluate their possible associations with milk content.
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Somatic Cell sentence examples within milk yield milk
Differences in the DIM, milk yield, milk fat content and somatic cell count of cows evaluated in both experiments were implicated as factors that could confound investigations into the relationship between IRT and laterality.
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The scope of this experiment was to study the effects of Saccharomyces cerevisiae fermentation product (SCFP; NutriTek, Diamond V) on milk yield, milk composition, somatic cell count, rumination activity, and immunometabolic profile (inflammation) of dairy cows during the peripartum period.
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Somatic Cell sentence examples within primordial germ cell
Similar to many other organisms, zebrafish primordial germ cells (PGCs) are specified at a location distinct from that of gonadal somatic cells.
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The genetic data suggest that in order to initiate the process of stem cell niche assembly, Notch signaling is activated among non-equipotent cells via distant induction, where germline Delta is delivered to somatic cells located several diameters away via cellular projections generated by primordial germ cells.
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Somatic Cell sentence examples within human induced pluripotent
Therefore, using human induced pluripotent stem cells (iPSC) reprogrammed from somatic cells of ALS patients, with both hereditary and sporadic forms of the disease, and differentiated into cell subtypes of both the central nervous system (CNS) and peripheral nervous system (PNS), have become powerful complementary tools for investigating basic mechanisms of disease as well as a platform for drug discovery.
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In 2006/7 the scientific community was overwhelmed (again) by the breakthrough discovery of Takahashi and Yamanaka who discovered the four transcription factors critical for cells’ pluripotency, thus providing the unique opportunity to reprogram any somatic cell into human-induced pluripotent stem cell (iPSCs).
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Somatic Cell sentence examples within milk yield fat
11773T>C SNPs of PRLR(L2) were significantly associated with milk yield, fat%, and protein%, and mRNA and protein levels of PRL and PRLR in milk somatic cells.
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This study aims to assess the differences between the basic lactation variables (milk yield, fat %, protein %, lactose % and somatic cell count) in the Alpine goat and the local breed Verzasca goat from a Bayesian point of observation.
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Somatic Cell sentence examples within fat protein lactose
Cows were milked twice daily, and weekly samples (composite samples of morning and afternoon milkings) were analyzed to determine total solids, fat, protein, lactose, and somatic cell count.
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Data including 93,815 test day records of 6343 Holstein cows in 162 herds were analyzed for milk yield, contents of fat, protein, lactose and solids-not-fat (SNF), milk urea nitrogen (MUN), and somatic cell score (SCS).
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Somatic Cell sentence examples within cow level risk
ABSTRACT Aims To assess potential cow-level risk factors for clinical mastitis during the dry period in cows infused with internal teat sealant (ITS) alone at drying off, and associations with elevated somatic cell counts (SCC) at the first herd test, or clinical mastitis in the subsequent lactation.
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The associated cow-level risk factors for culling such as lactation value (relative production level), parity number, rolling average of inseminations over all parities, very high fat-protein ratio (highFPR) and very low fat-protein ratio (lowFPR) in early lactation, test-day somatic cell count, were fitted in the model.
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Somatic Cell sentence examples within traits milk yield
Results Our results showed no evidence for any pleiotropic QTL effects of the polled locus on test-day production traits milk yield and fat percentage, on the mastitis indicator ‘somatic cell score’, and on several female fertility traits, i.
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In addition, a list of milk traits, including the native pH of the milk and several milk production and composition traits (milk yield; the fat, protein, and dried extract percentages; and the somatic cell count), were also analyzed for the studied animals.
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Somatic Cell sentence examples within total bacteria count
In this study, the association between milk lactose content and other milk constituents (protein and fat), somatic cell count (SCC), and total bacteria count (TBC) was valuated using a database of bulk tank milk (BTM) samples from dairy farms in southern Brazil.
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By means of a longitudinal study, individual half udder milk samples (n = 132) were collected at different lactation periods and assessed for milk yield and physicochemical composition, somatic cell count (SCC), total bacteria count (TBC) and microbiological culture.
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Somatic Cell sentence examples within milk urea nitrogen
Production traits included milk yield (MKG), protein percentage (PRO%), fat percentage (FAT%), somatic cell score (SCS) and milk urea nitrogen (MUN) from the first official test-day in first lactation.
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Simple Summary Organic dairy cows were used to evaluate the effect of two pasture production systems on milk, fat, and protein production, somatic cell score, milk urea nitrogen, body weight, body condition score, and activity and rumination.
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Somatic Cell sentence examples within standard plate count
The aim of this study was to investigate the effect of herd management practices on milk quality according to somatic cell count, standard plate count and electrical conductivity.
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The aim of this study was to investigate the effect of herd management practices on milk quality according to somatic cell count (SCC), standard plate count (SPC) and electrical conductivity (EC).
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Somatic Cell sentence examples within germ cell differentiation
The brain is composed of various differentiated cells, and the testis also contains various differentiated cells, such as germ cells, and somatic cells that support germ cell differentiation, such as Sertoli and Leydig cells.
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We computed transcriptional signatures and identified specific markers for nine states of germ cell differentiation, and 23 somatic cell types and subtypes.
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Somatic Cell sentence examples within fat % protein
Milk fat (%), protein (%), lactose (%), and somatic cell count (SCC, ‘000) were evaluated on 16 occasions.
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The following parameters were recorded: milk yield (MY, kg/d), percent milk fat (%), protein (PP, %), dry matter (DMP, %) and lactose (LP, %), urea content (UC, mg/L) as well as natural logarithm for somatic cell count (LnSCC, ln).
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Somatic Cell sentence examples within stem cell research
In the area of stem cell research, fusion of somatic cells into pluripotent cells such as mouse embryonic stem (ES) cells induces reprogramming of the somatic nucleus, and can be used to study the effect of trans-acting factors from the pluripotent cell on the pluripotent state of somatic nucleus.
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Apart from paving the ways to augment stem cell research and therapies, somatic cell nuclear transfer (SCNT) holds unique ability for a wide range of health applications such as patient-specific or isogenic cells for regenerative medicine and breeding transgenic animals for biomedical applications.
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Somatic Cell sentence examples within human embryonic stem
To recapitulate the symptoms and drug response of COVID‐19 patients in vitro, SARS‐CoV‐2 studies using physiologically relevant human embryonic stem (ES)/induced pluripotent stem (iPS) cell‐derived somatic cells and organoids are ongoing.
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Somatic Cell sentence examples within fat protein ratio
Body weight, rumination time, milk fat/protein ratio, milk yield, milk lactose, milk electrical conductivity, milk somatic cell count and consumption of concentrated feed were registered by Lely Astronaut® A3 milking robots.
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Somatic Cell sentence examples within Milk Somatic Cell
Real-time PCR found that cows with different genetic variants of the promoter demonstrated different levels of expression of LALBA mRNA in milk somatic cells (MSC).
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The study was conducted to understand the transcriptional pattern of different classes of protease-pathways associated genes (CTSB, CTSD, CTSH, CTSL, CTSK, CTSS, CTSZ, PLAU, PLAT) and potential protease inhibitors (SERPIN E2 and SERPIN F2) in 40 milk somatic cells (MSC) samples isolated during early, peak, mid and late lactation stages of Sahiwal cows and Murrah buffaloes - the two most important dairy breeds of India.
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Somatic Cell sentence examples within Human Somatic Cell
It is considered that ATMPs such as human somatic cells modified ex vivo, recombinant virus-based vectors, including those containing genome editing nucleic acid sequences, pose negligible risk to the environment.
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Here, we use genome engineering to delete the promoter of XIST to knockout expression from the Xi in non-cancerous diploid human somatic cells.
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Somatic Cell sentence examples within Adult Somatic Cell
Somatic Cell sentence examples within Gonadal Somatic Cell
Somatic Cell sentence examples within Normal Somatic Cell
For LINE-1 retrotransposition may result in genome instability, it was strictly restricted by organisms, and its expression was therefore barely detected in normal somatic cells.
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The large size of the oocytes of 1 μL, or 100 000 times bigger than a normal somatic cell, permits simple injection of DELs, thus resolving the fundamental problem of delivering DELs across cell membranes for in vivo screening.
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Somatic Cell sentence examples within Differentiated Somatic Cell
Somatic Cell sentence examples within Testicular Somatic Cell
Background: Leydig cells (LCs) are testicular somatic cells that are the major producers of testosterone in males.
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This review discusses the recent knowledge on the response of testicular somatic cells to heat stress and, specifically, regarding the relevant contributions of heat, germ cell depletion and inflammatory reactions on the functions of Sertoli and Leydig cells.
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Somatic Cell sentence examples within Mammalian Somatic Cell
At the level of mammalian somatic cells in renewal tissues, events or conditions that can tip this balance toward instability have attracted special interest in connection with carcinogenesis.
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dumerilii displays a high level of DNA methylation comparable to that of mammalian somatic cells.
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Somatic Cell sentence examples within High Somatic Cell
Somatic Cell sentence examples within Ovarian Somatic Cell
Ovarian somatic cells are derived in vitro from pluripotent embryonic stem cells Nudging germ cell precursors into functionally mature oocytes and spermatozoa is a key aspect of in vitro gametogenesis and a major challenge in the study of reproductive biology.
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Here, we developed a single-cell multi-omics sequencing method, scChaRM-seq, that enables simultaneous profiling of the DNA methylome, transcriptome, and chromatin accessibility in single human oocytes and ovarian somatic cells.
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Somatic Cell sentence examples within Reprogram Somatic Cell
Forced and maintained expression of four transcription factors OCT4, SOX2, KLF4 and c-MYC (OSKM), can reprogram somatic cells into induced Pluripotent Stem Cells (iPSCs) and a limited OSKM induction is able to rejuvenate the cell physiology without changing the cell identity.
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BACKGROUND
Four transcription factors, Oct4, Sox2, Klf4, and c-Myc (the Yamanka factors), can reprogram somatic cells to induced pluripotent stem cells (iPSCs).
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Somatic Cell sentence examples within Reprogramming Somatic Cell
Advancements in reprogramming somatic cells into induced pluripotent stem cells (iPSCs) have provided a strong framework for in vitro disease modeling, gene correction and stem cell-based regenerative medicine.
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iPSCs are derived by reprogramming somatic cells from a wide variety of tissues such as skin biopsies and then differentiating them into iPSC-MSCs.
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