Introduction to Soft Tissue Tumors

Schwannomas are benign slow-growing tumors that constitute 8% of all soft-tissue tumors.

The Bone and Soft Tissue Tumor (BSTT) registry is a nationwide, organ-specific cancer registry for bone and soft-tissue tumors in Japan.

Due to the rarity of this entity, a cautious exclusion process of all plausible differential diagnosis must be undertaken, in order to not miss the possibility of soft-tissue tumors, primarily malignant high-grade sarcomas.

While frozen-section margin analysis is largely effective in the management of soft-tissue tumors (accuracy [ 95%), myxofibrosarcoma’s microscopic tumor extension increases the risk of false-negative intraoperative margin analysis.

Quantification of tumor burden by medical imaging is often used in our daily clinical practice to assess the effectiveness of various anticancer therapies in soft-tissue tumors.

While myositis ossificans can often mimic malignant soft-tissue tumors, it has many unique findings that can aid in diagnostic differentiation.

The aims of this educational review are to learn the semiological basis of soft-tissue lesions and, with the help of diagnostic algorithms, to apply the current recommendations for the management of soft-tissue tumors.

Background Desmoid-type fibromatosis (DTF) is a rare kind of soft-tissue tumors of unknown origin, which is a benign mesenchymal neoplasm with monoclonal proliferation with local invasion, easy recurrence and non-distant metastasis.

Hemangiopericytomas (HPCs) are rare soft-tissue tumors, their presence on the head is rare.

Tenosynovial giant cell tumor is the common term used to describe a group of soft-tissue tumors that share a common etiologic link.

Since it is rare in orthopedic surgery, its diagnostis is less common and often initially mistaken with soft-tissue tumors.

Intraneural lipomas are rare soft-tissue tumors that can occur particularly within the median nerve.

Infantile hemangiomas (IHs) are the most common vascular soft-tissue tumors of newborns and early childhood with a prevalence rate of approximately 4%-5% in infancy.

Initially, they manifest as a painless tumor that can be confused with other more frequent pathologies such as soft-tissue tumors, lipomas, hematomas, or abscesses.

Soft tissue tumors are often accompanied with elevated skin temperature; however, studies concerning the relationship between soft-tissue tumors and skin temperature elevation are scarce.

Bone and soft-tissue tumors display a wide range of metabolic activity on flurodeoxyglucose positron emission tomography/computerized tomography (FDG PET/CT) imaging due to their varying histopathological features.

Conclusion: The structure of the model was highly accordant with the real ones, which can be of great help in evaluating the blood vessel changes in blood vessel-related diseases, bone and soft-tissue tumors, and creating accurate surgical plans.

Clinicians should note that, despite being benign, soft-tissue tumors accompanied by inflammation with angiogenesis and repetitive intratumoral bleeding can cause disseminated intravascular coagulation, albeit rarely.

Glomus tumors are a mostly benign neoplasm that constitutes less than 4% of upper-limb soft-tissue tumors.

Background: Benign soft-tissue tumors are very frequently received specimen in surgical pathology as compare to malignant one.

Musculoskeletal interventions are increasingly used with palliative and curative intent in the multidisciplinary treatment of oncology patients with bone and soft-tissue tumors.

Glomus tumors are benign neoplasms that arise from neuromyoarterial glomus bodies accounting for <2% of soft-tissue tumors.

Accordingly, it should be considered in the differential diagnosis of soft-tissue tumors in the major salivary glands for better management.

Solitary fibrous tumors (SFTs) are rare soft-tissue tumors that often occur in body cavities, especially the pleural space.

Dermatofibroma, also known as “fibrous histiocytoma”, is one of the most common cutaneous soft-tissue tumors.

· US is an initial imaging study for the evaluation of superficial soft-tissue tumors.

Objective This study aims to explore MRI-based tumoral and intratumoral radiomics approaches on distinguishing malignant from benign soft-tissue tumors using handcrafted and deep learning-based features.

CONCLUSION Our study identifies a multiparametric signature for disease subtyping, providing a strong impetus for switching from qualitative to quantitative analysis of deep soft-tissue tumors of the neck.

Background: Wide resection of malignant bone and soft-tissue tumors of the extremities may impair the functions of the affected limbs.

Materials and Methods: Seven schwannomas out of 174 soft-tissue tumors on the foot and ankle were retrieved from our Institute in a 3-year period, and 42 schwannomas on the foot and ankle in the literature in a 30-year period were reviewed.

We report a patient with spinal angiolipoma, vertebral hemangioma along with subcutaneous lipomas and angiolipomas, exhibiting the entire histopathological spectrum of these related soft-tissue tumors.

Nevertheless, by their recapitulation of the donor tissue architecture, they provide an interesting and important tool to study the huge variety of soft-tissue tumors.

Although hemangioma is considered as the most common soft-tissue tumors of the head and neck, it is relatively rare in the oral cavity and uncommonly encountered by dental professionals.

Malignant peripheral nerve sheath tumors (MPNSTs) are unusual and aggressive malignant soft-tissue tumors that comprise 5–10% of all soft-tissue sarcomas.

5% of all soft-tissue tumors.

It is characterized by intestinal polyposis and various bone and soft-tissue tumors, including osteomas, epidermal and dermal cysts, lipomas and fibromas.

The PDGFRB sequencing appears to have a high value for diagnosis, prognosis, and therapy of soft-tissue tumors in children.

Imaging appearances of peripheral nerve sheath tumors by MRI are difficult distinguish from soft-tissue tumors.

We examined by morphology and immunohistochemistry 1072 sarcoma specimens representing 22 types, in addition to 236 benign bone and soft-tissue tumors.

It is very rare accounting for less than 3% of all soft-tissue tumors.

Introduction: Granular Cell Tumors (GCTs) of the orbit are rare-entity soft-tissue tumors, and few reports have been published in the literature.

If left untreated, they can give rise to benign soft-tissue tumors.

Synovial sarcoma is one of the common soft-tissue tumors of the body and is usually found on the lower extremity, head-and-neck regions.

Methods: Nine patients underwent reconstruction with a TFP after the wide resection of malignant bone and soft-tissue tumors of the femur between January 2003 and April 2014.

Angioleiomyomas are benign soft-tissue tumors that present painfully and are more commonly found in the extremities.

This case proposes that, although rare, SFT should be considered in the differential diagnosis of soft-tissue tumors in the major salivary glands.

MATERIAL AND METHODS A total of 64 patients with 64 histologically confirmed soft-tissue tumors were retrospectively included.

The purpose of this study is to evaluate the diagnostic outcome of ultrasound (US)-guided core needle biopsy (CNB) of soft-tissue tumors and to assess the factors associated with significant diagnostic failure.

From the present study, we conclude that Magnetic Resonance Imaging (MRI) is a well-established imaging tool for the characterization of soft-tissue tumors.

Rationale: Solitary fibrous tumors (SFTs) are rare soft-tissue tumors characterized with spindle-cell, which occur more common in the chest and rarely seen in the abdomen.

More than 20% of soft-tissue tumors belong to the group of adipocytic neoplasms.

This article reviews the key features and treatment options of the more commonly encountered benign and malignant shoulder bone and soft-tissue tumors and tumor-like conditions.

They represent 15% of the soft-tissue tumors.