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Single Arm Trial sentence examples within randomized controlled trial



Mindfulness-based interventions for social anxiety disorder: A systematic review and meta-analysis



Memantine for Episodic Migraine: A Systematic Review and Meta-analysis


Single Arm Trial sentence examples within multicenter open label



Safety and efficacy of low-dose PI3K inhibitor taselisib in adult patients with CLOVES and Klippel-Trenaunay syndrome (KTS): the TOTEM trial, a phase 1/2 multicenter, open-label, single-arm study.



A phase II study of anlotinib combined with STUPP regimen in the treatment of patients with newly diagnosed glioblastoma (GBM).


Single Arm Trial sentence examples within prospective open label



Pivotal Study of Leadless Tibial Nerve Stimulation with eCoin® for Urgency Urinary Incontinence: An Open-Label, Single Arm Trial.



Differential response to scrambler therapy by neuropathic pain phenotypes



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Single Arm Trial sentence examples within Ius Single Arm Trial



Abstract P1-15-14: Neoadjuvant liposomal doxorubicin and carboplatin is effective and tolerable for the treatment of triple negative breast cancer



Non-pegylated liposomal doxorubicin (NPLD, Myocet®) + carboplatin in patients with platinum sensitive ovarian cancers: A ARCAGY-GINECO phase IB-II trial.


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10.3389/fphar.2021.642511

Efficacy of Conversion Surgery Following Apatinib Plus Paclitaxel/S1 for Advanced Gastric Cancer With Unresectable Factors: A Multicenter, Single-Arm, Phase II Trial


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10.3390/cancers13071683

Successive Osteosarcoma Relapses after the First Line O2006/Sarcome-09 Trial: What Can We Learn for Further Phase-II Trials?


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10.3988/jcn.2021.17.3.344

Fimasartan-Based Blood Pressure Control after Acute Cerebral Ischemia: The Fimasartan-Based Blood Pressure Control after Acute Cerebral Ischemia Study


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10.1016/j.psychres.2021.113935

Mindfulness-based interventions for social anxiety disorder: A systematic review and meta-analysis



Memantine for Episodic Migraine: A Systematic Review and Meta-analysis


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10.1038/s41416-020-01208-6

Metformin plus lrinotecan in patients with refractory colorectal cancer: a phase 2 clinical trial



A multicenter confirmatory single-arm trial of the safety and efficacy of a transanal drain for prevention of anastomotic leakage after surgery for rectal cancer.


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10.1097/MD.0000000000023859

Integrated cognitive behavioral therapy for chronic pain


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10.1158/1078-0432.CCR-21-0327

FDA Approval Summary: Pembrolizumab for the Treatment of Tumor Mutational Burden–High Solid Tumors


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10.1016/j.euo.2021.02.010

Immune Checkpoint Inhibitors in Front-line Therapy for Urothelial Cancer.


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10.3390/microorganisms9051026

Effect of Lacticaseibacillus paracasei Strain Shirota on Improvement in Depressive Symptoms, and Its Association with Abundance of Actinobacteria in Gut Microbiota


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10.3389/fnut.2021.666243

Chaya Leaf Decreased Triglycerides and Improved Oxidative Stress in Subjects With Dyslipidemia



Acupuncture and Derived Therapies for Pain in Palliative Cancer Management: Systematic Review and Meta-Analysis Based on Single-Arm and Controlled Trials.



Pyronaridine-Artesunate (Pyramax®) for the Treatment of Artemisinin- and Piperaquine-Resistant Plasmodium falciparum in the Central Highlands of Vietnam.


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10.1016/j.ejca.2021.03.029

Clinical effectiveness of olaparib monotherapy in germline BRCA-mutated, HER2-negative metastatic breast cancer in a real-world setting: phase IIIb LUCY interim analysis.


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10.1161/CIRCOUTCOMES.120.007600

Monotherapy Anticoagulation to Expedite Home Treatment of Patients Diagnosed With Venous Thromboembolism in the Emergency Department: A Pragmatic Effectiveness Trial


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10.4103/jmas.JMAS_35_19

Enhanced recovery after surgery in laparoscopic distal gastrectomy: Protocol for a prospective single-arm clinical trial


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10.1007/s40274-021-7665-4

Pembrolizumab in dMMR/MSI-H unresectable or metastatic endometrial cancer: substantial gain in life-years at acceptable cost in the US



Telehealth Diabetes Prevention Intervention for the Next Generation of African American Youth: Protocol for a Pilot Trial



Preliminary evidence for the impact of digital life stories about aged care residents on staff knowledge and understanding regarding those residents; A single arm trial.


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10.1186/s12889-021-10794-w

Can a ‘rewards-for-exercise app’ increase physical activity, subjective well-being and sleep quality? An open-label single-arm trial among university staff with low to moderate physical activity levels


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10.1007/s00464-021-08542-7

Outcomes associated with the use of a new powered circular stapler for left-sided colorectal reconstructions: a propensity score matching-adjusted indirect comparison with manual circular staplers


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10.1038/s41467-021-21085-8

Efficacy and tolerability of bevacizumab in patients with severe Covid-19


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10.5152/balkanmedj.2021.20121

Efficacy and Safety of Bevacizumab-Combined Chemotherapy for Advanced and Recurrent Endometrial Cancer: A Systematic Review and Meta-analysis.


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10.1136/bmjopen-2021-051484

Clinical efficacy and security of glycyrrhizic acid preparation in the treatment of anti-SARS-CoV-2 drug-induced liver injury: a protocol of systematic review and meta-analysis



How to choose a time zero for patients in external control arms.


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10.1097/JU.0000000000001733

Pivotal Study of Leadless Tibial Nerve Stimulation with eCoin® for Urgency Urinary Incontinence: An Open-Label, Single Arm Trial.


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10.1080/14670100.2021.1940629

Cochlear implant surgery: Learning curve in virtual reality simulation training and transfer of skills to a 3D-printed temporal bone – A prospective trial


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10.1016/s0090-8258(21)00788-5

A phase II trial of short-course Hyperthermic IntraPEritoneal Chemotherapy (HIPEC) for high tumor burden ovarian cancer: updated report with preliminary survival outcomes


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10.1007/s13187-021-02026-x

A Web-based Lifestyle Intervention for Cancer Survivors: Feasibility and Acceptability of SurvivorSHINE.


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10.1186/s13073-021-00826-w

Comprehensive molecular characterization of gastric cancer patients from phase II second-line ramucirumab plus paclitaxel therapy trial


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10.1108/jhr-03-2021-0179

A mixed-method systematic review of text-based telehealth interventions in eating disorder management


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10.1007/s12671-021-01606-8

mHealth Mindfulness Intervention for Women with Moderate-to-Moderately-Severe Antenatal Depressive Symptoms: a Pilot Study Within an Integrated Health Care System



Laminopathies’ Treatments Systematic Review: A Contribution Towards a ‘Treatabolome’


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10.1272/jnms.JNMS.2021_88-518

Effects of topiroxostat administration on brain natriuretic peptide levels in heart failure patients with a preserved ejection fraction: A pilot study.


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10.1016/S2152-2650(21)01882-6

ABCL-289: Matching-Adjusted Indirect Comparison (MAIC) of Axicabtagene Ciloleucel (Axi-Cel) and Lisocabtagene Maraleucel (Liso-Cel) in Relapsed or Refractory (R/R) Large B-Cell Lymphoma (LBCL) After Two or More Prior Lines of Therapy


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10.1097/CAD.0000000000001202

The power of kindness: curative treatment with metronomic combination in advanced hepatocellular carcinoma.


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10.3389/fsurg.2021.671849

Percutaneous Mechanical Atherectomy Plus Thrombectomy Using the Rotarex®S Device Followed by a Drug-Coated Balloon for the Treatment of Femoropopliteal Artery In-stent Restenosis: A Prospective Single-Center, Single-Arm Efficacy Trial (PERMIT-ISR Trial)


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10.1038/s41467-020-20814-9

Association of PET-based estradiol-challenge test for breast cancer progesterone receptors with response to endocrine therapy.


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10.1080/13696998.2021.1974763

Cost-effectiveness of nivolumab monotherapy in the third-line treatment of small cell lung cancer.


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10.1371/journal.pone.0247620

Epidemiological and clinical burden of EGFR Exon 20 insertion in advanced non-small cell lung cancer: A systematic literature review



An Avatar-Led Digital Smoking Cessation Program for Sexual and Gender Minority Young Adults: Intervention Development and Results of a Single-Arm Pilot Trial


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10.1177/11297298211020867

Intervention with selution SLR™ Agent Balloon for Endovascular Latent Limus therapy for failing AV Fistulas (ISABELLA) Trial: Protocol for a pilot clinical study and pre-clinical results.


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10.1371/journal.pone.0247972

A pilot study evaluating GSK1070806 inhibition of interleukin-18 in renal transplant delayed graft function


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10.1016/j.psyneuen.2020.105114

Neural responses to threat and reward and changes in inflammation following a mindfulness intervention



Clinical Performance of CAD/CAM All-Ceramic Tooth-Supported Fixed Dental Prostheses: A Systematic Review and Meta-Analysis


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10.1080/23744235.2021.1982140

Effectiveness of ezetimibe in human immunodeficiency virus patients treated for hyperlipidaemia: a systematic review and meta-analysis.


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10.1016/j.ijrobp.2021.07.738

Long Term Follow-Up of a Single-Institution Prospective Study.


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10.3390/medicina57070652

Systematic Review of Mind-Body Interventions to Treat Myalgic Encephalomyelitis/Chronic Fatigue Syndrome


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10.1016/S2152-2650(21)01862-0

ABCL-030: Safety of Ambulatory High-Dose Methotrexate (HDMTX) Administration Among Hematological Malignancies Patients in a Tertiary Care Center


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10.1177/2152656720988565

Evaluation of In-Office Cryoablation of Posterior Nasal Nerves for the Treatment of Rhinitis


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10.1016/j.clgc.2021.02.001

A Single-arm Phase II Trial of Neoadjuvant Cabazitaxel and Cisplatin Chemotherapy for Muscle-Invasive Transitional Cell Carcinoma of the Urinary Bladder.



Prospective Multi-Center Korean Registry of Transcatheter Arterial Chemoembolization with Drug-Eluting Embolics for Nodular Hepatocellular Carcinoma: A Two-Year Outcome Analysis


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10.1200/JCO.2021.39.15_SUPPL.11530

Outcome of patients with recurrent/refractory osteosarcoma enrolled in three recent phase II trials: A report from the Children’s Oncology Group.


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10.1016/j.jval.2020.09.014

Assessing the Value of Cemiplimab for Adults With Advanced Cutaneous Squamous Cell Carcinoma: A Cost-Effectiveness Analysis.


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10.20944/PREPRINTS202105.0296.V1

Clinical Performance of CAD/CAM All-ceramic Tooth-supported Fixed Dental Prostheses: A Systematic Review and Meta-analysis


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10.1200/JCO.2021.39.15_SUPPL.E20532

Chemoradiation-induced pneumonitis in patients with unresectable stage III non-small cell lung cancer: A meta-analysis.


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10.36469/jheor.2021.19008

Comparative Effectiveness of Remestemcel-L-rknd versus Ruxolitinib in Pediatric Patients with Steroid-Refractory Acute Graft-Versus-Host Disease using Simulated Treatment Comparisons



Single-arm oncology trials and the nature of external controls arms.


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10.1016/s0090-8258(21)00672-7

Interim analysis of the immune-related endpoints of the mismatch repair deficient (dMMR) and proficient (MMRp) endometrial cancer cohorts from the GARNET study


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10.1016/j.athoracsur.2021.04.045

STS INTERMACS Database: The Key to Conduct Single-arm Trials in Advanced Heart Failure Patients.


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10.1186/s13613-021-00848-y

Effects of remote ischemic conditioning on microcirculatory alterations in patients with sepsis: a single-arm clinical trial


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10.1016/j.cmi.2021.08.007

Pretomanid for tuberculosis: a systematic review.



A two-stage drop-the-losers design for time-to-event outcome using a historical control arm.


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10.1016/S2666-5247(20)30198-1

Estimation of the correlates of protection of the rVSVΔG-ZEBOV-GP Zaire ebolavirus vaccine: a post-hoc analysis of data from phase 2/3 clinical trials


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10.1016/J.JVAL.2021.01.015

Use of External Comparators for Health Technology Assessment Submissions Based on Single-Arm Trials.


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10.1097/QAI.0000000000002694

Effect of Text Messaging Plus Peer Navigation on Viral Suppression Among Youth With HIV in the iCARE Nigeria Pilot Study.


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10.1038/s41436-021-01290-y

Safety and efficacy of low-dose PI3K inhibitor taselisib in adult patients with CLOVES and Klippel-Trenaunay syndrome (KTS): the TOTEM trial, a phase 1/2 multicenter, open-label, single-arm study.


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10.1136/ANNRHEUMDIS-2021-EULAR.2136

POS1136 PHARMACOKINETICS OF PEGLOTICASE AND METHOTREXATE POLYGLUTAMATE(S) IN PATIENTS WITH UNCONTROLLED GOUT RECEIVING PEGLOTICASE AND CO-TREATMENT OF METHOTREXATE


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10.1080/0284186X.2021.1871946

Efficacy evaluation of anticancer agents in single-arm clinical trials: analysis of review reports from Pharmaceuticals and Medical Devices Agency


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10.1001/jamaoncol.2021.0275

Assessment of Pembrolizumab Therapy for the Treatment of Microsatellite Instability-High Gastric or Gastroesophageal Junction Cancer Among Patients in the KEYNOTE-059, KEYNOTE-061, and KEYNOTE-062 Clinical Trials.



Incentives for smoking cessation in a rural pharmacy setting: The Tobacco Free Communities program.


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10.23736/S0390-5616.21.05389-3

Are injectable regenerative therapies effective in the treatment of Degenerative Disc Disease? A systematic literature review.


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10.1038/S41598-021-89667-6

Differential response to scrambler therapy by neuropathic pain phenotypes



Bayesian Sequential Monitoring of Single-Arm Trials: A Comparison of Futility Rules Based on Binary Data


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10.1177/03331024211034508

BoNT-A efficacy in high frequency migraine: an open label, single arm, exploratory study applying the PREEMPT paradigm.



Comparison of Treatments for Nonmetastatic Castration-Resistant Prostate Cancer: Matching-Adjusted Indirect Comparison and Network Meta-Analysis.


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10.1158/1078-0432.CCR-21-2639

Real-world Evidence in Support of Oncology Product Registration: A Systematic Review of New Drug Application and Biologics License Application Approvals from 2015-2020.


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10.1007/s12671-021-01760-z

Negative Mood and Food Craving Strength Among Women with Overweight: Implications for Targeting Mechanisms Using a Mindful Eating Intervention


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10.1186/s12879-021-06602-w

Three-day regimen of oseltamivir for post-exposure prophylaxis of influenza in hospital wards: a study protocol for a prospective, multi-center, single-arm trial


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10.1016/J.JVAL.2021.03.004

How Assessment-Schedule Matching Limits Bias When Comparing Progression-Free Survival in Single-Arm Studies: An Application in Second-Line Urothelial Carcinoma Treatments.



Efficacy and Safety of Multi-Session Transcranial Direct Current Stimulation on Social Cognition in Schizophrenia: A Study Protocol for an Open-Label, Single-Arm Trial



Feasibility of a Mobile Health App for Routine Outcome Monitoring and Feedback in SMART Recovery Mutual Support Groups: Stage 1 Mixed Methods Pilot Study.


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10.1093/SLEEP/ZSAB072.373

374 Cognitive Behavioral Therapy with Exercise in Adults with Insomnia and Short Sleep: Daytime Function Outcomes from a Pilot Study


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10.36118/pharmadvances.2021.13

Pharmacovigilance, drug interactions, pharmacogenetics and therapeutic drug monitoring of anticancer agents: a valuable support for clinical practice


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10.1016/j.jacep.2021.01.019

Safety and Effectiveness of a Next-Generation Contact Force Catheter: Results of the TactiSense Trial.


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10.1038/s41440-021-00670-w

Renin–angiotensin system inhibitor use and the risk of mortality in hospitalized patients with COVID-19: a meta-analysis of randomized controlled trials


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10.1016/j.jvir.2021.04.027

Society of Interventional Radiology Quality Improvement Standards on Percutaneous Ablation of Non-Small Cell Lung Cancer and Metastatic Disease to the Lungs.


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10.1007/s12185-020-03044-z

A study of carfilzomib and dexamethasone in patients with relapsed and refractory multiple myeloma in China


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10.1016/j.ijrobp.2021.07.212

A Phase II Trial of Individualized Stereotactic Ablative Radiotherapy for Lung Tumors (iSABR).


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10.1097/01.REO.0000000000000268

Cognitive Rehabilitation Programs for Survivors of Breast Cancer Treated With Chemotherapy: A Systematic Review


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10.1007/s12529-021-09965-1

Preliminary Evaluation of a 1-Day Acceptance and Commitment Therapy Workshop for Increasing Moderate-to-Vigorous Physical Activity in Adults with Overweight or Obesity


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