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Modeling the impact of amino acid substitution in a monoclonal antibody on cation exchange chromatography



Computational Saturation Screen Reveals the Landscape of Mutations in Human Fumarate Hydratase


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A single amino acid mutant in the EAR motif of IbMYB44.2 reduced the inhibition of anthocyanin accumulation in the purple-fleshed sweetpotato.



The structure-based cancer-related single amino acid variation prediction


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Multiplexed assays reveal effects of missense variants in MSH2 and cancer predisposition



Predicting potentially permissive substitutions that improve the fitness of A(H1N1)pdm09 viruses bearing the H275Y NA substitution




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Comparison of 10 emerging SARS-CoV-2 Variants: infectivity, animal tropism, and antibody neutralization



Infectivity and antigenicity of SARS-CoV-2 B.1.617 variants


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Evidence for Deleterious Antigenic Imprinting in SARS-CoV-2 Immune Response



Roles of membrane transporters: connecting the dots from sequence to phenotype.


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TRP-BERT: Discrimination of transient receptor potential (TRP) channels using contextual representations from deep bidirectional transformer based on BERT



Hepatitis B Core Protein Capsids.


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Natural variants in SARS-CoV-2 S protein pinpoint structural and functional hotspots: implications for prophylaxis and therapeutic strategies



Natural variants in SARS-CoV-2 Spike protein pinpoint structural and functional hotspots with implications for prophylaxis and therapeutic strategies


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Engineering of Ancestors as a Tool to Elucidate Structure, Mechanism, and Specificity of Extant Terpene Cyclase



Improved thermostability of proteinase K and recognizing the synergistic effect of Rosetta and FoldX approaches.


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Complete map of SARS-CoV-2 RBD mutations that escape the monoclonal antibody LY-CoV555 and its cocktail with LY-CoV016



Complete map of SARS-CoV-2 RBD mutations that escape the monoclonal antibody LY-CoV555 and its cocktail with LY-CoV016


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Alternative LC-MS/MS Platforms and Data Acquisition Strategies for Proteomic Genotyping of Human Hair Shafts



Elucidation of familial relationships using hair shaft proteomics.


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Conserved C‐terminal motifs in odorant receptors instruct their cell surface expression and cAMP signaling



In silico analyses of penicillin binding proteins in Burkholderia pseudomallei uncovers SNPs with utility for phylogeography, species differentiation, and sequence typing


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Antagonistic Effects of Point Mutations on Charge Recombination and a New View of Primary Charge Separation in Photosynthetic Proteins



Human and viral membrane–associated E3 ubiquitin ligases MARCH1 and MIR2 recognize different features of CD86 to downregulate surface expression


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Investigating single amino acid substitutions in PIM1 kinase: A structural genomics approach



Role of the reaction-structure coupling in temperature compensation of the KaiABC circadian rhythm


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Self-assembled Structures Formed by Fmoc modified aliphatic amino acids



Structural basis for a bacterial Pip system plant effector recognition protein


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10.1073/pnas.2019462118

Structural basis for a bacterial Pip system plant effector recognition protein


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10.1101/2021.06.17.448844

Expression and function of SLC38A5, an amino acid-coupled Na+/H+ exchanger, in triple-negative breast cancer and its relevance to macropinocytosis


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10.37191/MAPSCI-2582-7960-2(1)-014

Covid-19 Mutations and How the Vaccine Enhances Immune Intelligence


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10.1080/2162402X.2020.1870062

Characterization of CD8+ T-cell responses to non-anchor-type HLA class I neoantigens with single amino-acid substitutions


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10.30564/JER.V3I1.2884

Covid-19 Mutations and the Effect of Different Vaccines on Immune Memory



Phylogenetic Analysis of European Brown Hare Syndrome Virus Strains from Poland (1992–2004)


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10.3389/fvets.2021.675631

Penicillin Treatment Failure in Rabbit Syphilis Due to the Persistence of Treponemes (Treponema paraluisleporidarum Ecovar Cuniculus) in the Focus of Infection


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10.20944/PREPRINTS202106.0410.V1

Substitution Arg140Gly in HA/H7 Reduced the Virulence Highly Pathogenic Avian Influenza Virus H7N1


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10.1016/j.virol.2021.03.017

Loss of p24 from the Bombyx mori nucleopolyhedrovirus genome results in the formation of cuboidal occlusion bodies.


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10.1101/2021.04.15.440003

Deep mutational scanning of the plasminogen activator inhibitor-1 functional landscape



Towards the stable chelation of radium for biomedical applications with an 18-membered macrocyclic ligand†


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10.1073/pnas.2020429118

Comparative parallel analysis of RNA ends identifies mRNA substrates of a tRNA splicing endonuclease-initiated mRNA decay pathway



Insights into the Activation of a Crustacean G Protein-Coupled Receptor: Evaluation of the Red Pigment-Concentrating Hormone Receptor of the Water Flea Daphnia pulex (Dappu-RPCH R)


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10.1101/2021.03.25.436926

Disrupting hierarchical control of nitrogen fixation enables carbon-dependent regulation of ammonia excretion in soil diazotrophs


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10.1007/s11103-021-01134-y

Identification and functional characterization of a PDR transporter in Tripterygium wilfordii Hook.f. that mediates the efflux of triptolide.


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10.1021/jacsau.0c00103

Engineering a Cytochrome P450 for Demethylation of Lignin-Derived Aromatic Aldehydes


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10.1002/biot.202100238

Identification and analysis of sugar transporters capable of co-transporting glucose and xylose simultaneously.


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10.1073/pnas.2018731118

A single historical substitution drives an increase in acetylcholine receptor complexity


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10.1038/s41577-021-00628-6

Structural insights into the evolution of the RAG recombinase.


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10.1007/s10529-021-03135-9

A single point mutation converts a glutaryl-7-aminocephalosporanic acid acylase into an N-acyl-homoserine lactone acylase


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10.1093/molbev/msab285

Simultaneous expression of UV and violet SWS1 opsins expands the visual palette in a group of freshwater snakes.


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10.1007/s00438-021-01795-w

Analysis of natural variation of the rice blast resistance gene Pike and identification of a novel allele Pikg.


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10.1016/J.JAS.2021.105367

Palaeopathology and amino acid δ13C analysis: Investigating pre-Columbian individuals with tuberculosis at Pica 8, northern Chile (1050-500 BP)


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10.1172/jci.insight.143324

A GRM7 mutation associated with developmental delay reduces mGlu7 expression and produces neurological phenotypes


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10.1091/mbc.E19-10-0585

Pannexin 1 mutation found in melanoma tumor reduces phosphorylation, glycosylation, and trafficking of the channel-forming protein


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10.3389/fcimb.2021.656620

Plasmodium yoelii Erythrocyte Binding Like Protein Interacts With Basigin, an Erythrocyte Surface Protein


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10.1101/2021.07.17.452804

ACE2 binding is an ancestral and evolvable trait of sarbecoviruses



Cardiolipin targets a dynamin-related protein to the nuclear membrane



HvLEAFY controls the early stages of floral organ specification and inhibits the formation of multiple ovaries in barley.


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10.1021/acs.jpcb.1c01725

Site-Specific Backbone and Side-Chain Contributions to Thermodynamic Stabilizing Forces of the WW Domain.


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10.1021/acs.analchem.1c03481

High-Resolution Mapping of Amino Acid Residues in DNA-Protein Cross-Links Enabled by Ribonucleotide-Containing DNA.


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10.20944/PREPRINTS202101.0439.V1

The Change P82L in the Rift Valley Fever Virus NSs Protein Confers Attenuation in Mice Not Related with a Type-I IFN Antagonistic Phenotype


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10.1038/s42003-021-01745-7

Endosomal TLR3 co-receptor CLEC18A enhances host immune response to viral infection


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10.1161/ATVBAHA.121.316867

Receptor and Molecular Mechanism of AGGF1 Signaling in Endothelial Cell Functions and Angiogenesis.



Mutations in transmembrane proteins: diseases, evolutionary insights, prediction and comparison with globular proteins



Self-assembly of amino acids toward functional biomaterials


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10.1101/2021.10.03.462970

β-amyloid−driven synaptic depression requires PDZ protein interaction at AMPA-receptor subunit GluA3



Missense Mutations in the CrrB Protein Mediate Odilorhabdin Derivative Resistance in Klebsiella pneumoniae


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10.1371/journal.ppat.1009956

Selective autophagic receptor NbNBR1 prevents NbRFP1-mediated UPS-dependent degradation of βC1 to promote geminivirus infection


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10.1186/s13062-021-00292-9

Polymorphism on human aromatase affects protein dynamics and substrate binding: spectroscopic evidence



Impact of single amino acid substitution on the structure and function of TANK‐binding kinase‐1


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10.1371/journal.pgen.1009265

yama, a mutant allele of Mov10l1, disrupts retrotransposon silencing and piRNA biogenesis


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10.1101/2021.05.18.444643

Rules for designing protein fold switches and their implications for the folding code


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10.3892/ol.2020.12305

Overexpression of monocarboxylate transporter 4 promotes the migration and invasion of non-carcinogenic L929 fibroblast cells


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10.1038/s41574-021-00470-9

The importance of the RET gene in thyroid cancer and therapeutic implications



Functional and Structural Characterization of Acquired Pan-Aminoglycoside Resistance 16S rRNA Methyltransferase NpmB1.


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10.1248/bpb.b20-01013

Protonation State of a Histidine Residue in Human Oligopeptide Transporter 1 (hPEPT1) Regulates hPEPT1-Mediated Efflux Activity.


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10.1016/j.cmi.2021.03.001

Molecular analysis of clinical isolates of ceftazidime-avibactam-resistant Klebsiella pneumoniae.


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10.1016/j.bbabio.2021.148493

Exchange of a single amino acid residue in the cryptophyte phycobiliprotein lyase GtCPES expands its substrate specificity.


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10.1101/2021.09.08.459503

An ultrasensitive microfluidic approach reveals correlations between the physico-chemical and biological activity of experimental peptide antibiotics


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10.26434/CHEMRXIV.14152976.V1

Unusual Aggregation Properties of Single Amino Acid L-Lysine Hydrochloride


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10.1101/2021.09.07.459283

Simultaneous expression of UV and violet SWS1 opsins expands the visual palette in a group of freshwater snakes


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10.1093/labmed/lmab047

Whole-Exome Sequencing Identifies a Recurrent Small In-Frame Deletion in MYO15A Causing Autosomal Recessive Nonsyndromic Hearing Loss in 3 Iranian Pedigrees.


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10.1101/2021.09.04.458985

Spectrum graph-based de-novo sequencing algorithm MaxNovo achieves high peptide identification rates in collisional dissociation MS/MS spectra


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10.1021/acsptsci.0c00193

GLP-1 Val8: A Biased GLP-1R Agonist with Altered Binding Kinetics and Impaired Release of Pancreatic Hormones in Rats.


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10.1016/j.jsb.2021.107732

The crystal structure of yeast regulatory subunit reveals key evolutionary insights into Protein Kinase A oligomerization.


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10.1101/2021.02.17.431744

Frequent intergenotypic recombination between the non-structural and structural genes is a major driver of epidemiological fitness in caliciviruses


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10.1101/2021.03.06.434200

Biochemical reconstitution defines new functions for membrane-bound glycosidases in assembly of the bacterial cell wall


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10.1016/j.conb.2021.07.010

Molecular foundations of prion strain diversity


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10.1186/s12864-021-07823-8

Single nucleotide replacement in the Atlantic salmon genome using CRISPR/Cas9 and asymmetrical oligonucleotide donors


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10.3389/fmolb.2021.702341

Characterization of the Cancer-Associated Meprin Βeta Variants G45R and G89R


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10.1021/acsinfecdis.0c00837

Evolution of Resistance to Phenazine Antibiotics in Staphylococcus aureus and Its Role During Coinfection with Pseudomonas aeruginosa.


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10.1016/J.IJMS.2021.116685

Subtle chirality effects of a D/l-Cysteine on the intrinsic acidity and conformation of isomeric tripeptides ACA and AdCA


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10.1016/j.scr.2021.102277

Generation of patient-specific induced pluripotent stem cell line (CSUi002-A) from a patient with isolated dystonia carrying TOR1A mutation.


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10.3389/fgene.2021.662751

Omics Profiling of S2P Mutant Fibroblasts as a Mean to Unravel the Pathomechanism and Molecular Signatures of X-Linked MBTPS2 Osteogenesis Imperfecta


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10.1101/2021.03.03.21252812

Genome sequencing and analysis of an emergent SARS-CoV-2 variant characterized by multiple spike protein mutations detected from the Central Visayas Region of the Philippines


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10.1101/2021.02.05.429901

Active microrheology using pulsed optical tweezers to probe viscoelasticity of Lamin A towards diagnosis of laminopathies


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10.1093/g3journal/jkab312

Diverse wMel variants of Wolbachia pipientis differentially rescue fertility and cytological defects of the bag of marbles partial loss of function mutation in Drosophila melanogaster.


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10.1093/g3journal/jkab304

Simple-to-use CRISPR-SpCas9/SaCas9/AsCas12a vector series for genome editing in Saccharomyces cerevisiae


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10.1080/14686996.2021.1944783

Improved anti-cancer effect of epidermal growth factor-gold nanoparticle conjugates by protein orientation through site-specific mutagenesis


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10.3390/plants10091885

The First Report of Target-Site Resistance to Glyphosate in Sweet Summer Grass (Moorochloa eruciformis)


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10.1101/2021.08.10.455817

Molecular Understanding of Calorimetric Protein Unfolding Experiments


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