Introduction to Selective Ablation

Unexpectedly, selective ablation of either Aire-expressing medullary thymic epithelial cells or extrathymic Aire-expressing cells (eTACs) mapped the IUGR phenotype exclusively to eTACs.

Selective ablation or chemogenetic suppression of RVM GPER+ neurons resulted in mechanical alloknesis and increased scratching in response to pruritogens, whereas chemogenetic activation of GPER+ neurons abrogated itch responses, indicating that GPER+ neurons are antipruritic.

We demonstrate herein that selective ablation of PHD2 expression in Treg (PHD2ΔTreg mice) leads to a spontaneous systemic inflammatory syndrome, as evidenced by weight loss, development of a rectal prolapse, splenomegaly, shortening of the colon and elevated expression of IFN-γ in the mesenteric lymph nodes, intestine and spleen.

Following successful ablation of cancer cells in cell culture and zebrafish tumor-xenograft models, it is hypothesized that a cancer treatment can be developed using safe microwave irradiation for selective ablation of tumor cells in vivo using carbon nanotube-Antibody (CNT-Ab) conjugates as a targeting agent.

Selective ablation of the superior colliculus-projecting GABAergic RGCs, leaving other GABAergic RGCs intact, reduces the looming stimulus-induced defensive response without affecting image-forming functions; it also significantly enhances glucose metabolism in the superior colliculus, as determined by [18F]-fluorodeoxyglucose PET (FDG PET).

We demonstrate herein that selective ablation of PHD2 expression in Treg (PHD2{Delta}Treg mice) leads to a spontaneous systemic inflammatory syndrome, as evidenced by weight loss, development of a rectal prolapse, splenomegaly, shortening of the colon and elevated expression of IFN-{gamma} in the mesenteric lymph nodes, intestine and spleen.

The adaptations of such pathogenic memory cells to chronic inflammation offers entirely new therapeutic options for their selective ablation and the regeneration of immunological tolerance.

Here we show that selective ablation of Bmal1 (Cre/loxP system) from medium spiny neurons of the striatum induces sexual dimorphic alterations in alcohol consumption in mice, resulting in augmentation of voluntary alcohol intake in males and repression of intake in females.

As concerns about the potential risk of graft-related severe adverse events, such as tumor formation from residual pluripotent cells, currently restrict their applicability, we established an optimized tool for therapeutic intervention that allows drug-controlled, specific and selective ablation of either iPSCs or the whole graft through genetic safety switches.

A selective ablation of Fgfr1 aborted the increase of serum active full-length FGF23 and the enhanced expression of Galnt3 in the bone by a high phosphate diet.

A role of feed-forward inhibition was tested by selective ablation of GluD1 from PV neurons which produced modest reduction in mIPSCs.

(2) Selective ablation of BDNF in microglia stimulates neural precursor proliferation.

The transdifferentiated endothelial-like and pericyte-like cells secrete trophic factors to support proliferation of tumor cells, and their selective ablation results in reduced tumor growth and recurrence post-treatment.

Examining conditional transgenic mice with selective ablation of solute carrier family 16, member 1 (Slc16a1, which encodes the monocarboxylate transporter 1, MCT1) in macrophages, we found that MCT1 contributes to macrophage metabolism, phenotype, and function, specifically in regard to phagocytosis and supporting peripheral nerve regeneration.

Importantly, selective ablation of Y1R from adipocytes protects against diet-induced obesity.

To date, only few experimental models of selective ablation of astrocytes are known.

Furthermore, we generated transgenic rats for selective ablation of these cells.

AV node ablation should probably be considered earlier in the treatment of patients with supraventricular arrhythmias and HF, especially in cases that are unsuitable for selective ablation of the specific arrhythmia.

Here we show that selective ablation of the PI3Kγ isoform dampens tumour initiation and growth in a mouse model of carcinogen-initiated and obesity-promoted hepatocellular carcinoma (HCC).

Among these techniques, radiofrequency (RF) was investigated for the selective ablation of liver tissue.

The origin of this selective ablation behavior and its relationship with the material band gaps were discussed.

Selective ablation of PGC-1α attenuates diet-induced obesity through enhancing fatty acid oxidation and thermogenesis by upregulation of NT-PGC-1α in brown adipose tissue (BAT).

Here, we show that mice with selective ablation of 4E-BP2 in PCs display a reduced number of PCs, increased regularity of PC action potential firing, and deficits in motor learning.

Using a mouse model useful for the study of SZ we show that a selective ablation of NMDA receptors (NMDAr) in cortical and hippocampal interneurons during early postnatal development results in an E/I imbalance in vivo, with synaptic inputs to pyramidal neurons shifted towards excitation in the adult mutant medial prefrontal cortex (mPFC).

In the SVZ and the SGZ, neural stem/progenitor cells (NSPCs) express the glial fibrillary acidic protein (GFAP) and selective ablation of these NSPCs drastically decreases cell proliferation in vitro and in vivo.

Selective ablation of GluD1 from the central amygdala or injection of Cbln1 into the central amygdala in normal animals led to changes in averse and fear-learning behaviors.

The femtosecond laser selective ablation strategy for laser patterning of metal-based films provides a unique scheme for the rapid fabrication of metal mesh-type TCEs under the mask-free condition and room temperature.

Pharmacological inhibition of microglial displacement of GABAergic presynapses or selective ablation of microglia in CD11bDTR mice promotes the generation of complex FSs.

Selective ablation of spinal Y1-INs with an NPY-conjugated saporin neurotoxin attenuates the development of peripheral nerve injury-induced mechanical and cold hypersensitivity.

Finally, exercise tolerance was closely dependent on carotid body (CB) function since their selective ablation impaired exercise capacity in HF.

METHODS Selective ablation of Dicer in AQP2-expressing cells (DicerAQP2Cre+ mice) was used to investigate the role of miRNAs in the kidney collecting duct of mice.

Selective ablation of ipsi-RGCs (<2% of RGCs) in the adult retina drastically reduces the hunting success of mice.

Selective ablation for the IPV with radiofrequency ablation catheter was performed.

Moreover, the selective ablation of Rcn3 in AECIIs significantly alleviated severity of the mouse emphysema in response to intratracheal installation of PPE.

We examined the role of FOXO1 by selective ablation of FOXO1 in chondrocytes mediated by Col2α1 driven Cre recombinase.

On the PTO single target, laser irradiation caused selective ablation of Pb, resulting in Ti-rich cone-shaped pillar structure on the surface, whereas the irradiated surface of PbO and TiO2 pieces was smoother.

Here, in a murine model bearing long‐lived plasma cells secreting anti‐OVA and ‐chicken gamma globulin (CGG) antibodies, we describe the first‐time use of an antigen‐antibody (OVA/anti‐CD138 antibody) conjugate for in vivo labeling and selective ablation of plasma cells that secrete antibodies specific for the antigen OVA.

Glacier thinning was not homogenous over time related to the uneven distribution of supraglacial debris causing differential ablation or the selective ablation effects of subglacial water channels.

Here, we questioned the striatal functional consequences of the selective ablation of SSTi in the striatum at the behavioural and cellular levels.

Selective ablation of CSF-cNs or inhibition of their neurosecretion reduced host survival upon infection.

These results suggest that selective ablation of ARGP and IRGP could effectively inhibit the cardioinhibitory limb of vasovagal reflex, and one possible mechanism is the weakening of cardiac parasympathetic control.

In contrast, selective ablation of Syt11 in excitatory forebrain neurons using a conditional knockout did not affect life span but impaired synaptic plasticity and memory.

MRI-guided laser interstitial thermal therapy (LITT) is the selective ablation of a lesion or a tissue using heat emitted from a laser device.

EUS-guided RFA is a minimally invasive approach that offers high-quality real-time imaging guidance during selective ablation of pancreatic lesions.

Here, we investigated the consequences of its selective ablation in newborn neurons.

To determine the contribution of CC to cardiorespiratory variables, selective ablation of chemoreceptor neurons within the retrotrapezoid nucleus (RTN) was performed via injection of saporin toxin conjugated to substance P (SSP-SAP).

This paper will present the development of a suitable process for the gentle, selective ablation of nickel‑chromium on polyimide substrates by means of ultrashort-pulse lasers.

Selective ablation of Prdm12 in postmitotic POMC neurons led to early-onset obesity, accelerated linear growth, as well as impaired glucose tolerance, which recapitulates symptoms of POMC/MC4R deficiency in humans.

To achieve highly selective ablation of lacZ-positive cells in a biological milieu in vivo, we developed an activatable photosensitizer, SPiDER-killer-βGal, targeted to β-galactosidase encoded by the lacZ reporter gene.

In this work, we investigated changes in the morphology of intrinsically photosensitive retinal ganglion cells (ipRGCs), M1 subtype, and pupillary light reflex following local and selective ablation of photoreceptors in mice.

Apnoea/hypopnoea incidence (AHI), breathing variability, respiratory–cardiovascular coupling, cardiac autonomic control and cardiac function were analysed in HF rats with or without selective ablation of RVLM‐C1 neurones.

Methods Studies were undertaken in vitro and in the normal male rat to characterize and quantify selective ablation of prostate glandular cells exposed to fexapotide triflutate (FT) injections.

Selective ablation of Phox2b-expressing NTS neurons notably attenuated a hypercapnic ventilatory response.

Therefore, we pharmacologically investigated the selective ablation of CerS6 using antisense oligonucleotides (ASO) in obese insulin resistance animal models.

Previous work had shown that selective ablation of cholinergic interneurons disrupts locomotion and enhanced dopamine transmission triggered by an acute stressor, indicating this cell population plays a critical role in adaptive stress processing [4].

Whole‐cell voltage‐clamp showed the involvement of microglia in neuronal LTP, as selective ablation or disruption of microglia with clodronate in rat hippocampal slices abolished LTP.

Selective ablation of CD8+ T cells in mice expressing the ALS-associated superoxide dismutase-1 (SOD1)G93A mutant decreased spinal motoneuron loss.

However, surface morphology differed greatly in the two cases, HIPIB irradiation induced significant selective ablation of nickel binder, forming a wavy surface of “hill-valley” topography, whereas HIPEB irradiation caused notable surface melting but with less selective ablation, forming a flatter surface with occurrence of apparent cracks and blow holes.

Selective ablation of senescent cells using the senolytic drug combination dasatinib plus quercetin (DQ) alleviates IPF-related dysfunction in bleomycin-administered IPF mouse model.

Transtracheal assessment of CP may allow for minimally invasive and selective ablation of cardiac innervation, extending the cardiac sympathectomy denervation benefits to those not suitable for surgery.

Our recent study found that selective ablation of the distal part of the ligament of Marshall (LOMLSPV) could suppress ventricular arrhythmias (VAs) during acute myocardial infarction (AMI).

The study aimed to investigate whether selective ablation of only right anterior GP (ARGP) and right inferior GP (IRGP) was effective in a canine model of vasovagal syncope.

The results showed that MTZ (Metronidazole) treatment of Tg(mylpfa:cfp-nfsB) zebrafish larvae can lead to muscle injury by selective ablation of muscle cells.

Selective ablation of leptin receptors in endothelial cells promoted endothelial dysfunction, which was restored by Nox1 inhibition.

Central amygdala NPY neuron-specific Npy overexpression mimics the obese phenotype seen in a combined stress and high-fat-diet model, which is prevented by the selective ablation of Npy.

Main Points SC MCT1 deficiency causes hypomyelination of sensory, but not motor, axons during aging Enlarged node length of sensory axons is evident in mutant mouse with SC-specific MCT1 deletion Selective ablation of MCT1 within SCs impairs glycolytic and mitochondrial functions SC-specific MCT1 deficiency impairs proteins that regulate myelin and lipid metabolism in peripheral nerves.

Wang et al, entitled “Selective ablation of atrial ganglionated plexus attenuates vasovagal reflex in a caninemodel.

A selective ablation with MVD provides the best response in such recurrences.

Administration of autophagy initiation inhibitor (3-MA or selective ablation of autophagy related proteins) relieves TBM-induced CRC suppression, while combination use of autophagy flux inhibitor chloroquine (CQ) slightly augments TBM-induced cell death, suggesting that impaired autophagylysosomes accumulation contributes to TBM-induced growth inhibition in CRC cells.

Further, selective ablation of the cytosolic part of the MALAT1 system only, the enzymatically MALAT1-derived mascRNA, resulted in massive induction of TNF (P = 0.

Accordingly, the selective ablation of GLIPR1L1 leads to compromised sperm function characterized by a reduced ability to undergo the acrosome reaction and a failure of IZUMO1 redistribution.

Selective ablation of neurons in the FC, successfully accomplished using colchicine, significantly impaired acquisition of novel visual-contextual memory in rats, without affecting retrieval of familiar visual-contextual memories.

Selective ablation of senescent cells using dasatinib plus quercetin (DQ) alleviates IPF-related dysfunction in bleomycin-administered mice.

Selective ablation of Hoxb8-lineage microglia or the Hoxb8 gene revealed that dysfunction in this cell type causes severe over-grooming and anxiety-like behavior and stress responses.

Antibody-drug conjugates (ADC) have emerged over the last decade as one of the most promising new tools for the selective ablation of tumor cells.

Selective ablation of the fan-shaped body pioneers altered the architecture of the larval fan-shaped body primordium but did not result in gross abnormalities of the trajectories of unicolumnar neurons, indicating that axonal pathfinding of the two systems may be controlled independently.

Debruyne and his colleagues for their interest in our study concerning selective ablation of atrial ganglionated plexus (GP) for vasovagal reflex.

3 pg/cell), which is highly beneficial for the selective ablation of cancer cells via light-triggered intracellular heat generation.

We present results of cow femoral bone with a 355 nm nanosecond (ns) and a 1064 nm picosecond (ps) pulsed laser sources that allow us to discuss the influence on the process of pulse duration and the selective ablation through high energy absorption (as bone highly absorbs 355 nm radiation).

Such approach enables selective ablation of the immature proliferating cells and thereby prevents subsequent tumor formation.

To uncover new neural circuits that may contribute towards vulnerability to AN or might be affected by AN, we employed the specific diphtheria toxin receptor-expressing mice (AgRP-DTR) which, by the selective ablation of AgRP neurons, allow to test the impact of an impaired AgRP circuit function under the activity-based anorexia (ABA) paradigm.

To explore this possibility, we utilized transgenic mice (Sepw1 NP67) expressing Cre recombinase in striatal patches to target these neurons for selective ablation with a virus driving Cre-dependent expression of caspase 3.