Introduction to Ros Generation
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Ros Generation sentence examples within mitochondrial membrane potential
In vitro ROS generation assay and Mitochondrial membrane potential measurement following combination treatment confirmed elevated intra-cellular ROS level (≈7 folds; indicating oxidative stress) and membrane depolarization (indicating mitochondrial dysfunction), respectively, in mCRPC lines.
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Additionally, rPLP2 exposed barrier cells displayed features of cell death, including Annexin/PI positivity, depolarized the mitochondrial membrane potential, and ROS generation.
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Ros Generation sentence examples within cell cycle arrest
Ros Generation sentence examples within cancer cell line
Furthermore, the target compounds exhibited cytotoxicity at low micromolar concentration against lung (A549), colon (HCT-116), and breast (MDA-MB-231, and MCF-7) cancer cell lines, induced the ROS generation and altered the mitochondrial membrane potential of highly aggressive MDA-MB-231 cells.
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Five human cancer cell lines from tumor origins treatable with PDT were utilized to investigate ROS generation, apoptosis induction, and cell cycle distribution.
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Ros Generation sentence examples within apoptotic cell death
Moreover, complex 4 promoted apoptotic cell death and possibly the paraptotic pathway, as well as higher ROS generation under irradiation than in dark conditions.
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We also observed that QC induces a signaling cascade by inducing apoptotic cell death by increasing ROS generation and altering HSP70 expression; which presumably involves ERK regulation.
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Ros Generation sentence examples within mitogen activated protein
Upon CDDP treatment, EA predominantly enhanced ROS generation, ASK1-p38/c-Jun N-terminal kinase (JNK) mitogen-activated protein kinase (MAPK) pathway activation, and ultimately cell death, all of which were suppressed either by co-treatment of the NADPH oxidase (Nox) inhibitor Apocynin, or by knocking out its regulatory protein, receptor-interacting protein 1 (RIP1).
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BA also reduced c-Jun N-terminal kinases (JNK) phosphorylation and ROS generation in iBMDMs activated with LPS, but had no effect on other mitogen-activated protein kinases (MAPKs) family proteins such as extracellular signal-regulated kinase (ERK) or p38.
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Ros Generation sentence examples within aggregation induced emission
Herein, cyclometalated iridium (III) complexes (Ir) with aggregation-induced emission (AIE) feature, high photoinduced ROS generation efficiency, two-photon excitation, and mitochondria-targeting capability were designed and further encapsulated into biocompatible nanoparticles (NPs).
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The digestion of poly(e-caprolactone) segments by bacterial lipase destructs micelles and the aggregation-induced emission feature of cd-PTTA leads to ROS generation after light illumination.
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Ros Generation sentence examples within caspase 3 activity
Mannitol, identified as the major component of the most bioactive fraction, protected SH-SY5Y cells against the 6-OHDA neurotoxicity mediating ROS generation mitigation, mitochondrial dysfunction, and DNA damage, together with the Caspase-3 activity inhibition.
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The caspase-3 activity as well as the ROS generation were significantly increased in a dose-dependent manner compared to control.
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Ros Generation sentence examples within acetyl l cysteine
The inhibition of ROS generation by N-acetyl-l-cysteine not only recovered cell migration and viability, but also reduced β-catenin accumulation and JNK and ERK activation.
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Furthermore, MICAL2 knockdown attenuated intracellular ROS generation, while MICAL2 overexpression led to a decrease in the p-YAP/YAP ratio and promoted YAP nuclear localization and cell proliferation, effects that were reversed by pretreatment with the ROS scavenger N-acetyl-L-cysteine (NAC) and SOD-mimetic drug tempol.
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Ros Generation sentence examples within nicotinamide adenine dinucleotide
Excess ROS generation is catalysed by xanthine oxidase, uncoupled nitric oxide synthases, the mitochondrial electron transport chain and the nicotinamide adenine dinucleotide phosphate (NADPH) oxidases.
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Specifically, nitrogen-containing chemicals promote ROS generation, which disrupts the activity of the metabolic enzyme cytochrome P450s, leading to the activation of nicotinamide adenine dinucleotide phosphate oxidase.
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Ros Generation sentence examples within induced cell death
This finding strongly suggests that ROS generation is a direct cause of induced cell death.
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Interestingly, the pretreatment of neural stem cells with the N-acetylcysteine (ROS scavenger) attenuated EPX-induced cell death, disruption of neural stem cells properties, ROS generation and apoptosis.
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Ros Generation sentence examples within white light irradiation
Herein, poly[2-methoxy-5-(2′-ethylhexyloxy)-p-phenylenevinylene] (PPV) was used as the core to prepare a conjugated polymer nanoparticle (PPVN) modified with anti-EGFRvIII (PPVN-A) that exhibited high ROS generation ability under white light irradiation.
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Several control studies have been performed with the respective sensitizers alone in presence of white light irradiation and separately in their own absorption regions to confirm the enhanced ROS generation with dual sensitizers under white light irradiation.
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Ros Generation sentence examples within related factor 2
Elevated ROS generation was concomitant with decreased expression of NF-E2- related factor 2 (NRF2), superoxide dismutases (SOD-1,2) and thioredoxins (TrX-1,2).
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Moreover, SiNPs triggered oxidative stress as confirmed by the dose-dependent ROS generation, down-regulated nuclear factor erythroid 2-related factor 2 (NRF2) signaling, together with GSH depletion in SiNPs-treated BEAS-2B cells.
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Ros Generation sentence examples within improved cell viability
In vitro, co-treatment with BSP protected against HG-induced ROS generation, NLRP3 inflammasome activation, and IL-1β secretion in BMDMs, and improved cell viability and decreased ROS levels in CMECs.
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05 µM BM reduced TBHP-induced excessive ROS generation, improved cell viability, increased malondialdehyde level and decreased superoxide dismutase level.
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Ros Generation sentence examples within activated protein kinase
Many signaling pathways that are regulated by exercise-induced ROS generation, such as adenosine monophosphate-activated protein kinase (AMPK), mitogen activated protein kinase (MAPK), nuclear respiratory factor2 (NRF2), and PGC-1α are involved in skeletal muscle responses to physical exercise, such as increased glucose uptake, mitochondriogenesis, and hypertrophy, among others.
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Mitochondrial sirtuins preserve mitochondrial function by increasing mitochondrial metabolism, inhibiting ROS generation by activating the antioxidant enzyme manganese-dependent superoxide dismutase (MnSOD), decreasing apoptosis by activating the forkhead homeobox type O (FOXO) and P53 pathways, and increasing autophagy through AMP-activated protein kinase (AMPK)/mTOR signaling.
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Ros Generation sentence examples within cell viability reduced
Furthermore, overexpression of A20 enhanced cell viability, reduced apoptosis, and inhibited ROS generation and inflammatory factor secretion.
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Chrysoeriol significantly increased cell viability, reduced ROS generation, and increased the occurrence of antioxidant molecules in H2O2-treated ARPE-19 cells.
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Ros Generation sentence examples within dose dependent manner
Furthermore, ROS generation and JNK phosphorylation occurred in a dose-dependent manner in the cells treated with compound #2.
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The results showed that both agonist β-adrenergic modify in a dose-dependent manner oxide-reduction response through ROS generation, glutathione peroxidase activity, and intracellular GSH content; and de release of liver enzymes associated with hepatocellular damage like gamma glutamyl-transpeptidase, aspartate aminotransferase, alanine aminotransferase.
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Ros Generation sentence examples within Intracellular Ros Generation
Ros Generation sentence examples within Induced Ros Generation
Meanwhile, JSH-23 suppressed RANKL-induced ROS generation via the TRAF6/Rac1/NOX1 pathway and the enhanced expression of Nrf2/HO-1.
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Moreover, inhibition of mitochondrial permeability transition pore (MPTP) by CsA (an MPTP inhibitor) dramatically attenuated OGD-induced ROS generation (from 100% to 56.
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Ros Generation sentence examples within Mitochondrial Ros Generation
In addition, KA-induced lipid peroxidation, cytochrome c release and mitochondrial ROS generation were also attenuated by Anti-134.
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Overexpression of TREM2 suppressed mitochondrial ROS generation, inhibited NLRP3/caspase-1 inflammasome activation, and finally protected BMDMs from gasdermin D-mediated pyroptosis during pulmonary E.
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Ros Generation sentence examples within Increased Ros Generation
Ros Generation sentence examples within Excessive Ros Generation
Dynamin-related protein 1 (Drp1) mediated mitochondrial fission is the main reason and the result of excessive ROS generation.
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A decrease in expression of Bcl-2 and subsequent excessive ROS generation would be the mechanism for ERH-augmented mitochondrial-related apoptosis in AIMs-treated MKN28 cells.
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Ros Generation sentence examples within Enhanced Ros Generation
Upon CDDP treatment, EA predominantly enhanced ROS generation, ASK1-p38/c-Jun N-terminal kinase (JNK) mitogen-activated protein kinase (MAPK) pathway activation, and ultimately cell death, all of which were suppressed either by co-treatment of the NADPH oxidase (Nox) inhibitor Apocynin, or by knocking out its regulatory protein, receptor-interacting protein 1 (RIP1).
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Ros Generation sentence examples within Reduced Ros Generation
Ros Generation sentence examples within Efficient Ros Generation
The formed nanocomposite has excellent photostability, good biocompatibility, and efficient ROS generation under NIR light excitation via Forster resonance energy transfer (FRET), enabling NIR light excited PDT.
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Owing to the lower work function of Au NPs, the photo-induced electrons are easier to transfer and assemble on their surfaces, resulting in the increased separation of the electron-hole pairs with efficient ROS generation.
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Ros Generation sentence examples within Mediated Ros Generation
The same phenomenon of heme mediated ROS generation could be manipulated to initiate tumour suppression via ferroptosis, but the therapeutic doses are yet to be determined.
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The stability of APO-NPs checked after six months showed minimal AO decline in comparison to APO only, indicating that designed nano formulation has enhanced therapeutic efficacy for modulating NOX mediated ROS generation.
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Ros Generation sentence examples within High Ros Generation
Herein, poly[2-methoxy-5-(2′-ethylhexyloxy)-p-phenylenevinylene] (PPV) was used as the core to prepare a conjugated polymer nanoparticle (PPVN) modified with anti-EGFRvIII (PPVN-A) that exhibited high ROS generation ability under white light irradiation.
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As compared with inorganic materials, organic sonosensitizers exhibit a defined chemical structure, controlled synthesis process, excellent biodegradability, and high ROS generation.
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Ros Generation sentence examples within Decreased Ros Generation
Ros Generation sentence examples within Higher Ros Generation
Moreover, complex 4 promoted apoptotic cell death and possibly the paraptotic pathway, as well as higher ROS generation under irradiation than in dark conditions.
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Higher pinacidil concentration was associated with higher ROS generation at 5 min post-reperfusion (T2), although this was significantly lower compared with the IR group, as well as with increased expression levels of antioxidant proteins and phase II detoxification enzymes downstream of the Nrf2 and Nrf2-ARE pathways.
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Ros Generation sentence examples within Inhibited Ros Generation
Furthermore, overexpression of A20 enhanced cell viability, reduced apoptosis, and inhibited ROS generation and inflammatory factor secretion.
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The results obtained showed that pre-treatment with both the extract and the isolated compounds was effective in protecting the SH-SY5Y cells from MPP+-induced neurotoxicity and inhibited ROS generation, ATP depletion as well as apoptosis induction in the SH-SY5Y cells.
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Ros Generation sentence examples within Increasing Ros Generation
Kaempferol promoted apoptosis in vitro by increasing ROS generation, which was involved in Akt/mTOR signaling.
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44), as well as in decreasing mitochondrial membrane potential (≈16% compared with single agent, and 32% with control) and increasing ROS generation (6 times to control, and 3-4 times to single agent).
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