Introduction to Response Modeling

This taskforce evaluated scientific advances since the original release of USEtox and identified two major aspects that required refinement, namely integrating near-field and far-field exposure, and improving human dose-response modeling.

Furthermore, the proposed biresponse modeling with mixed estimators is validated using simulation data.

Item response modeling demonstrated good item discrimination for problematic smartphone use (a > 1.

We collected fault kinematic indicators, joint orientations, and documented fumarolic alterations of microcrystalline quartz in the Bishop Tuff and combined those field observations with fault response modeling to assess whether strike-slip activity played a key role in the development of fumarolic pathways.

This complicates logistical dose-response modeling and establishment of a threshold value characterizing the chronic toxicity of PFAS to ecological receptors.

Using three independent samples of gay and bisexual men, the present research developed two abbreviated versions of the GCSS using nonparametric item response modeling and validated them.

In this study, we leverage the resolving power of concentration-response modeling through benchmark concentration (BMC) analysis to interpret untargeted metabolomics data from differentiated cultures of HepaRG cells exposed to a panel of reference compounds and integrate data in a potency-aligned framework with matched transcriptomic data.

Computational methods for genomic dose-response integrate dose-response modeling with bioinformatics tools to evaluate changes in molecular and cellular functions related to pathogenic processes.

Here we present and test a hybrid impulse response modeling framework (HIRM) that combines the strengths of process-based SCMs in an idealized impulse response model, with HIRM’s input derived from the output of a process-based model.

However, a design that is efficient for synergy testing is not necessarily desirable for dose–response modeling and the latter is important for future development on drug interaction analysis.

Here, we present the Compositional Perturbation 27 Autoencoder (CPA), which combines the interpretability of linear models with the flexibility of 28 deep-learning approaches for single-cell response modeling.

Artificial intelligence (AI) techniques have been widely applied to infectious disease outbreak detection and early warning, trend prediction, and public health response modeling and assessment.

We reviewed Cr(VI) inhalation unit risk estimates developed by researchers and regulatory agencies for environmental and occupational exposures and the underlying epidemiologic data, updated a previously published MOA analysis, and conducted dose-response modeling of rodent carcinogenicity data to evaluate the need for alternative exposure-response data and risk assessment approaches.

To test these possibilities, we investigated the presence, maturity, and localization of adult functions in children using probabilistic shared response modeling, a machine learning approach for functional alignment.

Moreover, the simulation results show that the application of edge computing can significantly reduce the calculation time of the optimal scheduling problem with price-based demand response modeling of large-scale users.

This study evaluated the effects of single therapeutic and supratherapeutic doses of TBP-PI-HBr on the heart rate-corrected QT interval (QTc) by assessing the concentration-QT interval relationship using exposure-response modeling.

Thermal response modeling is performed for the Heatshield for Extreme Entry Environment Technology (HEEET), a dual layer woven thermal protection system.

The Musical instrument classification for individual instruments and family is verified using impulse response modeling.

Here, we present the compositional perturbation autoencoder (CPA), which combines the interpretability of linear models with the flexibility of deep-learning approaches for single-cell response modeling.

The deciphering of the measurements, obtained by current state-of-the-art instruments, to obtain the composition of complex gas mixtures that include polyatomic molecules and volatile organic compounds (VOCs) often requires having recourse to instrument response modeling supplemented by theoretical chemical models.

, user response modeling, to enhance the learning of the state and action representations for the recommender agents.

Furthermore, through a set of specific experiments the paper demonstrates the behavior of the converter under fault, preparing the outline for the fault response modeling of distributed energy resources.

The progress recently made with response modeling and field calibration of pressure fluctuation measurement systems now allows to propose more realistic power spectral density models over an extremely large frequency band.

6 Experimentation and Modeling Strategies II: Single Array and Response Modeling.

We used kinetic calcium flux and high-content imaging to derive quantitative measures as inputs into Bayesian population concentration-response modeling of the effects of each chemical.

As an example, evaluation of a recent dose-response modeling using eight epidemiological studies of inorganic arsenic and bladder cancer demonstrated that the pooled risk estimate was markedly affected by the single study that was ranked as having a high risk of bias, based on the above factors.

Nonparametric item response modeling and cognitive psychometric modeling are presented as alternatives for relaxing the first two assumptions, respectively.

Bayesian concentration–response modeling of individual chemicals or their mixtures was performed for a total of 47 phenotypes to derive point-of-departure (POD) values.

Approaches included (1) quantitative systems pharmacology modeling to predict dose–response relationships, (2) dose–response modeling and model‐based meta‐analysis for dose selection and efficacy comparisons, (3) population pharmacokinetics (PKs) modeling to characterize PKs and quantify population variability in PK parameters, (4) regression modeling to evaluate ertugliflozin dose‐proportionality and the impact of uridine 5'‐diphospho‐glucuronosyltransferase (UGT) 1A9 genotype on ertugliflozin PKs, and (5) physiologically‐based PK modeling to assess the risk of UGT‐mediated drug–drug interactions.

Single-response modeling indicated that the kinetics of lipolysis in the small intestinal phase were impacted by the emulsion particle size at the beginning of this phase.

We also developed a novel gene expression signature-based concentration-response modeling approach and compared the results to a previously implemented workflow for concentration-response analysis of transcriptomics data using BMDExpress.

baking, frying, roasting), for multi-residue analyses linked to quality and safety, or reaction kinetics for multi-response modeling.

With the rapid development of computers and computational techniques, discrete-based numerical approaches with desirable properties have been increasingly developed but not yet extensively applied to seismic response modeling in complex fractured media.

Dose-response modeling of in vitro micronucleus test (IVMNT) data was evaluated to determine if the approach has value in discriminating among different tobacco products.

Theoretical analyses, including force sensing and control working principle demonstration, force–strain model derivation, and dynamics response modeling, are carried out.

Thus, our results demonstrate a clear potential for time-aware response modeling approaches for marketing campaigns.

Similarly, recent advances in machine learning approaches enabled by single-cell data start to address prediction tasks in perturbation response modeling.

A full quadratic version of equations with the 95% confidence level was applied for the response modeling.

We also report our new mechanical response modeling results for predicted AM microstructures.

Chapter 33 of “Explanatory Response Models” by De Boeck and Wilson, observes that the regression approach can be applied in the explanatory item response modeling where item responses are the dependent variables and the predictors’ role can be played by the properties of persons, items, and the pairs of persons and items.

In this paper, we find that a valid and reliable index of cognitive load can be obtained through item response modeling of student performance.

Here we test the presence, maturity, and localization of adult functions in children using shared response modeling, a machine learning approach for functional alignment.

The responses were modeled using D-optimal mixture design: the viscosity response modeling was best fitted with quadratic model for R1AD produced adhesives, while R4AD and R7AD produced adhesives were fitted with Cubic model.

Pharmacometric analyses (population pharmacokinetics [popPK] and exposure-response modeling) were conducted across doses to inform dose selection for further development.

All calibrated models may be applied to commercial FEA software as a sufficient solution for rapid mechanical response modeling of human AT subtendons or for the purpose of future development of comprehensive patient-specific models of human lower limbs.

The work presented here is focused on impulse response modeling of noted produced by box shaped acoustic guitar.

Explanatory item response modeling (EIRM) enables researchers and practitioners to incorporate item and person properties into item response theory (IRT) models.

Due to the lack of flow rate data of springs in many areas of Italy, spring response modeling could be a useful tool for supporting proper water resource management.

5% formalin produces a biphasic pain response modeling both acute and inflammatory pain, measured as time spent attending to the injected paw over the course of one hour.

In toxicological studies , a wide range of statistical models have been utilized for do se-response modeling and risk assessment with no particular model recei ving a universal acceptance.

Conclusion Our dose–exposure–response modeling and simulation indicates effects were largely saturated at finerenone 20 mg and doses of both 10 and 20 mg once daily appear safe and efficacious at reducing albuminuria.

An item response modeling procedure is discussed that can be used for point and interval estimation of the individual true score on any item in a measuring instrument or item set following the popular and widely applicable graded response model.

These results suggest that dose-response modeling of metatranscriptomic gene expression is a useful tool in soil microbial health assessment.

We discuss variability in in vivo data used as a reference for NAM development and validation; the quantitative uncertainty in concentration–response modeling for high-throughput in vitro bioactivity screening; the uncertainties associated with in vitro to in vivo extrapolation using toxicokinetic information; and the quantitative uncertainty in the experimental inputs and modeled outputs from quantitative structure activity relationship models for prediction of point of departure doses.

This paper explores how personality factors affect substance use disorders (SUDs) using explanatory item response modeling (EIRM).

The use of accurate system response modeling has been proven to be an essential key of SPECT image reconstruction, with its usage leading to overall improvement of image quality.

It explained and familiarized the methodological community with core design features that NAEP had pioneered: the use of randomization in the sampling of items, the imputation of plausible values for consistent population inference, and the integration of item response modeling with latent regression models, to name just a few.

When latent variables are used as outcomes in regression analysis, a common approach that is used to solve the ignored measurement error issue is to take a multilevel perspective on item response modeling (IRT).

Previous BN studies were limited to the assessment slope safety and did not include pipeline response modeling (Peng et al.

To achieve the aim of the study, explanatory item response modeling (EIRM) framework based on generalized linear mixed modeling (GLMM) was used.

Microarray profiling in the context of toxicity testing in animals has been used for years to identify mechanisms of toxicity, derive points of departure using dose–response modeling, and determine human relevance.

We developed ‘inception loops’, a closed-loop experimental paradigm combining in vivo recordings from thousands of neurons with in silico nonlinear response modeling.

Extensive metrology and plasma response modeling with IPEC and M3D-C1 indicate that misalignment of the toroidal field coil (TF) center rod, while small, produces the largest resonant error field among the sources considered.

Finite impulse response modeling was applied to estimate the temporal dynamics of brain responses during cognitive reappraisal (v.

OBJECTIVE To improve dose-response modeling approaches for the PS and other syndromes of effects by accounting for differing severity levels among the endpoints.

Using confirmatory factor analysis, Graded Response Modeling (GRM) based on Item Response Theory (IRT) provided technical informative details about each item of scale.

Analyzing the analytical flame response modeling concepts in detail, we find that the surface integration, which is required to compute the change of the global heat-release rate from the instantaneous flame front deflections, constitutes the most significant geometry-related property affecting the FTF.

Dose–response modeling showed that a number of genes exhibited non-linear bi-phasic responses, which was verified by digital droplet PCR.

This research aims to simulate bio-contamination risk propagation under real-life conditions in the water distribution system (WDS) of Lille University’s Scientific City Campus (France), solving the source identification and the response modeling.

Multidimensional item‐response modeling was conducted on symptom ratings of the Positive and Negative Syndrome Scale, Young Mania Rating Scale, and Montgomery‐Åsberg Depression Rating Scale in the multicentre Bipolar‐Schizophrenia Network on Intermediate Phenotypes (B‐SNIP) consortium, which included 933 patients with a diagnosis of schizophrenia (N=397), schizoaffective disorder (N=224), or bipolar I disorder with psychosis (N=312).

Additionally, a smaller (T384) and a larger version (T1500) of T1000 were used for dose-response modeling to test the effect of gene set size.

Here, we compare three approaches to qAOP building: empirical dose-response modeling, Bayesian network (BN) calibration, and systems biology (SB) modeling.