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Rapamycin suppresses the PI3K/AKT/mTOR signaling pathway by targeting SIRT1 in esophageal cancer



miR-132-3p promotes the cisplatin-induced apoptosis and inflammatory response of renal tubular epithelial cells by targeting SIRT1 via the NF-κB pathway.


Regulating Sirt1 sentence examples within regulating sirt1 expression



Ginsenoside Rg1 attenuates premature ovarian failure of D-gal induced POF mice through downregulating p16INK4a and upregulating SIRT1 expression.



The ameliorative effect of terpinen-4-ol on ER stress-induced vascular calcification depends on SIRT1-mediated regulation of PERK acetylation.


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10.2174/1871523020666210830164152

Ginsenoside Rg1 attenuates premature ovarian failure of D-gal induced POF mice through downregulating p16INK4a and upregulating SIRT1 expression.



NF-κB inducible miR-30b-5p aggravates joint pain and loss of articular cartilage via targeting SIRT1-FoxO3a-mediated NLRP3 inflammasome



Rapamycin suppresses the PI3K/AKT/mTOR signaling pathway by targeting SIRT1 in esophageal cancer


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10.3389/fendo.2021.639165

Bone Marrow-Derived Mesenchymal Stem Cells Ameliorate Sepsis-Induced Acute Kidney Injury by Promoting Mitophagy of Renal Tubular Epithelial Cells via the SIRT1/Parkin Axis


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10.3389/fncel.2021.654340

Cannabidiol Induces Autophagy to Protects Neural Cells From Mitochondrial Dysfunction by Upregulating SIRT1 to Inhibits NF-κB and NOTCH Pathways



Human umbilical cord-derived mesenchymal stem cell therapy ameliorates lupus through increasing CD4+ T cell senescence via MiR-199a-5p/Sirt1/p53 axis


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10.1016/j.envpol.2021.118390

Lycopene mitigates DEHP-induced hepatic mitochondrial quality control disorder via regulating SIRT1/PINK1/mitophagy axis and mitochondrial unfolded protein response.


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10.1186/s12865-021-00421-z

Glycyrrhizin improves the pathogenesis of psoriasis partially through IL-17A and the SIRT1-STAT3 axis



Inhibitory Effect of Paeonol on Apoptosis, Oxidative Stress, and Inflammatory Response in Human Umbilical Vein Endothelial Cells Induced by High Glucose and Palmitic Acid Induced Through Regulating SIRT1/FOXO3a/NF-κB Pathway.



Roflumilast Attenuates Doxorubicin-Induced Cardiotoxicity by Targeting Inflammation and Cellular Senescence in Cardiomyocytes Mediated by SIRT1


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10.1186/s12931-021-01793-x

Protectin conjugates in tissue regeneration 1 restores lipopolysaccharide-induced pulmonary endothelial glycocalyx loss via ALX/SIRT1/NF-kappa B axis


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10.1016/j.phrs.2021.105629

The ameliorative effect of terpinen-4-ol on ER stress-induced vascular calcification depends on SIRT1-mediated regulation of PERK acetylation.



Mangiferin prevents myocardial infarction‐induced apoptosis and heart failure in mice by activating the Sirt1/FoxO3a pathway


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10.1016/j.mce.2021.111455

Up-regulation of GLP-1R improved the dysfunction of late EPCs under hyperglycemia by regulating SIRT1 expression


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10.1038/s41380-021-01143-9

Introducing ADNP and SIRT1 as new partners regulating microtubules and histone methylation


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10.4149/neo_2021_210218N222

Circ-sirt1 inhibits growth and invasion of gastric cancer by sponging miR-132-3p/miR-212-3p and upregulating sirt1 expression.


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10.1111/1750-3841.15757

Protective effects of ginsenoside Rc against acute cold exposure-induced myocardial injury in rats.


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10.1080/21655979.2021.1915672

The interaction of miR-181a-5p and sirtuin 1 regulated human bone marrow mesenchymal stem cells differentiation and apoptosis.



Spermidine inhibits vascular calcification in chronic kidney disease through modulation of SIRT1 signaling pathway



The effects of compound centella formula on OxInflammation and silent information regulator 1 in a high-fat diet/streptozotocin-induced diabetic kidney disease rat model



Effect of Propylene Glycol Alginate Sodium Sulfate Nanoparticles on Myocardial Injury in Diabetic Rats via Silent Information Regulator 1/ Hypoxia-Inducible Factor-1 Alpha Pathway.



Hypothalamic GHR—SIRT1 Axis in Fasting



Hyperoside Attenuate Inflammation in HT22 Cells via Upregulating SIRT1 to Activities Wnt/β-Catenin and Sonic Hedgehog Pathways


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10.1016/j.intimp.2021.108022

miR-132-3p promotes the cisplatin-induced apoptosis and inflammatory response of renal tubular epithelial cells by targeting SIRT1 via the NF-κB pathway.


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10.1016/j.lfs.2021.119435

Activation of AMPK restored impaired autophagy and inhibited inflammation reaction by up-regulating SIRT1 in acute pancreatitis.



Paeoniflorin Protects against ANIT-Induced Cholestatic Liver Injury in Rats via the Activation of SIRT1-FXR Signaling Pathway


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10.21203/RS.3.RS-154937/V1

The ameliorative effect of terpinen-4-ol on ER stress-induced vascular calcification depends on sirt1-mediated regulation of PERK acetylation


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10.1007/s10753-021-01561-5

Exosomes Secreted by Mesenchymal Stem Cells Induce Immune Tolerance to Mouse Kidney Transplantation via Transporting LncRNA DANCR.


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10.3389/fcell.2021.686848

GDF11 Alleviates Pathological Myocardial Remodeling in Diabetic Cardiomyopathy Through SIRT1-Dependent Regulation of Oxidative Stress and Apoptosis



Hyperbaric Oxygen via Mediating SIRT1-Induced Deacetylation of HMGB1 Improved Cerebral Ischemia/Reperfusion injury.



Roux-en-Y Gastric Bypass Improves Hepatic Glucose Metabolism Involving Upregulation of Sirt1 in Type 2 Diabetes Mellitus


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10.1016/j.ijbiomac.2021.08.013

A review study on the modulation of SIRT1 expression by miRNAs in aging and age-associated diseases.



Exosomal lncRNA-p21 derived from mesenchymal stem cells protects epithelial cells during LPS-induced acute lung injury by sponging miR-181.



LncRNA Sirt1-AS upregulates Sirt1 to attenuate aging related deep venous thrombosis


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10.21203/RS.3.RS-585446/V1

Exosomes Secreted by Mesenchymal Stem Cells Induce Immune Tolerance to Kidney Transplantation via Transporting lncRNA DANCR


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10.1507/endocrj.EJ20-0747

Honokiol regulates endoplasmic reticulum stress by promoting the activation of the sirtuin 1-mediated protein kinase B pathway and ameliorates high glucose/high fat-induced dysfunction in human umbilical vein endothelial cells.



MicroRNA-138-5p drives the progression of heart failure via inhibiting sirtuin 1 signaling


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10.1016/j.pupt.2021.102034

Gentiopicroside ameliorates ovalbumin-induced airway inflammation in a mouse model of allergic asthma via regulating SIRT1/NF-κB signaling pathway.


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10.1016/j.taap.2021.115545

Sulforaphane inhibits blue light-induced inflammation and apoptosis by upregulating the SIRT1/PGC-1α/Nrf2 pathway and autophagy in retinal pigment epithelial cells.


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10.21203/RS.3.RS-604268/V1

Air Pollution-Regulated E-Cadherin Mediates Contact Inhibition of Proliferation via the Hippo Signaling Pathways in Emphysema


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10.1186/s12906-019-2524-6

Shen Shuai IIRecipe attenuates renal injury and fibrosis in chronic kidney disease by regulating NLRP3 inflammasome and Sirt1/Smad3 deacetylation pathway


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10.1186/s12935-019-0819-9

Hypoxia promotes colorectal cancer cell migration and invasion in a SIRT1-dependent manner



Ginsenoside Rg1 Regulates SIRT1 to Ameliorate Sepsis-Induced Lung Inflammation and Injury via Inhibiting Endoplasmic Reticulum Stress and Inflammation


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10.1007/s11010-019-03506-x

Hydrogen sulfide modulates SIRT1 and suppresses oxidative stress in diabetic nephropathy



High Fructose Intake and Adipogenesis



Corrigendum to: Low cardiac lipolysis reduces mitochondrial fission and prevents lipotoxic heart dysfunction in Perilipin 5 mutant mice


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10.19540/j.cnki.cjcmm.20181204.013

[Effect of geniposidic acid on hepato-enteric circulation in cholestasis rats through Sirt1-FXR signaling pathway].


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10.1590/1414-431X20197992

Artesunate promotes Th1 differentiation from CD4+ T cells to enhance cell apoptosis in ovarian cancer via miR-142



Acetaminophen Responsive miR-19b Modulates SIRT1/Nrf2 Signaling Pathway in Drug-Induced Hepatotoxicity.


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10.1016/j.brainres.2019.01.013

Maresin 1 attenuates the inflammatory response and mitochondrial damage in mice with cerebral ischemia/reperfusion in a SIRT1-dependent manner


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10.1177/1947603519847736

The New Role of Sirtuin1 in Human Osteoarthritis Chondrocytes by Regulating Autophagy.


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10.1016/j.gene.2019.144144

miR-22 inhibits synovial fibroblasts proliferation and proinflammatory cytokine production in RASF via targeting SIRT1.


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10.1016/j.cbi.2019.03.021

miR-221 promotes lens epithelial cells apoptosis through interacting with SIRT1 and E2F3.



Curcumin and resveratrol suppress dextran sulfate sodium-induced colitis in mice


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10.26355/eurrev_201908_18717

MicroRNA-579-3p promotes the progression of osteoporosis by inhibiting osteogenic differentiation of mesenchymal stem cells through regulating Sirt1.


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10.1016/j.neuroscience.2018.11.024

MALAT1 lncRNA Induces Autophagy and Protects Brain Microvascular Endothelial Cells Against Oxygen–Glucose Deprivation by Binding to miR-200c-3p and Upregulating SIRT1 Expression


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10.1080/10495398.2019.1636808

Comparison of apoptosis between bovine subcutaneous and intramuscular adipocytes by resveratrol via SIRT1



Melatonin protects against COPD by attenuating apoptosis and endoplasmic reticulum stress via upregulating SIRT1 expression in rats.


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10.1186/s10020-019-0085-2

miR-122 promotes hepatic lipogenesis via inhibiting the LKB1/AMPK pathway by targeting Sirt1 in non-alcoholic fatty liver disease


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10.1016/j.bbrc.2019.10.140

MicroRNA-22 inhibition prevents doxorubicin-induced cardiotoxicity via upregulating SIRT1.



HuoXue QianYang QuTan Recipe attenuates left ventricular hypertrophy in obese hypertensive rats by improving mitochondrial function through SIRT1/PGC-1α deacetylation pathway


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10.2174/1871520619666190114160457

Nicotinamide Overcomes Doxorubicin Resistance of Breast Cancer Cells through Deregulating SIRT1/Akt Pathway.


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10.1038/s41419-019-1569-2

Nicotinamide mononucleotide promotes osteogenesis and reduces adipogenesis by regulating mesenchymal stromal cells via the SIRT1 pathway in aged bone marrow



microRNA‐34a aggravates coxsackievirus B3‐induced apoptosis of cardiomyocytes through the SIRT1‐p53 pathway


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10.1016/j.intimp.2019.105886

Suppression of NLRP3 and NF-κB signaling pathways by α-Cyperone via activating SIRT1 contributes to attenuation of LPS-induced acute lung injury in mice.



I157172, a novel inhibitor of cystathionine γ-lyase, inhibits growth and migration of breast cancer cells via SIRT1-mediated deacetylation of STAT3.



Resveratrol Reduced Liver Damage After Liver Resection in a Rat Model by Upregulating Sirtuin 1 (SIRT1) and Inhibiting the Acetylation of High Mobility Group Box 1 (HMGB1)



Tetramethylpyrazine partially relieves hypoxia‐caused damage of cardiomyocytes H9c2 by downregulation of miR‐449a


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10.1097/SHK.0000000000001185

Total Salvianolic Acid Injection Prevents Ischemia/Reperfusion-Induced Myocardial Injury Via Antioxidant Mechanism Involving Mitochondrial Respiratory Chain Through the Upregulation of Sirtuin1 and Sirtuin3


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10.1177/2058738418821837

Possible treatment for cutaneous lichen planus: An in vitro anti-inflammatory role of Angelica polysaccharide in human keratinocytes HaCaT


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10.1080/21691401.2019.1621328

Long noncoding RNA SNHG15 enhances the development of colorectal carcinoma via functioning as a ceRNA through miR-141/SIRT1/Wnt/β-catenin axis


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10.1080/21691401.2019.1640711

Quercetin supports cell viability and inhibits apoptosis in cardiocytes by down-regulating miR-199a



SIRT1 facilitates primordial follicle recruitment independent of deacetylase activity through directly modulating Akt1 and mTOR transcription


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10.1097/SHK.0000000000001351

Tudca Ameliorates Liver Injury Via Activation of SIRT1-FXR Signaling in a Rat Hemorrhagic Shock Model.


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10.1111/1440-1681.13226

Metformin alleviates renal injury in diabetic rats by inducing Sirt1/FoxO1 autophagic signal axis


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