Introduction to Regulating Cancer

In this study, we investigated whether the miR-503-5p targeting of the CD97 3′-untranslated region (3′-UTR) contributes to ovarian cancer metastasis as well as the underlying mechanism regulating cancer progression.

All of this evidence suggests that these nonlinearly expressed genes may play a central role in regulating cancer progression.

Herein, we summarize current insights into the role of GPC3 in regulating cancer development through Wnt and other signaling pathways, including YAP and hedgehog cascades.

Background: There is increasing evidence that circular RNAs (circRNAs) participate in regulating cancer progression.

The roles of long noncoding RNAs (lncRNA) in regulating cancer metabolism at the level of both glycolysis and gluconeogenesis are mostly unknown.

SIGNIFICANCE PGRMC1 plays an essential role in regulating cancer progression and metastasis of cervical cancer cells, thus serving as a potential therapeutic target for cervical cancer.

These models allow researchers to culture cells in conditions that include features of the in vivo TME implicated in regulating cancer progression, such as extracellular matrix (ECM) stiffness, integrin binding to the ECM, immune and stromal cells, growth factor and cytokine depots, and a three-dimensional geometry more representative of the in vivo TME than tissue culture polystyrene (TCPS).

The cross-talk between cancer cells and the stromal microenvironment plays a key role in regulating cancer invasion.

The present study aimed to explore the long non-coding RNA (lncRNA) expression profiles and correlation of lnc-PKD2-2-3 with tumor features and prognosis, and to investigate its effect on regulating cancer-cell stemness and its potential as a cancer stem cell (CSC) marker in cholangiocarcinoma (CCA).

Relative to several other p21-activated kinase (PAK) family members, the role of PAK3 in regulating cancer cell functions remains unclear.

Senescence is a result of cellular stress and is a potential mechanism for regulating cancer.

In the present study, we investigated the role of ACTN4 in regulating cancer cell stemness and chemoresistance in cervical cancer.

OBJECTIVE Emerging evidence has indicated that microRNAs (miRNAs) play crucial roles in regulating cancer carcinogenesis; however, its role in oral squamous cell carcinoma (OSCC) remains largely unknown.

Thus, it is necessary to develop an effective method for imaging and regulating cancer-related piRNAs to diagnose and treat cancers.

This review summarizes Prx isoforms and their basic functions, the relationship between the expression level and the physiological role of Prxs in cancer cells, and their roles in regulating cancer-associated signaling pathways.

Drugs targeting the TME are currently being studied, and a better understanding of the TME in regulating cancer epigenetics and metabolism may hold the key to identifying novel therapeutic targets.

Recent studies have enabled the identification of important factors regulating cancer progression, such as Pax-5.

BackgroundCathepsin L (CTSL) is a cysteine protease known to have important roles in regulating cancer cellular resistance to chemotherapy.

Ras-related C3 botulinum toxin substrate 1 (RAC1) is essential in regulating cancer progression.

Finally, the therapeutic strategies targeting molecules and pathways regulating cancer mitochondrial alterations are highlighted.

These findings of this study will contribute to the establishment of a novel therapeutic antidote toPDACs that are difficult to treat by regulating cancer-associated fibroblasts (CAFs) throughtargeting the identified pathway.

Altogether, these results suggest tissue context and mechanisms of Wnt pathway activation may profoundly influence its role in regulating cancer metabolism.

Materials & methods: In vitro/vivo extreme limiting dilution analysis and the side population assay were used to investigate the role of claudin-3 in regulating cancer stemness in nonsquamous NSCLC.

The purpose of this study was to explore the mechanism of active compound of Bohadschia argus on regulating cancer cell survival.

We further applied the probe to quantitatively analyze the stoichiometry of O-GlcNAcylation between sorafenib-sensitive and sorafenib-resistant liver cancer cells, which lays the foundation for mechanistic investigation of O-GlcNAcylation in regulating cancer chemoresistance.

Growing evidence suggests that long non‐coding RNAs NORAD and miR‐205 play a significant role in regulating cancer progression and metastasis.

This led us to search the potent therapeutic target for regulating cancer metabolism in treatment.

Jumonji domain containing 2A (JMJD2A), a member of the JmjC domain-containing family of JMJD2 proteins, is capable of regulating cancer-associated genes, including genes involved in the cell cycle, proliferation, apoptosis, invasion and metastasis.

In this review, we summarized the current progress of research on cytoplasmic lncRNAs and their roles in regulating cancer signaling and tumor progression, further characterization of which may lead to effective approaches for cancer prevention and therapy.

Molecular signaling: Two components of same pathway have divergent effectsOne of the key signaling pathways involved in regulating cancer cell growth and survival is not linearly connected in luminal breast cancers, as researchers had long assumed.

Voltage gated K+ (KV) channels play an important role in regulating cancer cell proliferation and are considered as potential target for cancer treatment.

05) thereby negatively regulating cancer cell proliferation.

In a word, IL1A SNPs play an essential role in upregulating cancer susceptibility, and current analysis provides detail date for further study in the future.

Thus, OCT4B19kDa may play a crucial role in regulating cancer cell survival and adaption in a rigid environment.

Moreover, silencing of Akt1 and 2 isoforms was found to decrease the expression of proteins regulating cancer cell survival and proliferation such as cyclooxygenase-2, B-cell lymphoma 2 (Bcl-2), cyclin D1, and survivin.

Background and aims: microRNA-605 (miR-605) is dysregulated in multiple cancers and plays crucial roles in regulating cancer progression.

Non-coding RNAs (ncRNA), which account for more than 75% genome transcripts, have unique functions in regulating cancer pathogenesis.

MiRNAs play important roles in regulating cancer cell proliferation, stemness maintenance, tumorigenesis, cancer metastasis, and cancer therapeutic resistance.

Our data reveal a non-canonical function of YAP1 and TEAD4 as ERα cofactors in regulating cancer growth, highlighting the potential of YAP/TEAD as possible actionable drug targets for ERα+ breast cancer.

BackgroundThe tumor microenvironment has a critical role in regulating cancer cell behavior.

In this study, we reported that DDB1 functions as a tumor-promoting factor in PDAC by regulating cancer cell proliferation, epithelial-mesenchymal transition (EMT) and chemoresistance.

Here, we review the relevance of cytokines and growth factors provided by immunosuppressive immune cells in regulating cancer-cell plasticity.

But whether and how BED finger domain function in regulating cancer proliferation is unknown.

In this review, we describe the characteristics and other members of the DLC1 family and delineate the signal pathways DLC1 involved in regulating cancer cell growth, colony formation, apoptosis, senescence, autophagy, migration and invasion.

show that the specific lipid binding of the diglycine variant of cytohesin‐1 is needed for HGF‐dependent cell migration and establishment of the leading edge, thereby regulating cancer cell migration following activation of the proto‐oncogenic receptor tyrosine kinase Met.

A better understanding of their roles in regulating cancer may provide novel biomarkers or therapeutic targets for diagnosis and treatment.

Thrombospondin-1 (THSB1) is a component of the ECM with a role in regulating cancer development and tumour vasculature.

The epidermal growth factor receptor (EGFR) pathway substrate 8 (Eps8) gene is involved in regulating cancer progression and is considered an attractive target for specific cancer immunotherapy.

The PPP serves a vital role in regulating cancer cell growth and involves many enzymes.

One such transcription factor possibly regulating cancer is RUNX2, the master gene of early and late osteogenesis.

This work provides a further understanding of SAM-Au NPs regulating cancer cell migration, which might be helpful to functionalize the Au NP surface in drug delivery system.

Liver X receptors (LXRs) are involved in various diseases associated with lipid disorders, and in regulating cancer cell proliferation.

However, the biological functions of CRL4 and the underlying mechanism regulating cancer chemoresistance are still largely elusive.

It can be secreted and transferred to recipient cells through the corresponding target genes, and play a role of regulating cancer progression.

These results strongly suggest that nicotine-induced polarization of N2-neutrophils plays a critical role in regulating cancer cell plasticity.

The EGFR/Eps8 complex is involved in regulating cancer progression and might be an ideal target for antitumor therapy.

The cellular microenvironment plays an important role in regulating cancer progress.

The results of our study show that NORAD plays an important role in regulating cancer cell functions of osteosarcoma, possibly through endogenously competing with hsa‐miR‐199a‐3p.

EPHA5 mediates trastuzumab resistance in HER2‐positive breast cancers through regulating cancer stem cell–like properties.

Gene expression analysis and western blot were used to investigate the underlying mechanisms of ROS in regulating cancer metastasis.

Because it is not possible to starve tumors of glucose in vivo, we sought to identify the mechanisms regulating cancer cell death upon glucose deprivation and then design combinations of inhibitors to mimic glucose deprivation-induced cell death.

Exosomes are tiny vesicles and play a significant role in regulating cancer-related signaling pathways.

However, the detailed molecular mechanism of circRNAs in regulating cancer progression is still unclear.

OBJECTIVE Histone deacetylase 11 (HDAC11) is a class Ⅳ member of histone deacetylase family, and its role in regulating cancer cell invasion and metastasis remains unclear.

Long non-coding RNAs (lncRNAs) play a critical role in regulating cancer progression and metastasis.

This provides new insight into a potential approach for the treatment of lung cancer by regulating cancer stemness.

The interaction between extracellular matrices and cancer cells plays an important role in regulating cancer cell behaviors.

MicroRNAs (miRNAs) are small, non‑coding RNAs that have been reported to play roles as oncogenes or tumour suppressors in all types of cancer, including GC, by post‑transcriptionally regulating cancer‑related genes.

Key molecules promoting migration and invasion exist in the extracellular matrix, and include chondroitin 4‐sulfate (C4S) and chondroitin 6‐sulfate (C6S), functionally important carbohydrate chains of chondroitin sulfate proteoglycans that participate in regulating cancer development.