Introduction to Registered Trials

However, patients with hepatitis B virus (HBV) infection have been traditionally excluded from most registered trials of this form of treatment.

SEARCH METHODS We searched multiple databases and clinical trial registers on 4 November 2020 for published and 'grey' literature and registered trials.

Among the registered trials, 43% had been completed, and 34.

Among prospectively registered trials, 25% displayed discrepancies between registration and publications, and for 17% we judged these discrepancies as favoring statistical significance.

Currently, only a few registered trials (n = 11) and published studies (n = 14) exist in this area.

We also searched trial registers for ongoing and registered trials (http://www.

Conclusions: Generally, women with CVD in the United States were underrepresented in FDA registered trials started in 2002–2017.

RESULTS Three randomized control trials and 13 registered trials were identified.

3% of all registered trials.

METHODS We searched Cochrane Central, MEDLINE, and EMBASE for eligible studies, reference lists of relevant reviews, registered trials, and relevant conference proceedings.

Trials related to infectious disease were less likely to specify an English requirement than all registered trials (10.

A machine learning-based model was trained on pairs (publications linked to specific registered trials).

We searched the Cochrane Central Register of Controlled Trials, MEDLINE, and Embase for eligible studies, reference lists of relevant reviews, registered trials, and relevant conference proceedings.

gov to provide an overview of the registered trials investigating stem cell therapy for heart diseases.

Methods and analysis: We will search the following 4 databases of registered trials and 7 electronic databases from inception to March 2021:Cochrane Stroke Group, Cochrane Central Register of Controlled, the World Health Organization International Clinical Trials Registry Platform, the Chinese Clinical Trial Registry; PubMed, MEDLINE, Embase, CNKI, VIP, WanFang, and CBM.

Results: The number of ongoing registered trials showed continuous growth from 2007 Q1 to 2019 Q4 (from 33,739 to 80,319 trials).

Key Points Question Do registered trials that evaluate the use of probiotics and routinely used antibiotics in children differ in their publication rates? Findings This cross-sectional analysis of 265 unique probiotic trials and 136 unique antibiotic trials in the ClinicalTrials.

More than half of the registered trials were related to the ayurvedic products.

RESULTS Screening of 42 095 database records and 3425 registered trials identified 480 published and 537 registered trials meeting inclusion criteria.

Of the registered trials listed in the ClinicalTrials.

Results CTG had the highest number of registered trials at 2622, followed by PACTR with 1501 and ISRCTN with 507 trials.

One hundred and twenty two registered trials on COVID-19 were extracted from the CTRI database.

In addition, the databases for prospectively registered trials and other systematic reviews will be screened.

A total of 87 registered trials were identified with which most of them were performed by using extracts or pure compounds (n = 60) while few were conducted with GSL-rich foods (n = 27).

CONCLUSION This study confirmed that even though all registered trials had the involvement of Portuguese institutions as a recruiting center, not all the published trials had Portuguese investigators as authors, mainly those initiated by the industry.

However, 93% of these registered trials are still not completed with published results and there is no picture available about methodological dimensions of these ongoing trials with fMRI as an outcome measure.

To our knowledge, no bibliometric analysis of these publications has been performed so far, nor have registered trials been analysed to anticipate future publication trends.

Interventional studies dominate observational studies among all AYUSH registered trials.

We searched publicly available databases, references lists of relevant reviews, registered trials, and relevant conference proceedings.

eu searches produced five registered trials of which three were completed and with results.

gov) were also searched to identify registered trials with reported findings.

Results We located five registered trials sponsored by Juul Labs that appeared covered by the FDAAA 2007 in the public data.

The registered trials were reviewed, and data were independently extracted by two reviewers based on the inclusion criteria.

However, given the quality of the included RCTs, more preregistered trials are needed that explicitly examine the efficacy of EGb.

In prospectively registered trials, apatinib has been proven to be effective against GC, HCC, lung cancer, breast cancer, sarcoma, esophageal cancer, colorectal cancer, ovarian cancer, cervical cancer, cholangiocarcinoma, diffuse large B-cell lymphoma, nasopharyngeal carcinoma, and differentiated thyroid cancer.

Additionally, preregistered trials were associated with more complete intervention reporting.

The search was limited to oral or potentially oral agents, with at least a putative anti-SARS-CoV-2 virus mechanism, and with at least 3 registered trials.

gov from 1 January to 16 November 2020, as these sources capture approximately 95% of registered trials recruiting in Australia.

During the last decades, several studies have focused on developing treatments for EB patients and significant progress has been made, as reflected by numerous publications, patents, and registered trials available.

Among the registered trials, 36% (27/75) were pro- and 64% (48/75) were retrospectively registered.

Another 111 unpublished but registered trials in 17 411 children were identified.

The most promising category of drain fluid BM was the extravasated intra luminal substances (EILS) and five registered trials of these BM were found.

The objective of the study was to provide a comprehensive analysis of registered trials in such field based on ClinicalTrials.

Study selection After screening eight major trial registries and 7844 records, we identified 178 registered trials and 38 publications describing 35 trials, including 25 peer-reviewed publications and 13 pre-prints.

Most of the articles we have gathered are unregistered trials, and the majority of methods are unproven.

Methods This cross-sectional analysis characterizes availability of results in trial registries and publications among registered trials performed during the 2009 H1N1 influenza, 2014 Ebola, and 2016 Zika pandemics.

The search was limited to oral or potentially oral agents, with at least a putative anti-SARS-CoV-2 virus mechanism and with at least five registered trials.

In this issue of The Journal, successful completion of registered trials in urology was analyzed (page 1159).