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Refractory B sentence examples within chimeric antigen receptor
Immunotherapy with T cells engineered to express a chimeric antigen receptor (CAR T cells) is reshaping the management of patients with relapsed or refractory B-cell malignancies.
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Chimeric antigen receptor T-cells (CAR-T) are improving outcomes in pediatric and adult patients with relapsed or refractory B-cell acute lymphoblastic leukemias and subtypes of non-Hodgkin Lymphoma.
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Refractory B sentence examples within cell acute lymphoblastic
In Europe, tisagenlecleucel (Kymriah™) has a marketing authorization for the treatment of relapsed/refractory B-cell acute lymphoblastic leukemia in children and young adults and for the relapsed/refractory diffuse large B-cell lymphoma (DLBCL).
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This therapy is now standard of care for relapsed or refractory B-cell acute lymphoblastic leukemia (B-ALL), the most common malignancy of childhood, and in high-grade B-cell lymphomas, the most common lymphoma in Canada.
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Refractory B sentence examples within single particle soot
In this study, the first observations of the size distribution and mixing state of individual refractory black carbon (rBC) particles in the South Asian outflow to the south-eastern Arabian Sea and the northern and equatorial Indian Ocean regions are presented based on measurements using a single particle soot photometer (SP2) aboard the Integrated Campaign for Aerosols, gases, and Radiation Budget (ICARB-2018) ship during winter 2018 (16 January to 13 February).
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Number concentrations of refractory black carbon (rBC) measured by a single particle soot photometer ranged from 200 to 1200 cm−3 when SAPs were observed.
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Refractory B sentence examples within targeted chimeric antigen
CD19-targeted chimeric antigen receptor (CAR) T-cell therapy has demonstrated remarkable efficacy in patients with relapsed/refractory B-cell malignancies, however, is associated with toxicities including cytokine release syndrome (CRS), neurotoxicity, and impaired hematopoietic recovery.
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CD19-targeted chimeric antigen receptor (CAR) T cell therapy has shown high efficacy in patients with refractory B-cell malignancies such as non-Hodgkin lymphoma and acute lymphoblastic leukemia.
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Refractory B sentence examples within cell precursor acute
OBJECTIVE
Tisagenlecleucel is a CD19-directed, genetically modified, autologous T-cell immunotherapy indicated for pediatric and young adult patients with relapsed/refractory B-cell precursor acute lymphoblastic leukemia and for adult patients with relapsed/refractory diffuse large B-cell lymphoma.
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The CD19-targeting bispecific T-cell engager blinatumomab has shown remarkable efficacy in patients with relapsed/refractory B-cell precursor acute lymphoblastic leukemia.
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Refractory B sentence examples within targeting chimeric antigen
CD19-targeting chimeric antigen receptor (CAR) T cells have become an important therapeutic option for patients with relapsed and refractory B cell malignancies.
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To the Editor: CD19-targeting chimeric antigen receptor T (CAR-T) cell therapy is a revolutionary immunotherapy in treating relapsed or refractory B lineage malignancies.
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Refractory B sentence examples within precursor acute lymphoblastic
BACKGROUND
Despite treatment with novel therapies and allogeneic stem-cell transplant (allo-SCT) consolidation, outcomes in adult patients with relapsed or refractory B-precursor acute lymphoblastic leukaemia remain poor, underlining the need for more effective therapies.
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Blinatumomab is a BiTE® (bispecific T‐cell engager) immuno‐oncology therapy, which has demonstrated significant activity in patients with relapsed or refractory B‐cell precursor acute lymphoblastic leukemia (R/R B‐ALL); however, a subset of patients relapse.
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Refractory B sentence examples within hematopoietic cell transplantation
Furthermore, the encouraging activity of novel therapies such as inotuzumab and blinatumomab in chemo-refractory B-cell ALL has promoted an interest in introducing these agents early in Ph-like ALL management, which may lead to improved cure rates with frontline therapies, sparing more adults from undergoing early allogeneic hematopoietic cell transplantation (HCT).
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Allogeneic hematopoietic cell transplantation (allo-HCT) can be curative for relapsed or refractory B-cell lymphomas (BCL), though outcomes are worse in aggressive disease and most patients will still experience relapse.
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Refractory B sentence examples within Become Refractory B
Background: Prostate cancer (PCa) is one of the most commonly diagnosed cancers in men and usually becomes refractory because of recurrence and metastasis.
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Prostate cancer (PCa) is one of the most commonly diagnosed cancers in men and usually becomes refractory because of recurrence and metastasis.
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Refractory B sentence examples within Silica Refractory B
Are presents findings on the influence of the direction of transmission and the natural frequency of transducers on ultrasonic pulse method measurements of silica refractory bricks.
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Are presents findings on the influence of the direction of transmission and the natural frequency of transducers on ultrasonic pulse method measurements of silica refractory bricks.
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Refractory B sentence examples within Cause Refractory B
Refractory B sentence examples within Fireclay Refractory B
Fireclay refractory bricks were used for furnishing as they directly interfaced with the molten metal, while the flame blower was connected, assembled, and erected in the different segments.
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Fireclay refractory bricks were used for furnishing as they directly interfaced with the molten metal, while the flame blower was connected, assembled, and erected in the different segments.
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Refractory B sentence examples within refractory b cell
OBJECTIVE
Chimeric antigen receptor-modified T (CAR-T) cells have shown impressive results against relapsed/refractory B cell malignancies.
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Background The use of T cells expressing chimeric antigen receptor (CAR T) engineered to target CD19 constitutes breakthrough treatment for relapsed or refractory B cell non-Hodgkin lymphoma (R/R B-NHL).
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Refractory B sentence examples within refractory b lineage
To the Editor: CD19-targeting chimeric antigen receptor T (CAR-T) cell therapy is a revolutionary immunotherapy in treating relapsed or refractory B lineage malignancies.
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Chimeric antigen receptor (CAR) T cells directed against CD19 have achieved impressive outcomes for the treatment of relapsed/refractory B lineage lymphoid neoplasms.
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The variability of the mixing state of refractory black carbon aerosol (rBC) and the corresponding complicated light absorption capacity impose great uncertainty for its climate forcing assessment.
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We identified a cohort of 165 patients with relapsed or refractory B-cell lymphoma who received CAR T-cell therapy.
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However, approximately 50% of patients with relapsed or refractory B-ALL do not respond to blinatumomab, and the correlation between T cell phenotype and blinatumomab response remains unclear.
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In this paper, the COREX-3000 melting gasifier was dissected and sampled to obtain the macroscopic erosion appearance of refractories lining in the drip zone, and the erosion behavior and mechanism of refractory bricks in the drip zone were analyzed by means of chemical analysis, XRD, SEM and determination of physical characteristics.
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The aim of this article was to demonstrate a "back-to-basics" approach to a refractory bifid tongue injury in a toddler.
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In the phase 3 TOWER trial (NCT02013167), blinatumomab demonstrated superior overall survival (OS) than standard of care chemotherapy (SOC) in adults with relapsed/refractory BCP ALL.
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Otolaryngologists must be prepared to deal with severe or refractory bleeding by using medications, packing materials, and radiologic or surgical interventions.
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5 composite, consisting of refractory body-centered cubic (BCC) high-entropy alloy and carbide with many fine eutectic structures, was successfully synthesized by arc melting.
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Molecular dynamic simulations were performed to investigate the displacement cascade process in refractory bcc complex concentrated alloys, including equi-atomic binary, ternary, and quaternary systems made of the elements Mo, Nb, Ta and W.
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Background: Osteoporotic vertebral compression fractures (OVCF) due to severe and refractory back pain or neurological complications require surgical treatment.
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Blinatumomab, a bispecific CD3 to CD19 T cell-engaging antibody construct, is efficacious in relapsed/refractory B-ALL and has a favorable toxicity profile.
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5 mass reached 63 μg m−3 with the highest contribution from inorganic constituents, which was accompanied by a thick coating of refractory black carbon (rBC) that linearly increased with condensation-mode particles.
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Currently, similar oHSVs are being evaluated in early phase clinical trials for children and adults with relapsed or refractory brain tumors.
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This study reports our experience with treating biloma secondary to refractory biliary leak with TP/TF or EUS-TD, and evaluates the safety and outcomes associated with this approach.
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The results nonstationary thermophysical calculation of the temperature field of the corium and refractory blocks of the melt trap are presented in the article.
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These results show the promise of epcoritamab for treatment of newly-diagnosed or relapsed/refractory B-NHL patients, including those who became refractory to previous CD20-directed therapies.
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The advantages of precise articulation for dissection and suturing, tremor reduction, three-dimensional magnified visualization, and minimally invasive trocar sites have allowed for the management of such diverse disease as recurrent or refractory bladder neck stenoses, and radiation-induced ureteral strictures, with excellent perioperative and functional outcomes.
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METHODS
We conducted a pilot clinical trial of a humanized CD19 CAR T-cell product (huCART19) in children and young adults with relapsed or refractory B-ALL (n = 72) or B-lymphoblastic lymphoma (n = 2), treated in two cohorts: with (retreatment, n = 33) or without (CAR-naive, n = 41) prior CAR exposure.
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In an 83-patient study from Memorial Sloan Kettering Cancer Center in patients with relapsed/refractory B cell lymphoma or multiple myeloma, the majority patients had “recovered” (defined as hemoglobin >8 g/dL, platelets >50×103/µL, and absolute neutrophil count >1000/µL (without transfusion or growth factor support) at 3 months.
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The manuscript provides brief insights into the methodologies employed during the lining of refractory bricks and its project management, planning and commissioning to ensure project safety during battery no.
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These properties are superior to those of most refractory BCC high-entropy alloys reported in the literature.
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We present a case of the novel and successful treatment of severe, refractory bleeding and transfusion-dependence with antiangiogenic therapy in a patient with Heyde syndrome.
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5 ns enables a prompt control of number and energy of collectively accelerated protons in their separate bunches dumped into a sustainable and refractory B 4 C target.
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Chronic or refractory breathlessness adversely affects quality of life.
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The successful results of CAR T cell therapy in relapsed and refractory B-cell malignancies shifted the paradigm of cancer immunotherapy by awakening the scientific, clinical, and commercial interest in translating this technology for the treatment of solid cancers.
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Vemurafenib (VMF), a BRAF inhibitor, was approved for refractory BRAFV600E mutated LCH.
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Successful anti-CD19 CAR T-cell therapy was also reported in HIV-infected patients with refractory B-cell lymphoma.
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The service life of refractory brick in the slag tapping hole of the entrained flow gasifier was significantly lower than that in other locations.
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We assessed the efficacy and tolerability of pemetrexed and cisplatin combination therapy in patients with refractory bone and soft tissue sarcoma (STS).
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During high-temperature roasting, the liquid phase corrodes the surface of the refractory brick to form the initial deposit, whereafter, it binds the pellet powder and coal ash from the material layer, which causes the deposit to accumulate continuously.
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In this sense, this work evaluates changes in the sintering starting temperature when ashes from the combustion of agro-industrial wastes (exhausted olive cake and almond shell) are added (0–20 wt%) to two types of clays showing different plasticity and refractory behaviour.
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The prognosis of most patients with relapsed and/or refractory B cell non-Hodgkin lymphoma (R/R B-NHL), particularly those with aggressive histologies such as diffuse large B cell lymphoma or transformed follicular lymphoma, remains dismal.
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This research aims to study the influence of the sintering temperature on the microstructural and physical properties for application as refractory bricks.
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Lytic bacteriophages (or phages) have come under scrutiny as a potential antimicrobial for refractory bacterial infections.
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The quality of chemically bonded sand cores used during the manufacturing process of cast components is highly dependent on the properties of the sand, which constitutes the refractory base media of the core.
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Tisagenlecleucel, the first genetically engineered adoptive cellular therapy approved by the United States Food and Drug Administration, has revolutionized this field by demonstrating impressive clinical success in children and young adults with relapsed/refractory B‐cell acute lymphoblastic leukemia (r/r B‐ALL).
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We will show how the timescale for the core could be obtained by integrating results from the analyses of the radionuclides <sup>210</sup>Pb and <sup>137</sup>Cs with annual layer counting derived from pollen and refractory black carbon concentrations.
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28ζ-CAR T cells in CAYAs with relapsed or refractory B-ALL.
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This study is a multi-centre, single-blinded randomized controlled trial [1] investigating the use of Clorpactin instillation in patients with refractory BPS/IC.
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PATIENTS AND METHODS
Patients with treatment-refractory BRCA1/2 mutated cancer were included for treatment with off-label olaparib 300 mg twice daily until disease progression or unacceptable toxicity.
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