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INTRODUCTION AND OBJECTIVES: Recent level 1 data shows that focal therapy with vascular-targeted photodynamic treatment in Grade Group (GG) 1 prostate cancer (PCa) reduces pathological progression (PP) and radical treatment compared to active surveillance (AS) at 4 years follow-up.
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Modulation of cancer-associated fibrotic stroma reduces pathological progression of PDAC [abstract].
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Leriglitazone reduces pathologically activated microglia and protects neurons, astrocytes, and oligodendrocytes in experimental models of X-ALD.
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In contrast, continuous-wave ultrasound reduces pathological oscillations by silencing the STN.
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Here, we demonstrate that inhibition of p38α MAPK reduces pathological TDP-43 phosphorylation, aggregation, cytoplasmic mislocalization, and neurotoxicity.
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Conversely, transgenic overexpression of CIP reduces pathological dystrophic cardiomyopathy in old, syndromic mdx mice.
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Using a state-of-the-art rat model of compulsive cocaine seeking (resistance to a punishment associated with cocaine seeking), we show here that: first, subthalamic nucleus (STN) oscillatory activity during prior extended access to cocaine serves as a biomarker to predict vulnerable individuals that will compulsively seek the drug, a hallmark of addiction, and second, that in compulsive “addicted” rats, low (30 Hz) but not high (130 Hz), deep brain stimulation (DBS) of the STN efficiently reduces pathological cocaine seeking.
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Results revealed that Phil reduces pathological changes and improves renal function in LPS-induced AKI.
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INTRODUCTION AND OBJECTIVES: Recent level 1 data shows that focal therapy with vascular-targeted photodynamic treatment in Grade Group (GG) 1 prostate cancer (PCa) reduces pathological progression (PP) and radical treatment compared to active surveillance (AS) at 4 years follow-up.
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Next, we showed that Myriocin drammatically reduces pathological accumulation of lipid unorganized deposits in IB3 cells.
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Modulation of cancer-associated fibrotic stroma reduces pathological progression of PDAC [abstract].
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