Introduction to Reduced Responsiveness

We show that long-term exposure of ovarian cancer cells to TKIs leads to reduced responsiveness of intrinsically sensitive cancer cells over time.

In mice, administration of WT Bacteroides thetaiotaomicron, but not a SPT-deficient mutant, resulted in elevated levels of liver ceramides and reduced responsiveness to exogenously administered insulin.

However, the reduced responsiveness of bud set to both enhancement treatments suggest that the plants gradually acclimated to the modified climate, a finding that should also be investigated for other tree species.

“Rather, improving P2X7 activity should beneficially influence the reduced responsiveness of patients with SLE to vaccines.

Reduced responsiveness to aldosterone may persist for months after treatment of the underlying infection or repair of the urinary tract anomaly [3].

Partial sensory deprivation (deafferentation) by removing whiskers from the rat snout resulted in a reduced responsiveness of related cortical representations.

However, both algorithms also showed reduced responsiveness during disturbance episodes.

At higher intensities intracellular signaling might be responsible for diminished channel opening that causes widening the range of the pheromone dose-response and adaptation (reduced responsiveness) after strong stimuli.

This study examined the effect of sense modality (auditory/visual) on emotional dampening (reduced responsiveness to emotions with elevation in blood pressure).

Pregnancy is marked by B cell lymphocytopenia accompanied by reduced responsiveness to infectious agents.

Recent research shows that anthropogenic noise can lead to reduced responsiveness to risk and higher mortality.

However, the strict and inflexible planning system in England may have significantly reduced responsiveness of housing supply to raising demand for housing debt.

EGFR mutated most frequently in Tibetan LUAD, but TP53 only mutated in two patients, one of which harbored EGFR mutation as well suggesting reduced responsiveness to first line EGFR-TKIs.

However, low-SOR participants with ASD also showed distinct, nontypical neural response patterns, including reduced responsiveness to novel but similar stimuli and increases in prefrontal-amygdala regulation across the sensory exposure.

At higher intensities intracellular signaling might be responsible for diminished channel opening that causes widening the range of the pheromone dose-response and adaptation (reduced responsiveness) after strong stimuli.

It affects the respiratory drive causing reduced responsiveness to hypoxia or hypercapnia, potentially causing life-threatening hypoventilation on rare occasions.

Reduced responsiveness to reward has been associated with both risk-prone and risk-averse behavior, common features of externalizing and internalizing psychopathology, respectively.

OBJECTIVE Low levels of alpha activity (8-13Hz) mirror a state of enhanced responsiveness, whereas high levels of alpha are a state of reduced responsiveness.

Before the operation, some analogous symptoms, like apathy and reduced responsiveness, appeared; the symptoms lasted for a month and remitted after the operation.

The patients showed severe behavioral disturbances, memory and cognitive impairment, episodes of reduced responsiveness, but no seizures, and normal MRI.

Nevertheless, OBS comes at the cost of reduced responsiveness, whereas BPO shifts the cost and delivery performance frontier.

In hermaphrodites, dopamine increases the low activity state by suppression of octopamine signaling in the sex-shared SIA neurons, which have reduced responsiveness to octopamine in males.

BACKGROUND Obesity is thought to be associated with poor asthma control, increased health resource utilization, and reduced responsiveness to inhaled corticosteroids.

SNP rs479200 in the EGLN1 gene is associated with reduced responsiveness to hypoxia.

The patients showed severe behavioral disturbances, memory and cognitive impairment, episodes of reduced responsiveness, but no seizures, and normal MRI.

Effective anti-HBV therapy did not affect viral specific Tregs/Th17 cells frequency or IL-35 expression in CHB patients, however, reduced responsiveness of CD4+ T cells or Tregs to IL-35 stimulation in vitro.

Arabidopsis lon2 mutants exhibit reduced responsiveness to the peroxisomally-metabolized auxin precursor indole-3-butyric acid (IBA), heightened degradation of several peroxisomal matrix proteins, and impaired processing of proteins harboring N-terminal peroxisomal targeting signals; these defects are ameliorated by preventing autophagy.

Larvae exposed to DomA at 2 days post-fertilization (dpf), but not at 1 or 4 dpf, showed consistent deficits in startle behavior including reduced responsiveness and altered kinematics.

Resistance to thyroid hormone beta (RTHβ) is a syndrome characterized by reduced responsiveness of peripheral tissues to thyroid hormone (TH).

A defining feature of sleep is reduced responsiveness to external stimuli, but the mechanisms gating sensory-evoked arousal remain unclear.

The finding that cannabis altered circuitry and distorted behavior in occasional, but not chronic users, suggests reduced responsiveness of the reward circuitry to cannabis intoxication in chronic users.

The proband's fibroblasts showed reduced responsiveness to T3 compared to those of another affected family member.

These effects varied across eccentricities and correlate with the degree of amblyopia but not with one another, suggesting two independent cortical deficits: a reduced responsiveness as well as reduced fidelity of spatial representation.

A number of syndromes are associated with reduced responsiveness to thyroid hormones, expanding the original definition of thyroid hormone resistance, firstly described by Refetoff and collaborators in 1967, which is characterized by elevated circulating levels of T4 and T3 with measurable serum TSH concentrations, as a consequence of mutations of thyroid hormone receptor beta (TRβ), recently named as RTHβ.

Early postnatal Tmem67 mutant cerebellum had disrupted ciliogenesis and reduced responsiveness to Shh signalling.

However, reduced responsiveness/resistance to artemisinin derivatives and to ACTs, an increasing problem in South-East Asia is a major concern.

RESULTS Response bias, indicating a reduced responsiveness, and high and very low frequency components of Heart rate variability, indicating an increased parasympathetic activity, contribute to the regression of trait fatigue.

Conclusions Our results suggest that structural damage to motor fibres may lead to reduced responsiveness in PDOC patients across all diagnostic sub-categories, and therefore behavioural assessments may underestimate the level of retained cognitive function and awareness across the PDOC spectrum.

Although BAT during lactation responds to various experimental manipulations, these responses are typically reduced to ∼50% of the absolute values achieved outside reproduction, with insulin and noradrenaline resistance being the hallmarks of BAT reduced responsiveness.

BackgroundSepsis, a life-threatening organ dysfunction caused by a dysregulated systemic immune response to infection, associates with reduced responsiveness to subsequent infections.

Adjuvanted influenza vaccines constitute a key element towards inducing neutralizing antibody responses in populations with reduced responsiveness, such as infants and elderly subjects, as well as in devising antigen-sparing strategies.

The finding that cannabis altered circuitry and distorted behavior in OUs, but not CUs, suggests reduced responsiveness of the reward circuitry to cannabis intoxication in chronic users Taken together, the results suggest a pharmacodynamic mechanism for the development of tolerance to cannabis impairment.

Conversely, forced overexpression of H-Ferritin significantly suppressed the cisplatin-mediated elevation of intracellular ROS subsequently leading to a reduced responsiveness in OVCAR8 cells.

Many of these patients have cachexia, which is associated with increased cancer therapy toxicity and possibly reduced responsiveness to immunotherapy.

In the tumor microenvironment, inflammation promotes tumorigenesis on several levels, influencing cellular proliferation, survival, angiogenesis, metastasis, and reduced responsiveness to chemotherapeutic agents.

The impairment apparently reflects reduced responsiveness of TLR3.

Background: Resistance to thyroid hormone (RTH) is an inherited syndrome characterized by reduced responsiveness of target tissues to thyroid hormone.