Introduction to Recognition Domain

Sentence Examples

Discover more insights into Recognition Domain

Keywords frequently search together with Recognition Domain

Narrow sentence examples with built-in keyword filters

Recognition Domain sentence examples within β galactoside containing

β galactoside containing

These biological functions can be initiated through interactions formed between the conserved carbohydrate recognition domain and β-galactoside-containing glycoconjugates.

Design and Development of Galectin-Specific Inhibitors

β galactoside containing

Galectin-1 (Gal-1) is the first member of galectin family, which has a carbohydrate recognition domain, specifically binds towards β-galactoside containing oligosaccharides.

Investigations on the binding specificity of β-galactoside analogues with human galectin-1 using molecular dynamics simulations.

More β galactoside containing sentences More Sentences

Recognition Domain sentence examples within Carbohydrate Recognition Domain

Carbohydrate Recognition Domain

Antibody responses against different antigens, which include Serum anti-lectin IgG, Salivary anti-CRD (carbohydrate recognition domain) Ig A, and Stool anti-CRD (carbohydrate recognition domain) IgA were estimated by ELISA periodically thrice, in acute stage after 06 and 09 months and between 12 and 15 months.

Humoral Immune Responses to Amebic Liver Abscess

Carbohydrate Recognition Domain

The extended SRLS analysis is applied to 15N-H relaxation from the carbohydrate recognition domain of galectin-3 (Gal3C) in complex with two diastereomeric ligands, S and R.

Structural Dynamics from NMR Relaxation by SRLS Analysis: Local Geometry, Potential Energy Landscapes, and Spectral Densities.

More Carbohydrate Recognition Domain sentences More Sentences

Recognition Domain sentence examples within Antigen Recognition Domain

Antigen Recognition Domain

This prevents damage to antigen recognition domains and recognition sites for secondary antibodies that can decrease the signal of immunodetection techniques.

Immunodetection of Lung IgG and IgM Antibodies against SARS-CoV-2 via Enzymatic Liquefaction of Respiratory Samples from COVID-19 Patients.

Antigen Recognition Domain

This field has been revolutionized by the advent of chimeric antigen receptor (CAR) T cell therapy that is utilizing an antigen recognition domain to redirect patients’ T cells to selectively attack cancer cells.

JAK/STAT-Dependent Chimeric Antigen Receptor (CAR) Expression: A Design Benefiting From a Dual AND/OR Gate Aiming to Increase Specificity, Reduce Tumor Escape and Affect Tumor Microenvironment

More Antigen Recognition Domain sentences More Sentences

Recognition Domain sentence examples within Target Recognition Domain

Target Recognition Domain

The majority of phase-variable Type III DNA methyltransferase genes sequenced to date have multiple alleles that differ in their central target recognition domain (TRD) and it is hypothesized that every allelic variant methylates a different target sequence and regulates the switching of expression of a distinct phasevarion.

Moraxella catarrhalis phasevarions

Target Recognition Domain

The target recognition domain stabilizes the enlarged major groove via shape complementarity rather than base-specific interactions, permitting substrate diversity.

Substrate deformation regulates DRM2-mediated DNA methylation in plants

More Target Recognition Domain sentences More Sentences

Recognition Domain sentence examples within Pattern Recognition Domain

Pattern Recognition Domain

In addition, we summarize the current practices in cluster analysis of spectroscopy and contrast these with cluster analysis literature from the machine learning and pattern recognition domain.

Cluster Analysis for IR and NIR Spectroscopy: Current Practices to Future Perspectives

Pattern Recognition Domain

In computer vision and pattern recognition domain, dynamic research is going on in face recognition.

Adaptive morphological and bilateral filtering with ensemble convolutional neural network for pose-invariant face recognition

More Pattern Recognition Domain sentences More Sentences

Recognition Domain sentence examples within Speech Recognition Domain

Speech Recognition Domain

Last but not least, we show that four promising defense methods for adversarial attack from the speech recognition domain become ineffective on SRSs against FAKEBOB, which calls for more effective defense methods.

Who is Real Bob? Adversarial Attacks on Speaker Recognition Systems

Speech Recognition Domain

In this paper, we propose to apply object detection methods from the vision domain on the speech recognition domain, by treating audio fragments as objects.

SpeechYOLO: Detection and Localization of Speech Objects

More Speech Recognition Domain sentences More Sentences

Recognition Domain sentence examples within Activity Recognition Domain

Activity Recognition Domain

This requirement stimulates the advancement of the transfer learning research area that minimizes the use of labeled data by transferring knowledge from the existing activity recognition domain.

Atypical Sample Regularizer Autoencoder for Cross-Domain Human Activity Recognition

Activity Recognition Domain

This study provides an efficient and convenient-to-use solution for the smartphone applications in human activity recognition domain.

Information Augmentation for Human Activity Recognition and Fall Detection using Empirical Mode Decomposition on Smartphone Data

More Activity Recognition Domain sentences More Sentences

Recognition Domain sentence examples within Visual Recognition Domain

Visual Recognition Domain

This paper introduces an agent-centric approach to handle novelty in the visual recognition domain of handwriting recognition (HWR).

Handwriting Recognition with Novelty

Visual Recognition Domain

FeatherV1 is the first publicly available bird's plumage dataset for machine learning, and it can raise interest for a new task in fine-grained visual recognition domain.

Feathers dataset for fine-grained visual categorization

More Visual Recognition Domain sentences More Sentences

Recognition Domain sentence examples within Substrate Recognition Domain

Substrate Recognition Domain

Multiple gene clusters consisting of cellulases and hemicellulases associated with substrate recognition domain were identified in the genome.

Hybrid Genome Assembly for Predicting Functional Potential of a Novel Streptomyces Strain as Plant Biomass Valorisation Agent.

Substrate Recognition Domain

Here we present two crystal structures of the LNK substrate recognition domain, the SH2 domain, bound to phosphorylated motifs from JAK2 and EPOR, and biochemically define the basis for target recognition.

Structural and functional analysis of target recognition by the lymphocyte adaptor protein LNK

More Substrate Recognition Domain sentences More Sentences

Recognition Domain sentence examples within Dna Recognition Domain

Dna Recognition Domain

CamA contains an N-terminal domain for catalyzing methyl transfer, and a C-terminal DNA recognition domain.

Clostridioides difficile specific DNA adenine methyltransferase CamA squeezes and flips adenine out of DNA helix

Dna Recognition Domain

In this chapter, we describe artificial control of mitochondrial transcription based on mtDNA sequence information with a new type of compounds termed MITO-PIPs, which encompasses two domains: pyrrole-imidazole polyamide as DNA recognition domain and mitochondrial penetrating peptide as the mitochondria-targeting domain.

Sequence-Specific Control of Mitochondrial Gene Transcription Using Programmable Synthetic Gene Switches Called MITO-PIPs.

More Dna Recognition Domain sentences More Sentences

Recognition Domain sentence examples within recognition domain 4

recognition domain 4

However, the fine details of its ligand specificity, and specifically that of carbohydrate-recognition domain 4, the most functionally relevant C-type lectin domain within the receptor, are not completely understood.

A fresh trim provides a new look at the human mannose receptor

recognition domain 4

C-type carbohydrate-recognition domain 4 (CRD4) of the receptor contains the site for Ca2+-dependent interaction with sugars.

Structural analysis of carbohydrate binding by the macrophage mannose receptor CD206

More recognition domain 4 sentences More Sentences

More Recognition Domain sentence examples
10.1007/978-3-030-63046-1_2

Galectin-3 (Gal-3; Mac-2) is a carbohydrate-binding lectin that is remarkable for its chimeric structure, comprised of an N-terminal oligomerization domain and a C-terminal carbohydrate-recognition domain.

Galectin-3 Promotes ROS, Inflammation, and Vascular Fibrosis in Pulmonary Arterial Hypertension.

More Recognition Domain sentence examples
10.1016/j.jbc.2021.100922

However, the fine details of its ligand specificity, and specifically that of carbohydrate-recognition domain 4, the most functionally relevant C-type lectin domain within the receptor, are not completely understood.

A fresh trim provides a new look at the human mannose receptor

More Recognition Domain sentence examples
10.3390/antibiotics10050541

PtCLec2 contains a single carbohydrate-recognition domain (CRD) with a conserved QPD motif, which was predicted to have galactose specificity.

A C-Type Lectin Highly Expressed in Portunus trituberculatus Intestine Functions in AMP Regulation and Prophenoloxidase Activation

More Recognition Domain sentence examples
10.1016/j.fsi.2021.06.007

Open reading frame of OmLec1 contains a 570 bp, encoding a protein of 189 amino acids that includes a signal peptide and a single carbohydrate-recognition domain.

A C-type lectin with a single CRD from Onychostoma macrolepis mediates immune recognition against bacterial challenge.

More Recognition Domain sentence examples
10.1126/scitranslmed.abb5191

Here, we construct a double-chain chimeric receptor, termed as synthetic T cell receptor (TCR) and antigen receptor (STAR), which incorporates antigen-recognition domain of antibody and constant regions of TCR that engage endogenous CD3 signaling machinery.

Chimeric STAR receptors using TCR machinery mediate robust responses against solid tumors

More Recognition Domain sentence examples
10.1080/13803395.2021.1962252

We aimed to assess aging effects on an extended version of the test, which captures further associative memory abilities beyond the recall and recognition domains measured in the original version.

Worse associative memory recall in healthy older adults compared to young ones, a face-name study in Spain and Mexico.

More Recognition Domain sentence examples
10.3390/insects12060559

separata larvae was constructed and a total of 35 CTLs containing single or dual carbohydrate-recognition domains (CRDs) were identified from unigenes.

Identification of 35 C-Type Lectins in the Oriental Armyworm, Mythimna separata (Walker)

More Recognition Domain sentence examples
10.1038/s41419-020-03367-z

Galectin-1 contains a carbohydrate-recognition domain (CRD) as a member of the lectin family.

Galectin-1 accelerates high-fat diet-induced obesity by activation of peroxisome proliferator-activated receptor gamma (PPARγ) in mice

More Recognition Domain sentence examples
10.1016/J.AQUACULTURE.2021.736582

Galectins are a family of lectins that bind β-galactoside sugars through their conserved carbohydrate-recognition domains (CRDs) and play integral roles in the innate immune systems of vertebrates and invertebrates.

Molecular characterization and functional study of galectin-related proteins from the Japanese flounder (Paralichthys olivaceus)

More Recognition Domain sentence examples
10.1016/j.dci.2021.104239

2 protein consisted of a signal peptide at the N terminal and a carbohydrate-recognition domain (CRD) with a mutated mannose-binding (Glu-Pro-Ala; EPA) motif at the C terminal, and thereby has a putative secreted mannose-binding C-type lectin architecture.

A novel C-type lectin LvCTL 4.2 has antibacterial activity but facilitates WSSV infection in shrimp (L. vannamei).

More Recognition Domain sentence examples
10.1073/pnas.2026246118

Its carboxyl-terminal carbohydrate-recognition domain is essential for this effect, and its N-terminal domain, which contributes to the self-association property of the protein, is also critical, suggesting that this promoting effect is dependent on the functional multivalency of galectin-3.

Galectin-3 promotes noncanonical inflammasome activation through intracellular binding to lipopolysaccharide glycans

More Recognition Domain sentence examples
10.1016/j.cbpb.2021.110633

The teleost fucose-type lectin (FTL) family includes proteins that preferentially bind fucose and display tandemly arrayed carbohydrate-recognition domains (CRDs) or are found in mosaic combinations with other domains.

F-type lectin from serum of the Antarctic teleost fish Trematomus bernacchii (Boulenger, 1902): Purification, structural characterization, and bacterial agglutinating activity.

More Recognition Domain sentence examples
10.1038/s41592-020-01001-6

We show that the megabody design principles are applicable to different scaffold proteins and recognition domains of compatible geometries and are amenable for efficient selection from yeast display libraries.

Megabodies expand the nanobody toolkit for protein structure determination by single-particle cryo-EM

More Recognition Domain sentence examples
10.1016/j.jbc.2021.100368

C-type carbohydrate-recognition domain 4 (CRD4) of the receptor contains the site for Ca2+-dependent interaction with sugars.

Structural analysis of carbohydrate binding by the macrophage mannose receptor CD206

More Recognition Domain sentence examples
10.1016/j.dci.2021.104066

Carbohydrate-recognition domains (CRDs) endow C-type lectins with the function of recognizing and scavenging non-self factors.

C-type lectin with a QPN motif from swimming crab Portunus trituberculatus displays broad nonself-recognition ability and functions as an opsonin.

More Recognition Domain sentence examples
10.1007/978-1-0716-1016-9_19

These oligomeric lectin-like proteins are assembled from subunits consisting of a collagen-like triple helix and a trimeric fibrinogen-like recognition domain.

Analysis of the Ligand Recognition Specificities of Human Ficolins Using Surface Plasmon Resonance.

More Recognition Domain sentence examples
10.1016/J.AQREP.2021.100640

C-type lectin (CTL) proteins contain special carbohydrate-recognition domains (CRDs) and play vital roles in activating the innate immune system.

Molecular characterization and expression analysis of a novel C-type lectin (CTL) gene in yellow catfish Pelteobagrus fulvidraco

More Recognition Domain sentence examples
10.1016/S2352-3026(21)00057-0

Chimeric antigen receptors (CAR) are fusion proteins containing an antigen-recognition domain coupled to a T-cell activation domain (eg, CD3ζ [CD247]) and to a costimulatory domain (eg, CD28 or 4-1BB [TNFRSF9, also known as CD137]).

CAR T-cell therapy for multiple myeloma: state of the art and prospects.

More Recognition Domain sentence examples
10.1016/j.autrev.2021.102931

The fundamental strategy is to engineer the recognition domains in CAR products for precisely targeting the components in the pro-inflammatory milieu.

Therapeutic potential of chimeric antigen receptor based therapies in autoimmune diseases.

More Recognition Domain sentence examples
10.1145/3475720.3484443

Processing and analyzing historical manuscripts is considered one of the most challenging problems in the document analysis and recognition domain.

Evaluation of Deep Learning Techniques for Content Extraction in Spanish Colonial Notary Records

More Recognition Domain sentence examples
10.1093/gbe/evab048

These variants are mostly mapped to the substrate-recognition domains of F-box proteins and the extracellular and intracellular regions of csGPCRs, possibly resulting in advantages during adaptation by affecting protein degradation and the sensing of environmental cues, respectively.

Large Genetic Diversity and Strong Positive Selection in F-Box and GPCR Genes among the Wild Isolates of Caenorhabditis elegans

More Recognition Domain sentence examples
10.29399/npa.25056

Across all four periods of assessment of BD group, statistically significant variation was only observed in the instant recall, learning and recognition domains of RAVLT and word test and color test domains of ST; however, it was not sufficient to distinguish the BD group separating from the control group.

Seasonality in Bipolar Disorder: Impact on Mood Symptoms, Psychosocial Functioning, Neurocognition, and Biological Rhythm.

Learn more from Recognition Domain

Keywords related to Recognition

Keywords related to Domain

Recognition Domain
Encyclopedia

What is/are Recognition Domain?

Recognition Domain - Galectin-3 (Gal-3; Mac-2) is a carbohydrate-binding lectin that is remarkable for its chimeric structure, comprised of an N-terminal oligomerization domain and a C-terminal carbohydrate-recognition domain. [1] However, the fine details of its ligand specificity, and specifically that of carbohydrate-recognition domain 4, the most functionally relevant C-type lectin domain within the receptor, are not completely understood. [2] PtCLec2 contains a single carbohydrate-recognition domain (CRD) with a conserved QPD motif, which was predicted to have galactose specificity. [3] Open reading frame of OmLec1 contains a 570 bp, encoding a protein of 189 amino acids that includes a signal peptide and a single carbohydrate-recognition domain. [4] Here, we construct a double-chain chimeric receptor, termed as synthetic T cell receptor (TCR) and antigen receptor (STAR), which incorporates antigen-recognition domain of antibody and constant regions of TCR that engage endogenous CD3 signaling machinery. [5] We aimed to assess aging effects on an extended version of the test, which captures further associative memory abilities beyond the recall and recognition domains measured in the original version. [6] separata larvae was constructed and a total of 35 CTLs containing single or dual carbohydrate-recognition domains (CRDs) were identified from unigenes. [7] Galectin-1 contains a carbohydrate-recognition domain (CRD) as a member of the lectin family. [8] Galectins are a family of lectins that bind β-galactoside sugars through their conserved carbohydrate-recognition domains (CRDs) and play integral roles in the innate immune systems of vertebrates and invertebrates. [9] 2 protein consisted of a signal peptide at the N terminal and a carbohydrate-recognition domain (CRD) with a mutated mannose-binding (Glu-Pro-Ala; EPA) motif at the C terminal, and thereby has a putative secreted mannose-binding C-type lectin architecture. [10] Its carboxyl-terminal carbohydrate-recognition domain is essential for this effect, and its N-terminal domain, which contributes to the self-association property of the protein, is also critical, suggesting that this promoting effect is dependent on the functional multivalency of galectin-3. [11] The teleost fucose-type lectin (FTL) family includes proteins that preferentially bind fucose and display tandemly arrayed carbohydrate-recognition domains (CRDs) or are found in mosaic combinations with other domains. [12] We show that the megabody design principles are applicable to different scaffold proteins and recognition domains of compatible geometries and are amenable for efficient selection from yeast display libraries. [13] C-type carbohydrate-recognition domain 4 (CRD4) of the receptor contains the site for Ca2+-dependent interaction with sugars. [14] Carbohydrate-recognition domains (CRDs) endow C-type lectins with the function of recognizing and scavenging non-self factors. [15] These oligomeric lectin-like proteins are assembled from subunits consisting of a collagen-like triple helix and a trimeric fibrinogen-like recognition domain. [16] C-type lectin (CTL) proteins contain special carbohydrate-recognition domains (CRDs) and play vital roles in activating the innate immune system. [17] Chimeric antigen receptors (CAR) are fusion proteins containing an antigen-recognition domain coupled to a T-cell activation domain (eg, CD3ζ [CD247]) and to a costimulatory domain (eg, CD28 or 4-1BB [TNFRSF9, also known as CD137]). [18] The fundamental strategy is to engineer the recognition domains in CAR products for precisely targeting the components in the pro-inflammatory milieu. [19] Processing and analyzing historical manuscripts is considered one of the most challenging problems in the document analysis and recognition domain. [20] These variants are mostly mapped to the substrate-recognition domains of F-box proteins and the extracellular and intracellular regions of csGPCRs, possibly resulting in advantages during adaptation by affecting protein degradation and the sensing of environmental cues, respectively. [21] Across all four periods of assessment of BD group, statistically significant variation was only observed in the instant recall, learning and recognition domains of RAVLT and word test and color test domains of ST; however, it was not sufficient to distinguish the BD group separating from the control group. [22]

β galactoside containing

These biological functions can be initiated through interactions formed between the conserved carbohydrate recognition domain and β-galactoside-containing glycoconjugates. [1] Galectin-1 (Gal-1) is the first member of galectin family, which has a carbohydrate recognition domain, specifically binds towards β-galactoside containing oligosaccharides. [2] Galectins, a family of evolutionarily conserved lectins, are characterized by sequence homology in the carbohydrate-recognition domain (CRD), atypical secretion via an ER-Golgi-independent pathway and the ability to recognize β-galactoside-containing saccharides. [3]

Carbohydrate Recognition Domain

Antibody responses against different antigens, which include Serum anti-lectin IgG, Salivary anti-CRD (carbohydrate recognition domain) Ig A, and Stool anti-CRD (carbohydrate recognition domain) IgA were estimated by ELISA periodically thrice, in acute stage after 06 and 09 months and between 12 and 15 months. [1] The extended SRLS analysis is applied to 15N-H relaxation from the carbohydrate recognition domain of galectin-3 (Gal3C) in complex with two diastereomeric ligands, S and R. [2] Antifungals packaged in liposomes are targeted specifically to where the pathogen is, through binding to the fungal cell walls or exopolysaccharide matrices using the carbohydrate recognition domains of pathogen receptors. [3] MGL contains an extracellular calcium-dependent (C-type) carbohydrate recognition domain (CRD) that specifically binds terminal N-acetylgalactosamine glycan residues such as the Tn and sialyl-Tn antigens found on tumor cells, as well as other N- and O-glycans displayed on certain viruses and parasites. [4] This protein is susceptible to cleavage of its linker-peptides by several proteases, and the resulting cleaved forms, N-terminal carbohydrate recognition domain (CRD) and C-terminal CRD, bind to various glycans. [5] Isolated constructs composed only of the neck and carbohydrate recognition domain of SP-D also bind to histone H4 and partially limit neutrophil responses to it. [6] These biological functions can be initiated through interactions formed between the conserved carbohydrate recognition domain and β-galactoside-containing glycoconjugates. [7] The interaction of human galectin-8 and its two separate N-terminal and C-terminal carbohydrate recognition domains (CRD) to their natural ligands has been analysed using a synergistic combination of experimental NMR and ITC methods, and molecular dynamics simulations. [8] This indicator is composed of a highly conserved carbohydrate recognition domain (CRD) that accounts for the binding affinity of β-galactosides. [9] Galectins are soluble carbohydrate binding proteins that can bind β-galactose-containing glycoconjugates by means of a conserved carbohydrate recognition domain (CRD). [10] Galectin-1 (Gal-1), a prototype member of this family, presents a carbohydrate recognition domain (CRD) with specific affinity for β-galactosides such as N-acetyllactosamine (β-d-Galp-(1 → 4)-d-GlcpNAc), and mediate numerous physiological and pathological processes. [11] Recent studies have highlighted the similarity between Galectin-3′s carbohydrate recognition domain and the so-called “galectin fold” present on the N-terminal domain of the S1 sub-unit of the SARS-CoV-2 spike protein. [12] The three-dimensional model of PpeL revealed that it consists of three β-prism domains tandemly arranged with each one presenting a different carbohydrate recognition domain (CRD). [13] The predicted amino acid sequence of CaCLR is a single transmembrane receptor with a typical carbohydrate recognition domain (CRD) at its C-terminus. [14] The interaction of multi-LacNAc (Galβ1-4GlcNAc)-containing N-(2-hydroxypropyl) methacrylamide (HPMA) copolymers with human galectin-1 (Gal-1) and the carbohydrate recognition domain (CRD) of human galectin-3 (Gal-3) was analyzed using NMR methods in addition to cryo-electron-microscopy and dynamic light scattering (DLS) experiments. [15] These regulatory effects occur extracellularly, through their carbohydrate recognition domain (CRD) interacting with glycans expressed on the virus surface, as well as endogenously, in a cell–cell interaction manner. [16] The carbohydrate recognition domain (CRD) has been identified within a cysteine-rich region in the lectin heavy subunit and has an amino acid sequence identity to the receptor-binding domain of hepatocyte growth factor (HGF). [17] Here, we investigate this question by introducing minor changes in ligand structure and characterizing the effects of these on ligand affinity to the carbohydrate recognition domain of galectin-3, using a combination of isothermal titration calorimetry, X-ray crystallography, NMR relaxation, and computational approaches including molecular dynamics (MD) simulations and grid inhomogeneous solvation theory (GIST). [18] The predicted CaGal-9 protein contained two non-identical carbohydrate recognition domains (CRDs), namely, N-CRD and C-CRD. [19] The predicted primary OmCTL structure contains a signal peptide, a single carbohydrate recognition domain (CRD) and an EPN/WND motif required for carbohydrate-binding specificity. [20] Furthermore, aortic rings assays demonstrated that the lectin could relax pre-contracted aortic rings with the participation of the carbohydrate recognition domain (CRD) and nitric oxide (NO) when endothelial tissue is preserved. [21] All predicted ToCTL proteins contained a single carbohydrate recognition domain (CRD). [22] AG interacts with carbohydrate recognition domain (CRD) 2 of galectin-9 with high affinity, and galectin-9 associates with transforming growth factor β-activated kinase 1 (TAK1) via CRD2 to trigger subsequent activation of extracellular signal-regulated kinase (ERK) as well as induction of the expression of matrix metalloproteinases (MMPs). [23] Cellintrinsic galectin3 harbors a functional carbohydrate recognition domain as determined by affinity purification. [24] Herein, we prepared the first library of steryl d-glucosides and determined that they preferentially signal through the carbohydrate recognition domain of human Mincle, rather than the amino acid consensus motif. [25] Galectin-1 (Gal-1) is the first member of galectin family, which has a carbohydrate recognition domain, specifically binds towards β-galactoside containing oligosaccharides. [26] Meanwhile, SCARA4, a SR-A member with a carbohydrate recognition domain instead of the SRCR domain at the C terminus, shows low affinity for modified LDL and very-low-density lipoprotein but binds in a Ca2+-independent manner. [27] Molecular- and cell-based assays indicate that glycan binding–triggered Gal-3 LLPS (or LLPS-like) is driven mainly by dynamic intermolecular interactions between the Gal-3 NT and the carbohydrate recognition domain (CRD) F-face, although NT–NT interactions appear to contribute to a lesser extent. [28] Galectins, or galactose binding proteins, are widely distributed in nature from sponges to humans and are defined by highly conserved carbohydrate recognition domains (CRDs). [29] CgCLec-TM1 was able to bind Escherichia coli and Vibrio splendidus through its carbohydrate recognition domain and then activated CgERK by inducing its phosphorylation. [30] The structural information reveals that it consists of a monovalent dimer composed of subunits with one Carbohydrate Recognition Domain (CRD), which is the main active site to interact with various glycoproteins, and carbohydrates in the body to regulate cellular functions. [31] In our results, SmCLEC4EL showed conserved synteny with CLEC4E-like genes from several fish species in genome, and possessed a typical type II transmembrane CTL architecture: an N-terminal intracellular region, a transmembrane domain and a C-terminal extracellular region which contained a predicted carbohydrate recognition domain (CRD). [32] The studies revealed that compound 7e was stable within the subsite C of galectin carbohydrate recognition domain while 6i fluctuated throughout the simulation. [33] Galectins also function as intracellular and extracellular disease regulators mainly through the binding of their carbohydrate recognition domain to glycoconjugates. [34] At first, the experimentally confirmed inhibitors were docked into all three selectins’ carbohydrate recognition domains to assess the suitability of the screening procedure. [35] The On-GRP possessed a carbohydrate recognition domain. [36] This association was reduced with a β-galactoside LacdiNAc (GalNAcβ1,4GlcNAc), a selective ligand of Gal-3, which binds to the carbohydrate recognition domain (CRD) in the Gal-3 molecule. [37] UA-LipoFuc5 was internalized through the C-type carbohydrate recognition domain of the cell membrane. [38] The carbohydrate recognition domain (CRD) is the key component of C-type lectins (CTLs) with the capacity to recognize and eliminate invading pathogens. [39] The combination of the 19F with standard proton saturation transfer difference (1H-STD-NMR) data, assisted by molecular dynamics (MD) simulations, permits us to successfully define this new binding epitope, where Man coordinates a Ca2+ ion of the lectin carbohydrate recognition domain (CRD) through the axial OH-2 and equatorial OH-3 groups, thus mimicking the Fuc/DC-SIGN binding architecture. [40] ABSTRACT Galectins are a family of proteins with conserved carbohydrate recognition domains (CRDs) that bind to specific glycans, including the glycans on the surface of pathogens, and therefore play a role in cytokine secretion, cell activation, migration, adhesion and apoptosis. [41] In this article, we used genetically encoded fragment‐based discovery (GE‐FBD) approach to identify glycopeptides that bind to the carbohydrate recognition domain of the human galectin‐3 (G3C). [42] Sequence analysis revealed that ChGal contains four carbohydrate recognition domains (CRDs), each containing the conserved carbohydrate-binding motifs H-NPR and WG-ER. [43] Using a novel monoclonal antibody (mAb) (Clone P4D2) that binds the C-terminal carbohydrate recognition domain (CRD) of galectin-9, we demonstrate unique agonistic properties resulting in MM cell apoptosis. [44] In the present study, open reading frame (ORF) encoding neck and carbohydrate recognition domain (NCRD) of goat conglutinin gene ligated to the vector pRSET-A was expressed in E. [45] Background: Fc-mannose-binding lectin (FcMBL), an engineered version of the blood opsonin MBL that contains the carbohydrate recognition domain (CRD) and flexible neck regions of MBL fused to the Fc portion of human IgG1, has been shown to bind various microbes and pathogen-associated molecular patterns (PAMPs). [46] In the current study, a novel C-type lectin receptor (named CgCLec-HTM) with a signal peptide, a carbohydrate recognition domain, a transmembrane domain, and a nonclassical ITAM (hemITAM) in the cytoplasmic tail was identified from oyster Crassostrea gigas. [47] Inhibitors of galectins have evolved from natural oligosaccharides toward more drug-like truncated galactoside scaffolds that only retain key specific interactions of the galactose scaffolds with the galectin carbohydrate recognition domains. [48]

Antigen Recognition Domain

This prevents damage to antigen recognition domains and recognition sites for secondary antibodies that can decrease the signal of immunodetection techniques. [1] This field has been revolutionized by the advent of chimeric antigen receptor (CAR) T cell therapy that is utilizing an antigen recognition domain to redirect patients’ T cells to selectively attack cancer cells. [2] Conventional polymerase chain reaction (PCR)-based HLA typing mainly focuses on the polymorphic exons encoding the antigen recognition domains. [3] Typically, the antigen recognition domain of CAR-T cells is a single-chain variable fragment (scFv) linked to a costimulatory domain and a cytoplasmic activation domain, such as CD28, 4-1BB, and CD3ζ [3, 4]. [4] The CAR includes an extracellular antigen recognition domain derived from an antibody, a transmembrane domain or hinge, and intracellular costimulation and signaling domains that activate the T cell. [5]

Target Recognition Domain

The majority of phase-variable Type III DNA methyltransferase genes sequenced to date have multiple alleles that differ in their central target recognition domain (TRD) and it is hypothesized that every allelic variant methylates a different target sequence and regulates the switching of expression of a distinct phasevarion. [1] The target recognition domain stabilizes the enlarged major groove via shape complementarity rather than base-specific interactions, permitting substrate diversity. [2] In this way, the catalytic center of the distal 3A2 is directed to the linker DNA, with its target recognition domain (TRD) loop and the catalytic loop inserted into the major groove and the minor groove, respectively. [3] In this work, a novel DNA circle capture probe with multiple target recognition domains was designed to develop an electrochemical biosensor for ultrasensitive detection of microRNA-21 (miRNA-21) and miRNA-155 simultaneously. [4]

Pattern Recognition Domain

In addition, we summarize the current practices in cluster analysis of spectroscopy and contrast these with cluster analysis literature from the machine learning and pattern recognition domain. [1] In computer vision and pattern recognition domain, dynamic research is going on in face recognition. [2] Multimodal learning, also known as multi-view learning, data integration, or data fusion, is an emerging field in signal processing, machine learning, and pattern recognition domains. [3] , have emerged through practices in pattern recognition domain. [4]

Speech Recognition Domain

Last but not least, we show that four promising defense methods for adversarial attack from the speech recognition domain become ineffective on SRSs against FAKEBOB, which calls for more effective defense methods. [1] In this paper, we propose to apply object detection methods from the vision domain on the speech recognition domain, by treating audio fragments as objects. [2]

Activity Recognition Domain

This requirement stimulates the advancement of the transfer learning research area that minimizes the use of labeled data by transferring knowledge from the existing activity recognition domain. [1] This study provides an efficient and convenient-to-use solution for the smartphone applications in human activity recognition domain. [2]

Visual Recognition Domain

This paper introduces an agent-centric approach to handle novelty in the visual recognition domain of handwriting recognition (HWR). [1] FeatherV1 is the first publicly available bird's plumage dataset for machine learning, and it can raise interest for a new task in fine-grained visual recognition domain. [2]

Substrate Recognition Domain

Multiple gene clusters consisting of cellulases and hemicellulases associated with substrate recognition domain were identified in the genome. [1] Here we present two crystal structures of the LNK substrate recognition domain, the SH2 domain, bound to phosphorylated motifs from JAK2 and EPOR, and biochemically define the basis for target recognition. [2]

Dna Recognition Domain

CamA contains an N-terminal domain for catalyzing methyl transfer, and a C-terminal DNA recognition domain. [1] In this chapter, we describe artificial control of mitochondrial transcription based on mtDNA sequence information with a new type of compounds termed MITO-PIPs, which encompasses two domains: pyrrole-imidazole polyamide as DNA recognition domain and mitochondrial penetrating peptide as the mitochondria-targeting domain. [2]

recognition domain 4

However, the fine details of its ligand specificity, and specifically that of carbohydrate-recognition domain 4, the most functionally relevant C-type lectin domain within the receptor, are not completely understood. [1] C-type carbohydrate-recognition domain 4 (CRD4) of the receptor contains the site for Ca2+-dependent interaction with sugars. [2]