Introduction to Receptor Mediating

What is/are Receptor Mediating?

Receptor Mediating - In this review, we summarize the current theories and knowledge of cholestatic itch, emphasizing MRGPRX4 as a bile acid and bilirubin receptor mediating cholestatic itch in humans. ^[1] We concluded that the LvAPN1 was involved in AHPND pathogenesis and acted as a VPAHPND toxin receptor mediating the toxin penetration into hemocytes. ^[2] RAGE is the main receptor mediating the pro-inflammatory signalling induced by AGEs. ^[3] VEGF binds and activates VEGF receptor 1 (VEGFR1) and VEGFR2, with VEGFR2 being the principal receptor mediating VEGF-induced angiogenesis while VEGFR1 has a negative regulatory effect on this process. ^[4] One of its functions is to act as a receptor mediating the ligand internalization. ^[5] Taken together, our data suggest that NudCL2 functions as an autophagy receptor mediating the selective degradation of mother centriole-capping CP110 to promote ciliogenesis, which is indispensable for embryo development in vertebrates. ^[6] Among them, D1R is the most abundantly expressed dopamine receptor in the CNS and is the central receptor mediating excitatory dopamine signaling in multiple dopaminergic pathways. ^[7] Although it is widely accepted that the neonatal Fc receptor, FcRn, is the receptor mediating IgG transfer across both the placenta and small intestine, it remains unclear whether FcRn also mediates serum IgG transfer across the mammary barrier to colostrum/milk, especially in large domestic animals. ^[8] The serotonin receptor mediating the suppressive effects of fluoxetine is uncertain, because serotonin antagonists with different patterns of receptor selectivity failed to reverse the effects of fluoxetine. ^[9] It is the central receptor mediating excitatory dopamine signaling in multiple dopaminergic pathways. ^[10] Experiments under controlled conditions show that UVR8 is the main photoreceptor mediating the phototropic response to narrowband UV-B radiation, and phototropins and cryptochromes control the response to narrowband blue light. ^[11] The two related peptides arginine vasopressin (AVP) and oxytocin (OT) play an essential role in peripheral and central stress adaptation and have a shared receptor mediating their function. ^[12] The UV RESISTANCE LOCUS 8 (UVR8) is a photoreceptor mediating photomorphogenic responses to UV-B. ^[13] Finally, males had higher levels of natural killer cells negative for CD16, a key receptor mediating antibody-dependent cell cytotoxicity, a major mechanism of antitumor efficacy by therapeutic antibodies such as elotuzumab. ^[14] Aryl hydrocarbon receptor (AhR) is an important receptor mediating the toxic effects of many environmental compounds, and is also involved in regulating tumor cell migration. ^[15] In addition, integrin-αV/β5 was just identified as the key receptor mediating Zika virus infection in the CNS. ^[16] These findings point to potentially an alternate receptor mediating the calcification response in the absence of RAGE. ^[17] To conclude, SARS-CoV-2 infection might damage to male reproductive system via ACE2 receptor mediating and male patients were reportedly slightly more affected than women by SARS-CoV-2 infections. ^[18] Conclusions Estrogen receptor α seems to be the predominant receptor mediating estrogen action in postpartum perineal and vaginal granulation tissue. ^[19] Angiotensin-converting enzyme 2 (ACE2), as a receptor mediating the cellular entry of SARS-CoV-2, has become a hot spot for researchers. ^[20] These findings imply that NQO2 works as a flavone receptor mediating autophagy and may contribute to other hepatic effects of flavonoids. ^[21] Cryptochrome 1 (CRY1) is the major photoreceptor mediating blue light-dependent photomorphogenic responses, such as inhibition of hypocotyl elongation. ^[22] In contrast to the growing body of evidence for the pleiotropic effects of the peptide, the receptor mediating these effects and the exact signaling cascades remain still unknown. ^[23] Cholecystokinin A receptor (CCKAR) is a key receptor mediating satiety. ^[24] Besides, we propose CD147, and not ACE2, as the leading receptor mediating S protein signalling in cardiac PC. ^[25] By assaying mutant strains lacking single or multiple methyl-accepting chemotaxis proteins, the receptor mediating the response to C2 to C12 alcohols was identified as McfP, the ortholog of the P. ^[26] Altogether, our data implicate Y5R as the main NPY receptor mediating its stimulatory effect on cell motility. ^[27] Sodium-taurocholate cotransporting polypeptide (NTCP) is the key receptor mediating HBV invasion, while other molecules also exhibit important roles in ensuring efficient and productive HBV infection. ^[28] The receptor was reported to be a novel membrane estrogen receptor mediating rapid non-genomic responses. ^[29] Using a cell-based functional assay, we found that TAS2R7 responds to a broad range of divalent and trivalent salts, including zinc, calcium, magnesium, copper, manganese, and aluminum, but not to potassium, suggesting TAS2R7 may act as a metal cation receptor mediating bitterness of divalent and trivalent salts. ^[30] In addition to its unstable and adhesive nature, BDNF can activate p75NTR, a receptor mediating cellular functions opposite to those of TrkB. ^[31] We examined the time-frame and host sites at which HBV integrates in HepG2 cells overexpressing sodium taurocholate co-transporting polypeptide (NTCP) receptor mediating HBV entry. ^[32] Purpose: Kinase insert domain receptor (KDR) is the primary vascular endothelial growth factor receptor mediating survival, growth, and migration of endothelial cells and is expressed also in various tumor cells through autocrine production. ^[33] The KD value of VU0255035 against the muscarinic receptor mediating nonselective cation channel activation was 17. ^[34] Analysis of a collection of stepwise- and multiple-deletion mutants of Ps29 revealed that the RS_RS07350 homolog (designated McpC) and McpP (chemoreceptor mediating both positive chemotaxis to phosphate and negative chemotaxis to maleate) are chemoreceptors for citrate. ^[35] Identification of a novel cell death receptor mediating IGFBP‐3‐induced anti‐tumor effects in breast and prostate cancer. ^[36] Porcine sialoadhesin (pSn) is a crucial porcine reproductive and respiratory syndrome virus (PRRSV) receptor mediating the attachment and internalization of virus into its major target cells, porcine alveolar macrophages (PAMs). ^[37] RATIONALE To elucidate the physiological function of APP, we sought to identify the cell-surface receptor mediating its effects on synaptic function. ^[38] In summary, these findings reveal that pSRA, which is predominantly expressed in alveolar macrophages is likely to be an important receptor mediating recognition and uptake of bacteria in pig lungs. ^[39] Here, we identify the target of NS1 as the mRNA export receptor complex, nuclear RNA export factor 1–nuclear transport factor 2-related export protein 1 (NXF1–NXT1), which is the principal receptor mediating docking and translocation of mRNAs through the nuclear pore complex via interactions with nucleoporins4,5. ^[40] Here, using immunostaining and Tf-flux assays, FACS analysis, and fluorescence imaging, we report localization of Tf receptor 1 (TfR1), the cognate Tf receptor mediating cellular holo-Tf (hTf) acquisition, to the apical brush border of the PT, with expression gradually declining along the PT in mouse and rat kidneys. ^[41] Taken together, our findings fully support the concept that S1P is a potent osteoanabolic molecule, although S1P3 is not the sole receptor mediating this influence. ^[42] Rhodopsin is a light-driven G protein-coupled receptor mediating signal transduction in eyes. ^[43] Although an existence of this feedback loop is well-documented, its precise mechanism, signaling pathways, and the particular E-type prostanoid (EP) receptor mediating this feedback are elusive. ^[44] These changes, induced by digoxin and marinobufagenin on GJIC and TER, were not observed on MDCK-R, a modified MDCK cell line that has a genetically induced insensitive α1 subunit, indicating that Na-K-ATPase acts as a receptor mediating the actions of both ECG. ^[45] Short-hairpin RNA gene silencing identified NOTCH2 as the key receptor mediating NOTCH effects on hMSC-TERT cells. ^[46] Anillin-actin binding protein (ANLN) has been identified as being involved in PI3K/PTEN signaling, which is critical in cell life/death control, and kinase insert domain receptor (KDR) encodes a key receptor mediating the cancer angiogenesis/metastasis switch. ^[47] CR3 is also uniquely expressed by human cervical epithelial cells where it is the key receptor mediating Neisseria gonorrhoeae (Ng) cervicitis. ^[48] EP2 is the dominant PGE2 receptor mediating the induction of COX‐2 at parturition, which can be attenuated by simultaneous activation of PI3K coupled to the EP4 receptor. ^[49]

Key Receptor Mediating

Finally, males had higher levels of natural killer cells negative for CD16, a key receptor mediating antibody-dependent cell cytotoxicity, a major mechanism of antitumor efficacy by therapeutic antibodies such as elotuzumab. ^[1] In addition, integrin-αV/β5 was just identified as the key receptor mediating Zika virus infection in the CNS. ^[2] Cholecystokinin A receptor (CCKAR) is a key receptor mediating satiety. ^[3] Sodium-taurocholate cotransporting polypeptide (NTCP) is the key receptor mediating HBV invasion, while other molecules also exhibit important roles in ensuring efficient and productive HBV infection. ^[4] Short-hairpin RNA gene silencing identified NOTCH2 as the key receptor mediating NOTCH effects on hMSC-TERT cells. ^[5] Anillin-actin binding protein (ANLN) has been identified as being involved in PI3K/PTEN signaling, which is critical in cell life/death control, and kinase insert domain receptor (KDR) encodes a key receptor mediating the cancer angiogenesis/metastasis switch. ^[6] CR3 is also uniquely expressed by human cervical epithelial cells where it is the key receptor mediating Neisseria gonorrhoeae (Ng) cervicitis. ^[7]

Important Receptor Mediating

Aryl hydrocarbon receptor (AhR) is an important receptor mediating the toxic effects of many environmental compounds, and is also involved in regulating tumor cell migration. ^[1] In summary, these findings reveal that pSRA, which is predominantly expressed in alveolar macrophages is likely to be an important receptor mediating recognition and uptake of bacteria in pig lungs. ^[2]

Principal Receptor Mediating

VEGF binds and activates VEGF receptor 1 (VEGFR1) and VEGFR2, with VEGFR2 being the principal receptor mediating VEGF-induced angiogenesis while VEGFR1 has a negative regulatory effect on this process. ^[1]