Introduction to Randomized Controlled Trial

Yet major prospective randomized-controlled trials defining the merits of AF ablation have consistently excluded patients requiring hemodialysis [1,3,8].

BACKGROUND The SlowMo study demonstrated the effects of SlowMo, an eight-session digitally supported reasoning intervention, on paranoia in a large-scale randomized-controlled trial with 362 participants with schizophrenia-spectrum psychosis.

METHOD A systematic review of randomized-controlled trials (RCTs) was conducted to investigate the efficacy of hydrocortisone in the prevention and curative treatment of post-traumatic stress symptoms.

Background Randomized-controlled trials demonstrate that high coronary heart disease (CHD) polygenic risk score modifies statin CHD relative risk reduction, but it is unknown if the association extends to statin users undergoing routine care.

The current study is a preliminary randomized-controlled trial (RCT) comparing I-CAT (n = 18) with treatment as usual (TAU; n = 18) in individuals in the early stages of SSD.

54%), randomized-controlled trials (26.

Methods A pilot randomized-controlled trial of HFIT system versus sham was conducted across 5 orthopedic and pain center sites in California, USA.

We investigated frailty and pre-frailty prevalence by 5 instruments in community-dwelling older adults enrolled to a randomized-controlled trial in 5 European countries.

Studies including adults aged ≥ 16 years with acute hypoxic respiratory failure and randomized-controlled trials that compared two different oxygenation devices (COT, NPPV, or HFNC) before tracheal intubation were included.

Further large and randomized-controlled trials that investigate dose-dependent effects of CGs in addition to contemporary therapy of heart failure and atrial fibrillation are needed.

If confirmed, these findings can help to inform patient selection and inclusion criteria for randomized-controlled trials evaluating IAF as rescue after MT.

Prospective randomized-controlled trials are necessary to confirm the previously collected data.

Seventeen randomized-controlled trials were included with a total of 1,477 participants.

Patients and methods: A randomized-controlled trial study was carried out in the operating room (OR) in Zagazig University Hospital including 92 patients.

Methods In a randomized-controlled trial, we examined the effects of OLP plus treatment as usual (TAU) compared to TAU alone on symptom reduction in people with allergic rhinitis (N = 54) over the course of two weeks.

Implications for a randomized-controlled trial are discussed.

Randomized-controlled trials have confirmed substantial reductions in lung cancer mortality with low-dose computed tomography (LDCT) screening.

BACKGROUND There is increasing evidence from randomized-controlled trials demonstrating that nutritional support improves clinical outcomes in the population of malnourished medical inpatients.

We believe that randomized-controlled trials comparing vonoprazan to PPIs are required to clarify suggestions in the original article by balancing management strategies after gastroduodenal ESD between the groups.

There is an urgent need for randomized-controlled trials.

Methods We conducted a three-armed randomized-controlled trial of CETA delivered in its standard form (8–12 sessions), a brief form (five-sessions), and a wait-control condition.

Literature searches were conducted in the following databases; ProQuest, MEDLINE, Ebsco, EMBASE, Cochrane, Scopus, and Science Direct for randomized-controlled trial studies.

Individual randomized-controlled trials for adult patients undergoing cardiac catheterization were included.

A randomized-controlled trial is required to determine the impact of omega-3 supplementation in treating these conditions in this population.

We conducted a systematic review, meta-analysis, trial sequential analysis (TSA), and meta-regression of randomized-controlled trials to ascertain the benefit of IL-6 blockade with tocilizumab for COVID-19.

prehabilitation studies were mostly cohort studies (41%) or randomized-controlled trials (38%) of multimodal (49%), or exercise-only (44%) interventions that were applied before surgery (94%).

We present a pre-registered (ACTRN12616000125426), double-blinded (medication), randomized-controlled trial that compared the effects of acute exposure to a natural (versus built) environment and medication (versus placebo) on Attention Network Task performance.

Subsequently, 31 studies from 29 observational studies and 2 randomized-controlled trials (RCTs), which included a total of 517 patients with TAK that met the inclusion and exclusion criteria, were selected.

METHODS This pragmatic open-label randomized-controlled trial evaluated 81 older adults hospitalized in an internal medicine ward and diagnosed with delirium.

Although certain predictors of response have been identified in this large single-center review, these findings need to be confirmed by a multicenter randomized-controlled trial to determine predictors of response to ATG for CLAD.

Methods In this randomized-controlled trial, totally 225 women with type 2 diabetes mellitus (T2DM) and VD deficiency were randomly allocated to five groups: (1) mindfulness, (2) mindfulness and VD, (3) mindfulness and placebo, (4) VD, and (5) placebo.

MethodsA prospective, randomized-controlled trial design is applied.

We conducted a systematic review of randomized-controlled trials (RCTs) to characterize the scope, methodology, and outcomes of research on interventions aimed at improving health literacy among these vulnerable populations.

Subsequently, 31 studies from 29 observational studies and 2 randomized-controlled trials (RCTs), which included a total of 517 patients with TAK that met the inclusion and exclusion criteria, were selected.

Thus, the adjunct potential of melatonin in clinical neurostimulation has not been evaluated under the umbrella of randomized-controlled trials and deserves increased attention as melatonin interacts and shares pathways relevant for noninvasive and invasive neurostimulation therapies.

MethodsIn a randomized-controlled trial, we assessed the benefits of the intervention firstly on pain and secondly on anxiety, as measured using numerical rating scales.

The amount of real-world data (RWD) available from sources other than randomized-controlled trials (RCTs) has grown ultra-rapidly in recent years.

As randomized-controlled trials (RCTs) are important in generating research evidence, we decided to investigate the extent, if any, the inferential statistical framework in published RCTs in child health research have changed over 10 years.

These findings lead to the set-up of a multi-center randomized-controlled trial, currently running, comparing basic to advanced laparoscopic techniques.

In two randomized-controlled trials, BHP was shown to improve breastfeeding initiation and duration of any and exclusive breastfeeding.

The inclusion criteria included randomized-controlled trials (RCTs), prospective or retrospective cohort studies that studied adult males (≥15years of age), conducted in SSA and published between January 2005 and April 2019 with an update from 2019 to 2020.

Most studies were either randomized-controlled trials (n=10) or observational studies (n=7) and study settings were both public and private.

There has been no prospective and adequately powered randomized-controlled trial to determine whether exercise, when compared to standard treatment, can normalize non-dipping (ND) in patients with hypertension.

STUDY DESIGN Observational cohort study nested within a randomized-controlled trial.

Methods We did a comprehensive search in electronic databases from inception through July 2020 for randomized-controlled trials, using the keywords “sodium-glucose cotransporter-2 inhibitor”, “dapagliflozin”, “heart failure”, “cardiovascular outcomes”, “major adverse cardiovascular events”, “all-cause mortality”, and “cardiovascular death”.

Data were based on the baseline sample of the “Sanadak” randomized-controlled trial.

Methods We searched six databases from inception until August 2021 for randomized-controlled trials and observational studies enrolling adult patients (≥ 16 years) with SCI from any cause requiring mechanical ventilation.

The next step is to conduct a randomized-controlled trial to compare the efficacy and safety of initial NKF to the standard cannulation in a non-selective patient population undergoing ERCP.

Methods Following the guidelines of the PRISMA statement, we conducted a systematic review, synthesizing the evidence from randomized-controlled trials (RCTs) investigating the efficacy of post-inpatient aftercare treatments for AN.

Discussion The study investigates the effectiveness of the iBA program for maternal depressive symptoms and psychological aggression toward children, as well as implementation outcomes, in a randomized-controlled trial.

Results A total of eight studies (three randomized-controlled trials, one prospective study, and four cross-sectional studies) were reviewed.

A recent randomized-controlled trial on platelet transfusions in preterm infants with PDA failed to show any benefit for liberal vs.

This report accompanies the RESPECT study, a randomized-controlled trial (RCT) comparing trastuzumab monotherapy with trastuzumab-plus-chemotherapy for early HER2-positive breast cancer.

Methods: A systematic review of the literature from the last 10 years was done by searching clinical trials and randomized-controlled trials on Pubmed that discuss nutrition, supplementation, and lifestyle changes associated with “Pancreatic Cancer.

enhanced standard clinical care (SCC+) will be administered in a cluster-randomized-controlled trial (RCT).

Methods and analysis: This is a single-center, open-label, parallel design, superiority randomized-controlled trial with 2 treatment arms.

We conducted a one-stage meta-analysis of reconstructed individual patient data (IPD) from randomized-controlled trials to summarize the effects of colchicine on cardiovascular outcomes in patients with CAD.

However, considering the number of included studies and potential limitations, more large-scale, head-to-head, well-designed randomized-controlled trials (RCTs) are needed to confirm these findings.

Risk of bias assessments conducted using MINORS criteria for the non-randomized, observational studies, and the Cochrane tool for the randomized-controlled trial.

Patients and Methods: A randomized-controlled trial (an interventional study) was conducted among 110 first grade medical students.

The significant increases in healthy lifestyle knowledge and physical activity found in the current study are promising, but a larger, randomized-controlled trial is needed to determine efficacy.

Objective:This systematic review and meta-analysis aimed to identify, summarize, and synthesize the available evidence from randomized-controlled trials (RCTs) investigating psychological interventions aimed at improving sleep and related secondary outcomes such as anxiety and depression in healthy young adults.

Randomized-controlled trials (RCT) that enrolled patients with laboratory-confirmed influenza receiving neuraminidase inhibitors (NAI) or baloxavir comparing to placebo were assessed.

A systematic review and meta-analysis of randomized-controlled trials (RCTs) examining growth and neurodevelopmental outcomes after zinc supplementation in preterm infants.

Real-world data offers advantages over randomized-controlled trials including expeditious access to and analysis of data and the availability of large numbers of patients.

METHODS Primary randomized-controlled trials (RCT's) of AOD's in post-menopausal women with documentation of vertebral fracture rates (VFR) or hip fracture rates (HFR) were extracted from meta-analyses and PubMed through February 2021.

In one recent randomized-controlled trial, HBsAg loss rates at 72 weeks were superior in the Peg-IFN and tenofovir (TDF)-treated patients as compared to patients receiving Peg-IFN alone or TDF alone (9% vs.

Background Randomized-controlled trials of messenger RNA (mRNA) vaccine protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) included relatively few elderly participants.

Methods: In strict accordance with the inclusion and exclusion criteria, the Cochrane Library, Embase, Web of Science, and PubMed were retrieved for randomized-controlled trials (from 1980 to 2021).

The Acute Venous Thrombosis: Thrombus Removal with Adjunctive Catheter-Directed Thrombolysis (ATTRACT) trial is the largest and most comprehensive randomized-controlled trial to date evaluating CDT compared to anticoagulation alone for the treatment of acute symptomatic proximal lower extremity DVT.

Searches for empirical randomized-controlled trials of psychological interventions with children in African countries were carried out in major databases.

Methods This nonrandomized-controlled trial was conducted from March 2015 to June 2019.

However, further double blind, randomized-controlled trials are warranted.

DESIGN A stepped wedge cluster randomized-controlled trial was conducted.

METHODS A randomized-controlled trial was conducted on 210 primipara women.

Methods In this multicenter randomized-controlled trial, participants were randomized to standard generalized counseling or opioid-specific perioperative counseling.

Results Six randomized-controlled trials were included in the literature review of postoperative pain and adverse effects.

METHODS We will conduct a prospective, single-blind, pragmatic, randomized-controlled trial to compare our tailored multi-disciplinary perioperative pathway against current standard of care practices.

RESULTS Four randomized-controlled trials, one open-label clinical study and one case series reported on the efficacy of ketamine/esketamine on subjective measures of general functioning.

A double blinded, randomized-controlled trial (RCT) from the authors’ center demonstrated that supplementation with a multi-strain probiotic preparation for 7 days leads to a decrease in the rate of gastrointestinal Candida colonisation by 35%, a reduction in the rate of candiduria by 50%, and a trend toward a lower risk of candidemia [2].

This article presents the results of a prospective randomized-controlled trial investigating the effects of a digital decision support and feedback system, which includes two components of patient-specific recommendations: (a) a clinical strategy recommendation and (b) adaptive recommendations for patients at risk for treatment failure.

Methods: ESCAPE NA1 was a multicenter randomized-controlled trial comparing medical treatments nerinetide vs.

The findings of the study are in contrast to two previous randomized-controlled trials reporting decreased pain scores and opioid requirements for up to 72 hr after robotic-assisted hysterectomy and laparoscopic hand-assisted donor nephrectomy with the use of LB compared with BH.

In a prospective randomized-controlled trial, 85 patients with knee OA (Kellgren-Lawrence 2) were randomized to receive a single intraarticular injection of HYAJOINT Plus (3 ml, 20 mg/ml) followed by 3 ml PRP (the combined-injection group, N = 43) or a single injection of 3 ml PRP (the one-injection group, N = 42).

6 to state “we now have two randomized-controlled trials that would not demonstrate a marked effect of the drug compared to placebo.

Phase 3 randomized-controlled trials have provided promising results of COVID-19 vaccine efficacy, ranging from 50-95% against symptomatic disease as the primary endpoints, resulting in emergency use authorization/listing for several vaccines.

Materials and methods We conducted a single-center, double-blind, randomized-controlled trial comparing Oral Acetazolamide plus Corrected body (prone) position (CP+A) versus Corrected body (prone) position alone(CP−A) from January 2014 to September 2015 in the Neurosurgery ward of Shariati Teaching Hospital, Tehran University of Medical Sciences, Tehran, Iran.

The lack of high-quality evidence-based studies including randomized-controlled trials and longitudinal data to guide clinicians to develop the optimal management of this condition is problematic.

This paper outlines the protocol of the LetSync study, a pilot randomized-controlled trial of an mHealth app intervention developed using the Framework of Dyadic HIV Care Engagement to improve care-engagement outcomes among Black sexual-minority male couples living with HIV.

Meta-analysis of randomized-controlled trials (RCTs) aimed at improving growth after transplantation has evidenced that steroid minimization by itself is an effective approach in pre-pubertal children; however, several patients still require GH therapy, if the reduced exposure to steroids is not a satisfactory measure [7, 8].

As a contribution to the growing literature on women's empowerment in agriculture, this article draws on a randomized-controlled trial (RCT) to evaluate a gender empowerment project among coffee producers in Honduras.

DESIGN Single-blinded, randomized-controlled trial.

Patients and Methods: We conducted a two-group randomized-controlled trial in 42 consecutive patients undergoing a PAO for symptomatic developmental dysplasia of the hip (DDH).

Methods This study was a single centre, prospective, patient-, observer-, and surgeon-blinded, randomized-controlled trial in which 90 patients undergoing an open abdominal hysterectomy with a midline incision were randomized to receive a TAP block with plain bupivacaine (group bupivacaine), liposomal bupivacaine (group liposomal), or a mixture of liposomal bupivacaine and plain bupivacaine (group mixture).

The present randomized-controlled trial incorporated virtual reality (VR) technology into Approach Bias Modification (ABM) to improve efficacy.

Methods: In this study, we analyze outcome and long-term follow-up data from the EVIDENT study, a large (N = 1,013) randomized-controlled trial comparing an Internet intervention for depression (Deprexis) with care as usual.

ELIGIBILITY CRITERIA We included registered randomized-controlled trials published in journals between January 2015 and December 2019.

Patients and methods In this randomized-controlled trial, a total of 40 adult patients (13 males, 27 females; mean age: 47.

Furthermore, propensity-score matching (PSM) was applied to mimic randomized-controlled trials and reduce selection bias.

Methods A prospective, randomized-controlled trial design is applied.