Introduction to Randomized Clinical
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Randomized Clinical sentence examples within double blind placebo
Randomized Clinical sentence examples within intensive care unit
Effect of a buffered crystalloid solution vs saline on acute kidney injury among patients in the intensive care unit: the SPLIT randomized clinical trial.
Effect of a buffered crystalloid solution vs saline on acute kidney injury among patients in the intensive care unit: the SPLIT randomized clinical trial.
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METHODS
The sample of this prospective, parallel two-armed, single-blind non-randomized clinical trial study included 86 intubated patients treated in the cardiovascular surgery intensive care unit between September 2016 and December 2017.
METHODS
The sample of this prospective, parallel two-armed, single-blind non-randomized clinical trial study included 86 intubated patients treated in the cardiovascular surgery intensive care unit between September 2016 and December 2017.
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Randomized Clinical sentence examples within acute ischemic stroke
How frequently this discrepancy occurs is elegantly illustrated in the MR CLEAN (Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands) registry study where operator mTICI and core laboratory mTICI scores were compared.
How frequently this discrepancy occurs is elegantly illustrated in the MR CLEAN (Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands) registry study where operator mTICI and core laboratory mTICI scores were compared.
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Methods: We included patients from the MR CLEAN trial (Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands) who received good quality noncontrast CT images 24 hours and 1 week after stroke onset.
Methods: We included patients from the MR CLEAN trial (Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands) who received good quality noncontrast CT images 24 hours and 1 week after stroke onset.
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Randomized Clinical sentence examples within cross sectional study
This cross-sectional study assesses the frequency and thoroughness of reporting of sociodemographic variables in randomized clinical trials published in 5 high-impact health journals from January 2014 to July 2020.
This cross-sectional study assesses the frequency and thoroughness of reporting of sociodemographic variables in randomized clinical trials published in 5 high-impact health journals from January 2014 to July 2020.
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Results: Four studies were included in the review (3 cross-sectional studies and 1 nonrandomized clinical trial).
Results: Four studies were included in the review (3 cross-sectional studies and 1 nonrandomized clinical trial).
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Randomized Clinical sentence examples within progression free survival
METHODS
This is a systematic review and meta-analysis of randomized clinical trials (RCTs) on the use of metformin as adjunctive therapy when combined with standard chemotherapy on the outcomes of progression-free survival (PFS), overall survival (OS), overall response rate (ORR), and clinical benefit rate (CBR).
METHODS
This is a systematic review and meta-analysis of randomized clinical trials (RCTs) on the use of metformin as adjunctive therapy when combined with standard chemotherapy on the outcomes of progression-free survival (PFS), overall survival (OS), overall response rate (ORR), and clinical benefit rate (CBR).
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Median overall (OS) and progression-free survival (PFS) outcomes were summarized for targeted cancer drugs that were evaluated as monotherapies in clinical trials, contributions of targeted drugs to combination therapies in terms of survival benefit were analyzed, survival outcomes of FDA-approved first-line targeted therapies in different cancers were investigated, and the correlation between the absolute OS gain (ΔOS) and PFS gain (ΔPFS) as well as the hazard ratios for PFS (HRPFS) and OS (HROS) between comparative arms of available randomized clinical trials was evaluated.
Median overall (OS) and progression-free survival (PFS) outcomes were summarized for targeted cancer drugs that were evaluated as monotherapies in clinical trials, contributions of targeted drugs to combination therapies in terms of survival benefit were analyzed, survival outcomes of FDA-approved first-line targeted therapies in different cancers were investigated, and the correlation between the absolute OS gain (ΔOS) and PFS gain (ΔPFS) as well as the hazard ratios for PFS (HRPFS) and OS (HROS) between comparative arms of available randomized clinical trials was evaluated.
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Randomized Clinical sentence examples within coronary artery disease
Currently, no large or randomized clinical studies have assessed the incidence of cardiovascular events in patients with endometriosis in Asia to investigate whether incident EM is associated with a higher risk of new-onset coronary artery disease (CAD).
Currently, no large or randomized clinical studies have assessed the incidence of cardiovascular events in patients with endometriosis in Asia to investigate whether incident EM is associated with a higher risk of new-onset coronary artery disease (CAD).
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Management of concomitant coronary artery disease (CAD) in these patients remains controversial with no randomized clinical trials to guide decision making in this cohort.
Management of concomitant coronary artery disease (CAD) in these patients remains controversial with no randomized clinical trials to guide decision making in this cohort.
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Randomized Clinical sentence examples within percutaneous coronary intervention
BACKGROUND
Recent guidelines and randomized clinical trials favor the multivessel percutaneous coronary intervention (MV-PCI) strategy undertaken immediately or staged after primary PCI in patients with ST-segment elevation myocardial infarction (STEMI) and multivessel disease.
BACKGROUND
Recent guidelines and randomized clinical trials favor the multivessel percutaneous coronary intervention (MV-PCI) strategy undertaken immediately or staged after primary PCI in patients with ST-segment elevation myocardial infarction (STEMI) and multivessel disease.
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Randomized clinical trials showed no improvement in the rates of mortality or myocardial infarction with revascularization (largely by percutaneous coronary intervention) compared with optimal medical therapy alone, even in the setting of moderate to severe ischemia.
Randomized clinical trials showed no improvement in the rates of mortality or myocardial infarction with revascularization (largely by percutaneous coronary intervention) compared with optimal medical therapy alone, even in the setting of moderate to severe ischemia.
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Randomized Clinical sentence examples within body mass index
Key Points Question What is the effect of providing an intervention to prevent childhood dental caries earlier (during pregnancy and at ages 6, 12, and 18 months) rather than later (aged 24, 30, and 36 months) on intake of unhealthy foods and body mass index among Aboriginal and/or Torres Strait Islander children at age 36 months? Findings In this secondary analysis of 448 mothers and 454 children enrolled in a randomized clinical trial, no differences in discretionary food intake were found between 2 groups of children, but those who received the intervention earlier had greater z scores for weight, arm circumference, and body mass index than children who received the intervention later.
Key Points Question What is the effect of providing an intervention to prevent childhood dental caries earlier (during pregnancy and at ages 6, 12, and 18 months) rather than later (aged 24, 30, and 36 months) on intake of unhealthy foods and body mass index among Aboriginal and/or Torres Strait Islander children at age 36 months? Findings In this secondary analysis of 448 mothers and 454 children enrolled in a randomized clinical trial, no differences in discretionary food intake were found between 2 groups of children, but those who received the intervention earlier had greater z scores for weight, arm circumference, and body mass index than children who received the intervention later.
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Design, Setting, and Participants
This double-masked, placebo-controlled, 48-week, phase 2 randomized clinical trial was conducted among adults with type 2 diabetes, body mass index between 28 and 40, and glycated hemoglobin (HbA1c) levels between 6.
Design, Setting, and Participants
This double-masked, placebo-controlled, 48-week, phase 2 randomized clinical trial was conducted among adults with type 2 diabetes, body mass index between 28 and 40, and glycated hemoglobin (HbA1c) levels between 6.
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Randomized Clinical sentence examples within control group n
DESIGN
In this randomized clinical trial, 174 primiparous women in their first stage of labor were selected and assigned to three groups: GB21 acupressure group (n = 58), sham group (n = 58), and control group (n = 58).
DESIGN
In this randomized clinical trial, 174 primiparous women in their first stage of labor were selected and assigned to three groups: GB21 acupressure group (n = 58), sham group (n = 58), and control group (n = 58).
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Materials and Methods: In this randomized clinical trial study, 126 women who were referred to Afzalipour Infertility Center between December 2018 to December 2019 undergoing in vitro fertilization/intracytoplasmic sperm injection cycles were enrolled and assigned to two groups of: a case (n = 62) and a control group (n = 64).
Materials and Methods: In this randomized clinical trial study, 126 women who were referred to Afzalipour Infertility Center between December 2018 to December 2019 undergoing in vitro fertilization/intracytoplasmic sperm injection cycles were enrolled and assigned to two groups of: a case (n = 62) and a control group (n = 64).
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Randomized Clinical sentence examples within real clinical practice
In the resolution of the Expert panel, it was stated that according data from randomized clinical trials and real clinical practice and due to low immunogenic potential of Erelzi, it can be used in initial therapy and in switching from other bDMARDs therapy in patients, who develop adverse reactions or face loss of their therapy effectiveness.
In the resolution of the Expert panel, it was stated that according data from randomized clinical trials and real clinical practice and due to low immunogenic potential of Erelzi, it can be used in initial therapy and in switching from other bDMARDs therapy in patients, who develop adverse reactions or face loss of their therapy effectiveness.
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Cytokine-targeted therapy using antibodies against TNF-α and antibodies to IL-12/IL-23 have already shown high efficiency and safety in randomized clinical trials, as well as in real clinical practice in patients with IBD.
Cytokine-targeted therapy using antibodies against TNF-α and antibodies to IL-12/IL-23 have already shown high efficiency and safety in randomized clinical trials, as well as in real clinical practice in patients with IBD.
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Randomized Clinical sentence examples within real world setting
Though, there is a tremendous gap between the outcomes in randomized clinical trials and real-world settings, where long-term outcomes are not as good as expected.
Though, there is a tremendous gap between the outcomes in randomized clinical trials and real-world settings, where long-term outcomes are not as good as expected.
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The performance of CGM systems in children is important, since they have benefits for glycemic control, in pediatric and in adult subjects, as proven in randomized clinical trials and in real-world settings.
The performance of CGM systems in children is important, since they have benefits for glycemic control, in pediatric and in adult subjects, as proven in randomized clinical trials and in real-world settings.
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Randomized Clinical sentence examples within double blinded placebo
METHODS
This study was a multicenter, double-blinded, placebo-controlled, randomized clinical trial of 130 participants, comparing bilateral infiltration of puborectalis and iliococcygeus muscles with 0.
METHODS
This study was a multicenter, double-blinded, placebo-controlled, randomized clinical trial of 130 participants, comparing bilateral infiltration of puborectalis and iliococcygeus muscles with 0.
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Randomized Clinical sentence examples within systematic literature search
Methods: A systematic literature search was performed in PubMed and Ovid for randomized clinical trials (RCTs) comparing AI-aided colonoscopy with conventional colonoscopy for polyp detection.
Methods: A systematic literature search was performed in PubMed and Ovid for randomized clinical trials (RCTs) comparing AI-aided colonoscopy with conventional colonoscopy for polyp detection.
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Data Synthesis A systematic literature search on randomized clinical trials (RCTs), nonrandomized trials and other systematic reviews was performed.
Data Synthesis A systematic literature search on randomized clinical trials (RCTs), nonrandomized trials and other systematic reviews was performed.
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Randomized Clinical sentence examples within academic medical center
To inform our local treatment algorithms in the absence of randomized clinical trial results, we performed a rapid analysis of the first 11 hospitalized COVID-19 patients treated with tocilizumab at our academic medical center.
To inform our local treatment algorithms in the absence of randomized clinical trial results, we performed a rapid analysis of the first 11 hospitalized COVID-19 patients treated with tocilizumab at our academic medical center.
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Studies included an initial workplace pilot study, two workplace randomized clinical trials (RCTs), one RCT in a health care system, and two pilot implementation studies conducted in a workplace and in an academic medical center.
Studies included an initial workplace pilot study, two workplace randomized clinical trials (RCTs), one RCT in a health care system, and two pilot implementation studies conducted in a workplace and in an academic medical center.
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Randomized Clinical sentence examples within single center open
Methods Between June 28, 2017, and June 29, 2019, a single-center, open-label, non-inferiority, randomized clinical trial was conducted at the Department of General Surgery, Ruijin Hospital (North), Shanghai Jiaotong University School of Medicine in Shanghai, China.
Methods Between June 28, 2017, and June 29, 2019, a single-center, open-label, non-inferiority, randomized clinical trial was conducted at the Department of General Surgery, Ruijin Hospital (North), Shanghai Jiaotong University School of Medicine in Shanghai, China.
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Methods
This study was a single center open-label randomized clinical trial which included adult pneumonia patients using vancomycin in Peking University First Hospital.
Methods
This study was a single center open-label randomized clinical trial which included adult pneumonia patients using vancomycin in Peking University First Hospital.
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Randomized Clinical sentence examples within single center prospective
Randomized Clinical sentence examples within cognitive behavioral therapy
Key Points Question Is a single-session pain relief class noninferior to 8 sessions of cognitive behavioral therapy (CBT) at 3 months after treatment? Findings In this 3-arm randomized clinical trial that included 263 adults with chronic low back pain, a single-session pain management skills class was noninferior to 8 weeks of CBT and superior to a health education class for pain catastrophizing and multiple secondary outcomes at 3 months after treatment.
Key Points Question Is a single-session pain relief class noninferior to 8 sessions of cognitive behavioral therapy (CBT) at 3 months after treatment? Findings In this 3-arm randomized clinical trial that included 263 adults with chronic low back pain, a single-session pain management skills class was noninferior to 8 weeks of CBT and superior to a health education class for pain catastrophizing and multiple secondary outcomes at 3 months after treatment.
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Key Points Question What is the effectiveness of collaborative care with cognitive behavioral therapy for treating adolescents with persistent postconcussive symptoms? Findings In this randomized clinical trial of 200 adolescents, those who received collaborative care reported fewer postconcussive symptoms at 3 and 12 months and higher health-related quality of life at 12 months compared with a control group receiving usual care.
Key Points Question What is the effectiveness of collaborative care with cognitive behavioral therapy for treating adolescents with persistent postconcussive symptoms? Findings In this randomized clinical trial of 200 adolescents, those who received collaborative care reported fewer postconcussive symptoms at 3 and 12 months and higher health-related quality of life at 12 months compared with a control group receiving usual care.
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Randomized Clinical sentence examples within multicenter double blind
Design, Setting, and Participants
This multicenter, double-blind, placebo-controlled randomized clinical trial was conducted at the First Affiliated Hospital of Anhui Medical University in Hefei, China (lead site), and 12 other tertiary hospitals in Anhui Province, China.
Design, Setting, and Participants
This multicenter, double-blind, placebo-controlled randomized clinical trial was conducted at the First Affiliated Hospital of Anhui Medical University in Hefei, China (lead site), and 12 other tertiary hospitals in Anhui Province, China.
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Design, Setting, and Participants
This multicenter, double-blind, active-comparator, superiority randomized clinical trial enrolled patients from April 27, 2015, to May 16, 2019, who were aged 18 to 55 years and had been diagnosed with multiple sclerosis per 2010 McDonald criteria, with a relapsing course from the onset, Expanded Disability Status Scale (EDSS) scores of 0 to 5.
Design, Setting, and Participants
This multicenter, double-blind, active-comparator, superiority randomized clinical trial enrolled patients from April 27, 2015, to May 16, 2019, who were aged 18 to 55 years and had been diagnosed with multiple sclerosis per 2010 McDonald criteria, with a relapsing course from the onset, Expanded Disability Status Scale (EDSS) scores of 0 to 5.
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Randomized Clinical sentence examples within metastatic colorectal cancer
Key Points Question Does sequential scheduling of bevacizumab administration in combination with chemotherapy improve treatment efficacy in patients with metastatic colorectal cancer in keeping with the tumor vascular normalization hypothesis? Findings In this phase 3 randomized clinical trial of 230 patients, the primary end point objective response rate did not significantly differ between the sequential and the concomitant schedule of bevacizumab administration in combination with standard oxaliplatin-based regimens.
Key Points Question Does sequential scheduling of bevacizumab administration in combination with chemotherapy improve treatment efficacy in patients with metastatic colorectal cancer in keeping with the tumor vascular normalization hypothesis? Findings In this phase 3 randomized clinical trial of 230 patients, the primary end point objective response rate did not significantly differ between the sequential and the concomitant schedule of bevacizumab administration in combination with standard oxaliplatin-based regimens.
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Our aim was to assess the potential regional differences in outcomes among patients with metastatic colorectal cancer (mCRC) participating in international randomized clinical trials (RCTs).
Our aim was to assess the potential regional differences in outcomes among patients with metastatic colorectal cancer (mCRC) participating in international randomized clinical trials (RCTs).
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Randomized Clinical sentence examples within multicenter open label
STUDY DESIGN
The MeDiGes study was a multicenter, open-label, parallel arms, randomized clinical trial performed at two hospitals in Málaga (Spain), enrolling women with GDM who needed pharmacological treatment.
STUDY DESIGN
The MeDiGes study was a multicenter, open-label, parallel arms, randomized clinical trial performed at two hospitals in Málaga (Spain), enrolling women with GDM who needed pharmacological treatment.
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We conducted a phase lll, multicenter, open-label, randomized clinical trial on mCRC patients treated with panitumumab.
We conducted a phase lll, multicenter, open-label, randomized clinical trial on mCRC patients treated with panitumumab.
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Randomized Clinical sentence examples within clinical decision making
To optimize clinical decision-making, we conducted a systematic review and meta-analysis of published randomized clinical trials to characterize the efficacy and the risk of adverse events (AEs) in patients treated with ICIs plus anti-VEGF therapy.
To optimize clinical decision-making, we conducted a systematic review and meta-analysis of published randomized clinical trials to characterize the efficacy and the risk of adverse events (AEs) in patients treated with ICIs plus anti-VEGF therapy.
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reporting is particularly important for randomized clinical trials (RCTs) because these may directly influence clinical decision making, but abstracts are also a key component of all original articles.
reporting is particularly important for randomized clinical trials (RCTs) because these may directly influence clinical decision making, but abstracts are also a key component of all original articles.
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Randomized Clinical sentence examples within prospective double blind
Methods: This prospective, double-blind, parallel-group, randomized clinical trial was conducted to compare the effect of topical use of intravenous (IV) TXA compared with PANP on controlling anterior epistaxis in patients who take aspirin or clopidogrel.
Methods: This prospective, double-blind, parallel-group, randomized clinical trial was conducted to compare the effect of topical use of intravenous (IV) TXA compared with PANP on controlling anterior epistaxis in patients who take aspirin or clopidogrel.
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Material and Methods: A prospective, double-blind randomized clinical trial involving adult patients undergoing elective hip surgery, performed under subarachnoid block.
Material and Methods: A prospective, double-blind randomized clinical trial involving adult patients undergoing elective hip surgery, performed under subarachnoid block.
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Randomized Clinical sentence examples within phase 3 double
Methods: TrilynX is a multinational, Phase 3, double-blind, placebo-controlled, randomized clinical study assessing the efficacy of xevinapant in combination with concurrent CRT compared with placebo in combination with CRT for LA-HNSCC.
Methods: TrilynX is a multinational, Phase 3, double-blind, placebo-controlled, randomized clinical study assessing the efficacy of xevinapant in combination with concurrent CRT compared with placebo in combination with CRT for LA-HNSCC.
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Design, Setting, and Participants
This phase 3, double-blinded, randomized clinical trial included healthy adults aged 18 to 45 years randomized to 1 of three 3A-HBV groups or 1 control group receiving 1A-HBV.
Design, Setting, and Participants
This phase 3, double-blinded, randomized clinical trial included healthy adults aged 18 to 45 years randomized to 1 of three 3A-HBV groups or 1 control group receiving 1A-HBV.
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Randomized Clinical sentence examples within stepped wedge cluster
DESIGN, SETTING, AND PARTICIPANTS
Two-arm, single-blind (blinded outcomes assessor), stepped-wedge, cluster-randomized clinical trial.
DESIGN, SETTING, AND PARTICIPANTS
Two-arm, single-blind (blinded outcomes assessor), stepped-wedge, cluster-randomized clinical trial.
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Design, Setting, and Participants
HuCare2 was a multicenter, incomplete, stepped-wedge cluster randomized clinical trial, conducted from May 30, 2016, to August 28, 2019, in three 5-center clusters of cancer centers representative of hospital size and geographic location in Italy.
Design, Setting, and Participants
HuCare2 was a multicenter, incomplete, stepped-wedge cluster randomized clinical trial, conducted from May 30, 2016, to August 28, 2019, in three 5-center clusters of cancer centers representative of hospital size and geographic location in Italy.
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Randomized Clinical sentence examples within large sample size
Randomized Clinical sentence examples within patients undergoing elective
METHODS
This double-blind randomized clinical trial was conducted in patients undergoing elective oesophagogastroduodenoscopy, who met the inclusion criteria.
METHODS
This double-blind randomized clinical trial was conducted in patients undergoing elective oesophagogastroduodenoscopy, who met the inclusion criteria.
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METHODS: This was a subinvestigation of a blinded, parallel-group, randomized clinical trial of patients undergoing elective aortic valve replacement surgery at the Cleveland Clinic main campus, titled “Effect of 6% Hydroxyethyl Starch 130/0.
METHODS: This was a subinvestigation of a blinded, parallel-group, randomized clinical trial of patients undergoing elective aortic valve replacement surgery at the Cleveland Clinic main campus, titled “Effect of 6% Hydroxyethyl Starch 130/0.
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Randomized Clinical sentence examples within neonatal intensive care
Methods This single-blind randomized clinical trial was performed over the period between February 2019 and March 2020 in the neonatal intensive care unit of Babol Rouhani Hospital, Iran.
Methods This single-blind randomized clinical trial was performed over the period between February 2019 and March 2020 in the neonatal intensive care unit of Babol Rouhani Hospital, Iran.
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Design, Setting, and Participants
This cohort study analyzed the Mega Donna Mega study, a randomized clinical trial that provided enteral fatty acid supplementation at 3 neonatal intensive care units in Sweden.
Design, Setting, and Participants
This cohort study analyzed the Mega Donna Mega study, a randomized clinical trial that provided enteral fatty acid supplementation at 3 neonatal intensive care units in Sweden.
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Randomized Clinical sentence examples within systolic blood pressure
We included all randomized clinical trials (RCTs) evaluating the effects of inositol supplementation on systolic blood pressure (SBP) and/or diastolic blood pressure (DBP) in humans.
We included all randomized clinical trials (RCTs) evaluating the effects of inositol supplementation on systolic blood pressure (SBP) and/or diastolic blood pressure (DBP) in humans.
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Randomized clinical trials on human subjects, studies that measured systolic blood pressure (SBP) and diastolic blood pressure (DBP) as outcomes, and studies that measured plasma glucose level as the outcome were included.
Randomized clinical trials on human subjects, studies that measured systolic blood pressure (SBP) and diastolic blood pressure (DBP) as outcomes, and studies that measured plasma glucose level as the outcome were included.
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Randomized Clinical sentence examples within open label non
Randomized Clinical sentence examples within transcatheter aortic valve
Since then, transcatheter aortic valve implantation (TAVI) has been expanding to a choice of treatment of aortic valve stenosis (AS) by conducting a large-scale randomized clinical trial in prohibitive risk, high-risk, intermediate risk, and low risk patients.
Since then, transcatheter aortic valve implantation (TAVI) has been expanding to a choice of treatment of aortic valve stenosis (AS) by conducting a large-scale randomized clinical trial in prohibitive risk, high-risk, intermediate risk, and low risk patients.
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Tamburino C, Bleiziffer S, Thiele H, Scholtz S, Hildick-Smith D, Cunnington M, Wolf A, Barbanti M, Tchetchè D, Garot P, Pagnotta P, Gilard M, Bedogni F, Van Belle E, Vasa-Nicotera M, Chieffo A, Deutsch O, Kempfert J, Søndergaard L, Butter C, Trillo-Nouche R, Lotfi S, Möllmann H, Joner M, Abdel-Wahab M, Bogaerts K, Hengstenberg C, Capodanno D (2020) Comparison of self-expanding bioprostheses for transcatheter aortic valve replacement in patients with symptomatic severe aortic stenosis: SCOPE 2 randomized clinical trial.
Tamburino C, Bleiziffer S, Thiele H, Scholtz S, Hildick-Smith D, Cunnington M, Wolf A, Barbanti M, Tchetchè D, Garot P, Pagnotta P, Gilard M, Bedogni F, Van Belle E, Vasa-Nicotera M, Chieffo A, Deutsch O, Kempfert J, Søndergaard L, Butter C, Trillo-Nouche R, Lotfi S, Möllmann H, Joner M, Abdel-Wahab M, Bogaerts K, Hengstenberg C, Capodanno D (2020) Comparison of self-expanding bioprostheses for transcatheter aortic valve replacement in patients with symptomatic severe aortic stenosis: SCOPE 2 randomized clinical trial.
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Randomized Clinical sentence examples within total knee arthroplasty
Methods A double-blind randomized clinical trial was conducted on 40 patients aged 40 - 70 years under spinal anesthesia candidate for total knee arthroplasty in Golestan hospital, Ahwaz, Iran, in 2017-2018.
Methods A double-blind randomized clinical trial was conducted on 40 patients aged 40 - 70 years under spinal anesthesia candidate for total knee arthroplasty in Golestan hospital, Ahwaz, Iran, in 2017-2018.
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Methods: This prospective randomized clinical investigation was undertaken at a tertiary care centre after obtaining written informed consent from ASA I&II patients scheduled for elective total knee arthroplasty under spinal anaesthesia, belonging to the age group of 18 and 60 years.
Methods: This prospective randomized clinical investigation was undertaken at a tertiary care centre after obtaining written informed consent from ASA I&II patients scheduled for elective total knee arthroplasty under spinal anaesthesia, belonging to the age group of 18 and 60 years.
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Randomized Clinical sentence examples within first line therapy
Study Selection
Randomized clinical trials (RCTs) published in English that had at least 12 months of follow-up and compared clinical outcomes of ablation vs AADs as first-line therapy in adults with AF.
Study Selection
Randomized clinical trials (RCTs) published in English that had at least 12 months of follow-up and compared clinical outcomes of ablation vs AADs as first-line therapy in adults with AF.
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The lack of randomized clinical trials and biomarker studies that analyze the optimal therapeutic sequence for patients with BRAFV600 mutated patients makes the choice of a first-line therapy difficult.
The lack of randomized clinical trials and biomarker studies that analyze the optimal therapeutic sequence for patients with BRAFV600 mutated patients makes the choice of a first-line therapy difficult.
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Randomized Clinical sentence examples within second line setting
Methods Randomized clinical trials evaluating systemic agents in first and second line settings in aHCC from inception to April 2020 were identified by searching PubMed, EMBASE, and Cochrane Databases and the annual ASCO and ESMO conferences from 2017 to 2020.
Methods Randomized clinical trials evaluating systemic agents in first and second line settings in aHCC from inception to April 2020 were identified by searching PubMed, EMBASE, and Cochrane Databases and the annual ASCO and ESMO conferences from 2017 to 2020.
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We included phase III randomized clinical trials comparing anti-PD-1/PD-L1 single-agent or in combination with chemotherapy (chemoimmunotherapy) for advanced gastric or esophageal cancers in the first- or second-line settings.
We included phase III randomized clinical trials comparing anti-PD-1/PD-L1 single-agent or in combination with chemotherapy (chemoimmunotherapy) for advanced gastric or esophageal cancers in the first- or second-line settings.
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Randomized Clinical sentence examples within long term efficacy
We evaluated acceptance and short as well as long-term efficacy of our 8-session internet-based GSH program in a randomized clinical trial with an immediate treatment group, and two waitlist control groups, which differed with respect to whether patients received positive expectation induction during waiting or not.
We evaluated acceptance and short as well as long-term efficacy of our 8-session internet-based GSH program in a randomized clinical trial with an immediate treatment group, and two waitlist control groups, which differed with respect to whether patients received positive expectation induction during waiting or not.
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METHODS
We designed a single-center randomized clinical trial to compare the long-term efficacy of ofatumumab versus rituximab in children and young adults with nephrotic syndrome maintained in remission with prednisone and calcineurin inhibitors.
METHODS
We designed a single-center randomized clinical trial to compare the long-term efficacy of ofatumumab versus rituximab in children and young adults with nephrotic syndrome maintained in remission with prednisone and calcineurin inhibitors.
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Randomized Clinical sentence examples within acute myocardial infarction
Effect of a restrictive vs liberal blood transfusion strategy on major cardiovascular events among patients with acute myocardial infarction and anemia: the REALITY randomized clinical trial.
Effect of a restrictive vs liberal blood transfusion strategy on major cardiovascular events among patients with acute myocardial infarction and anemia: the REALITY randomized clinical trial.
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Persian Polypill will be an open labeled, parallel two arm, randomized clinical trial conducting on patients hospitalized because of an acute myocardial infarction (AMI).
Persian Polypill will be an open labeled, parallel two arm, randomized clinical trial conducting on patients hospitalized because of an acute myocardial infarction (AMI).
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Randomized Clinical sentence examples within ” 1 published
Errors in Byline and Author Contributions: In the Original Investigation titled “Effect of Family Navigation on Diagnostic Ascertainment Among Children at Risk for Autism: A Randomized Clinical Trial From DBPNet,”1 published online January 11, 2021, there was an error in the author byline and in the Author Contributions.
Errors in Byline and Author Contributions: In the Original Investigation titled “Effect of Family Navigation on Diagnostic Ascertainment Among Children at Risk for Autism: A Randomized Clinical Trial From DBPNet,”1 published online January 11, 2021, there was an error in the author byline and in the Author Contributions.
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Errors in Byline and Author Contributions: In the Original Investigation titled “Effect of Family Navigation on Diagnostic Ascertainment Among Children at Risk for Autism: A Randomized Clinical Trial From DBPNet,”1 published online January 11, 2021, there was an error in the author byline and in the Author Contributions.
Errors in Byline and Author Contributions: In the Original Investigation titled “Effect of Family Navigation on Diagnostic Ascertainment Among Children at Risk for Autism: A Randomized Clinical Trial From DBPNet,”1 published online January 11, 2021, there was an error in the author byline and in the Author Contributions.
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Randomized Clinical sentence examples within reduced ejection fraction
Design, Setting, and Participants
This cluster randomized clinical trial was conducted at 161 US hospitals and included 5647 patients (2675 intervention vs 2972 usual care) followed up after a hospital discharge for acute heart failure with reduced ejection fraction (HFrEF).
Design, Setting, and Participants
This cluster randomized clinical trial was conducted at 161 US hospitals and included 5647 patients (2675 intervention vs 2972 usual care) followed up after a hospital discharge for acute heart failure with reduced ejection fraction (HFrEF).
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Pharmacological approach to heart failure with reduced ejection fraction (HFrEF) is evolving, as recently published large randomized clinical trials have implemented the disposal of HFrEF treatments with four new classes of drugs, namely angiotensin receptor/neprilysin inhibitor , sodium-glucose co-transporters 2 inhibitors , soluble guanylate cyclase modulators and myosin activators, which have proved to further improve patients' quality of life and long-term outcomes.
Pharmacological approach to heart failure with reduced ejection fraction (HFrEF) is evolving, as recently published large randomized clinical trials have implemented the disposal of HFrEF treatments with four new classes of drugs, namely angiotensin receptor/neprilysin inhibitor , sodium-glucose co-transporters 2 inhibitors , soluble guanylate cyclase modulators and myosin activators, which have proved to further improve patients' quality of life and long-term outcomes.
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Randomized Clinical sentence examples within single center double
DESIGN
A single-center, double-blinded, randomized clinical trial (NCT01304927), 307 infertile men were randomized (1:1) to a single dose of 300,000 IU cholecalciferol followed by 1,400 IU cholecalciferol + 500 mg of calcium daily (n=151) or placebo (n=156) for 150 days.
DESIGN
A single-center, double-blinded, randomized clinical trial (NCT01304927), 307 infertile men were randomized (1:1) to a single dose of 300,000 IU cholecalciferol followed by 1,400 IU cholecalciferol + 500 mg of calcium daily (n=151) or placebo (n=156) for 150 days.
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Methods: In this single-center, double-blinded, randomized clinical trial, 24 anesthetized brain tumor patients were randomly assigned to ephedrine or phenylephrine.
Methods: In this single-center, double-blinded, randomized clinical trial, 24 anesthetized brain tumor patients were randomly assigned to ephedrine or phenylephrine.
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Randomized Clinical sentence examples within observational studies comparing
All randomized clinical trials (RCTs) and observational studies comparing all-cause mortality after treatment with CABG versus PCI for patients with NSTE-ACS with minimum follow-up length of 6 months were included.
All randomized clinical trials (RCTs) and observational studies comparing all-cause mortality after treatment with CABG versus PCI for patients with NSTE-ACS with minimum follow-up length of 6 months were included.
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PubMed/Medline/Embase/CENTRAL/CINAHL were searched for randomized clinical trials (RCT) and observational studies comparing MIPO with nailing for humeral shaft fractures.
PubMed/Medline/Embase/CENTRAL/CINAHL were searched for randomized clinical trials (RCT) and observational studies comparing MIPO with nailing for humeral shaft fractures.
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Randomized Clinical sentence examples within 12 month follow
Key Points Question Is E-WORTH, a culturally tailored HIV and sexually transmitted infection (STI) prevention intervention, effective in reducing STIs and condomless sex among Black women in community supervision programs (CSPs)? Findings In this randomized clinical trial of 352 women, participants assigned to the E-WORTH condition, compared with those in an HIV testing–only control condition, had 54% lower odds of testing positive for any STI at the 12-month follow-up and reported 38% fewer acts of condomless vaginal or anal intercourse during the 12-month period.
Key Points Question Is E-WORTH, a culturally tailored HIV and sexually transmitted infection (STI) prevention intervention, effective in reducing STIs and condomless sex among Black women in community supervision programs (CSPs)? Findings In this randomized clinical trial of 352 women, participants assigned to the E-WORTH condition, compared with those in an HIV testing–only control condition, had 54% lower odds of testing positive for any STI at the 12-month follow-up and reported 38% fewer acts of condomless vaginal or anal intercourse during the 12-month period.
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Methods An open-label randomized clinical trial was performed to compare EMF with standard care during a 12-month follow-up period on two sites of the Sint Maartenskliniek (Nijmegen and Boxmeer) in the Netherlands.
Methods An open-label randomized clinical trial was performed to compare EMF with standard care during a 12-month follow-up period on two sites of the Sint Maartenskliniek (Nijmegen and Boxmeer) in the Netherlands.
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Randomized Clinical sentence examples within artery bypass graft
The results of coronary artery bypass graft surgery (CABG) performed with and without the support of cardiopulmonary bypass have already been widely discussed and studied, including through a few large randomized clinical trials.
The results of coronary artery bypass graft surgery (CABG) performed with and without the support of cardiopulmonary bypass have already been widely discussed and studied, including through a few large randomized clinical trials.
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Historically, the 15 randomized clinical trials comparing coronary artery bypass graft surgery and percutaneous coronary intervention for intervention in coronary artery disease have been criticized for profound selection bias (‘cherry-picking’ of patients).
Historically, the 15 randomized clinical trials comparing coronary artery bypass graft surgery and percutaneous coronary intervention for intervention in coronary artery disease have been criticized for profound selection bias (‘cherry-picking’ of patients).
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Randomized Clinical sentence examples within coronary heart disease
CNKI, Wanfang, SinoMed, PubMed, Cochrane Library and EMbase databases were retrieved on computer, and the randomized clinical trial(RCT) on Gingko Ketone Ester Dropping Pills in treating angina pectoris and coronary heart disease, which were published from the database establishment to December 31, 2019, were comprehensively collected.
CNKI, Wanfang, SinoMed, PubMed, Cochrane Library and EMbase databases were retrieved on computer, and the randomized clinical trial(RCT) on Gingko Ketone Ester Dropping Pills in treating angina pectoris and coronary heart disease, which were published from the database establishment to December 31, 2019, were comprehensively collected.
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BACKGROUND
Previously, observational studies have identified associations between higher levels of dietary-derived antioxidants and lower risk of coronary heart disease (CHD), whereas randomized clinical trials showed no reduction in CHD risk following antioxidant supplementation.
BACKGROUND
Previously, observational studies have identified associations between higher levels of dietary-derived antioxidants and lower risk of coronary heart disease (CHD), whereas randomized clinical trials showed no reduction in CHD risk following antioxidant supplementation.
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Randomized Clinical sentence examples within placebo controlled double
The aim of this study is to evaluate varoglutamstat in a state-of-the-art designed, placebo-controlled, double-blind, randomized clinical trial for safety and tolerability, efficacy on cognition, and effects on brain activity and AD biomarkers.
The aim of this study is to evaluate varoglutamstat in a state-of-the-art designed, placebo-controlled, double-blind, randomized clinical trial for safety and tolerability, efficacy on cognition, and effects on brain activity and AD biomarkers.
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This placebo-controlled, double-blind, randomized clinical trial was conducted among metabolic syndrome patients.
This placebo-controlled, double-blind, randomized clinical trial was conducted among metabolic syndrome patients.
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Randomized Clinical sentence examples within prospective single center
We conducted a prospective, single-center randomized clinical trial to assess whether hand holding can reduce patient anxiety, pain, and dissatisfaction during PBx.
We conducted a prospective, single-center randomized clinical trial to assess whether hand holding can reduce patient anxiety, pain, and dissatisfaction during PBx.
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METHODS This prospective, single-center, non-randomized clinical trial was conducted at the endoscopy center of Shengjing Hospital of China Medical University.
METHODS This prospective, single-center, non-randomized clinical trial was conducted at the endoscopy center of Shengjing Hospital of China Medical University.
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Randomized Clinical sentence examples within open label prospective
Method: We performed a non-contact, open-label, prospective randomized clinical trial comparing intranasally applied Lactococcus lactis W136 with saline irrigation alone in patients within 96 hours of diagnosis of SARS-COV-2 infection not requiring supplemental oxygen.
Method: We performed a non-contact, open-label, prospective randomized clinical trial comparing intranasally applied Lactococcus lactis W136 with saline irrigation alone in patients within 96 hours of diagnosis of SARS-COV-2 infection not requiring supplemental oxygen.
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Research design and methods This open-label, prospective, single-center, randomized clinical trial recruited NAFLD patients with type 2 diabetes mellitus and a hepatic fat fraction of at least 10% as assessed based on the MRI-proton density fat fraction (MRI-PDFF).
Research design and methods This open-label, prospective, single-center, randomized clinical trial recruited NAFLD patients with type 2 diabetes mellitus and a hepatic fat fraction of at least 10% as assessed based on the MRI-proton density fat fraction (MRI-PDFF).
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Randomized Clinical sentence examples within segment elevation myocardial
The efficacy of thrombus aspiration (TA) for various culprit lesions in ST-segment elevation myocardial infarction has not been sufficiently evaluated, this directed recent randomized clinical trials to question its clinical benefits.
The efficacy of thrombus aspiration (TA) for various culprit lesions in ST-segment elevation myocardial infarction has not been sufficiently evaluated, this directed recent randomized clinical trials to question its clinical benefits.
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BACKGROUND
To compare effectiveness and safety of clopidogrel, prasugrel, and ticagrelor among all-comers with ST-segment Elevation Myocardial Infarction (STEMI) and extend the knowledge from randomized clinical trials.
BACKGROUND
To compare effectiveness and safety of clopidogrel, prasugrel, and ticagrelor among all-comers with ST-segment Elevation Myocardial Infarction (STEMI) and extend the knowledge from randomized clinical trials.
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Randomized Clinical sentence examples within double blind parallel
Methods A phase 2, double-blind, parallel-group, placebo-controlled, 6-month randomized clinical trial was performed to evaluate the safety and efficacy of subcutaneously administered GV1001.
Methods A phase 2, double-blind, parallel-group, placebo-controlled, 6-month randomized clinical trial was performed to evaluate the safety and efficacy of subcutaneously administered GV1001.
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METHODS
A double-blind, parallel-group, placebo-controlled and randomized clinical study was performed in 50 healthy male and female volunteers aged 20 to 40 years, in Finland.
METHODS
A double-blind, parallel-group, placebo-controlled and randomized clinical study was performed in 50 healthy male and female volunteers aged 20 to 40 years, in Finland.
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Randomized Clinical sentence examples within long term survival
While many retrospective case series that examined different drug therapies for acute exacerbations of IPF have been published in the literature (8), no therapy other than lung transplantation has been shown to provide long-term survival in a randomized clinical trial.
While many retrospective case series that examined different drug therapies for acute exacerbations of IPF have been published in the literature (8), no therapy other than lung transplantation has been shown to provide long-term survival in a randomized clinical trial.
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Conclusions Our newly devised long-term survival-predictive nomogram based on clinical and genomic data can be used to advise patients regarding their potential outcomes and account for confounding factors in nonrandomized clinical trials.
Conclusions Our newly devised long-term survival-predictive nomogram based on clinical and genomic data can be used to advise patients regarding their potential outcomes and account for confounding factors in nonrandomized clinical trials.
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Randomized Clinical sentence examples within tumor necrosis factor
The aim of the current study was to perform a meta-analysis of randomized clinical trials regarding the effect of resveratrol in decreasing the levels of inflammatory cytokines, including interleukin (IL)-1, IL-6, IL-8, and tumor necrosis factor (TNF)-α in a combination of inflammatory diseases.
The aim of the current study was to perform a meta-analysis of randomized clinical trials regarding the effect of resveratrol in decreasing the levels of inflammatory cytokines, including interleukin (IL)-1, IL-6, IL-8, and tumor necrosis factor (TNF)-α in a combination of inflammatory diseases.
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We therefore aimed to evaluate the efficacy of the tumor necrosis factor (TNF) antagonist golimumab comparing white to non-white participants, using individual participant level data from phase 2/3 randomized clinical trials of TNF antagonist therapy in ulcerative colitis (UC).
We therefore aimed to evaluate the efficacy of the tumor necrosis factor (TNF) antagonist golimumab comparing white to non-white participants, using individual participant level data from phase 2/3 randomized clinical trials of TNF antagonist therapy in ulcerative colitis (UC).
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Randomized Clinical sentence examples within sodium glucose cotransporter
The article discusses the results of a number of randomized clinical trials evaluating the cardioprotective effect of modern classes of hypoglycemic agents: dipeptidyl peptidase-4 (DPP-4) inhibitors, glucagon-like peptide-1 (GLP-1) receptor agonists, sodium-glucose cotransporter-2 (SGLT-2) inhibitors.
The article discusses the results of a number of randomized clinical trials evaluating the cardioprotective effect of modern classes of hypoglycemic agents: dipeptidyl peptidase-4 (DPP-4) inhibitors, glucagon-like peptide-1 (GLP-1) receptor agonists, sodium-glucose cotransporter-2 (SGLT-2) inhibitors.
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The pharmacological HF management has remained unchanged for a decade, however, several randomized clinical trials have demonstrated the potential clinical benefits of sodium-glucose cotransporter-2 inhibitors, an antidiabetic agent, by reducing the rate of hospitalizations for HF, cardiovascular death, and all-cause death.
The pharmacological HF management has remained unchanged for a decade, however, several randomized clinical trials have demonstrated the potential clinical benefits of sodium-glucose cotransporter-2 inhibitors, an antidiabetic agent, by reducing the rate of hospitalizations for HF, cardiovascular death, and all-cause death.
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