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Randomised Controlled sentence examples within two arm parallel
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Randomised Controlled sentence examples within cross sectional study
Of the 26 cross-sectional studies and three longitudinal cohort studies which met the inclusion criteria, only two were randomised controlled trials (RCTs).
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Methods Fifteen consecutive patients from two randomised controlled trials (RCTs) were included in this cross-sectional study.
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Randomised Controlled sentence examples within quasi experimental study
Randomised Controlled sentence examples within non inferiority trial
We carried out a randomised controlled non-inferiority trial to compare serological responses in dogs following vaccination with doses stored under cold chain conditions with those stored within a locally made Passive Cooling Device (“Zeepot”) under fluctuating temperature conditions.
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Methods and analysis The SchistoSAM study is an open-label, two-arm, individually randomised controlled non-inferiority trial, with a follow-up of 48 weeks.
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Randomised Controlled sentence examples within body mass index
Methods and analysis This randomised controlled trial will compare the efficacy of a telehealth versus self-directed lifestyle intervention in lowering 24-hour SBP in patients with overweight/obesity (body mass index ≥25 kg/m2) and 24-hour SBP 120–160 mm Hg.
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MATERIALS AND METHODS
The method used was planned secondary analysis of data from women with a pre-pregnancy body mass index (BMI) ≥30 kg/m2 giving birth by elective CS in a multicentre randomised controlled trial of a prophylactic closed-incision negative pressure wound therapy dressing.
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Randomised Controlled sentence examples within multicentre open label
METHODS
This multicentre, open-label, randomised controlled, phase 3 trial was done at 22 clinical research sites in nine countries (Botswana, Brazil, India, South Africa, Tanzania, Thailand, Uganda, the USA, and Zimbabwe).
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Methods This was a multicentre, open-label, phase 3 randomised controlled trial based at cancer centres and acute care hospitals in England, Scotland, and Wales.
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Randomised Controlled sentence examples within also searched clinical
We also searched clinical trials databases and the reference lists of retrieved articles for randomised controlled trials (RCTs) and quasi-randomised trials.
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We also searched clinical trials databases, conference proceedings, and the reference lists of retrieved articles for randomised controlled trials (RCTs) and quasi-RCTs.
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Randomised Controlled sentence examples within observational cohort study
Eligibility criteria for study selection Randomised controlled trials and observational cohort studies in a community setting that allowed comparison between delayed versus no antibiotic prescribing, and delayed versus immediate antibiotic prescribing.
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METHODS Data were obtained from pharmacokinetic sub-studies in a randomised controlled trial and an observational cohort study, both of which enrolled adults with drug-resistant pulmonary tuberculosis.
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Randomised Controlled sentence examples within multicentre parallel group
STUDY DESIGN, SIZE, DURATION This multicentre, parallel group, superiority, blinded and pragmatic randomised controlled trial is being carried out in seven participating centres in Belgium.
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METHODS
STROKESTOP was a multicentre, parallel group, unmasked, randomised controlled trial done in Halland and Stockholm in Sweden.
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Randomised Controlled sentence examples within multicentre double blind
METHODS
This was a multicentre, double-blind, phase 3, randomised controlled trial (PROTECT) comparing the immunogenicity and safety of TAV with MAV in 28 community and hospital sites in the USA, Finland, Canada, and Belgium.
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Dabrafenib and trametinib versus dabrafenib and placebo for Val600 BRAF-mutant melanoma: a multicentre, double-blind, phase 3 randomised controlled trial.
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Randomised Controlled sentence examples within intensive care unit
In this multicentre randomised controlled trial, conducted in 32 intensive care units, we randomly assigned patients to tracheal tube + stylet or tracheal tube alone (i.
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Methods: We conducted a multi-center, open-label, randomised controlled trial comparing standard prophylactic dose versus intermediate dose enoxaparin in adults who were hospitalized with COVID-19 and admitted to an intensive care unit (ICU) and/or had laboratory evidence of coagulopathy.
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Randomised Controlled sentence examples within systematic literature review
Based on a systematic literature review, one randomised controlled trial, MAVORIC, was identified showing favourable results in patients with MF and SS.
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Methods
A systematic literature review of the PubMed and Central Register of Controlled Trials (Cochrane) databases by using the search term 'greater trochanter fracture and hip fracture' was conducted for Randomised Controlled Trials (RCT's), including prospective and retrospective non-experimental studies.
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Randomised Controlled sentence examples within retrospective cohort study
Results
58 out of 84 studies met the inclusion criteria, of which 13 were classified as systematic reviews and 45 were quantitative studies (comprising randomised controlled trials, retrospective cohort studies, case control, cross-sectional, surveys, observational and descriptive studies).
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Study selection Randomised controlled trials (RCTs), prospective and retrospective cohort studies involving the comparison of ceramic and metal-ceramic implant-supported FDPs were selected using the PICOS model for the meta-analysis.
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Randomised Controlled sentence examples within patient reported outcome
We compare patient reported outcomes of a multicentre randomised controlled trial of retropubic (TVT-GYNECARETM ) versus transobturator (TOT-MONARCTM ) tape surgery at 12 years.
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This article describes how routine databases can be used to address the current paucity of high-quality evidence; they can be used in a range of study designs, including randomised controlled trials and quasi-experimental designs, and may also be able to contribute quality of life or patient-reported outcome measures.
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Randomised Controlled sentence examples within interrupted time series
We considered randomised controlled trials (RCTs), non-randomised clinical trials (NRCTs), controlled before-after studies (CBAs), and interrupted time series analyses (ITS) evaluating interventions to improve outcomes for people with multimorbidity in primary care and community settings.
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SELECTION CRITERIA
We included randomised controlled trials (RCTs), controlled before-and-after (CBAs) and interrupted time series studies (ITSs).
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Randomised Controlled sentence examples within low back pain
High-quality comparative-effectiveness and randomised controlled trials with longer follow-up periods that aim to establish the efficacy and cost-effectiveness of low back pain management are warranted.
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Background This paper describes the statistical analysis plan for a randomised controlled trial of a Healthy Lifestyle Program (HeLP) for low back pain targeting multiple health risks and behaviours, weight, physical activity, diet and smoking, to improve disability.
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Randomised Controlled sentence examples within longitudinal cohort study
Headline study findings included: a longitudinal cohort study demonstrating no evidence for a harmful effect of non-steroidal anti-inflammatory drugs (NSAIDs) in terms of COVID-19 related deaths; a Global Burden of Disease study reporting a 102% increase in crude incidence rate of OA in 2017 compared to 1990; a longitudinal study reporting cartilage thickness loss was associated with only a very small degree of worsening in pain over 2 years; an exploratory analysis of a non-OA randomised controlled trial (RCT) finding reduced risk of total joint replacement with an Interleukin -1β inhibitor (canakinumab); a significant relationship between cumulative disadvantage and clinical outcomes of pain and depression mediated by perceived discrimination in a secondary analysis from a RCT; worsening socioeconomic circumstances were associated with future arthritis diagnosis in an innovative natural experiment (with implications for unique research possibilities arising from the COVID-19 pandemic context).
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METHODS
This longitudinal cohort study was conducted at Nowshero Feroze, Sindh from 2013 to 2014 and comprised data drawn from children who participated in a randomised controlled trial, that assessed responsive stimulation and nutrition interventions in the first two years of life.
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Randomised Controlled sentence examples within open label parallel
In this narrative review, we use data from the Salford Lung Study; two prospective, 12-month, open-label, parallel-group, phase III randomised controlled trials conducted in primary care in the UK; to highlight the importance of capturing treatment modifications when attempting to evaluate safety events according to actual treatment exposure.
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This was an open-label, parallel-group, 6-month, randomised controlled trial in adults with uncontrolled asthma (asthma control test (ACT) score less than 20) on fixed-dose inhaled corticosteroids/long-acting β-agonist maintenance therapy (n=437).
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Randomised Controlled sentence examples within chronic obstructive pulmonary
The Salford Lung Studies (SLS) were real-world randomised controlled trials set within UK primary care that assessed the effectiveness and safety of initiating once-daily fluticasone furoate/vilanterol versus continuing usual care in patients with chronic obstructive pulmonary disease or asthma.
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IntroductionIdentifying undiagnosed COPD is high priority 1 Systematic, targeted case-finding in ever-smokers is cost-effective, outperforming routine primary care;however, even within the research setting of TargetCOPD, only 38% responded to screening questionnaires determining spirometry need 1 We explored the feasibility of an alternative - database search and triage of patient record by GP, to create an at-risk group for spirometry, as part of an integrated respiratory service development MethodsAn EMIS GP database search was iteratively developed to identify patients at risk of COPD, which included ever-smokers 35–90 years, who had also received relevant medication or had multiple respiratory consultations In protected time, three non-specialist GPs reviewed the record to identify likely airways disease and triaged to screening spirometry, diagnostic spirometry, no testing indicated or coding required (as diagnostic criteria already present) The patient and their GP were informed of COPD and asthma diagnoses ResultsOf 1231 patients in 20 practices who were highlighted by the search and received triage of their record, 8% (98) required coding, 41% (500), were triaged to screening spirometry and 15% (180) direct to diagnostic spirometry 37% (453) were considered irrelevant Triage time was 12 patients/hour In total, 81 COPD and 53 asthma cases were identified 65% (93/143) of patients attended on first invitation for spirometry and 55% of those who had diagnostic spirometry had airways disease;COPD (22) and asthma (14) After screening spirometry, 20%(7) went on to be diagnosed with COPD At project termination due to COVID-19, 537 patients had yet to be invited for spirometry and no second invitations had been sent Availability of diagnostic spirometry and its interpretation in primary care was variable, especially when complex;specialist support was required ConclusionsOur search strategy was specific, creating a manageable sample for clinical triage and follow-up spirometry in routine settings The process resulted in a high rate of diagnoses after spirometry and allowed rapid recognition of uncoded patients, equating to ≈69 additional COPD cases over routine care1 ReferenceJordan RE, et al Targeted case-finding for chronic obstructive pulmonary disease versus routine practice in primary care (TargetCOPD): a cluster-randomised controlled trial LancetRespir Med 2016;4(9):720–730.
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Randomised Controlled sentence examples within systematic literature search
METHOD
We conducted a systematic literature search for randomised controlled trials in nine databases.
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METHODS
Based on established national (AWMF) and international guidelines as well as the Cochrane Library, we performed a systematic literature search on PubMed (NLM), focusing on randomised controlled trials.
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Randomised Controlled sentence examples within blinded parallel group
Methods and analysis An assessor-blinded parallel group randomised controlled design with embedded health economic evaluation and process evaluation will compare the effects of n=270 participants randomly allocated to an experimental group (motivational interviewing) or a control group (dietary advice).
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The Effect of complex weigHt-reducing interventiOns on rhythm control in oBese subjects wITh Atrial Fibrillation (HOBIT-AF) is a single-blinded, parallel-group randomised controlled trial with 18-month follow-up to assess the effect of complex weight-reducing interventions supported by the use of smart technologies and bariatric surgery on the arrhythmia burden in obese individuals following CA for AF.
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Randomised Controlled sentence examples within long term follow
Randomised Controlled sentence examples within methods process evaluation
Randomised Controlled sentence examples within single centre prospective
Randomised Controlled sentence examples within single blind parallel
Methods In this single-blind, parallel-group, open-label, randomised controlled trial, infants aged 2 months were recruited by community health staff in districts 4 and 7 of Ho Chi Minh City, Vietnam.
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We will conduct a single blind, parallel group, cluster randomised controlled trial encompassed by a 2 (condition: self-distanced, self-immersed) x 2 (time: baseline and post-intervention) mixed factorial design with approximately 200 elite athletes to test these perspectives empirically.
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Randomised Controlled sentence examples within multi centre parallel
Methods The INHALE Randomised Controlled Trial is a multi-centre, parallel study exploring the potential of the BioFire FilmArray molecular diagnostic to guide antibiotic treatment of HAP/VAP in intensive care units (ICU); it identifies pathogens and key antibiotic resistance in around 90 min.
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In this context, we conducted a multi-centre, parallel group, randomised controlled feasibility study on awake prone positioning in non-intubated patients with COVID-19 pneumonia requiring supplemental oxygen.
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Randomised Controlled sentence examples within 6 month follow
Randomised Controlled sentence examples within first line treatment
Selective laser trabeculoplasty versus eye drops for first-line treatment of ocular hypertension and glaucoma (LiGHT): a multicentre randomised controlled trial.
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International guidelines have stated the need for a multicentre randomised controlled trial (RCT) to determine whether a non-invasive outpatient (shockwave lithotripsy [SWL]) or surgical (ureteroscopy [URS]) intervention should be the first-line treatment for those needing active intervention.
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Randomised Controlled sentence examples within continuous positive airway
Wimms AJ, Kelly JL, Turnbull CD, McMillan A, Craig SE, O’Reilly JF, Nicol AH, Hedley EL, Decker MD, Willes LA, Calverley PMA, Benjafield AV, Stradling JR, Morrell MJ, on behalf of the MERGE trial investigators† (2020) Continuous positive airway pressure versus standard care for the treatment of people with mild obstructive sleep apnoea (MERGE): a multicentre, randomised controlled trial.
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