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Radical Cure sentence examples within glucose 6 phosphate

glucose 6 phosphate

Background Glucose-6-phosphate dehydrogenase (G6PD) deficiency greatly hinders Plasmodium vivax malaria radical cure and further elimination due to 8-aminoquinolines-associated hemolysis.

Real-life implementation of a G6PD deficiency screening qualitative test into routine vivax malaria diagnostic units in the Brazilian Amazon (SAFEPRIM study)

glucose 6 phosphate

Rapid tests for glucose-6-phosphate dehydrogenase (G6PD) are extremely important for determining G6PD deficiency, a widespread metabolic disorder which triggers hemolytic anemia in response to primaquine and tafenoquine medication, the most effective drugs for the radical cure of malaria caused by Plasmodium parasites.

Rapid quantitative assays for glucose-6-phosphate dehydrogenase (G6PD) and hemoglobin combined on a capillary-driven microfluidic chip.

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Radical Cure sentence examples within % 95 %

% 95 %

According to the model, while achieving elimination in only few settings in Brazil, tafenoquine rollout in 2021 is estimated to improve the mean effective radical cure rate from 42% (95% uncertainty interval [UI] 41%–44%) to 62% (95% UI 54%–68%) among clinical cases, leading to a predicted 38% (95% UI 7%–99%) reduction in transmission and over 214,000 cumulative averted cases between 2021 and 2025.

Estimated impact of tafenoquine for Plasmodium vivax control and elimination in Brazil: A modelling study

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Radical Cure sentence examples within Effective Radical Cure

Effective Radical Cure

According to the model, while achieving elimination in only few settings in Brazil, tafenoquine rollout in 2021 is estimated to improve the mean effective radical cure rate from 42% (95% uncertainty interval [UI] 41%–44%) to 62% (95% UI 54%–68%) among clinical cases, leading to a predicted 38% (95% UI 7%–99%) reduction in transmission and over 214,000 cumulative averted cases between 2021 and 2025.

Estimated impact of tafenoquine for Plasmodium vivax control and elimination in Brazil: A modelling study

Effective Radical Cure

Background Liver transplantation (LT) is the only effective radical cure for all types of end-stage liver diseases.

Clinical utility of ABCB1 single nucleotide polymorphism on tacrolimus dose requirements in Egyptian liver transplant patients

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Radical Cure sentence examples within Vivax Radical Cure

Vivax Radical Cure

Plasmodium vivax radical cure requires the administration of a blood schizonticide for killing blood-stage parasites and the addition of a drug able to kill hypnozoites, the dormant parasite stages residing in the liver of infected patients.

Primaquine for Plasmodium vivax radical cure: What we do not know and why it matters.

Vivax Radical Cure

vivax radical cure.

Clinical utility of tafenoquine in the prevention of relapse of Plasmodium vivax malaria: a review on the mode of action and emerging trial data

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Radical Cure sentence examples within Free Radical Cure

Free Radical Cure

Currently, free radical cured polygraphic varnishes are most widespread.

Does the increase of radiation energy really reduce the risk of photoinitiator migration from polygraphic varnish to packed product? The influence of UV radiation dose on the migration of 4-phenylbenzophenone from polyacrylate varnish in food packaging

Free Radical Cure

Currently, free radical cured varnishes are most widespread.

Effect of food packaging material on some physicochemical properties of polyacrylate varnish layers

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Radical Cure sentence examples within Encounter Radical Cure

Encounter Radical Cure

Single Encounter Radical Cure and Prophylaxis (SERCAP) describes an ideal anti-malarial drug that cures all malaria in a single dose.

SERCAP: is the perfect the enemy of the good?

Encounter Radical Cure

OBJECTIVES Rapid rate-of-kill (RoK) is a key parameter in the target candidate profile 1 (TCP1) for the next-generation antimalarial drugs for uncomplicated malaria, termed Single Encounter Radical Cure and Prophylaxis (SERCaP).

The relative rate of kill of the MMV Malaria Box compounds provides links to the mode of antimalarial action and highlights scaffolds of medicinal chemistry interest.

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Radical Cure sentence examples within Malarium Radical Cure

Malarium Radical Cure

Background Glucose-6-phosphate dehydrogenase (G6PD) deficiency greatly hinders Plasmodium vivax malaria radical cure and further elimination due to 8-aminoquinolines-associated hemolysis.

Real-life implementation of a G6PD deficiency screening qualitative test into routine vivax malaria diagnostic units in the Brazilian Amazon (SAFEPRIM study)

Malarium Radical Cure

NPC1161B, the (R)-(−) enantiomer with outstanding potential for malaria radical cure, treatment of visceral leishmaniasis and pneumocystis pneumonia infections is poised for clinical development.

Enantioselective Interactions of Anti-Infective 8-Aminoquinoline Therapeutics with Human Monoamine Oxidases A and B †

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Radical Cure sentence examples within radical cure treatment

radical cure treatment

Up to now, the pathogenic mechanism and radical cure treatment for COVID-19 are still unknown.

Coronavirus disease 2019 (COVID-19) complicated with acute myocardial infarction: etiology and nursing experience of three case reports.

radical cure treatment

vivax morbidity after radical cure treatment and related risk factors was conducted in Central Vietnam.

Plasmodium vivax morbidity after radical cure: A cohort study in Central Vietnam

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Radical Cure sentence examples within radical cure recommend

radical cure recommend

International recommendations for radical cure recommend fixed target doses of 0.

Development of weight and age-based dosing of daily primaquine for radical cure of vivax malaria

radical cure recommend

International recommendations for radical cure recommend fixed target doses of 0.

Development of Weight and Age-based Dosing of Daily Primaquine for Radical Cure of Vivax Malaria

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Radical Cure sentence examples within radical cure require

radical cure require

Plasmodium vivax radical cure requires the administration of a blood schizonticide for killing blood-stage parasites and the addition of a drug able to kill hypnozoites, the dormant parasite stages residing in the liver of infected patients.

Primaquine for Plasmodium vivax radical cure: What we do not know and why it matters.

radical cure require

Radical cure requires both blood schizontocidal and hypnozoitocidal chemotherapies.

Genotypes and phenotypes of G6PD deficiency among Indonesian females across diagnostic thresholds of G6PD activity guiding safe primaquine therapy of latent malaria

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Radical Cure sentence examples within radical cure efficacy

radical cure efficacy

Improved control of Plasmodium vivax malaria can be achieved with the discovery of new antimalarials with radical cure efficacy, including prevention of relapse caused by hypnozoites residing in the liver of patients.

Probing the distinct chemosensitivity of Plasmodium vivax liver stage parasites and demonstration of 8-aminoquinoline radical cure activity in vitro

radical cure efficacy

Improved control of malaria caused by Plasmodium vivax can be achieved with the discovery of new antimalarials with radical cure efficacy, including prevention of relapse caused by hypnozoites residing in the liver of vivax patients.

Probing the distinct chemosensitivity of Plasmodium vivax liver stage parasites and demonstration of 8-aminoquinoline radical cure activity in vitro

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10.3389/fphar.2021.644952

However, these treatments focus on improving symptoms of the disease and fail to achieve a radical cure; they also have certain toxic side effects.

Advances in the Application of Natural Products and the Novel Drug Delivery Systems for Psoriasis

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10.1186/s12936-021-03886-w

International recommendations for radical cure recommend fixed target doses of 0.

Development of weight and age-based dosing of daily primaquine for radical cure of vivax malaria

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10.21203/RS.3.RS-232561/V1

Factors such as adequate dosing, adherence, drug quality, and pharmacogenetics can impact the effectiveness of radical cure of P.

Increased Primaquine Total Dose in Patients with Multiple Plasmodium vivax Relapses Associated with Impaired CYP2D6 Activity: Report of Three Cases

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10.1177/0971721820960254

The other cycle occurred among men with screening detected cancer who initially eschewed radical treatments or imagined doing so, whose lives were often consumed with fear and surveillance, increasing demand for radical cures.

Prostate Cancer: People Transforming A Diagnosis, A Diagnosis Transforming People

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10.2147/TCRM.S269336

Safety and efficacy findings for TQ in Plasmodium vivax malaria prophylaxis and radical cure are summarized and some of the latest TQ-related studies (published in 2020 and 2021) are highlighted.

Safety and Efficacy of Tafenoquine for Plasmodium vivax Malaria Prophylaxis and Radical Cure: Overview and Perspectives

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10.1101/2021.07.05.21259877

Background: Primaquine is the only widely available drug for radical cure of Plasmodium vivax malaria.

Determinants of primaquine and carboxyprimaquine exposures in children and adults with Plasmodium vivax malaria

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10.21203/RS.3.RS-388461/V1

vivax requiring implementation of radical cure with primaquine.

Getting to Zero: Micro-Foci of Malaria In the Solomon Islands Requires Stratified Control

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10.1093/actrade/9780198869290.003.0007

The hype and controversy of human embryonic stem (ES) cells led the proponents of stem cell research to promise very rapid development of very radical cures.

7. Expectations: realistic and unrealistic

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10.52711/0974-360x.2021.00600

com/ Results: US- FDA Approved Orphan Drug ex: Tafenoquine - Treatment of malaria - Krintafel is indicated for the radical cure (prevention of relapse) of Plasmodium vivax malaria.

Regulatory Strategies for Orphan drug Development in USA–Europe

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10.21203/RS.3.RS-449398/V1

Collectively, the combination of TKIs and IRAK1/4 inhibitors is an attractive strategy to achieve a radical cure of CML.

Eradicating chronic myeloid leukemia stem cells by IRAK1/4 inhibitors

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10.36648/1590-8577.22.3.90-92

Surgical excision of intraperitoneal complex teratoma is the key to radical cure of the tumor.

Surgical Management of Neonatal Parapancreatic Giant Teratoma

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10.15585/mmwr.ss7002a1

Krintafel was approved for radical cure of P.

Malaria Surveillance — United States, 2017

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10.1007/s12149-021-01618-3

1 peptide, which represents a radioimmunotherapy strategy based on the combination of SIRT with a peptide–drug conjugate, could provide a treatment means for the radical cure of ATC.

Targeted radioimmunotherapy with the iodine-131-labeled caerin 1.1 peptide for human anaplastic thyroid cancer in nude mice

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10.1016/j.ribaf.2020.101345

Human capital accumulation is a radical cure for income inequality and poverty issues in the process of economic development.

Investments in human capital: The evidence from China’s new rural pension scheme

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10.1371/journal.pntd.0009720

Such evidence-based data will guide the expansion of primaquine and potentially tafenoquine for radical cure of P.

Prevalence of glucose-6-phosphate dehydrogenase deficiency (G6PDd), CareStart qualitative rapid diagnostic test performance, and genetic variants in two malaria-endemic areas in Sudan

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10.52692/1857-0011.2021.2-70.26

As a surgical treatment of maxillary sinusitis in the section of oro-maxillo-facial surgery, radical cure is used for 58.

Maxillary sinusitis of tumoral origin

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10.1155/2021/5524772

The etiology and pathogenesis of HUA are not fully understood, so there is no radical cure so far.

High-Throughput Untargeted Serum Metabolomics Analysis of Hyperuricemia Patients by UPLC-Q-TOF/MS

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10.21203/RS.3.RS-340883/V1

Background: The radical cure of Glioblastoma multiforme (GBM) is a troublesome medical problem, owing to its resistance to temozolomide chemotherapy and very poor surgical results or high relapse rate.

Targeting To Hedgehog Signalling Pathway Increase Sensitivity Anticancer Effects of Arsenic Trioxide Mediated By miR-326

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10.1208/s12249-021-02108-5

Primaquine (PQ), an 8-aminoquinoline antimalarial drug, has been widely used for the eradication of hypnozoites from the liver and, therefore, recognized as the radical cure of malaria.

Primaquine Loaded Solid Lipid Nanoparticles (SLN), Nanostructured Lipid Carriers (NLC), and Nanoemulsion (NE): Effect of Lipid Matrix and Surfactant on Drug Entrapment, in vitro Release, and ex vivo Hemolysis.

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10.1038/s41598-021-99152-9

Improved control of Plasmodium vivax malaria can be achieved with the discovery of new antimalarials with radical cure efficacy, including prevention of relapse caused by hypnozoites residing in the liver of patients.

Probing the distinct chemosensitivity of Plasmodium vivax liver stage parasites and demonstration of 8-aminoquinoline radical cure activity in vitro

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10.1186/s12936-021-03702-5

Background Wide-spread implementation of treatment regimens for the radical cure of vivax malaria is hindered by a range of factors.

Rolling out the radical cure for vivax malaria in Asia: a qualitative study among policy makers and stakeholders

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10.21037/hbsn-21-178

In highly selected cases (<1%), liver transplant (LT) might be considered in patients with NELM representing a potential chance of radical cure if proper patient selection is provided.

Neuroendocrine liver metastases treatment strategies: a viewpoint.

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10.1186/s41182-021-00339-7

vivax by primaquine for radical cure.

G6PD deficiency among malaria-infected national groups at the western part of Myanmar with implications for primaquine use in malaria elimination

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10.1128/AAC.01302-21

Primaquine is the only widely available drug for radical cure of Plasmodium vivax malaria.

Determinants of primaquine and carboxyprimaquine exposures in children and adults with Plasmodium vivax malaria

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10.5772/INTECHOPEN.97320

vivax whereas primaquine is given to eliminate latent liver stage infections (a method known as radical cure).

Plasmodium vivax and Drug Resistance

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10.1093/infdis/jiab537

Treatment with clofazimine alone, clofazimine plus azithromycin, and atovaquone plus azithromycin was ineffective and failed to eliminate the parasites completely, while a 44-day treatment with clofazimine plus atovaquone was highly effective and resulted in a radical cure.

A combination of clofazimine‒atovaquone as a potent therapeutic regimen for the radical cure of Babesia microti infection in immunocompromised hosts.

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10.1371/journal.pmed.1003614

Elimination of both the blood and liver stages of the parasites (“radical cure”) is required to achieve a sustained clinical response and prevent ongoing transmission of the parasite.

Global economic costs due to vivax malaria and the potential impact of its radical cure: A modelling study

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10.1186/s12936-021-03869-x

Factors such as adequate dosing, adherence, drug quality, and pharmacogenetics can impact the effectiveness of radical cure of P.

Increased primaquine total dose prevents Plasmodium vivax relapses in patients with impaired CYP2D6 activity: report of three cases

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10.1186/s12936-021-03779-y

The majority of infections were afebrile suggesting the need for strong active case detection with radical cure with primaquine for P.

Getting to zero: micro-foci of malaria in the Solomon Islands requires stratified control

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10.2139/ssrn.3903938

Background: Tafenoquine (TQ) was recently approved as prophylaxis and radical cure for P.

Single Low Dose Tafenoquine Combined with Dihydroartemisinin-Piperaquine to Reduce P. Falciparum Transmission: A Phase 2 Single Blind Randomised Clinical Trial in Ouelessebougou, Mali

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10.1097/MD.0000000000027075

Conventional treatments for BCS do not solve practical problems, wherease liver transplantation has been only applied as a last-resort therapy and as the only opportunity for a radical cure.

Application of ex vivo liver resection and autotransplantation in treating Budd-Chiari syndrome secondary to end-stage hepatic alveolar echinococcosis

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10.3760/cma.j.cn115330-20210125-00037

Emergency surgery not only relieves respiratory obstruction and saves the lives of patients, but some patients can get a radical cure as well.

[Analysis of cases with emergency thyroid surgery].

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10.1093/jtm/taab087

vivax until radical cure with primaquine is possible.

Treatment of relapsing Plasmodium vivax malaria during pregnancy.

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10.1002/cpt.2313

Radical cure of vivax malaria requires hypnozoitocide therapy to prevent relapses.

Impact of CYP2D6 Genetic Variation on Radical Cure of Plasmodium vivax Malaria

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10.1093/ije/dyab168.161

To achieve elimination of malaria in South-East Asia, where prevalence of vivax malaria is high, we must prioritise the radical cure of vivax to eliminate the liver-stage of this species that causes relapses of infection.

787Multistate modelling to investigate the impact of recurrent malaria episodes on hospital admissions and mortality

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10.1371/journal.pmed.1003561

Cindy S Chu and co-authors review options for diagnosis, safe and radical cure, and relapse prevention of Plasmodium Vivax.

The prevention and treatment of Plasmodium vivax malaria

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10.1186/s12936-021-03685-3

Background Accumulating evidence suggest that compromised CYP2D6 enzyme activity caused by gene mutation could contribute to primaquine failure for the radical cure of vivax malaria.

The association of CYP2D6 gene polymorphisms in the full-length coding region with higher recurrence rate of vivax malaria in Yunnan Province, China

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10.21203/RS.3.RS-380013/V1

International recommendations for radical cure recommend fixed target doses of 0.

Development of Weight and Age-based Dosing of Daily Primaquine for Radical Cure of Vivax Malaria

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10.21037/apm-21-1193

Up to now, the pathogenic mechanism and radical cure treatment for COVID-19 are still unknown.

Coronavirus disease 2019 (COVID-19) complicated with acute myocardial infarction: etiology and nursing experience of three case reports.

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10.21203/RS.3.RS-185180/V1

Improved control of malaria caused by Plasmodium vivax can be achieved with the discovery of new antimalarials with radical cure efficacy, including prevention of relapse caused by hypnozoites residing in the liver of vivax patients.

Probing the distinct chemosensitivity of Plasmodium vivax liver stage parasites and demonstration of 8-aminoquinoline radical cure activity in vitro

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10.1128/AAC.00204-21

Food and Drug Administration in 2018 for the radical cure of Plasmodium vivax infection and for malaria prophylaxis.

Tafenoquine Is a Promising Drug Candidate for the Treatment of Babesiosis

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10.18203/2349-2902.ISJ20211285

Doctors declared that the radical cure of hernias should be undertaken by abdominal section.

A new self-made electric hook for laparoscopic inguinal hernia repair

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10.1186/s12951-021-00835-2

[2, 3] Currently, the treatment of cancer includes surgery [4], chemotherapy [4], targeted therapy [5], but it is still difficult to achieve a radical cure of the cancer due to the risk of recurrence and treatment resistance [1, 4].

Ultrasound targeted microbubble destruction combined with Fe-MOF based bio-/enzyme-mimics nanoparticles for treating of cancer

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10.1016/j.jiph.2020.12.009

However, a progressive race among numerous research groups to discover a radical cure for the COVID-19 is under way.

The growing complexity of COVID-19 drug and vaccine candidates: challenges and critical transitions

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10.3177/jnsv.67.91

Therefore, a radical cure for UC is desired.

Vitamin C Enema Advances Induction of Remission in the Dextran Sodium Sulfate-Induced Colitis Model in Rats.

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10.1007/s10151-020-02406-3

For women with recurrent and locally advanced pelvic malignancy, located anteriorly or anterior-laterally to the rectum, invading the cervix or vaginal vault, posterior pelvic exenteration (PPE) maybe the only chance of a radical cure [1].

Fascial space priority approach for laparoscopic supralevator posterior pelvic exenteration with nerve sparing: anatomy and technique

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10.1371/journal.pntd.0009610

Radical cure requires both blood schizontocidal and hypnozoitocidal chemotherapies.

Genotypes and phenotypes of G6PD deficiency among Indonesian females across diagnostic thresholds of G6PD activity guiding safe primaquine therapy of latent malaria

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10.17816/PSAIC724

CONCLUSION: Results of a retrospective multivariate analysis made it possible to develop an algorithm for substantiating surgical techniques, providing a radical cure for 95.

Substantiation of organ-preserving surgical treatment of children with nonparasitic spleen cysts

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10.1186/s12936-021-03743-w

Background The radical cure of Plasmodium vivax requires treatment with an 8-aminoquinoline drug, such as primaquine and tafenoquine, to eradicate liver hypnozoite stages, which can reactivate to cause relapsing infections.

Implementing radical cure diagnostics for malaria: user perspectives on G6PD testing in Bangladesh

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10.1101/2021.01.28.21250689

Radical cure is a form of therapy capable of addressing this problem.

Site-specific biases in phase-III clinical trials underestimate the effect of radical cure against Plasmodium vivax hypnozoites

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10.1016/j.biomaterials.2019.119636

However, single SDT dose is incapable of radical cure because the long-term hypoxia of tumor limits its therapeutic effect.

A pH/Ultrasound dual-response biomimetic nanoplatform for nitric oxide gas-sonodynamic combined therapy and repeated ultrasound for relieving hypoxia.

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10.21767/1791-809X.1000629

The radical cure was only made in one patient at the age of two years.

Tetralogy of Fallot in Four Down syndrome Patients in Setif, Algeria: Diagnosis and Clinical Aspects

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10.3760/CMA.J.ISSN.1673-4106.2019.03.006

Keep the mastoid bone bridge effect a radical cure tympanoplasty (Intact-bridge mastoitympanoplasty, IBM) both safely mastoid type to a certain extent effect a radical cure tympanoplasty (canal wall down CWD) postoperative retention and open mastoid hearing effect a radical cure tympanoplasty (canal wall up CWU) lesions cleared completely advantage.

Improvement and application of mastoidectomy for tympanoplasty with bone bridge retention

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10.3760/CMA.J.ISSN.1009-4598.2019.07.009

Conclusions The method of complete resection of tumor as early as possible can radical cure the ocular lymphangioma with intracapsular hemorrhage, which prevent the disease from deteriorating, and meeting the aesthetic requirements of satisfactory appearance.

Ocular lymphatic vascular malformation combined intracystic hemorrhage of surgical treatment

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10.3760/CMA.J.ISSN.1674-4756.2019.12.013

08% in the radical cure group, respectively, there was no significant difference (P> 0.

Clinical effects of laparoscopic surgery for the preservation of reproductive function in ovarian borderline tumors

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10.1093/annonc/mdz431.020

Surgical resection is the only possible effective means for radical cure of pancreatic cancer.

Screening of prognostic molecular biomarker for resectable pancreatic cancer

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10.1093/jtm/taz023

METHODS A standard literature search was performed on varying combinations of the terms tafenoquine, Arakoda, Kodatef, Krintafel, Kozenis, primaquine, G6PD deficiency, malaria prophylaxis and radical cure.

Tafenoquine and G6PD: a primer for clinicians.

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10.1021/acs.nanolett.9b02053

Our results suggested a strategy for designing multifunctional nanomedicines with simple construct and efficacious therapeutic response and presented the promising potential of PDT in radical cure of cancer.

A simple yet multifunctional nanoformulation for eradicating tumors and preventing recurrence with safely low administration dose.

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10.1097/QCO.0000000000000574

Single-dose tafenoquine provides equivalent efficacy to 14 days of primaquine for radical cure in P.

Tafenoquine: the new kid on the block.

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10.1615/critreveukaryotgeneexpr.2019025723

The development of pancreatic transplantation gives some hope in the radical cure of diabetes.

Stem Cell Therapy for Diabetes Mellitus: Recent Progress and Hurdles.

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10.3760/CMA.J.ISSN.1006-7876.2019.11.016

Amyotrophic lateral sclerosis (ALS) is a progressively aggravating fatal neurodegenerative disease, and there is no radical cure.

Therapies for amyotrophic lateral sclerosis

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10.21037/32489

Surgical resection remains the only way for the radical cure of pancreatic cancer.

TRIANGLE operation for borderline resectable pancreatic cancer in total pancreatectomy

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10.1097/MD.0000000000015600

Because there is no radical cure for CHF, and due to economic reasons, neither patient received liver transplantation.

Congenital hepatic fibrosis with polycystic kidney disease

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10.1093/milmed/usy368

The present study evaluates the effect of a reduction in particle size assessed by homogenization, sonication, and homogenization plus sonication on the bioavailability of imidazolidinedione (IZ), an antimalarial compound with known causal prophylactic activity and radical cure of relapsing malaria.

Improving Relative Bioavailability of Oral Imidazolidinedione by Reducing Particle Size Using Homogenization and Ultra-Sonication.

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10.1128/AAC.01965-18

vivax has been found in the major port city of Manaus but not in the main malaria hot spots across the Amazon Basin of Brazil, where CQ is routinely coadministered with primaquine (PQ) for radical cure of vivax malaria.

Monitoring the Efficacy of Chloroquine-Primaquine Therapy for Uncomplicated Plasmodium vivax Malaria in the Main Transmission Hot Spot of Brazil

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10.1056/NEJMoa1802537

vivax parasitemia and hypnozoites, termed “radical cure.

Tafenoquine versus Primaquine to Prevent Relapse of Plasmodium vivax Malaria

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10.1016/S0140-6736(19)31285-1

We aimed to assess the efficacy of a shorter course (7 days) of primaquine for radical cure of vivax malaria.

Short-course primaquine for the radical cure of Plasmodium vivax malaria: a multicentre, randomised, placebo-controlled non-inferiority trial

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10.1155/2019/2310639

Objective Cancer is one of the most dangerous diseases to human life and there is no radical cure for it.

Danshen Formulae for Cancer: A Systematic Review and Meta-Analysis of High-Quality Randomized Controlled Trials

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10.1097/CM9.0000000000000595

Background The symptomatic bradyarrhythmia is Class I indication for pacing therapy which is not a radical cure.

Initial experience with ablation of the innervation surrounding sinus and atrioventricular nodes to treat paroxysmal bradyarrhythmia

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10.14218/ERHM.2019.00004

The World Health Organization recommends a regimen of 3-day chloroquine plus 14 days of primaquine for radical cure.

Tafenoquine: A Breakthrough Drug for Radical Cure and Elimination of Malaria

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10.4269/ajtmh.19-0496

In the absence of widespread primaquine use for radical cure against P.

Declining Burden of Plasmodium vivax in a Population in Northwestern Thailand from 1995 to 2016 before Comprehensive Primaquine Prescription for Radical Cure

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10.1080/2000656X.2019.1661846

Although multiple treatments exist that can improve the hand malformations, there are currently still no radical cures for this disease because of its high recurrence rate.

Surgical management of hand deformities in patients with recessive dystrophic epidermolysis bullosa

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10.5897/AJPP2018.4980

Tafenoquine is a single dose medication for radical cure of P.

Modern approach of treatment on destroyable pathogenicity of malaria parasite: A review article

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10.1056/NEJMoa1710775

BACKGROUND Treatment of Plasmodium vivax malaria requires the clearing of asexual parasites, but relapse can be prevented only if dormant hypnozoites are cleared from the liver (a treatment termed “radical cure”).

Single-Dose Tafenoquine to Prevent Relapse of Plasmodium vivax Malaria

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10.1097/MD.0000000000015016

Splenectomy is the best therapeutic option for this entity and probably the only chance for radical cure.

Synchronous isolated splenic metastasis from cancer of hepatic flexure of colon

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10.1080/1120009X.2019.1665874

The aim of this study was to compare cost-utility of tafenoquine (TQ) and primaquine (PQ) for a radical cure (prevention of relapse) of Plasmodium vivax (PV) malaria in Serbia using A five-state, 1-month cycle Markov model.

Cost-utility of tafenoquine vs. primaquine for the radical cure (prevention of relapse) of Plasmodium vivax malaria

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10.21037/gs.2019.08.01

The individualized method of repair and reconstruction can achieve the effect of a radical cure of the tumor and the consideration of local morphology and function.

Primary repair and reconstruction of tumor defects in parotid masseter region: a report of 58 cases.

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10.1371/journal.pmed.1002784

vivax morbidity after radical cure treatment and related risk factors was conducted in Central Vietnam.

Plasmodium vivax morbidity after radical cure: A cohort study in Central Vietnam

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Radical Cure
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What is/are Radical Cure?

Radical Cure - However, these treatments focus on improving symptoms of the disease and fail to achieve a radical cure; they also have certain toxic side effects. [1] International recommendations for radical cure recommend fixed target doses of 0. [2] Factors such as adequate dosing, adherence, drug quality, and pharmacogenetics can impact the effectiveness of radical cure of P. [3] The other cycle occurred among men with screening detected cancer who initially eschewed radical treatments or imagined doing so, whose lives were often consumed with fear and surveillance, increasing demand for radical cures. [4] Safety and efficacy findings for TQ in Plasmodium vivax malaria prophylaxis and radical cure are summarized and some of the latest TQ-related studies (published in 2020 and 2021) are highlighted. [5] Background: Primaquine is the only widely available drug for radical cure of Plasmodium vivax malaria. [6] vivax requiring implementation of radical cure with primaquine. [7] The hype and controversy of human embryonic stem (ES) cells led the proponents of stem cell research to promise very rapid development of very radical cures. [8] com/ Results: US- FDA Approved Orphan Drug ex: Tafenoquine - Treatment of malaria - Krintafel is indicated for the radical cure (prevention of relapse) of Plasmodium vivax malaria. [9] Collectively, the combination of TKIs and IRAK1/4 inhibitors is an attractive strategy to achieve a radical cure of CML. [10] Surgical excision of intraperitoneal complex teratoma is the key to radical cure of the tumor. [11] Krintafel was approved for radical cure of P. [12] 1 peptide, which represents a radioimmunotherapy strategy based on the combination of SIRT with a peptide–drug conjugate, could provide a treatment means for the radical cure of ATC. [13] Human capital accumulation is a radical cure for income inequality and poverty issues in the process of economic development. [14] Such evidence-based data will guide the expansion of primaquine and potentially tafenoquine for radical cure of P. [15] As a surgical treatment of maxillary sinusitis in the section of oro-maxillo-facial surgery, radical cure is used for 58. [16] The etiology and pathogenesis of HUA are not fully understood, so there is no radical cure so far. [17] Background: The radical cure of Glioblastoma multiforme (GBM) is a troublesome medical problem, owing to its resistance to temozolomide chemotherapy and very poor surgical results or high relapse rate. [18] Primaquine (PQ), an 8-aminoquinoline antimalarial drug, has been widely used for the eradication of hypnozoites from the liver and, therefore, recognized as the radical cure of malaria. [19] Improved control of Plasmodium vivax malaria can be achieved with the discovery of new antimalarials with radical cure efficacy, including prevention of relapse caused by hypnozoites residing in the liver of patients. [20] Background Wide-spread implementation of treatment regimens for the radical cure of vivax malaria is hindered by a range of factors. [21] In highly selected cases (<1%), liver transplant (LT) might be considered in patients with NELM representing a potential chance of radical cure if proper patient selection is provided. [22] vivax by primaquine for radical cure. [23] Primaquine is the only widely available drug for radical cure of Plasmodium vivax malaria. [24] vivax whereas primaquine is given to eliminate latent liver stage infections (a method known as radical cure). [25] Treatment with clofazimine alone, clofazimine plus azithromycin, and atovaquone plus azithromycin was ineffective and failed to eliminate the parasites completely, while a 44-day treatment with clofazimine plus atovaquone was highly effective and resulted in a radical cure. [26] Elimination of both the blood and liver stages of the parasites (“radical cure”) is required to achieve a sustained clinical response and prevent ongoing transmission of the parasite. [27] Factors such as adequate dosing, adherence, drug quality, and pharmacogenetics can impact the effectiveness of radical cure of P. [28] The majority of infections were afebrile suggesting the need for strong active case detection with radical cure with primaquine for P. [29] Background: Tafenoquine (TQ) was recently approved as prophylaxis and radical cure for P. [30] Conventional treatments for BCS do not solve practical problems, wherease liver transplantation has been only applied as a last-resort therapy and as the only opportunity for a radical cure. [31] Emergency surgery not only relieves respiratory obstruction and saves the lives of patients, but some patients can get a radical cure as well. [32] vivax until radical cure with primaquine is possible. [33] Radical cure of vivax malaria requires hypnozoitocide therapy to prevent relapses. [34] To achieve elimination of malaria in South-East Asia, where prevalence of vivax malaria is high, we must prioritise the radical cure of vivax to eliminate the liver-stage of this species that causes relapses of infection. [35] Cindy S Chu and co-authors review options for diagnosis, safe and radical cure, and relapse prevention of Plasmodium Vivax. [36] Background Accumulating evidence suggest that compromised CYP2D6 enzyme activity caused by gene mutation could contribute to primaquine failure for the radical cure of vivax malaria. [37] International recommendations for radical cure recommend fixed target doses of 0. [38] Up to now, the pathogenic mechanism and radical cure treatment for COVID-19 are still unknown. [39] Improved control of malaria caused by Plasmodium vivax can be achieved with the discovery of new antimalarials with radical cure efficacy, including prevention of relapse caused by hypnozoites residing in the liver of vivax patients. [40] Food and Drug Administration in 2018 for the radical cure of Plasmodium vivax infection and for malaria prophylaxis. [41] Doctors declared that the radical cure of hernias should be undertaken by abdominal section. [42] [2, 3] Currently, the treatment of cancer includes surgery [4], chemotherapy [4], targeted therapy [5], but it is still difficult to achieve a radical cure of the cancer due to the risk of recurrence and treatment resistance [1, 4]. [43] However, a progressive race among numerous research groups to discover a radical cure for the COVID-19 is under way. [44] Therefore, a radical cure for UC is desired. [45] For women with recurrent and locally advanced pelvic malignancy, located anteriorly or anterior-laterally to the rectum, invading the cervix or vaginal vault, posterior pelvic exenteration (PPE) maybe the only chance of a radical cure [1]. [46] Radical cure requires both blood schizontocidal and hypnozoitocidal chemotherapies. [47] CONCLUSION: Results of a retrospective multivariate analysis made it possible to develop an algorithm for substantiating surgical techniques, providing a radical cure for 95. [48] Background The radical cure of Plasmodium vivax requires treatment with an 8-aminoquinoline drug, such as primaquine and tafenoquine, to eradicate liver hypnozoite stages, which can reactivate to cause relapsing infections. [49] Radical cure is a form of therapy capable of addressing this problem. [50]

glucose 6 phosphate

Background Glucose-6-phosphate dehydrogenase (G6PD) deficiency greatly hinders Plasmodium vivax malaria radical cure and further elimination due to 8-aminoquinolines-associated hemolysis. [1] Rapid tests for glucose-6-phosphate dehydrogenase (G6PD) are extremely important for determining G6PD deficiency, a widespread metabolic disorder which triggers hemolytic anemia in response to primaquine and tafenoquine medication, the most effective drugs for the radical cure of malaria caused by Plasmodium parasites. [2] Radical cure of Plasmodium vivax malaria in glucose-6-phosphate dehydrogenase (G6PD) deficient individuals employs weekly primaquine dosing. [3] Radical cure of Plasmodium vivax malaria in glucose-6-phosphate dehydrogenase (G6PD) deficient individuals employs weekly primaquine dosing. [4] Background To reduce the risk of drug-induced haemolysis, all patients should be tested for glucose-6-phosphate dehydrogenase (G6PD) deficiency (G6PDd) prior to prescribing primaquine (PQ)-based radical cure for the treatment of vivax malaria. [5]

% 95 %

According to the model, while achieving elimination in only few settings in Brazil, tafenoquine rollout in 2021 is estimated to improve the mean effective radical cure rate from 42% (95% uncertainty interval [UI] 41%–44%) to 62% (95% UI 54%–68%) among clinical cases, leading to a predicted 38% (95% UI 7%–99%) reduction in transmission and over 214,000 cumulative averted cases between 2021 and 2025. [1]

Effective Radical Cure

According to the model, while achieving elimination in only few settings in Brazil, tafenoquine rollout in 2021 is estimated to improve the mean effective radical cure rate from 42% (95% uncertainty interval [UI] 41%–44%) to 62% (95% UI 54%–68%) among clinical cases, leading to a predicted 38% (95% UI 7%–99%) reduction in transmission and over 214,000 cumulative averted cases between 2021 and 2025. [1] Background Liver transplantation (LT) is the only effective radical cure for all types of end-stage liver diseases. [2] Chloroquine or dihydroartemisinin-piperaquine with either 7- or 14-day primaquine regimens provided highly effective radical cure of vivax malaria on the Thailand-Myanmar border. [3] In coendemic regions, the timely elimination of malaria will require that safe and effective radical cure of both the blood and liver stages of the parasite is widely available for all patients at risk of malaria. [4]

Vivax Radical Cure

Plasmodium vivax radical cure requires the administration of a blood schizonticide for killing blood-stage parasites and the addition of a drug able to kill hypnozoites, the dormant parasite stages residing in the liver of infected patients. [1] vivax radical cure. [2] vivax radical cure to maximise impact of control in co-endemic areas. [3]

Free Radical Cure

Currently, free radical cured polygraphic varnishes are most widespread. [1] Currently, free radical cured varnishes are most widespread. [2]

Encounter Radical Cure

Single Encounter Radical Cure and Prophylaxis (SERCAP) describes an ideal anti-malarial drug that cures all malaria in a single dose. [1] OBJECTIVES Rapid rate-of-kill (RoK) is a key parameter in the target candidate profile 1 (TCP1) for the next-generation antimalarial drugs for uncomplicated malaria, termed Single Encounter Radical Cure and Prophylaxis (SERCaP). [2]

Malarium Radical Cure

Background Glucose-6-phosphate dehydrogenase (G6PD) deficiency greatly hinders Plasmodium vivax malaria radical cure and further elimination due to 8-aminoquinolines-associated hemolysis. [1] NPC1161B, the (R)-(−) enantiomer with outstanding potential for malaria radical cure, treatment of visceral leishmaniasis and pneumocystis pneumonia infections is poised for clinical development. [2]

radical cure treatment

Up to now, the pathogenic mechanism and radical cure treatment for COVID-19 are still unknown. [1] vivax morbidity after radical cure treatment and related risk factors was conducted in Central Vietnam. [2]

radical cure recommend

International recommendations for radical cure recommend fixed target doses of 0. [1] International recommendations for radical cure recommend fixed target doses of 0. [2]

radical cure require

Plasmodium vivax radical cure requires the administration of a blood schizonticide for killing blood-stage parasites and the addition of a drug able to kill hypnozoites, the dormant parasite stages residing in the liver of infected patients. [1] Radical cure requires both blood schizontocidal and hypnozoitocidal chemotherapies. [2]

radical cure efficacy

Improved control of Plasmodium vivax malaria can be achieved with the discovery of new antimalarials with radical cure efficacy, including prevention of relapse caused by hypnozoites residing in the liver of patients. [1] Improved control of malaria caused by Plasmodium vivax can be achieved with the discovery of new antimalarials with radical cure efficacy, including prevention of relapse caused by hypnozoites residing in the liver of vivax patients. [2]