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purified inactivated vaccine

Using a heterologous prime-boost strategy in rhesus macaques, we examine the effect of priming with DENV purified inactivated vaccines (PIVs) on a tetravalent live attenuated vaccine (LAV).

Enhanced dengue vaccine virus replication and neutralizing antibody responses in immune primed rhesus macaques

purified inactivated vaccine

Of these, a Zika purified inactivated vaccine (ZPIV), adjuvanted with aluminum hydroxide, developed by the Walter Reed Army Institute of Research (WRAIR), yielded high seroconversion rates.

Immunogenicity and protection conferred by an optimized purified inactivated Zika vaccine in mice.

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10.1016/j.isci.2021.102298

We used a well-characterized SARS-CoV-2 strain and an established Vero cell platform to produce large-scale GMP grade highly purified inactivated antigen.

Th1 skewed immune response of whole virion inactivated SARS CoV 2 vaccine and its safety evaluation

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10.1038/s41541-021-00339-y

Using a heterologous prime-boost strategy in rhesus macaques, we examine the effect of priming with DENV purified inactivated vaccines (PIVs) on a tetravalent live attenuated vaccine (LAV).

Enhanced dengue vaccine virus replication and neutralizing antibody responses in immune primed rhesus macaques

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10.1016/j.virol.2021.05.003

In this study, we established a Vero cell-adapted ZIKV strain (GMZ-002) and developed a purified inactivated virus (PIV) vaccine.

A purified inactivated vaccine derived from Vero cell-adapted zika virus elicits protection in mice.

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10.1371/journal.ppat.1009171

The purified inactivated virions with higher NA content show a more spherical morphology, a shift in the balance between the HA receptor binding and NA receptor release functions, and induce a better NA inhibitory antibody response in mice.

Balancing the influenza neuraminidase and hemagglutinin responses by exchanging the vaccine virus backbone

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10.3390/ph12030127

So that, different platforms (purified inactivated and live attenuated viruses, DNA and RNA nucleic acid based candidates, virus-like particles, subunit elements, and recombinant viruses) have been evaluated as vaccine candidates.

Therapeutic Advances Against ZIKV: A Quick Response, a Long Way to Go

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10.1016/j.vaccine.2019.04.013

Of these, a Zika purified inactivated vaccine (ZPIV), adjuvanted with aluminum hydroxide, developed by the Walter Reed Army Institute of Research (WRAIR), yielded high seroconversion rates.

Immunogenicity and protection conferred by an optimized purified inactivated Zika vaccine in mice.

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Purified Inactivated
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What is/are Purified Inactivated?

Purified Inactivated - We used a well-characterized SARS-CoV-2 strain and an established Vero cell platform to produce large-scale GMP grade highly purified inactivated antigen. [1] Using a heterologous prime-boost strategy in rhesus macaques, we examine the effect of priming with DENV purified inactivated vaccines (PIVs) on a tetravalent live attenuated vaccine (LAV). [2] In this study, we established a Vero cell-adapted ZIKV strain (GMZ-002) and developed a purified inactivated virus (PIV) vaccine. [3] The purified inactivated virions with higher NA content show a more spherical morphology, a shift in the balance between the HA receptor binding and NA receptor release functions, and induce a better NA inhibitory antibody response in mice. [4] So that, different platforms (purified inactivated and live attenuated viruses, DNA and RNA nucleic acid based candidates, virus-like particles, subunit elements, and recombinant viruses) have been evaluated as vaccine candidates. [5] Of these, a Zika purified inactivated vaccine (ZPIV), adjuvanted with aluminum hydroxide, developed by the Walter Reed Army Institute of Research (WRAIR), yielded high seroconversion rates. [6]

purified inactivated vaccine

Using a heterologous prime-boost strategy in rhesus macaques, we examine the effect of priming with DENV purified inactivated vaccines (PIVs) on a tetravalent live attenuated vaccine (LAV). [1] Of these, a Zika purified inactivated vaccine (ZPIV), adjuvanted with aluminum hydroxide, developed by the Walter Reed Army Institute of Research (WRAIR), yielded high seroconversion rates. [2]