Introduction to Prospective Randomized

Methods A single-blind prospective randomized controlled clinical trial was conducted.

A prospective randomized controlled clinical trial was performed, enrolling 70 consecutive patients who underwent TACE.

Methods: This prospective randomized controlled double blinded study was carried out on 60 patients aged above 50 years; American Society of Anesthesiologists physical status (ASA) I-III scheduled for total knee arthroplasty under spinal anesthesia.

Materials and Methods: This is a prospective randomized double-blinded study.

METHODS Ninety patients aged between 18 and 65 years and undergoing elective cancer breast surgery were included in this prospective randomized, double-blind study.

A prospective randomized double-blind study was conducted with 90 patients divided into three groups, with each group being administered one of three different LAs: lidocaine 2% 1/80,000, articaine 4% 1/200,000, and bupivacaine 0.

Methods We conducted a prospective randomized controlled clinical study on the participants diagnosed with melasma.

METHODS A prospective randomized, unblinded, controlled clinical study was conducted on patients admitted to the ED for LBP of unclear chronicity.

Study Design This was a prospective randomized controlled trial conducted at a tertiary university obstetric unit in Hong Kong.

Methods: This was a prospective randomized controlled trial conducted on 108 women undergoing mid trimester abortions at Patna medical college and hospital in 2019.

METHODS A multicentre prospective randomized controlled trial was conducted evaluating the use of a smartphone-based care management system for primary total knee arthroplasty (TKA) and partial knee arthroplasty (PKA).

Objective To explore the short-term effectiveness of domestic robot-assisted total knee arthroplasty (RATKA) conducted by a prospective randomized controlled trial.

Methods This prospective randomized open-label controlled trial included 64 patients 38 to 42 years old undergoing ART with or without Hishi extract between June 11, 2015 and July 12, 2019.

Methods This prospective randomized controlled trial included 222 pediatric patients scheduled for repair of a structural congenital malformation under general anesthesia.

Methods: This prospective randomized controlled study included 37 patients suffering from metacarpal neck fractures.

Methods: This prospective randomized examiner-masked sham- controlled study included 86 participants (142 eyes) with DED.

Methods This prospective randomized controlled trial study was performed on 400 patients who were divided into four groups of combined protocol (group 1), lidocaine group (group 2), Huffing maneuver group (group 3), and the control receiving normal saline (group 4).

METHODS This prospective randomized, controlled trial study was conducted from March 2016 to May 2018 on 60 children with a diagnosis APN in a tertiary hospital in Iran.

In a prospective randomized study, 60 patients were included from an Egyptian Intensive Care Unit.

METHODS A prospective randomized controlled trial was conducted for 101 preterm infants with NRDS, with a gestational age of ≤32+6 weeks or a birth weight of ≤1 500 g, who were admitted to the neonatal intensive care unit of Xiamen Maternal and Child Health Hospital from January 1, 2019 to June 30, 2020.

METHODS This prospective randomized study, approved by the institute's ethics committee, was carried out at a tertiary care center from December 2018 to June 2020.

This prospective randomized controlled trial was conducted in a tertiary care center with a follow-up period of 12 weeks.

METHODS This prospective randomized double-arm trial was conducted at a tertiary care hospital in Egypt from February to December 2020.

METHODS A single center prospective randomized controlled trial was conducted in a tertiary care hospital.

Design, Setting, and Participants This study was a single-center prospective randomized open-label blinded end point clinical trial.

Methods In a multicentre, prospective randomized open label, blinded end-point trial, we randomized patients with LVEF <40% and New York Heart Association functional class II or III, despite optimal medical therapy, to treatment (1:1:1) with the probiotic yeast Saccharomyces boulardii, the antibiotic rifaximin, or standard of care (SoC) only.

This multi-center prospective randomized controlled trial aimed to assess component positioning between TKA with and without iASSIST by 3D image assessment, and to clarify whether the iASSIST provides any benefit with regard to alignment accuracy.

This prospective randomized controlled trial aimed to compare bowel movement recovery in patients undergoing colon resection surgery between groups using traditional or SVV-based methods for intravenous fluid management.

Prospective randomized trials with a larger sample size and longer follow-up are needed for comparison with other techniques of IOL fixation and confirmation of long-term safety profile.

However, we recommend further investigations on a larger sample size in multi-center and prospective randomized controlled trials (RCTs) to evaluate the effects of different drugs on the shedding of the virus through body secretions.

Methods: A prospective randomized case control study undertaken in the Department of Obstetrics and Gynecology, Nepalgunj Medical College, Kolhapur from September 2019 to August 2020.

Methods: This was a prospective randomized case control study carried out between May 2017 and June 2020.

Subjects and Methods: This prospective randomized clinical trial included patients who underwent elective and emergency abdominal surgeries in the Department of General Surgery at Suez Canal University Hospitals.

MATERIALS AND METHODS This prospective randomized clinical trial included 40 orthodontic patients 12-17 years of age.

In this prospective randomized double-blind, placebo-controlled crossover trial, 38 patients with cervical myelopathy undergoing posterior cervical decompression and fusion were randomized to either sugammadex (2mg/kg) or placebo.

The HEMACORT trial was a prospective randomized, double-blind, placebo-controlled, multicentric study (NCT01380028).

The literature on the treatment of endometriosis-related pain is characterized by large gaps, there are only a few prospective randomized or placebo-controlled studies.

Erectile Dysfunction A Prospective Randomized Placebo-Controlled Study Evaluating the Effect of Low-Intensity Extracorporeal Shockwave Therapy (LI-ESWT) in Men With Erectile Dysfunction Following Radical Prostatectomy.

METHODS Eligible patients undergoing elective general surgery between August and October 2019 were enrolled into this prospective randomized controlled feasibility study.

Material and Methods: In this prospective randomized trial 90 adult female patients undergoing elective laparoscopic surgery under general anesthesia using LMA ProSeal™ as airway device were included.

PATIENTS AND METHODS: a prospective randomized Comparative clinical study included 200 patients admitted to ICU units of Al-Azhar university hospitals and El Haram hospital who had the following criteria: severe head injury, Cerebral trauma on and Glasgow Coma Scale [GCS]score 8 or less on the fourth day viewed by brain CT scan done without given any sedation.

Setting and design This is a prospective randomized comparative clinical study that was carried out at Alexandria Main University Hospital, Alexandria, Egypt.

A prospective randomized controlled trial comparing DPOC using multibending and conventional technique reported a significantly higher success rate of freehand intubation and advancement to the hilum or the obstructed segment of the bile duct, respectively, of 89.

It is a prospective randomized controlled trial comparing the efficacy of percutaneous tibial nerve stimulation versus sham for a shortened 6-week protocol of treatment in management of refractory OAB in non-neurogenic adult patients.

METHODS This prospective randomized single-blinded trial, carried out between 2008 and 2016, included 364 fourth-year medical students of two Swiss universities.

This study is a prospective randomized controlled single-blinded trial with parallel arms: the intervention arm received specific integrated yoga therapy; the control arm received routine standard care from 18 to 22 weeks of gestation until delivery.

Patients and methods This is a prospective randomized comparative study that recruited patients with visually significant cataract and no other ocular or systemic conditions that may influence the ocular sensation.

Patients and methods This was a prospective randomized study that recruited 284 patients with visually significant cataract for whom uneventful phacoemulsification with intraocular lens implantation was performed.

In a prospective randomized control trial, sacrospinous hysteropexy provides significantly lower reoperation rate for apical compartment prolapse in a long-term follow-up.

We recommend a prospective randomized controlled trials comparing navigated versus non-navigated for Gradius knee prosthesis with long-term follow-up.

Interestingly, a well-designed prospective randomized multicenter study (PIONEER-HF) showed an improved clinical outcome and stress/injury biomarker profile after in-hospital administration of sacubitril/valsartan (sac/val) as compared to enalapril, in hemodynamically stable patients with AHF.

Limited prospective randomized studies have been unable to show improved clinical outcomes with routine mechanical circulatory support (MCS) in patients with a high burden of coronary artery disease and reduced ejection fraction.

This small prospective randomized open-label study showed no clinically significant impacts of ARB therapy in mildly hypoxemic patients hospitalized with COVID-19 early in the pandemic.

Methods A prospective randomized open-label study was designed to identify differences in the fitting performance between mask wearing methods in three different types of KF94 mask with ear loops between January to March 2021.

Participants and Research Methods: This was a prospective randomized controlled trial involving patients with significant cataract and acute PACG who were not responsive to maximal medical therapy.

MAIN RESULTS We included two trials in the review: one prospective randomized trial involving 80 participants that compared conservative treatment to endovascular coiling, and one randomized controlled trial involving 136 participants that compared microsurgical clipping to endovascular coiling for unruptured intracranial aneurysms.

METHODS Patients aged 1 month-16 years undergoing elective FB were included in a prospective randomized controlled, nonblinded, single-center clinical trial and randomly assigned to receive oxygen via NC or HFNC.

A prospective randomized multi-center clinical trial was designed to evaluate the role of DCE-MRI based RT dose escalation in poor prognosis HNC.

METHODS A prospective randomized double blind controlled trial was conducted amongst 68 patients with impacted mandibular third molars.

This prospective randomized double-blind controlled trial was conducted on 43 post-partum females suffering from PDPH with visual analog score (VAS) ≥ 4 and Lybecker score ≥ 2.

Recent prospective randomized longitudinal studies comparing treatment modalities have reported stable or improved cognitive functions over time among most patients treated with HD-MTX-based chemotherapy alone or followed by consolidation with high-dose chemotherapy and autologous stem cell transplantation (ASCT), and cognitive decline in patients treated with consolidation WBRT; although reduced-dose WBRT was associated with less pronounced neurotoxicity.

We report the 12-year follow-up of the prospective randomized EBMT LYM1 trial to determine whether the benefit of brief duration rituximab maintenance (RM) on progression-free survival (PFS) in patients with relapsed follicular lymphoma (FL) receiving an autologous stem cell transplant (ASCT) is sustained.

This prospective randomized controlled study aimed to determine the optimal number of needle passes during EUS-FNB of solid pancreatic lesions, with 22G FNB needles and different sampling techniques.

OBJECTIVE  This prospective randomized controlled study aimed to compare the ultrasound-guided (USG) technique with the standard single-wall puncture technique for epicutaneo-caval catheter (ECC) placement in neonates.

OBJECTIVES This study was designed as a prospective randomized single-blind clinical trial to compare the anesthetic efficacy of inferior alveolar nerve block (IANB), IANB plus buccal infiltration, and IANB plus lingual infiltration of 4% articaine with 1:100,000 epinephrine in mandibular molars with irreversible pulpitis.

Results This prospective randomized controlled single-blind clinical study was performed on total (50) ASA status I or II patients, of age 3 to 6 years scheduled for hypospadias surgery.

Methods: This hospital based prospective randomized comparative study design was include patients of both sexes in age group of 2 to 14 years attending SMS hospital, Jaipur during April 2018 to June 2019 or till the sample size achieved, with due permission from the institutional ethic committee and review board and after taking written informed consent from the patient.

Aim of the Study: To evaluate the effect of nebulized magnesium sulfate on reduce the stress response induced tracheal intubation Material and Methods: Following institutional ethical committee approval and written informed consent, a prospective randomized double-blinded study was conducted in 100 cases divided into two equal groups.

A prospective randomized trial of HH patients to modified natural versus programmed frozen embryo transfer would best support this hypothesis.

A prospective randomized trial of patients with less than four 2pn zygotes to day 3 fresh embryo transfer vs PGT-A frozen embryo transfer is needed to confirm these findings.

Settings and Design : Prospective randomized, double-blinded controlled trial at a tertiary level pediatric cardiothoracic center.

Materials and Methods: This prospective randomized double-blinded controlled study was conducted on 150 full-term parturients undergoing CS under spinal anesthesia, who were divided into three groups, receiving saline or different drug doses: Group C: 0.

PATIENTS AND METHODS A prospective randomized control study included 40 burned patients who were treated in Burn unit from burn injuries ranged from 20 to 40%.

This prospective randomized study included 40 patients diagnosed with head and neck malignancies, requiring microvascular free flap reconstruction.

A shortcoming in blinding of the investigators to the mode of transportation is similar to blinding to the endovascular treatment in PROBE (Prospective Randomized Open, Blinded End-Point) design used in thrombectomy trials.

SETTING The Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial (CREST-2) is a multicenter prospective randomized open blinded end-point clinical trial of intensive medical management with or without revascularization by endarterectomy or stenting for asymptomatic high-grade carotid stenosis.

Methodology A hospital-based prospective randomized controlled study was conducted in the Department of Obstetrics and Gynaecology in tertiary care centre carried over a period of 18 months among 212 female patients in labour assigned in Group A squatting position and Group B lying down position.

Methods: This prospective randomized clinical investigation was undertaken at a tertiary care centre after obtaining written informed consent from ASA I&II patients scheduled for elective total knee arthroplasty under spinal anaesthesia, belonging to the age group of 18 and 60 years.

Methods This is a prospective randomized open label non-inferiority trial.

Methods: This is a prospective randomized open label non-inferiority trial.

Methods: This is a two-arm, parallel-group, prospective randomized placebo-controlled clinical trial.

Methods This is a two-arm, parallel-group, prospective randomized placebo-controlled clinical trial.

Experimental Design: SWOG S1216 is a phase III prospective randomized trial of androgen deprivation therapy (ADT) combined with orteronel or bicalutamide for mCSPC.

Prostate cancer patients eligible for androgen deprivation therapy who opted for orchiectomy were enrolled in prospective randomized study.

Subjects and methods We conducted a prospective randomized, single-blinded, placebo-controlled trial of 111 eligible pregnant women with type 1 diabetes and presented the results of 84 (intervention arm and control arm comprised 42 participants each) of them who successfully finished the trial in an academic hospital.

Second, a prospective randomized, double blinded, placebo-controlled cohort study was conducted.

Materials and Methods: The Double blind prospective randomized study included 60 parturients of ASA I and II with 37-41 weeks of singleton pregnancy in active labor, cervical dilatation >4 cm, with no obstetrical or medical complication, requesting painless labor, randomized into two groups (30 each) by a computer generated randomized sequence: Group R- received intrathecal 2.

Method: A prospective randomized study included 60 eligible patients aged over 60 years with newly diagnosed AML.

This was a prospective randomized controlled open-label study conducted on 60 chemotherapy-naive metastatic NSCLC.

Background: The purpose of this trial is to evaluate the success rate of salvage radiation therapy (SRT) for recurrence of prostate cancer (PCa) after radical prostatectomy with and without planning based on prostate specific membrane antigen (PSMA) positron emission tomography (PET) Methods: This is a multicenter, prospective, randomized, controlled, open-label, Phase 3 clinical imaging trial powered for clinical outcome at 5 years UCLA is the leading central site in which PSMA PET, clinical follow-up and data management are being done UCSF was a participating site in which PSMA PET imaging can be done SRT can be performed anywhere, patients are followed remotely by the UCLA investigators Patients scheduled for SRT for recurrence after primary prostatectomy and with PSA ≥ 0 1ng/ml at time of enrollment were eligible Patients were randomized to proceed with standard SRT allowing for any conventional imaging aside from PSMA PET/CT (control arm) or undergo a 68Ga-PSMA-11 PET/CT scan prior to SRT planning (investigational arm) The primary endpoint is the success rate of SRT at 5 years in patients who undergo SRT We report here the preliminary results of a secondary endpoint: the impact of PSMA PET on SRT planning by comparing the pre-randomization RT plans prospectively obtained on surveys before randomization to the actually delivered RT plans obtained after follow-up Results: Enrollment of the trial was complete 193 patients were enrolled from 09 06 2018 to 08 17 2020 7/90 patients (9%) in the control arm dropped-out the study because they underwent a PSMA PET at another institution, while 1/103 (1%) patients of the intervention arm dropped-out due to COVID-19 related complications After a median follow-up of 13 3 months (last follow-up date 09/01/2020), delivered RT plans were obtained in 60/83 (72%) and 70/102 (69%) of patients of the control and the PSMA arms, respectively Median PSA at enrollment was 0 32 ng/ml (IQR 0 17-1 35) and 0 22 ng/ml (IQR 0 14-0 50) in the control and PSMA arms, respectively There was a change between the intended pre-randomization RT plan and the actually delivered RT plan in 17/60 (28%) and 40/70 (57%) of the patients in the control and PSMA arms, respectively (p = 0 002) SRT was aborted in favor of systemic therapy and/or metastasis directed RT for extra-pelvic M1 disease in 2/60 (3%) and 12/70 (17%) of the control and PSMA arms, respectively (p = 0 17) Dose prescription and/or target volume delineation was changed in 2/60 (3%) and 1/70 (26%) in the control and PSMA arms, respectively (p = 0 001) Conclusions: In this prospective randomized phase 3 study, PSMA PET had an impact on the SRT plan in more than half of the patients Long-term follow-up will show if the impact of PSMA PET on SRT planning translates into improved outcome or not.

A prospective randomized clinical trial was performed in 2 groups: the control group (n = 65), which received standard verbal and written information, and the experimental group (n = 65), which received standard information and the video.

Methods: This prospective randomized study included 126 children submitted for cardiac surgery, and they were allocated into three groups: control group (n = 42); TXA group (n = 42):- received only TXA; and combined ethamsylate TXA group (n = 42):- received a combination of TXA and ethamsylate.

AIM: To compare clinical outcome and morbidity of xation of mesh using brin glue and tackers in trans-abdominal pre-peritoneal inguinal hernia repair METHODOLOGY: We did a prospective randomized comparative study in which we enrolled 50 patients undergoing laparoscopic hernia repair (TAPP).

Methods: This prospective randomized study was carried out on 90 pediatric patients of both sexes aged (2 -7) years with ASA physical status I/II scheduled for elective laparoscopic inguinal hernia repair.

Methods: This study is a prospective randomized controlled double-blind study.

STUDY DESIGN A prospective randomized controlled double-blind clinical study.

Methods: This is a prospective randomized controlled trial to study the effectiveness and safety of bosentan combined with vardenafil in the treatment of postoperative pulmonary hypertension in children with congenital heart disease.

The children with congenital heart disease who met the criteria were divided into an intervention group and a control group according to the random number table method, and prospective randomized controlled clinical trials were conducted.

A prospective randomized double-blinded trial assessed tourniquets effects on postoperative pain, swelling, and early outcome in TKA.

STUDY DESIGN Prospective randomized double-blinded trial.