Introduction to Plco Trial
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The PLCO trial showed no mortality benefit for PSA screening at 10 years, whereas the ERSPC trial demonstrated a 20% reduction in prostate cancer mortality at 9 years, though PSA screening was associated with a very high rate of overdiagnosis.
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Methods: We used data from a nested case-control study within the screening arm of the PLCO trial (353 endometrial cancer cases, 353 controls, age 55-74 years at enrollment).
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MISCAN-Lung was calibrated to the NLST and PLCO trials and incorporates birth-cohort-specific smoking trends and life expectancies.
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Conclusion: Prostatectomy seems to predict better overall and prostate cancer‐specific survival compared with radiation therapy among patients with clinically localized prostate cancer diagnosed within the PLCO trial.
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METHODS
Participants in the PLCO trial were recruited from the general population in the catchment areas of ten screening centres across the USA, without previous diagnosis of a prostate, lung, colorectal, or ovarian cancer or current cancer treatment.
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Methods: PLCO trial participants without a history of thyroid cancer before study enrollment who have complete information about prediagnostic BMI were included.
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ResultsIn contrast to the CAP and PLCO trial, the ERSPC study reports a reduced relative and absolute mortality risk.
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METHODS: We used the PLCO trial with 13-yr follow-up to identify 27,656 men in the screening arm with baseline PSA and outcome data.
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