Introduction to Placebo Controlled Double Blind

What is/are Placebo Controlled Double Blind?

Placebo Controlled Double Blind - This paper presents the protocol for a large placebo-controlled double-blind study designed with sufficient statistical rigor to measure the efficacy of rTMS treatment in patients with Alzheimer dementia. ^[1] A review of randomized multicenter placebo-controlled double-blind clinical trials conducted in different years in different countries on the effectiveness of EPs® 7630 is presented. ^[2] Methods and materials Eighty episodic migraineurs who randomly assigned into two equal groups to receive either vitamin D3 2000 IU/d or placebo for 12-week were enrolled in this placebo-controlled double-blind trial included. ^[3] Methods In a male-only parallel randomized placebo-controlled double-blind trial, we investigated the effects of IN-OXT (24 IU) on visual fixation on pictures of faces and emotion recognition in an interactive ball-tossing game that probed processing of social and nonsocial stimuli. ^[4] Methods Placebo-controlled double-blind randomised multicentre trial. ^[5] DesignWe designed a perspective, randomized placebo-controlled double-blind trial. ^[6] To clarify the effect of FA intake on skin barrier function (SBF), we conducted a placebo-controlled double-blind pilot trial. ^[7] METHODS As part of a monocentric randomized placebo-controlled double-blind study (registered at www. ^[8] In this study, we investigated the possible effect of vitamin B6 on bipolar disorder in manic episode with psychotic feature in a placebo-controlled double-blind clinical trial in a psychiatric hospital. ^[9] In a placebo-controlled double-blinded design, with two sessions separated by 28 days, during which participants received daily doses of probiotics (or a placebo), we investigate whether the prolonged and controlled intake of probiotics affects risk-taking behavior and intertemporal choices using incentivised economic tasks. ^[10] The influence of a topically applied formulation containing components of natural moisturizing factor (NMF) on barrier-related parameters of the stratum corneum (SC) was investigated in vivo using confocal Raman microspectroscopy in a randomized, placebo-controlled double-blind study on 12 volunteers for 14 days. ^[11] In a placebo-controlled double-blind, cross-over design, 14 adults with obesity (10 females; aged 56 ± 12 years; body mass index = 33. ^[12] METHODS Ultrasonography was performed blinded to clinical information of 30 joints of 75 patients with hand osteoarthritis, treated with prednisolone in a randomized placebo-controlled double-blind trial. ^[13] In this randomized placebo-controlled double-blinded study, subjects were allocated either 60 mg WS extract or placebo. ^[14] Few studies investigated the effect of deferiprone in PKAN, including a recent placebo-controlled double-blind multicenter trial, demonstrating radiological improvement with reduction of iron load in the basal ganglia and a trend to slowing of disease progression. ^[15] DESIGN A randomised placebo-controlled double-blind mechanistic study of rifaximin versus placebo was performed in cirrhotic patients with HE. ^[16] Background Endocannabinoid dysfunction in animal models of autism spectrum disorder (ASD) and accumulating, albeit anecdotal, evidence for efficacy in humans motivated this placebo-controlled double-blind comparison of two oral cannabinoid solutions in 150 participants (age 5–21 years) with ASD. ^[17] DESIGN Randomised, placebo-controlled double-blind study. ^[18] Methods This was a randomized placebo-controlled double-blind multicenter trial funded by the British Heart Foundation (PG/12/72/29743). ^[19] This study aimed to further investigate these results using a placebo-controlled double-blinded crossover design. ^[20] STUDY DESIGN This study was a randomized, placebo-controlled double-blind, clinical trial. ^[21] SELECTION CRITERIA Randomized placebo-controlled double-blind add-on trials of ESL in people with drug-resistant focal epilepsy. ^[22] METHODS This multicenter placebo-controlled double-blind randomized phase III trial (ClinicalTrials. ^[23] Most published studies are observational, but three randomized placebo-controlled double-blind trials have been completed: two large trials (N = 2,558 patients) with baricitinb demonstrated significant faster improvement in clinical status and reduction in the recovery time, as well as, significant reduction in the progression to invasive mechanical ventilation and mortality. ^[24] We designed a randomized placebo-controlled double-blind trial dividing the newborns into two groups. ^[25] The school-age follow-up (2014-2017) was based on a standardized web-based parental questionnaire and clinical evaluation by a physician including skin prick tests, allergen specific immunoglobulin E serum tests and placebo-controlled double-blind oral food challenges, if indicated. ^[26] METHODS To determine the role of 5-HT in OXT-induced attenuation of amygdala threat reactivity and sensitization/ desensitization, we conducted a parallel-group randomized placebo-controlled double-blind experiment during which n = 121 healthy subjects underwent a transient decrease in 5-HT signaling via acute tryptophan depletion (ATD+) or the corresponding placebo-control protocols before the administration of intranasal OXT or placebo intranasal spray, respectively. ^[27] We aim to investigate the effect and safety of peroral apremilast in women with GELP in a randomised placebo-controlled double-blinded clinical trial. ^[28] A randomized block placebo-controlled double-blind clinical trial in 60 volunteers (18-60years old) with oral wounds indicated that AC niosome gel accelerated wound closure, reduced pain due to the oral wounds and improved participants quality of life more than AC gel, triamcinolone gel and placebo gel. ^[29] Using a randomized within-patient placebo-controlled double-blind TRPMS protocol, we performed unilateral active stimulation along with contralateral sham stimulation every weekday for two weeks in 6 adults. ^[30] UNIFI (NCT02407236) was a placebo-controlled double-blind trial consisting of randomized induction and maintenance studies. ^[31] We performed a randomized placebo controlled double blind trial. ^[32]