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10.1016/j.ejmech.2021.113781

Pyrazolopyrimidines as anticancer agents: A review on structural and target-based approaches.


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10.2174/1871520621666210112115128

Multi-Component Reactions of Cyclohexan-1,3-dione: Synthesis of Fused Pyran, Pyridine, Thiophene and Pyrazole Derivatives with c-Met, AntiProliferative Activities.


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10.17344/ACSI.2020.6090

Multi-component Reactions of Cyclohexan-1,3-diketones to Produce Fused Pyran Derivatives with Antiproliferative Activities and Tyrosine Kinases and Pim-1 Kinase Inhibitions.


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10.1002/chem.202004954

Tunable anticancer activity of furoylthiourea-based Ru(II)-arene complexes and their mechanism of action.


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10.22541/AU.161298038.83786090/V1

Design of Amino Acid- and Carbohydrate-Based Anticancer Drugs to Inhibit PIM kinases, an In Silico Study


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10.17344/ACSI.2020.6182

New Approaches for the Synthesis of Heterocyclic Compounds Derived from Cyclohexan-1,3-dione with Anti-proliferative Activities.


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10.1016/S2152-2650(21)01821-8

MPN-161: A Phase I Study of TP-3654, an Oral PIM Kinase Inhibitor, in Patients with Intermediate-2 or High-Risk Primary or Secondary Myelofibrosis (MF)


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10.2174/1871520621666210119092325

The Uses of Dimedone for the Synthesis of Thiophene, Thiazole and Annulated Derivatives with Antitumor, Pim-1 Kinase Inhibitions, PAINS Evaluations and Molecular Docking.


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10.1158/1535-7163.MCT-20-0663

PP2A-activating Drugs Enhance FLT3 Inhibitor Efficacy through AKT Inhibition–Dependent GSK-3β–Mediated c-Myc and Pim-1 Proteasomal Degradation


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10.1158/1538-7445.AM2021-1345

Abstract 1345: Pharmacodynamic biomarkers for Pim inhibition with TP-3654 in patients with solid tumors


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10.1016/j.bioorg.2021.105171

Discovery of small molecule acting as multitarget inhibitor of colorectal cancer by simultaneous blocking of the key COX-2, 5-LOX and PIM-1 kinase enzymes.


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10.3389/fchem.2021.694870

Novel Bis-Thiazole Derivatives: Synthesis and Potential Cytotoxic Activity Through Apoptosis With Molecular Docking Approaches


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10.1038/s41434-019-0084-5

Safety profiling of genetically engineered Pim-1 kinase overexpression for oncogenicity risk in human c-kit+ cardiac interstitial cells



Safety profiling of genetically engineered Pim-1 kinase overexpression for oncogenicity risk in human c-kit+ cardiac interstitial cells


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10.2174/1871520619666190402153429

Synthesis of Tetrahydrobenzo[b]thiophene-3-carbohydrazide Derivatives as Potential Anti-cancer Agents and Pim-1 kinase Inhibitors.


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10.2174/1871520619666190730103425

Heterocyclization of 2-Arylidencyclohexan-1,3-dione: Synthesis of Thiophene, Thiazole and Isoxazole Derivatives with Potential Antitumor Activities.


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10.1016/j.bioorg.2019.103481

Apoptosis: A target for anticancer therapy with novel cyanopyridines.



PIM-1 kinase: a potential biomarker of triple-negative breast cancer



Understanding PIM-1 kinase inhibitor interactions with free energy simulation.


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10.1016/j.bioorg.2018.10.067

Synthesis, and anti-proliferative, Pim-1 kinase inhibitors and molecular docking of thiophenes derived from estrone.


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10.1016/j.bioorg.2019.103189

Dual VEGFR-2/PIM-1 kinase inhibition towards surmounting the resistance to antiangiogenic agents via hybrid pyridine and thienopyridine-based scaffolds: Design, synthesis and biological evaluation.


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10.3390/molecules24122255

In Vitro and In Vivo Anti-Breast Cancer Activities of Some Newly Synthesized 5-(thiophen-2-yl)thieno-[2,3-d]pyrimidin-4-one Candidates


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10.2174/1871520619666190416102144

Synthesis and Biological Evaluation of Novel 4,5,6,7-Tetrahydrobenzo[D]-Thiazol-2-Yl Derivatives Derived from Dimedone with Anti-Tumor, C-Met, Tyrosine Kinase and Pim-1 Inhibitions.


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10.6026/97320630015116

Re-positioning of known drugs for Pim-1 kinase target using molecular docking analysis


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10.1021/acs.jcim.9b00494

Discovery of Novel Pim-1 Kinase Inhibitors with a Flexible-Receptor Docking Protocol


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