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Pd Models sentence examples within 1 methyl 4
MethodsWe examined expression/activity of G6PD and its association with microglial activation and dopaminergic neurodegeneration in multiple chronic PD models generated by an intranigral/intraperitoneal injection of LPS, daily subcutaneous injection of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) for 6 days, or transgenic expression of A53T α-synuclein.
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Male Sprague–Dawley rats were used as 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced PD models.
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Pd Models sentence examples within Induced Pd Models
We used MPTP/MPP+-induced PD models, including MPTP-induced mice, primary cultures of mice mesencephalic neurons and MPP+-treated neuro-2a cells to examine the effects of UDCA on PD pathogenesis.
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However, the effects of cordycepin in rotenone-induced PD models and the possible mechanisms are still not fully understood.
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Pd Models sentence examples within Experimental Pd Models
In this review, we systemically summarized experimental PD models, including cellular and animal models used in preclinical studies, to understand the pathogenesis of PD.
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Rotenone, an organic pesticide, is commonly used for investigating the mechanism of neuronal degeneration in experimental PD models.
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Pd Models sentence examples within Vivo Pd Models
Here, we show that Fer exerted potent neuroprotective effects in both in vitro and in vivo PD models.
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The results revealed that 4d could significantly inhibit 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine/1-methyl-4-phenylpyridinium (MPTP/MPP+)-induced p38 mitogen-activated protein kinase (MAPK) activation in both in vitro and in vivo PD models, thus inhibiting the NF-κB-mediated neuroinflammation-related apoptosis pathway.
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Pd Models sentence examples within Drosophila Pd Models
Here, we describe some common approaches to analyze mitochondrial functions and morphological changes in Drosophila PD models.
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Morphological changes in mitochondria, along with dysfunction and degeneration of DA neurons, have been reported in many studies using Drosophila PD models.
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Pd Models sentence examples within Mouse Pd Models
Aiming to improve mouse PD models, we examined if neonatal partial SNc lesions could lead to adult mice with fewer SNc DA neurons that are endowed with larger axonal arbors because of compensatory mechanisms.
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The rounded nuclei in mouse PD models in vivo are, therefore, indicative of reduced actomyosin tension.
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Pd Models sentence examples within Established Pd Models
Pd Models sentence examples within Preclinical Pd Models
Pd Models sentence examples within Animal Pd Models
Animal PD models have been generated to study the effects of hormonal stress, but no in vitro model has yet been developed.
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Background: Exercise therapy has been widely applied in clinical rehabilitation as an important practical and side effect—free adjuvant therapy, with a significant effect in alleviating motor dysfunction of patients with Parkinson’s disease (PD) or animal PD models.
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Pd Models sentence examples within Vitro Pd Models
HAGLROS was increasingly expressed in MPTP-induced PD mouse model and MPP+-intoxicated SH-SY5Y cells and suppression of HAGLRO decreased apoptosis and autophagy in both in vivo and in vitro PD models.
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Pd Models sentence examples within Rodent Pd Models
TPBG-targeted cell sorting enriched FOXA2 + LMX1A + vmDA precursors and helped attain efficient behavioral recovery of rodent PD models with increased numbers of TH + , NURR1 + , and PITX3 + vmDA neurons in the grafts.
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Homotopic transplantation, into the substantia nigra, is now being pursued in rodent PD models as a way to achieve more complete circuitry repair.
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Pd Models sentence examples within Elegan Pd Models
elegans PD models have contributed to the uncovering of molecular and cellular mechanisms of disease, with a focus on the genes most commonly found as causative in familial PD and risk factors in idiopathic PD.
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Here we provide first in vivo evidence to support the above possibility using Caenorhabditis elegans PD models.
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Pd Models sentence examples within Variou Pd Models
This study suggests including various PD models in the school development plan to improve teachers’ pedagogical content knowledge, which will result in improved learning outcomes for students.
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A critical link between microglial NLRP3 inflammasome activation and the progression of both α‐syn pathology and dopaminergic neurodegeneration has been identified in various PD models in vivo.
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Pd Models sentence examples within Different Pd Models
Pd Models sentence examples within pd models adequately
Pd Models sentence examples within pd models suggest
Parthanatos is a distinct type of cell death caused by excessive activation of poly (ADP-ribose) polymerase-1 (PARP1), and the activation of PARP1 in PD models suggests that parthanatos may exist in PD pathophysiology.
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Studies in asthma and COPD models suggest that corticosteroids need a balanced redox environment to be effective and to reduce airway inflammation.
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Rat COPD models were established in smoke group and smoke+ drug group.
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We perform four state-of-the-art adversarial attacks (FGSM, BIM, JSMA and C & W) to evaluate TPD models trained on MNIST and CIFAR-10 and the average detection accuracy is 96.
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Previously, we showed that Salmeterol, a long-acting β2-adrenergic receptor (β2-AR) agonist, has neuroprotective effects in PD models in vitro and in vivo through the β-arrestin2-dependent inhibition of pro-inflammatory M1-type mediator production.
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Mechanistic PK-PD models of OP treatment have great potential to quantitatively predict the long-term effects of drugs on clinical outcomes and allow patient-specific estimation of bone gain, in particular via the integration of multiple treatment options and bone mineralization.
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The PK/PD models presented here may as well be applied to studies with similar designs as either study A or B.
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Pharmacokinetic (PK) and pharmacodynamic (PD) parameters were measured by ultraperformance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS), and the PK/PD models were established according to the parameters derived.
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This educational technique article will: (1) demonstrate how these 3D models can be used to enhance student perception and learning regarding RPDs; and (2) will demonstrate using videos and web-based portals to show how the 3D RPD models were created and then used for educational purposes.
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The marine SAV2, SAV3 and PD models using wellboat movements were able to correctly simulate the farms status (PD positive or PD negative) with the sensitivity of 84%, 85%, 84% and Specificity of 98%, 97% and 94%, respectively.
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Therefore, Cor protected dopamine neurons against rotenone-induced apoptosis through improving mitochondrial dysfunction in PD models.
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The resulting report summarises evidence from across healthcare and nonhealthcare sectors on the variety of CPD activities including areas of best practice; variations in different work settings; influence of ‘insight and intelligence’ and qualitative-based CPD models.
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Furthermore, PD mice were injected with serum-derived exosomes or neurons in PD models were exposed to exosomes derived from serum of PD mice.
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The results show that the proposed 3D-HMP and 3D-HVS DPD models have linearization performance in terms of adjacent channel power ratio below −50 dBc.
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The autonomous firing of STN neurons, which contributes to their tonic excitation of the extrastriatal basal ganglia and shapes their integration of synaptic input, is downregulated in PD models.
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The goal of this article is to describe the importance of professional development (PD), explain the crucial role library administrators’ serve in supporting PD, present characteristics of PD best practices, and offer examples of PD models that incorporate best practices.
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Applications and limitations of pre-clinical PK/PD models and future alternatives are reviewed in the context of HIV prevention.
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The chaperone protein Hsp70 has been reported to be effective in PD models, but its brain targeting is challenging.
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Further study indicates that suppression of oxidative stress and endoplasmic reticulum stress, as well as the inhibition of systemic inflammation in both peripheral tissues and brain, contribute to the neuroprotective effects of Dex in PD models.
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In this paper, several DPD models are studied and evaluated according to different criteria which characterize accuracy performance and emphasize numerical properties for hardware implementation.
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Upregulated Miro levels have been found to be responsible for the dysregulation in the PD models [48].
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The objective of this review was to provide an overview of pharmacokinetic/pharmacodynamic (PK/PD) models, focusing on drug‐specific PK/PD models and highlighting their value added in drug development and regulatory decision‐making.
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Moreover, the treatment of the boundary conditions is also problematic due to the non-local nature of PD models.
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” The aims were to discuss details of various PK/PD models and identify sound practices for deriving and utilizing PK/PD relationships to design optimal dosage regimens for patients.
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Population viral kinetic and PK/PD models were developed using NONMEM.
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Aggregated αSyn has been shown to induce ER stress and elicit neurotoxicity in PD models.
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This modeling approach is representative of the state-based PD models, whereas the resulting governing equations appear as the bond-based PD models.
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In this review, we summarize various iPSCs-based PD models either derived from PD patients through reprogramming technology or established by gene-editing technology, and the promising application of iPSC-based PD models for mechanistic studies and drug testing.
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PKPD models have driven the maintenance dose rate in target-controlled infusion pumps used for total intravenous anaesthesia.
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ALA has been reported to reduce oxidative stress and apoptosis in PD models, but its role in autophagy regulation of PD has been reported very little.
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A key outcome of these combined PKPD models are tumor static concentration (TSC) curves of dual or triple combination drug regimens that identify combination drug exposures predicted to arrest tumor growth.
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The purpose of this study was to validate the relationship between PPARγ and NF-κB in cigarette smoke (CS)-induced COPD models, and then to investigate whether the therapeutic effect of curcumin on COPD is achieved through modulating the PPARγ-NF-κB signaling pathway.
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This study presents a novel independent component analysis (ICA) method for the DPD models which is suitable for all three cases (intra-band contiguous, intra-band non-contiguous and inter-band non-contiguous) of CA.
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PK/PD models were built to link the PD measurements to nude mouse PK.
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A key outcome of these combined PKPD models are tumor static concentration (TSC) curves of dual or triple combination drug regimens that identify combination drug exposures predicted to arrest tumor growth.
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A series of PK/PD models where constructed using data derived from well-established screening protocols, using an in-vitro cell-based assays system in conjunction with a preclinical based in-vivo model using B.
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Furthermore, dosing regimens should be based on PK/PD models that ensure effective antibiotic exposure not in plasma, but primarily at the site of infection, mostly in the interstitial fluid (ISF).
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This suggests that the broad striatal transcriptional changes in neurodegeneration-based PD models are not direct effects of DA depletion, but are rather a result of DA neuronal death.
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