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This is the first clinical study to evaluate the dominant-negative PD-1 armored anti-CD19 CAR-T-cell.
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Highlights • This is the first study of dominant-negative PD-1 armored anti-CD19 CAR t cells on refractory b cell lymphoma, demonstrated that the modified CAR t cells were safe and tolerable without extra toxicity.
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Dominant negative PD 1 armored CAR T cells induce remission in refractory diffuse large B-cell lymphoma (DLBCL) patients [abstract].
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