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10.1101/590216

We recently identified the leucine-rich repeat adhesion protein, trophoblast glycoprotein (TPBG), as a novel PKCα-dependent phosphoprotein in retinal rod bipolar cells (RBCs).

Expression and distribution of Trophoblast Glycoprotein in the mouse retina

10.3389/fimmu.2019.00851

In this study we show that protein kinase C δ (PKCδ), a novel PKC isotype activated by diacylglycerol (DAG), regulates TCR-controlled MVB polarization toward the IS and exosome secretion.

Protein Kinase C δ Regulates the Depletion of Actin at the Immunological Synapse Required for Polarized Exosome Secretion by T Cells

10.1016/j.bpj.2018.11.2165

The novel PKC subtype, epsilon (ε), however, appears to differentially modulate GIRK subunits, an effect yet to be fully characterized.

Modulation of GIRK Channels by Protein Kinase C

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10.1002/jnr.24362

Protein Kinase C epsilon (PKCε) is a member of the novel PKC subfamily and plays a vital role in ischemic preconditioning.

Genetic inhibition of PKCε attenuates neurodegeneration after global cerebral ischemia in male mice

10.1124/mol.118.114595

Currently, modes of AC9 regulation include stimulation by Gαs, protein kinase C (PKC) βII, or calcium-calmodulin kinase II (CaMKII) and inhibition by Gαi/o, novel PKC isoforms, or calcium-calcineurin.

Insights into the Regulatory Properties of Human Adenylyl Cyclase Type 9

10.3389/fcell.2019.00226

Crucially, TCR dependent upregulation of the important T cell signaling lipid diacylglycerol (DAG), which is fundamental for activation of conventional and novel PKCs, was abolished in ΔNSM cells.

Role of Neutral Sphingomyelinase-2 (NSM 2) in the Control of T Cell Plasma Membrane Lipid Composition and Cholesterol Homeostasis

10.1002/cne.24850

We recently identified the leucine‐rich repeat (LRR) adhesion protein, trophoblast glycoprotein (TPBG), as a novel PKCα‐dependent phosphoprotein in retinal rod bipolar cells (RBCs).

Expression and distribution of trophoblast glycoprotein in the mouse retina

10.2337/DB19-1728-P

The novel PKC isoform, PKC-theta, is particularly enriched in T lymphocyte populations, serving a critical role in signal transduction after CD3/CD28 T cell receptor stimulation.

1728-P: Inhibition of PKC-Theta in Prediabetic NOD Mice Prevents Diabetes Onset and Increases Regulatory CD4 T Cells in a Subset of Animals

10.1158/1538-7445.AM2019-CT068

A Phase I trial of LXS196, a novel PKC inhibitor for metastatic uveal melanoma [abstract].

Abstract CT068: A Phase I trial of LXS196, a novel PKC inhibitor for metastatic uveal melanoma

10.1016/j.prostaglandins.2019.106346

ERK activation by the eicosanoid was reduced by the "pan" PKC inhibitor GF109203X but not by the classical PKC inhibitor Gö6976, suggesting the involvement of novel PKCs in this effect.

5-oxo-ETE activates migration of H295R adrenocortical cells via MAPK and PKC pathways.

10.1016/j.bbrc.2019.08.134

Classical and/or Novel PKC isoform inhibition changes the shape of the PC3 cells, they show a more rounded morphology, whereas PKD inhibition causes prostate cancer cell to elongate.

The role of PKC and PKD in CXCL12 directed prostate cancer migration.

10.1183/13993003.congress-2019.pa4399

The allergen induced decrease of CBF was abolished by GF 109203X, a novel PKC (n PKC) isoform inhibitor, whereas the decrease was not attenuated by Go-6976, a specific inhibitor of conventional PKC (Cpkc) isoform.

Late Breaking Abstract - The effects of allergen (DP/DF) on mucociliary transport of allergic rhinitis patients

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What is/are Novel Pkc?

Novel Pkc - We recently identified the leucine-rich repeat adhesion protein, trophoblast glycoprotein (TPBG), as a novel PKCα-dependent phosphoprotein in retinal rod bipolar cells (RBCs). [1] In this study we show that protein kinase C δ (PKCδ), a novel PKC isotype activated by diacylglycerol (DAG), regulates TCR-controlled MVB polarization toward the IS and exosome secretion. [2] The novel PKC subtype, epsilon (ε), however, appears to differentially modulate GIRK subunits, an effect yet to be fully characterized. [3] Protein Kinase C epsilon (PKCε) is a member of the novel PKC subfamily and plays a vital role in ischemic preconditioning. [4] Currently, modes of AC9 regulation include stimulation by Gαs, protein kinase C (PKC) βII, or calcium-calmodulin kinase II (CaMKII) and inhibition by Gαi/o, novel PKC isoforms, or calcium-calcineurin. [5] Crucially, TCR dependent upregulation of the important T cell signaling lipid diacylglycerol (DAG), which is fundamental for activation of conventional and novel PKCs, was abolished in ΔNSM cells. [6] We recently identified the leucine‐rich repeat (LRR) adhesion protein, trophoblast glycoprotein (TPBG), as a novel PKCα‐dependent phosphoprotein in retinal rod bipolar cells (RBCs). [7] The novel PKC isoform, PKC-theta, is particularly enriched in T lymphocyte populations, serving a critical role in signal transduction after CD3/CD28 T cell receptor stimulation. [8] A Phase I trial of LXS196, a novel PKC inhibitor for metastatic uveal melanoma [abstract]. [9] ERK activation by the eicosanoid was reduced by the "pan" PKC inhibitor GF109203X but not by the classical PKC inhibitor Gö6976, suggesting the involvement of novel PKCs in this effect. [10] Classical and/or Novel PKC isoform inhibition changes the shape of the PC3 cells, they show a more rounded morphology, whereas PKD inhibition causes prostate cancer cell to elongate. [11] The allergen induced decrease of CBF was abolished by GF 109203X, a novel PKC (n PKC) isoform inhibitor, whereas the decrease was not attenuated by Go-6976, a specific inhibitor of conventional PKC (Cpkc) isoform. [12]

novel pkc isoform

Currently, modes of AC9 regulation include stimulation by Gαs, protein kinase C (PKC) βII, or calcium-calmodulin kinase II (CaMKII) and inhibition by Gαi/o, novel PKC isoforms, or calcium-calcineurin. [1] The novel PKC isoform, PKC-theta, is particularly enriched in T lymphocyte populations, serving a critical role in signal transduction after CD3/CD28 T cell receptor stimulation. [2] Classical and/or Novel PKC isoform inhibition changes the shape of the PC3 cells, they show a more rounded morphology, whereas PKD inhibition causes prostate cancer cell to elongate. [3]