Introduction to Novel Pkc

We recently identified the leucine-rich repeat adhesion protein, trophoblast glycoprotein (TPBG), as a novel PKCα-dependent phosphoprotein in retinal rod bipolar cells (RBCs).

In this study we show that protein kinase C δ (PKCδ), a novel PKC isotype activated by diacylglycerol (DAG), regulates TCR-controlled MVB polarization toward the IS and exosome secretion.

The novel PKC subtype, epsilon (ε), however, appears to differentially modulate GIRK subunits, an effect yet to be fully characterized.

Protein Kinase C epsilon (PKCε) is a member of the novel PKC subfamily and plays a vital role in ischemic preconditioning.

Currently, modes of AC9 regulation include stimulation by Gαs, protein kinase C (PKC) βII, or calcium-calmodulin kinase II (CaMKII) and inhibition by Gαi/o, novel PKC isoforms, or calcium-calcineurin.

Crucially, TCR dependent upregulation of the important T cell signaling lipid diacylglycerol (DAG), which is fundamental for activation of conventional and novel PKCs, was abolished in ΔNSM cells.

We recently identified the leucine‐rich repeat (LRR) adhesion protein, trophoblast glycoprotein (TPBG), as a novel PKCα‐dependent phosphoprotein in retinal rod bipolar cells (RBCs).

The novel PKC isoform, PKC-theta, is particularly enriched in T lymphocyte populations, serving a critical role in signal transduction after CD3/CD28 T cell receptor stimulation.

A Phase I trial of LXS196, a novel PKC inhibitor for metastatic uveal melanoma [abstract].

ERK activation by the eicosanoid was reduced by the "pan" PKC inhibitor GF109203X but not by the classical PKC inhibitor Gö6976, suggesting the involvement of novel PKCs in this effect.

Classical and/or Novel PKC isoform inhibition changes the shape of the PC3 cells, they show a more rounded morphology, whereas PKD inhibition causes prostate cancer cell to elongate.

The allergen induced decrease of CBF was abolished by GF 109203X, a novel PKC (n PKC) isoform inhibitor, whereas the decrease was not attenuated by Go-6976, a specific inhibitor of conventional PKC (Cpkc) isoform.