Introduction to Novel Mitochondria Targeted

Mitochondria, which are directly involved in metabolic reprogramming, are used to design novel mitochondria-targeted anticancer agents.

The current study was conducted to assess effects of the novel mitochondria-targeted antioxidant "Mito-TEMPO" on ram sperm quality and fertility potential during the freeze-thawing process in a plant-based extender.

We therefore investigated protective effect of the novel mitochondria-targeted hydrogen sulfide (H2S) delivery molecules AP39 and AP123, and non-targeted control molecules on UVA-induced photoaging in normal human dermal fibroblasts (NDHFs) in vitro and the skin of BALB/c mice in vivo.

Herein, a novel mitochondria-targeted ratiometric fluorescent probe Mito-NA for ONOO− was designed rationally by regulating its intramolecular charge transfer (ICT) effect.

In this study, we investigated the possible protective effects of a novel mitochondria-targeted antioxidant MitoTEMPO on contractile dysfunction and structural defects of the rat papillary muscle caused by abdominal ischemia-reperfusion (AIR).

Herein, a novel mitochondria-targeted ratiometric fluorescent probe Mi-OCl-RP has been developed.

A novel mitochondria-targeted compound, HO-5114, demonstrated higher cytotoxicity against human breast cancer lines than its component-derivative, Mito-CP.

SS31 represents a novel mitochondria-targeted peptide which can guide drug to accumulate into mitochondria.

A novel mitochondria-targeted fluorescent probe for sensing SO2 derivatives was constructed by integrating phenanthroimidazole and cyanine moieties.

Methods A novel mitochondria-targeted peptide, namely KRSH, was synthesized and characterized.

Here, we describe the design, synthesis, and evaluation of novel mitochondria-targeted NO releasers, Nitric oxide (NO) is a physiological signaling molecule, whose biological production is precisely regulated at the subcellular level.

Herein, we developed a novel mitochondria-targeted fluorescent probe PF-MitoSOX Green in which the phosphinate moiety is utilized to recognize O2•- with high sensitivity and selectivity.

Based on these theoretical considerations, a novel mitochondria-targeted compound, SkQThy, was synthesized and its effects on rat liver mitochondria and yeast cells were examined.

Our findings suggest that MitoGamide, a novel mitochondria-targeted approach, offers cardioprotection in experimental diabetes and therefore may offer therapeutic potential for the treatment of cardiomyopathy in patients with diabetes.

Second, treatment with AP39, a novel mitochondria-targeted hydrogen sulfide donor, prevented ROS production, reduced HIF-1α protein levels, and diminished sFLT1 production.

Small molecule 5BMF is a novel mitochondria-targeted delocalized lipophilic cation (DLC) with good anti-tumor activity and fluorescence emission suitable for bioimaging.

Herein, we present a novel mitochondria-targeted ratiometric fluorescent probe (CS) for the detection of SO2 in living cells and zebrafishes.

A novel mitochondria-targeted superoxide-responsive nitric oxide donor was developed by incorporation of diphenylphosphinyl and triphenylphosphonium groups into diazeniumdiolate, enabling remarkable protection against ischemia/reperfusion injury in H9c2 cells and isolated rat hearts.