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10.1016/J.NFS.2021.05.002

Background This report represents the second part (Part 2) of a two-part report on investigating a novel hepatoprotective substance in ume extract.

Investigating a novel hepatoprotective substance from ume extract (heated Japanese apricot juice concentrate). Part 2: Elucidation of chemical structure

10.3892/etm.2021.10747

subtilis supplementation imparts novel hepatoprotective functions by improving intestinal permeability and homeostasis.

Dietary Bacillus subtilis supplementation alleviates alcohol-induced liver injury by maintaining intestinal integrity and gut microbiota homeostasis in mice

10.1177/1559325821996955

The lack of safety and efficacy of existing hepatoprotective agents urge the need to explore novel hepatoprotective agents.

In Vitro Antioxidant Activities and the Therapeutic Potential of Some Newly Synthesized Chalcones Against 4-Acetaminophenol Induced Hepatotoxicity in Rats

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10.1039/d1fo02081a

Therefore, ginsenoside Rk3 shows potential as a novel hepatoprotective agent to prevent drug-induced liver injury.

Hepatoprotective effects of ginsenoside Rk3 in acetaminophen-induced liver injury in mice by activation of autophagy.

10.1016/j.jep.2018.09.041

CONCLUSION Ginsenosides reverse the effects of LPS-induced hepatic CYP3A11/3A4 dysfunction, suggesting that the stabilization of the CYP3A11/3A4 expression in an injured liver appears a novel hepatoprotective mechanism of ginsenosides.

Reversing effects of ginsenosides on LPS-induced hepatic CYP3A11/3A4 dysfunction through the pregnane X receptor.

10.1038/s41419-019-1719-6

Our findings indicate a novel hepatoprotective role for GsdmD in noninfectious inflammation models via regulation of caspase-8 expression and downstream cell death pathways.

Gasdermin D protects against noninfectious liver injury by regulating apoptosis and necroptosis

10.1002/aid2.13125

In this pilot study, the seaweed derivative mixture can significantly reduce ALT, indicating that the combination of fucoidan and fucoxanthin might be a novel hepatoprotective supplement for NAFLD patients.

Low‐molecular‐weight fucoidan and high‐stability fucoxanthin decrease serum alanine transaminase in patients with nonalcoholic fatty liver disease—A double‐blind, randomized controlled trial

10.1172/JCI124376

Here, we have identified a novel hepatoprotective brain/brown adipose tissue (BAT)/liver axis.

Brown fat activation mitigates alcohol-induced liver steatosis and injury in mice.

10.1016/j.bcp.2019.08.001

In conclusion, TELL purveyed conceivable novel hepatoprotective mechanisms and attenuated events associated with acute hepatic injury via inhibition of TLR4 downstream axis and activation of Nrf-2 and PI3K/Akt signaling cascades.

Telluric acid ameliorates hepatic ischemia reperfusion-induced injury in rats: Involvement of TLR4, Nrf2, and PI3K/Akt signaling pathways.

10.36468/pharmaceutical-sciences.580

In conclusion, Tetracera akara extract exerted hepatoprotective effect against acute hepatotoxicity induced by carbon tetrachloride in Wistar rats, which could be due to the bioactive phytoconstituents present in the extract and these findings provide impetus for the development of a novel hepatoprotective herbal drug.

Protective Effect of Ethanol Extract of Roots of Tetracera akara (Burm. f.) Merr., on Carbon Tetrachloride-induced Hepatic Injury in Wistar Rats

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Novel Hepatoprotective - Background This report represents the second part (Part 2) of a two-part report on investigating a novel hepatoprotective substance in ume extract. [1] subtilis supplementation imparts novel hepatoprotective functions by improving intestinal permeability and homeostasis. [2] The lack of safety and efficacy of existing hepatoprotective agents urge the need to explore novel hepatoprotective agents. [3] Therefore, ginsenoside Rk3 shows potential as a novel hepatoprotective agent to prevent drug-induced liver injury. [4] CONCLUSION Ginsenosides reverse the effects of LPS-induced hepatic CYP3A11/3A4 dysfunction, suggesting that the stabilization of the CYP3A11/3A4 expression in an injured liver appears a novel hepatoprotective mechanism of ginsenosides. [5] Our findings indicate a novel hepatoprotective role for GsdmD in noninfectious inflammation models via regulation of caspase-8 expression and downstream cell death pathways. [6] In this pilot study, the seaweed derivative mixture can significantly reduce ALT, indicating that the combination of fucoidan and fucoxanthin might be a novel hepatoprotective supplement for NAFLD patients. [7] Here, we have identified a novel hepatoprotective brain/brown adipose tissue (BAT)/liver axis. [8] In conclusion, TELL purveyed conceivable novel hepatoprotective mechanisms and attenuated events associated with acute hepatic injury via inhibition of TLR4 downstream axis and activation of Nrf-2 and PI3K/Akt signaling cascades. [9] In conclusion, Tetracera akara extract exerted hepatoprotective effect against acute hepatotoxicity induced by carbon tetrachloride in Wistar rats, which could be due to the bioactive phytoconstituents present in the extract and these findings provide impetus for the development of a novel hepatoprotective herbal drug. [10]

novel hepatoprotective mechanism

CONCLUSION Ginsenosides reverse the effects of LPS-induced hepatic CYP3A11/3A4 dysfunction, suggesting that the stabilization of the CYP3A11/3A4 expression in an injured liver appears a novel hepatoprotective mechanism of ginsenosides. [1] In conclusion, TELL purveyed conceivable novel hepatoprotective mechanisms and attenuated events associated with acute hepatic injury via inhibition of TLR4 downstream axis and activation of Nrf-2 and PI3K/Akt signaling cascades. [2]

novel hepatoprotective agent

The lack of safety and efficacy of existing hepatoprotective agents urge the need to explore novel hepatoprotective agents. [1] Therefore, ginsenoside Rk3 shows potential as a novel hepatoprotective agent to prevent drug-induced liver injury. [2]