Introduction to Novel Hepatoprotective

Background This report represents the second part (Part 2) of a two-part report on investigating a novel hepatoprotective substance in ume extract.

subtilis supplementation imparts novel hepatoprotective functions by improving intestinal permeability and homeostasis.

The lack of safety and efficacy of existing hepatoprotective agents urge the need to explore novel hepatoprotective agents.

Therefore, ginsenoside Rk3 shows potential as a novel hepatoprotective agent to prevent drug-induced liver injury.

CONCLUSION Ginsenosides reverse the effects of LPS-induced hepatic CYP3A11/3A4 dysfunction, suggesting that the stabilization of the CYP3A11/3A4 expression in an injured liver appears a novel hepatoprotective mechanism of ginsenosides.

Our findings indicate a novel hepatoprotective role for GsdmD in noninfectious inflammation models via regulation of caspase-8 expression and downstream cell death pathways.

In this pilot study, the seaweed derivative mixture can significantly reduce ALT, indicating that the combination of fucoidan and fucoxanthin might be a novel hepatoprotective supplement for NAFLD patients.

Here, we have identified a novel hepatoprotective brain/brown adipose tissue (BAT)/liver axis.

In conclusion, TELL purveyed conceivable novel hepatoprotective mechanisms and attenuated events associated with acute hepatic injury via inhibition of TLR4 downstream axis and activation of Nrf-2 and PI3K/Akt signaling cascades.

In conclusion, Tetracera akara extract exerted hepatoprotective effect against acute hepatotoxicity induced by carbon tetrachloride in Wistar rats, which could be due to the bioactive phytoconstituents present in the extract and these findings provide impetus for the development of a novel hepatoprotective herbal drug.