Introduction to Novel Evidence

These data provide novel evidence that B1R blockade blunts orexin hyperactivity and constitutes a potential therapeutic target for the treatment of salt-sensitive hypertension.

This study provides novel evidence that lncRNA GAS5 may be a potential therapeutic target for HPMC EMT.

Altogether, the present results provide novel evidence on the transgenerational neurotoxic effects of permethrin, as well as mechanistic insight: a transient exposure induces persistent transcriptional and DNA methylation changes that may translate into transgenerational alteration of glutamatergic signaling and, thus, into behavioral alterations.

The analysis of smoking-duration within TP53 haplotypes showed that there were more carriers of haplotype1 (AGCCG), 2 (CCCGC) and 4 (CCCCG) in smoking-subgroup of >20 (years) (all P  Conclusion The present results provide novel evidence that the haplotype of TP53 htSNPs and interaction between genetic variation in TP53 and CD3EAP and smoking-duration may associate with lung cancer risk, and provide additional association between TP53 htSNP haplotypes and long-term smoking-related behavior.

We provide novel evidence that these inflammatory mediators can modulate the TRPV1 signaling pathway and suggest new potential therapeutic targets for fibromyalgia pain.

We provide novel evidence that these inflammatory mediators modulate the TRPV1 signaling pathway and suggest new potential therapeutic targets for chronic pain and depression.

Altogether, we provide novel evidence that fertilization significantly affects the functional groups of protistan consumers and parasites in crop-associated microbiomes, which have implications for the potential changes in their ecological functions under intensive agricultural managements.

Such information provides novel evidence-based findings on the appropriateness of different recovery strategies and may aid to improve the practitioners’ decision-making process when two consecutive games are played within 3 days.

We also provided novel evidence that TRIM16 might act as a prognostic and therapeutic target to assess and inhibit CRC progression.

In conclusion, this study provided novel evidence for the acquisition and transmission of plant growth-promoting bacterial endophytes by beneficial mirids.

This paper presents novel evidence for the influence of the disease environment, in particular malaria exposure, on the geographic location of Chinese economic activities in Africa.

This study presents novel evidence corresponding to reverse fault scarps produced during the Late Quaternary by three NNE and NNW trending faults in the outer forearc between 22.

2 cal ka BP were robustly identified as sourced from Michinmahuida volcano but where otherwise not correlated, providing novel evidence of pre Holocene activity of this volcanic center.

The current findings expand upon previous research demonstrating consistent relationships between poor sleep and increased dissatisfaction with cutaneous features, by providing novel evidence that body image disturbances are associated with symptoms of insomnia.

The results offer novel evidence that positive emotions fuel the capitalization process.

Originality/value The study offers novel evidence on the “glass ceiling” in Japanese businesses by investigating whether women’s access to management positions corresponds to effective decision power.

CONCLUSION Our analysis adds novel evidence that may contribute to the current debate on whether and to what extent countries in which all citizens have access to free healthcare and equal standards of healthcare services should subsidize VHI, especially when the coverage doubles the healthcare services provided by universal public insurance.

These findings add novel evidence about mitochondria and GBM, while fostering a novel therapeutic approach to restore healthy mitochondria through mTOR inhibition.

These novel evidences should be considered in the diagnostic workup of patients with uncharacterized AID starting during adulthood.

These novel evidences reveal a causal role of tau accumulation in linking MS cholinergic lesion to hippocampus‐dependent spatial cognitive damages as seen in the AD patients, and the new tau‐removal and autophagy‐promoting effects of donepezil may extend its application beyond simple symptom amelioration to potential disease modification.

We report novel evidence in relation to the framework of An and Chan (2008) and Goergen et al.

Conclusions: We report novel evidence of the prognostic role of DDR biomarkers on important patient outcomes in postmenopausal hormone-receptor-positive breast cancer patients treated with NAHT.

In summary, using data not included in prior studies of LATE or HS genomics, we replicated several previously reported gene-based associations and found novel evidence that specific risk alleles can differentially affect LATE-NC and HS.

However, we found novel evidence supporting a complex relationship between the two AR paralogs in the regulation of testes mass.

We find novel evidence that is in line with the adaptation hypothesis, meaning that starting a long-distance commuting episode is associated with an increase in commuting willingness.

We find novel evidence that education shapes rights and tolerance attitudes.

Background An Informatics Consult has been proposed in which clinicians request novel evidence from large scale health data resources, tailored to the treatment of a specific patient.

An Informatics Consult has been proposed in which clinicians request novel evidence from large scale health data resources, tailored to the treatment of a specific patient, with return of results in clinical timescales.

In summary, our comprehensive multi-proteomic characterization in antigen presentation machinery provides potentially novel evidence of poor immune response in osimertinib-resistant lung adenocarcinoma.

These provide potentially novel evidence from a swine model that cerebrovascular and neuronal pathologies likely both contribute to the dementia profile in a setting of cardiometabolic HF.

CONCLUSIONS The findings identify novel evidence of common therapeutic processes across DBT and MBT that may help to reduce self-harm.

CONCLUSION This study identifies novel evidence that patients with PTC have a higher MHR.

This constitutes novel evidence in support of the view that the ventrolateral ATL contributes to social cognition via a domain-general role in the retrieval of conceptual knowledge, and against claims of a specialised social function.

This constitutes novel evidence that high-confident recognition memory is accompanied by incidental reinstatement of associated category information in MTL subregions, and supports a functional model of the MTL that emphasises content-sensitive representations during both encoding and retrieval.

By offering novel evidence that developing a strong party system—in addition to electing women—is crucial for improving women’s representation in clientelistic settings, the results extend the literature on Islam, gender, and governance and offer insights into Islamist electoral success in clientelistic settings.

By modulating the interaction of visual and linguistic stimuli across the two experiments, we show that the verb's perfective aspect triggers the culmination inference incrementally during sentence processing, offering novel evidence for the continuous integration of linguistic processing with real-world visual information.

Our results were generally coherent with those reported in other real-world studies, and they added novel evidence about the economic impact of such therapies in a large and unselected cohort of NSCLC patients treated in daily clinical practice.

These findings added novel evidences for the immunological restoration process triggered by DAAs.

As well, these results yielded novel evidence that such motor planning processes in older adult rely on somatosensory cues from the effector limb.

The functional annotation of the target DEmRNAs yielded novel evidence in evaluating the precise functions of lncRNA in HBV-related HCC.

The data brings novel evidence about the psychobiological features of patients with dentofacial deformities, showing salivary variations of inflammatory biomarkers in these individuals.

This study provides the first insight into the proteomics of adult avian CSF and plasma and brings novel evidence supporting the adult neurogenesis in birds.

The insights generated in the current review will provide the impetus for an update of existing guidelines, will inform novel evidence-based genetic testing strategies used in clinics, and will identify gaps in our knowledge of male infertility genetics.

The insights generated in the current review will provide the impetus for an update of existing guidelines, will inform novel evidence-based genetic testing strategies used in clinics, and will identify gaps in our knowledge of male infertility genetics.

Then, we focus on the role of selective autophagy in ABA pathway control and review novel evidence on the involvement of autophagy in different parts of the ABA signaling pathway that are important for crosstalk with other hormones, particularly cytokinins and brassinosteroids.

We review novel evidence of laryngomalacia as a mechanism for this worsening of OSA and describe the incidence of laryngomalacia in this patient population.

In recent years, scientists have gained deeper understandings of 3D genome structures and revealed novel evidence linking 3D genome organization to various important cell events on the molecular level.

Genetic analyses revealed novel evidence of expression of a lethal recessive allele, and demonstrated how critically small effective population size can arise, thereby increasing inbreeding and loss of genetic variation.

Our results provide novel evidence regarding the autonomic dysfunction in SCI patients with AD compared to non-AD patients, posing non-invasively measured autonomic parameters as a powerful clinical tool to predict AD in SCI patients.

Novel evidence regarding the composition and health benefits of edible flowers is imperative and epitomizes an ample cause for their ingestion.

This study provides novel evidence suggesting that the relationship between Gf and divergent thinking may be largely driven by the top-down control of attention.

This study provides novel evidence suggesting that mitochondrial depletion and damage may be associated with chronic pain in PWH.

Recent experimental studies have clarified several determinant cellular and molecular targets of BBR in RA, and provided novel evidence supporting the promising therapeutic potential of BBR to combat RA.

This comprehensive analysis of the impact of early mobilization on postoperative complications and length of stay in a large HNC cohort provides novel evidence supporting adherence to the ERAS early mobilization recommendations.

This study presents novel evidence showing that group payments distributed proportional to effort are as effective as payments targeted to individuals in increasing public good provision.

The research produces novel evidence showing that the connectivity between neighborhoods differs for socioeconomically advantaged versus for disadvantaged movers.

CONCLUSIONS The present study provides novel evidence linking lifelong cumulated numbers of latent, persistent or repeated infection to functional ageing, plausibly via inflammatory and immune and other biological factors.

Taken together, our results provide novel evidence linking variation in inborn temperament with differences in the baseline morphological status of microglia cells and highlight the importance of considering the role of microglia not only in acute responses to stress but also in shaping enduring characteristics of emotionality.

Our findings provide novel evidence demonstrating the functioning of Strong Souls in a contemporary sample of Aboriginal youth, suggesting further modifications of the instrument are required before it can be used with confidence as a reliable measure in this population group.

CONCLUSIONS Our observations suggest that MSC-derived miR-181a-5p mitigates glucagon secretion of α-cells by regulating PTEN/AKT signaling, which provides novel evidence demonstrating the potential for MSCs in treating T2DM.

To improve the performance of combining conflicting evidence, an original and novel evidence combination method is presented based on the Pearson correlation coefficient and weighted graph.

A novel evidence combination rule called CR‐SLF is proposed based on soft likelihood functions (SLF) considering the ordered weighted average aggregation operator.

These experiments provide novel evidence toward sensory neuron specific modulation of pain in a sex-dependent manner.

Our findings illustrate a previously unknown regulatory mechanism in prostate cancer cell proliferation regulated by the MSI2‐AR axis and provide novel evidence towards a strategy against prostate cancer.

Novel evidence indicates that key regulatory and biosynthetic genes undergo mechanisms of gene expression regulation that are much more complex than what was imagined before: post-transcriptional mechanisms, with RNA splicing among the most common, indeed play crucial roles to fine-tune the expression of this trait in fruits and offer new substrate for the rise of genetic variables, thus providing further evolutionary flexibility to the character.

CONCLUSIONS Novel evidence indicates miRNA-mediated epigenetic regulation of AQP2 expression.

This novel evidence suggests that globalization may threaten job security of higher educated workers too.

Collectively, our novel evidence suggests that dividends help mitigate agency problems during high-EPU periods.