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RESULTS
A total of 22 comparative studies comprising 11 randomized controlled trials and 11 nonrandomized trials were included for the analysis.
RESULTS
A total of 22 comparative studies comprising 11 randomized controlled trials and 11 nonrandomized trials were included for the analysis.
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Twelve randomized controlled trials (n = 1131) delivered to medical patients were included in the review, and a further 11 nonrandomized trials (n = 300) were included in a secondary analysis.
Twelve randomized controlled trials (n = 1131) delivered to medical patients were included in the review, and a further 11 nonrandomized trials (n = 300) were included in a secondary analysis.
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Nonrandomized Trial sentence examples within 1 Nonrandomized Trial
In total, 22 studies were eligible including 7 randomized controlled trial, 1 nonrandomized trial, and 14 prospective observational studies.
In total, 22 studies were eligible including 7 randomized controlled trial, 1 nonrandomized trial, and 14 prospective observational studies.
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Focused Clinical Question: Does LIAEX within the first 4 weeks following SRC hasten symptom resolution? Summary of Key Findings: Two randomized controlled trials (RCT) and 1 nonrandomized trial involving adolescent athletes (10-19 y) were included.
Focused Clinical Question: Does LIAEX within the first 4 weeks following SRC hasten symptom resolution? Summary of Key Findings: Two randomized controlled trials (RCT) and 1 nonrandomized trial involving adolescent athletes (10-19 y) were included.
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Nonrandomized Trial sentence examples within Prospective Nonrandomized Trial
Materials and Methods: In this single-center prospective nonrandomized trial, a total of 62 patients who underwent CEA (c-CEA, n = 31; e-CEA, n = 31) for symptomatic ipsilateral ICA stenosis ≥50% between January 2018 and December 2019 were included.
Materials and Methods: In this single-center prospective nonrandomized trial, a total of 62 patients who underwent CEA (c-CEA, n = 31; e-CEA, n = 31) for symptomatic ipsilateral ICA stenosis ≥50% between January 2018 and December 2019 were included.
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Mature data from several randomized and prospective nonrandomized trials have contributed to the development of consensus guidelines for selecting the most appropriate candidates ABPI.
Mature data from several randomized and prospective nonrandomized trials have contributed to the development of consensus guidelines for selecting the most appropriate candidates ABPI.
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10.1016/j.apmr.2021.10.002
STUDY SELECTION
Randomized controlled trials (RCTs), nonrandomized trials, and cohort studies of observed physical activity (at least 10 sessions on 10 days) in participants with MS, CP, and SCI.
STUDY SELECTION
Randomized controlled trials (RCTs), nonrandomized trials, and cohort studies of observed physical activity (at least 10 sessions on 10 days) in participants with MS, CP, and SCI.
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10.1016/j.jstrokecerebrovasdis.2021.106102
RESULTS
The analysis included 51 studies (46 observational studies, one nonrandomized trial, and four randomized controlled trials) comprising 2361 patients.
RESULTS
The analysis included 51 studies (46 observational studies, one nonrandomized trial, and four randomized controlled trials) comprising 2361 patients.
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10.1016/j.jtocrr.2020.100107
We conducted a literature search of systematic reviews of randomized controlled and nonrandomized trials published between 2018 and 2019 that multiple physicians had reviewed independently.
We conducted a literature search of systematic reviews of randomized controlled and nonrandomized trials published between 2018 and 2019 that multiple physicians had reviewed independently.
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10.1016/j.ijrobp.2021.02.043
From the larger database of nonrandomized trials, we listed adverse events in specific organs/sites among patients with cancer who are treated with photons and protons to identify critical issues.
From the larger database of nonrandomized trials, we listed adverse events in specific organs/sites among patients with cancer who are treated with photons and protons to identify critical issues.
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10.3390/ijerph18147611
Quality appraisal analyses were performed for each study using the Cochrane Collaboration tools for randomized and nonrandomized trials.
Quality appraisal analyses were performed for each study using the Cochrane Collaboration tools for randomized and nonrandomized trials.
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10.1200/PO.21.00108
PURPOSE
Many immune checkpoint inhibitors (ICIs) have been approved on the basis of tumor response end points in nonrandomized trials, including objective response rate (ORR) and duration and depth of response.
PURPOSE
Many immune checkpoint inhibitors (ICIs) have been approved on the basis of tumor response end points in nonrandomized trials, including objective response rate (ORR) and duration and depth of response.
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10.1370/afm.2640
Four nonrandomized trials, 3 laboratory studies, 1 single-case experiment, and 1 RCT were identified.
Four nonrandomized trials, 3 laboratory studies, 1 single-case experiment, and 1 RCT were identified.
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10.2196/25295
Methods A single-arm, nonrandomized trial was performed to evaluate a digital DSMES program that includes remote monitoring and lifestyle change, in addition to comprehensive diabetes education staffed by a diabetes specialist.
Methods A single-arm, nonrandomized trial was performed to evaluate a digital DSMES program that includes remote monitoring and lifestyle change, in addition to comprehensive diabetes education staffed by a diabetes specialist.
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10.1097/HCO.0000000000000935
RECENT FINDINGS
Multiple randomized and nonrandomized trials have compared commercial and investigational TAVR valves.
RECENT FINDINGS
Multiple randomized and nonrandomized trials have compared commercial and investigational TAVR valves.
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10.1001/jamaoncol.2021.1649
Design, Setting, and Participants
A single-center, phase 2 nonrandomized trial enrolled patients from August 17, 2016, to June 5, 2018.
Design, Setting, and Participants
A single-center, phase 2 nonrandomized trial enrolled patients from August 17, 2016, to June 5, 2018.
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10.1055/s-0040-1714131
Data Synthesis A systematic literature search on randomized clinical trials (RCTs), nonrandomized trials and other systematic reviews was performed.
Data Synthesis A systematic literature search on randomized clinical trials (RCTs), nonrandomized trials and other systematic reviews was performed.
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10.1371/journal.pone.0254896
Randomized controlled trials (RCTs) and nonrandomized trials that involved using a technological medium e.
Randomized controlled trials (RCTs) and nonrandomized trials that involved using a technological medium e.
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10.2196/23412
Methods The SPARC intervention is being evaluated through the EMERALD (Enabling Mobilization, Empowerment, Risk Reduction, and Lasting Dignity) study, which consists of a prospective 2-group comparative nonrandomized trial (n=385), a cross-sectional survey (n=100), and in-depth interviews assessing SPARC implementation (n=45).
Methods The SPARC intervention is being evaluated through the EMERALD (Enabling Mobilization, Empowerment, Risk Reduction, and Lasting Dignity) study, which consists of a prospective 2-group comparative nonrandomized trial (n=385), a cross-sectional survey (n=100), and in-depth interviews assessing SPARC implementation (n=45).
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10.1080/14737175.2021.1903320
We included 5 observational studies and 3 nonrandomized trials reporting clinical outcomes of 140 CGH patients after GONBs.
We included 5 observational studies and 3 nonrandomized trials reporting clinical outcomes of 140 CGH patients after GONBs.
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10.1016/j.pcad.2021.06.006
Multiple randomized and nonrandomized trials and registries have demonstrated the safety and effectiveness of LAAO in patients who are suitable for short-term anticoagulation using a variety of post-procedural antithrombotic strategies.
Multiple randomized and nonrandomized trials and registries have demonstrated the safety and effectiveness of LAAO in patients who are suitable for short-term anticoagulation using a variety of post-procedural antithrombotic strategies.
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10.1055/s-0041-1722916
METHODS
We searched MEDLINE, EMBASE, and Cochrane Central for randomized controlled trials, nonrandomized trials, and quasi-experimental studies which evaluated CDS tools that were developed for inpatient pharmacists as a target user.
METHODS
We searched MEDLINE, EMBASE, and Cochrane Central for randomized controlled trials, nonrandomized trials, and quasi-experimental studies which evaluated CDS tools that were developed for inpatient pharmacists as a target user.
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10.1093/jn/nxab245
RESULTS
There were 84 articles [23 randomized controlled trials (RCTs), 21 nonrandomized trials, 8 observational studies, and 32 in vitro studies] included.
RESULTS
There were 84 articles [23 randomized controlled trials (RCTs), 21 nonrandomized trials, 8 observational studies, and 32 in vitro studies] included.
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10.1044/2020_AJSLP-20-00200
Method In this single-blinded, nonrandomized trial, 82 participants completed all aspects of the study.
Method In this single-blinded, nonrandomized trial, 82 participants completed all aspects of the study.
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10.1089/cap.2020.0162
Included studies focused on youth; had study design of randomized controlled trial (RCT), nonrandomized trial, or case review (n > 10); and included an outcome measure of treatment effectiveness.
Included studies focused on youth; had study design of randomized controlled trial (RCT), nonrandomized trial, or case review (n > 10); and included an outcome measure of treatment effectiveness.
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10.4103/ajns.AJNS_486_20
Materials and Methods: In this single-center prospective nonrandomized trial, a total of 62 patients who underwent CEA (c-CEA, n = 31; e-CEA, n = 31) for symptomatic ipsilateral ICA stenosis ≥50% between January 2018 and December 2019 were included.
Materials and Methods: In this single-center prospective nonrandomized trial, a total of 62 patients who underwent CEA (c-CEA, n = 31; e-CEA, n = 31) for symptomatic ipsilateral ICA stenosis ≥50% between January 2018 and December 2019 were included.
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10.3390/cancers13112694
In a phase II nonrandomized trial, we previously reported that prophylactic irradiation to the contralateral breast among BRCA carriers undergoing breast-conserving treatment significantly reduced subsequent contralateral breast cancer.
In a phase II nonrandomized trial, we previously reported that prophylactic irradiation to the contralateral breast among BRCA carriers undergoing breast-conserving treatment significantly reduced subsequent contralateral breast cancer.
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10.37766/inplasy2020.6.0067
The independent Newcastle Ottawa scale was used to conduct methodological quality assessment of nonrandomized trials.
The independent Newcastle Ottawa scale was used to conduct methodological quality assessment of nonrandomized trials.
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10.1007/s00103-021-03413-x
Fast, efficient, reliable, and practice-relevant evaluation of digital health applications is not achieved by turning to nonrandomized trials, but rather by better pragmatic randomized trials.
Fast, efficient, reliable, and practice-relevant evaluation of digital health applications is not achieved by turning to nonrandomized trials, but rather by better pragmatic randomized trials.
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10.23970/ahrqepccer241
Predefined criteria were used to select randomized controlled trials, quasiexperimental nonrandomized trials, and cohort studies that addressed the benefits and harms of observed physical activity (at least 10 sessions on 10 different days of movement using more energy than rest) in participants with multiple sclerosis, cerebral palsy, and spinal cord injury.
Predefined criteria were used to select randomized controlled trials, quasiexperimental nonrandomized trials, and cohort studies that addressed the benefits and harms of observed physical activity (at least 10 sessions on 10 different days of movement using more energy than rest) in participants with multiple sclerosis, cerebral palsy, and spinal cord injury.
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10.3174/ajnr.A7164
LIMITATIONS: The analysis was based on nonrandomized trials with a moderate risk of bias.
LIMITATIONS: The analysis was based on nonrandomized trials with a moderate risk of bias.
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10.14423/SMJ.0000000000001232
This study evaluated both randomized and nonrandomized trials of battlefield acupuncture for the treatment of both acute and chronic pain.
This study evaluated both randomized and nonrandomized trials of battlefield acupuncture for the treatment of both acute and chronic pain.
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10.1056/nejmoa2027372
CONCLUSIONS
In this nonrandomized trial, sitagliptin in combination with tacrolimus and sirolimus resulted in a low incidence of grade II to IV acute GVHD by day 100 after myeloablative allogeneic hematopoietic stem-cell transplantation.
CONCLUSIONS
In this nonrandomized trial, sitagliptin in combination with tacrolimus and sirolimus resulted in a low incidence of grade II to IV acute GVHD by day 100 after myeloablative allogeneic hematopoietic stem-cell transplantation.
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10.1093/fampra/cmab131
Thirty controlled, randomized, or nonrandomized trials were included in the systematic review.
Thirty controlled, randomized, or nonrandomized trials were included in the systematic review.
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10.4103/JCRT.JCRT_95_20
Of these 11 studies, involving 428 patients, 7 were randomized control trials (RCTs), 1 was a nonrandomized trial, and 3 were observational studies.
Of these 11 studies, involving 428 patients, 7 were randomized control trials (RCTs), 1 was a nonrandomized trial, and 3 were observational studies.
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10.1038/s41440-021-00670-w
We excluded studies with observational designs, nonrandomized trials, single-arm trials, and trials that did not report mortality outcomes.
We excluded studies with observational designs, nonrandomized trials, single-arm trials, and trials that did not report mortality outcomes.
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10.1111/cts.13090
Patient engagement in study design and novel nonrandomized trial designs may offer a path to increase clinical trial success.
Patient engagement in study design and novel nonrandomized trial designs may offer a path to increase clinical trial success.
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10.1182/blood.2019003809
Comparative trials are lacking, and recommendations must be based mainly on nonrandomized trials and will be influenced by personal experience.
Comparative trials are lacking, and recommendations must be based mainly on nonrandomized trials and will be influenced by personal experience.
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10.1016/j.clinthera.2021.04.010
One option for gathering data on tolerability and efficacy in children would be to use a nonrandomized trial to enroll parents willing to vaccinate their children and those who are hesitant.
One option for gathering data on tolerability and efficacy in children would be to use a nonrandomized trial to enroll parents willing to vaccinate their children and those who are hesitant.
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10.1002/lary.29815
METHODS
The study was a prospective, nonrandomized trial of 30 patients with submandibular sialolithiasis who received gland-preserving treatment by either sialendoscopy-assisted techniques (Scope group; 14 patients) or transoral sialithotomy with or without dochoplasty (No Scope group; 16 patients).
METHODS
The study was a prospective, nonrandomized trial of 30 patients with submandibular sialolithiasis who received gland-preserving treatment by either sialendoscopy-assisted techniques (Scope group; 14 patients) or transoral sialithotomy with or without dochoplasty (No Scope group; 16 patients).
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10.1177/03635465211039202
RESULTS
A total of 22 comparative studies comprising 11 randomized controlled trials and 11 nonrandomized trials were included for the analysis.
RESULTS
A total of 22 comparative studies comprising 11 randomized controlled trials and 11 nonrandomized trials were included for the analysis.
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10.3171/2019.4.JNS19347
OBJECTIVE
The objective of this open-label, nonrandomized trial was to evaluate the efficacy and safety of bilateral caudate nucleus deep brain stimulation (DBS) for treatment-resistant tinnitus.
OBJECTIVE
The objective of this open-label, nonrandomized trial was to evaluate the efficacy and safety of bilateral caudate nucleus deep brain stimulation (DBS) for treatment-resistant tinnitus.
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10.1111/jcpp.12980
Most evaluations of MBIs are either uncontrolled or nonrandomized trials.
Most evaluations of MBIs are either uncontrolled or nonrandomized trials.
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10.1016/j.jvs.2019.03.050
Randomized and nonrandomized trials that investigated HIIT for the treatment of IC were included, with no exclusions based on exercise modality, protocol, or use of a comparator arm.
Randomized and nonrandomized trials that investigated HIIT for the treatment of IC were included, with no exclusions based on exercise modality, protocol, or use of a comparator arm.
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10.1016/j.jaccao.2019.08.003
Objectives The authors performed a systematic review and meta-analysis of randomized and nonrandomized trials on the efficacy of dexrazoxane in patients with breast cancer who were treated with anthracyclines with or without trastuzumab.
Objectives The authors performed a systematic review and meta-analysis of randomized and nonrandomized trials on the efficacy of dexrazoxane in patients with breast cancer who were treated with anthracyclines with or without trastuzumab.
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10.1016/j.vaa.2019.06.010
STUDY DESIGN
Prospective, experimental, nonrandomized trial.
STUDY DESIGN
Prospective, experimental, nonrandomized trial.
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10.1148/radiol.2019182095
Otherwise, national databases, registries, and nonrandomized trials were used.
Otherwise, national databases, registries, and nonrandomized trials were used.
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10.1097/SLA.0000000000003514
Methods: A single-center, prospective, nonrandomized trial enrolled 100 consecutive PD for cancer.
Methods: A single-center, prospective, nonrandomized trial enrolled 100 consecutive PD for cancer.
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10.1097/ALN.0000000000002726
METHODS
This was an interventional, parallel assignment, nonrandomized trial.
METHODS
This was an interventional, parallel assignment, nonrandomized trial.
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10.7326/M18-0992
Retrospective studies, studies with no comparative group, nonrandomized trials, case reports, editorials, reviews, expert opinion, and studies published in a language other than English were excluded.
Retrospective studies, studies with no comparative group, nonrandomized trials, case reports, editorials, reviews, expert opinion, and studies published in a language other than English were excluded.
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10.1111/ajt.15267
In total, 230 studies were included: 19 (8%) randomized trials, 17 (7%) nonrandomized trials, and 194 (85%) observational studies.
In total, 230 studies were included: 19 (8%) randomized trials, 17 (7%) nonrandomized trials, and 194 (85%) observational studies.
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10.1097/PSY.0000000000000722
Twelve randomized controlled trials (n = 1131) delivered to medical patients were included in the review, and a further 11 nonrandomized trials (n = 300) were included in a secondary analysis.
Twelve randomized controlled trials (n = 1131) delivered to medical patients were included in the review, and a further 11 nonrandomized trials (n = 300) were included in a secondary analysis.
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10.1055/a-1014-2628
Based on nonrandomized trials, the current German guidelines recommend at least three cylinders with ≤ 14-gauge needle biopsy.
Based on nonrandomized trials, the current German guidelines recommend at least three cylinders with ≤ 14-gauge needle biopsy.
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10.1177/2373379919863304
A two-arm nonrandomized trial was conducted with 785 allied health and preprofessional teaching students studying first-year public health courses.
A two-arm nonrandomized trial was conducted with 785 allied health and preprofessional teaching students studying first-year public health courses.
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10.1093/cdn/nzz109
In total, 22 studies were eligible including 7 randomized controlled trial, 1 nonrandomized trial, and 14 prospective observational studies.
In total, 22 studies were eligible including 7 randomized controlled trial, 1 nonrandomized trial, and 14 prospective observational studies.
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10.2196/12281
Methods A systematic search of multiple databases from 1973 to July 2018 was conducted for randomized and nonrandomized trials investigating technology-supported self-guided nutrition and physical activity interventions.
Methods A systematic search of multiple databases from 1973 to July 2018 was conducted for randomized and nonrandomized trials investigating technology-supported self-guided nutrition and physical activity interventions.
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10.7326/M19-0458
Major eligibility criteria were a comparative evaluation of a self-management intervention for adults with epilepsy, delivered in the outpatient setting or by remote technology and using a randomized trial, nonrandomized trial, controlled beforeafter, or prospective cohort study design.
Major eligibility criteria were a comparative evaluation of a self-management intervention for adults with epilepsy, delivered in the outpatient setting or by remote technology and using a randomized trial, nonrandomized trial, controlled beforeafter, or prospective cohort study design.
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10.1097/DCR.0000000000001223
LIMITATIONS: The study was limited by being a retrospective, nonrandomized trial with short follow-up.
LIMITATIONS: The study was limited by being a retrospective, nonrandomized trial with short follow-up.
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10.1089/jwh.2019.7770
Results: This review includes 25 studies (17 randomized control trials plus eight nonrandomized trials).
Results: This review includes 25 studies (17 randomized control trials plus eight nonrandomized trials).
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10.4315/0362-028X.JFP-19-108
We identified 18 relevant randomized controlled trials (RCTs) and 29 nonrandomized trials.
We identified 18 relevant randomized controlled trials (RCTs) and 29 nonrandomized trials.
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10.32768/abc.201963102-112
Mature data from several randomized and prospective nonrandomized trials have contributed to the development of consensus guidelines for selecting the most appropriate candidates ABPI.
Mature data from several randomized and prospective nonrandomized trials have contributed to the development of consensus guidelines for selecting the most appropriate candidates ABPI.
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10.1097/HCO.0000000000000658
RECENT FINDINGS
In contrast to the results of previous nonrandomized trials, the STICH trial showed that patients with viability defined by nuclear perfusion imaging or dobutamine echocardiography did not have improved survival with CABG compared with optimal medical therapy.
RECENT FINDINGS
In contrast to the results of previous nonrandomized trials, the STICH trial showed that patients with viability defined by nuclear perfusion imaging or dobutamine echocardiography did not have improved survival with CABG compared with optimal medical therapy.
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10.1123/JSR.2019-0070
Focused Clinical Question: Does LIAEX within the first 4 weeks following SRC hasten symptom resolution? Summary of Key Findings: Two randomized controlled trials (RCT) and 1 nonrandomized trial involving adolescent athletes (10-19 y) were included.
Focused Clinical Question: Does LIAEX within the first 4 weeks following SRC hasten symptom resolution? Summary of Key Findings: Two randomized controlled trials (RCT) and 1 nonrandomized trial involving adolescent athletes (10-19 y) were included.
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10.1016/B978-0-12-812777-3.00014-3
Though there is much reason to be optimistic, the studies conducted to date with pediatric participants are almost exclusively small-scale and many are open-label, unblinded, nonrandomized trials or case reports.
Though there is much reason to be optimistic, the studies conducted to date with pediatric participants are almost exclusively small-scale and many are open-label, unblinded, nonrandomized trials or case reports.
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10.1249/MSS.0000000000001970
Methods Women with breast cancer scheduled for AC (n = 28) who participated in a nonrandomized trial of exercise training (ET; n = 14) or usual care (UC; n = 14) during AC completed a follow-up evaluation 12 months post-AC completion (16 months from baseline).
Methods Women with breast cancer scheduled for AC (n = 28) who participated in a nonrandomized trial of exercise training (ET; n = 14) or usual care (UC; n = 14) during AC completed a follow-up evaluation 12 months post-AC completion (16 months from baseline).
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10.1016/j.jpainsymman.2018.12.002
The most frequent study design was a one or more group, nonrandomized trial or cohort (67.
The most frequent study design was a one or more group, nonrandomized trial or cohort (67.
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