Introduction to Non Sentinel Node
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The aim of this study was to describe outcome data after the introduction of the technique at our centre, including analysis of false negative rate (FNR), predictive factors for positive sentinel node (SN) and non-sentinel node (NSN), as well as prognostic factors for melanoma-specific survival (MSS).
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When SM was stratified into three groups by increasing size a clear trend was demonstrated with increasing size showing an increasing percentage of patients having positive non-sentinel nodes.
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Objective To investigate the role of one-step nucleic acid amplification assay (OSNA) analysis, in the intra-operative tailoring of full nodal dissection, and to analyze the correlation between the type of sentinel node metastasis and the risk of non-sentinel node metastasis.
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All patients meeting inclusion criteria were assessed by determining the percentage of true positive and negative as well as false negative (by comparing histology of the excised sentinel lymph node with the histology of at least 10 non-sentinel nodes on permanent sections).
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The additional insight offered by ANS into the status of non-sentinel nodes has potential applications in an era of less frequent cALND.
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MethodsAn IRB compliant, retrospective electronic chart review (2010–2017) exploring surgical excision of atypical (non-pulmonary, non-breast, non-sentinel node) lesions guided by Tc-99m MAA perilesional injection.
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Forty percent of SNB-positive patients had involved non-sentinel nodes (SNs) in their completion lymph node dissection.
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Completion axillary lymph node dissection (c-ALND) may not be necessary for all patients as a significant number of patients have no further metastases in non-sentinel nodes (non-SN) and c-ALND may not improve survival.
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