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Mutant Models sentence examples within Evolutionary Mutant Models



Advancing human disease research with fish evolutionary mutant models.



QTL Mapping of Intestinal Neutrophil Variation in Threespine Stickleback Reveals Possible Gene Targets Connecting Intestinal Inflammation and Systemic Health


Mutant Models sentence examples within Esr1 Mutant Models



Abstract A008: PDX-based screen to evaluate and compare approved CDK4/6 inhibitors in breast cancer and determine palbociclib efficacy in additional tumor types



Abstract P6-20-08: Anti-tumor activity of elacestrant (RAD1901) in models harboring ESR1 mutations resistant to standard of care therapies


Mutant Models sentence examples within Zebrafish Mutant Models



Restoring Shank3 in a rostral sensorimotor brainstem nucleus rescues reduced light-evoked behaviors in shank3ab-/- zebrafish.



Metastable Atrial State Underlies the Primary Genetic Substrate for MYL4 Mutation-Associated Atrial Fibrillation



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Mutant Models sentence examples within Damaging Mutant Models



Structure analysis of deleterious nsSNPs in human PALB2 protein for functional inference



Structure analysis of deleterious nsSNPs in human PALB2 protein for functional inference


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10.1016/j.tig.2021.07.002

Advancing human disease research with fish evolutionary mutant models.


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10.1016/j.preteyeres.2021.100999

Of men and mice: Human X-linked retinoschisis and fidelity in mouse modeling


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10.6026//97320630017424

Structure analysis of deleterious nsSNPs in human PALB2 protein for functional inference


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10.1007/s00894-021-04749-6

Improving the specificity of organophosphorus hydrolase to acephate by mutagenesis at its binding site: a computational study


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10.1080/07391102.2021.1874530

Molecular mechanism study of EGFR allosteric inhibitors using molecular dynamics simulations and free energy calculations.


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10.1038/s41598-021-87751-5

A novel tissue specific alternative splicing variant mitigates phenotypes in Ets2 frame-shift mutant models


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10.1158/1538-7445.AM2021-2445

Abstract 2445: Alternative splicing dictates receptor tyrosine kinase fates in glioblastoma


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10.1093/EUROPACE/EUAB116.537

Human-based computational and experimental investigation of disease mechanisms in mutation-specific hypertrophic cardiomyopathy


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10.3390/cells10092311

Epigenetic Dysregulation of Mammalian Male Meiosis Caused by Interference of Recombination and Synapsis


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10.1038/s42003-021-02538-8

ALS-related FUS mutations alter axon growth in motoneurons and affect HuD/ELAVL4 and FMRP activity


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10.3390/brainsci11020152

Lysosome Function and Dysfunction in Hereditary Spastic Paraplegias


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10.1158/1538-7445.AM2021-1104

Abstract 1104: Repotrectinib increases effectiveness of MEK inhibitors in KRAS mutant cancer models


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10.35118/apjmbb.2021.029.3.07

In silico mutational analysis in RNA polymerase β subunit (rpoB) gene of rifampicin-resistant in Mycobacterium tuberculosis from Malaysia


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10.1172/jci.insight.145256

Superresolution microscopy reveals photoreceptor-specific subciliary location and function of ciliopathy-associated protein, Cep290.



Conditional Mutation of Hand1 in the Mouse Placenta Disrupts Placental Vascular Development Resulting in Fetal Loss in Both Early and Late Pregnancy



Pathogenic LRRK2 control of primary cilia and Hedgehog signaling in neurons and astrocytes of mouse brain.


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10.6026/97320630017424

Structure analysis of deleterious nsSNPs in human PALB2 protein for functional inference


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10.1101/2021.03.21.436338

Combined Inhibition of SHP2 and CXCR1/2 Promotes Anti-Tumor T Cell Response in NSCLC


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10.1080/07391102.2021.1930165

Mutations in passive residues modulate 3D-structure of NDM (New Delhi metallo-β-lactamase) protein that endue in drug resistance: a MD simulation approach.


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10.21203/RS.3.RS-83115/V1

Restoring Shank3 in a rostral sensorimotor brainstem nucleus rescues reduced light-evoked behaviors in shank3ab-/- zebrafish.


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10.1053/j.gastro.2021.03.022

Sequential administration of XPO1 and ATR inhibitors enhances therapeutic response in TP53-mutated colorectal cancer.


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10.1158/2159-8290.CD-21-0369

Combined Inhibition of SHP2 and CXCR1/2 Promotes Anti-Tumor T Cell Response in NSCLC.


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10.1523/JNEUROSCI.0041-21.2021

Photoreceptor Disc Enclosure Is Tightly Controlled by Peripherin-2 Oligomerization


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10.1158/1541-7786.MCR-18-1356

Paracrine Interaction of Cancer Stem Cell Populations Is Regulated by the Senescence-Associated Secretory Phenotype (SASP)


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10.1158/1535-7163.TARG-19-A008

Abstract A008: PDX-based screen to evaluate and compare approved CDK4/6 inhibitors in breast cancer and determine palbociclib efficacy in additional tumor types



Mutational Analysis of a Highly Conserved PLSSMXP Sequence in the Small Subunit of Bacillus licheniformis γ-Glutamyltranspeptidase


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10.36648/0975-9344.11.2.135

Production and Characterization of a New Variant of an Anti-Tnfα Antibody with Improved Affinity and Potency


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10.1007/978-3-030-24285-5_6

Role of Heat Shock Proteins (HSP) in Neuroprotection for Ischemic Stroke


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10.1007/978-1-4939-9581-3_13

Rat Models of Metabolic Syndrome.


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10.1186/s40478-019-0775-6

TERT expression is susceptible to BRAF and ETS-factor inhibition in BRAFV600E/TERT promoter double-mutated glioma


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10.1158/1538-7445.AM2019-LB-271

Abstract LB-271: Insight towards therapeutic susceptibility of KRAS mutant cancers from MRTX1257, a novel KRAS G12C mutant selective small molecule inhibitor


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10.1534/g3.119.400685

QTL Mapping of Intestinal Neutrophil Variation in Threespine Stickleback Reveals Possible Gene Targets Connecting Intestinal Inflammation and Systemic Health


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10.1158/1535-7163.TARG-19-A091

Abstract A091: Targeting homologous recombination repair defects in lung cancer


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10.1016/j.jmgm.2019.02.002

Quantifying correlations between mutational sites in the catalytic subunit of γ-secretase.


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10.1158/1538-7445.SABCS18-P6-20-08

Abstract P6-20-08: Anti-tumor activity of elacestrant (RAD1901) in models harboring ESR1 mutations resistant to standard of care therapies


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10.1210/JS.2019-MON-229

MON-229 IRX3 and IRX5 Regulate Downstream Targets that Promote Ovarian Follicle Integrity in Mice


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10.1016/j.envpol.2019.113329

Pxr- and Nrf2- mediated induction of ABC transporters by heavy metal ions in zebrafish embryos.


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10.1161/CIRCULATIONAHA.119.044268

Metastable Atrial State Underlies the Primary Genetic Substrate for MYL4 Mutation-Associated Atrial Fibrillation


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10.1158/1535-7163.MCT-19-0183

ERK Inhibitor LY3214996 Targets ERK Pathway–Driven Cancers: A Therapeutic Approach Toward Precision Medicine


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10.1186/s13287-019-1206-0

The non-homologous end-joining activity is required for Fanconi anemia fetal HSC maintenance


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10.1158/1538-7445.AM2019-955

Abstract 955: Musashi-2 regulates EGFR expression in NSCLC, cell proliferation and survival, response to EGFR inhibitors in EGFR-mutant NSCLC


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10.1158/1535-7163.MCT-19-0170

Tumor Intrinsic Efficacy by SHP2 and RTK Inhibitors in KRAS-Mutant Cancers


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10.1038/s41398-018-0364-7

Constitutional mislocalization of Pten drives precocious maturation in oligodendrocytes and aberrant myelination in model of autism spectrum disorder



QTL mapping of intestinal neutrophil variation and inflammation between threespine stickleback populations reveals links to neurodegenerative disease


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10.1504/IJBRA.2019.10022524

Computational study to understand mechanism of isoniazid drug resistance caused by mutation (R268H) in NADH dehydrogenase of Mycobacterium tuberculosis


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10.1158/1538-7445.AM2019-850

Abstract 850: Evaluating preclinical efficacy of anti-HER2 drug combinations using ER+/HER2 mutant models



The role of conserved arginine in the GH70 family: a computational study of the structural features and their implications on the catalytic mechanism of GTF-SI from Streptoccocus mutans.


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10.1038/s41598-019-45206-y

Structural, functional, and stability change predictions in human telomerase upon specific point mutations


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10.1080/07391102.2019.1590240

Understanding ligands driven mechanism of wild and mutant aryl hydrocarbon receptor in presence of phytochemicals combating Parkinson’s disease: an in silico and in vivo study


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10.1021/acsomega.8b01712

Three Novel Mutations I65S, R66S, and G86R Divulge Significant Conformational Variations in the PTB Domain of the IRS1 Gene


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10.1158/1538-7445.AM2019-LB-114

Abstract LB-114: RAF inhibitor LXH254 effectively inhibits B-and-CRAF, but not ARAF


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10.1016/j.bbr.2018.08.005

Juvenile Shank3b deficient mice present with behavioral phenotype relevant to autism spectrum disorder



Targeting microglia attenuates neuroinflammation‐related neural damage in mice carrying human PLP1 mutations


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