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CHAPTER 10:Conjugate-mediated Delivery of RNAi-based Therapeutics: Enhancing Pharmacokinetics–Pharmacodynamics Relationships of Medicinal Oligonucleotides



Single vs. repeated matrix metalloproteinase-13 knockdown with intra-articular short interfering RNA administration in a murine osteoarthritis model


Modified Sirna sentence examples within Fully Modified Sirna



S-Acyl-2-Thioethyl: A Convenient Base-Labile Protecting Group for the Synthesis of siRNAs Containing 5′-Vinylphosphonate



Intratracheal Administration of siRNA Triggers mRNA Silencing in the Lung to Modulate T Cell Immune Response and Lung Inflammation



Carboxymethyl dextran‐trimethyl chitosan coated superparamagnetic iron oxide nanoparticles: An effective siRNA delivery system for HIV‐1 Nef


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10.1039/9781788015714-00206

CHAPTER 10:Conjugate-mediated Delivery of RNAi-based Therapeutics: Enhancing Pharmacokinetics–Pharmacodynamics Relationships of Medicinal Oligonucleotides


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10.18502/ACTA.V57I2.1760

SiRNA delivery technology for cancer therapy: Promise and challenges


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10.1016/j.biomaterials.2018.11.010

Dual carrier-cargo hydrophobization and charge ratio optimization improve the systemic circulation and safety of zwitterionic nano-polyplexes.


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10.3390/molecules24020225

S-Acyl-2-Thioethyl: A Convenient Base-Labile Protecting Group for the Synthesis of siRNAs Containing 5′-Vinylphosphonate


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10.1016/j.jconrel.2019.06.022

Chemical modulation of siRNA lipophilicity for efficient delivery.



Model Affitin and PEG modifications onto siRNA lipid nanocapsules: cell uptake and in vivo biodistribution improvements


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10.1016/j.omtn.2019.02.013

Intratracheal Administration of siRNA Triggers mRNA Silencing in the Lung to Modulate T Cell Immune Response and Lung Inflammation


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10.1016/j.antiviral.2018.11.006

5′‐triphosphate siRNA targeting HBx elicits a potent anti‐HBV immune response in pAAV‐HBV transfected mice


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10.1021/acschembio.9b00273

Triplex Hybridization of siRNA with Bifacial Glycopolymer Nucleic Acid Enables Hepatocyte-Targeted Silencing.


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10.3390/pharmaceutics11040181

Effect of Cationic Lipid Type in Folate-PEG-Modified Cationic Liposomes on Folate Receptor-Mediated siRNA Transfection in Tumor Cells



Effect of Sugar 2′,4′-Modifications on Gene Silencing Activity of siRNA Duplexes


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10.1016/j.exer.2019.03.006

Cholesterol modification of SDF-1-specific siRNA enables therapeutic targeting of angiogenesis through Akt pathway inhibition.



Augmented antitumor activity of 5‐fluorouracil by double knockdown of MDM4 and MDM2 in colon and gastric cancer cells


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10.1021/acs.bioconjchem.8b00723

siRNA Delivery Using Dithiocarbamate-Anchored Oligonucleotides on Gold Nanorods.


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10.1126/sciadv.aav9322

Bottlebrush-architectured poly(ethylene glycol) as an efficient vector for RNA interference in vivo


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10.1080/03008207.2018.1539082

Single vs. repeated matrix metalloproteinase-13 knockdown with intra-articular short interfering RNA administration in a murine osteoarthritis model


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10.1021/acs.accounts.8b00650

Re-Engineering RNA Molecules into Therapeutic Agents.


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